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Chemical Composition, Pharmacological Effects and Clinical Applications of Cinobufacini

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Chinese Journal of Integrative Medicine 2024年第4期30卷 366-378页

作者： zuo qian XU Ding-qiao YUE Shi-jun FU Rui-jia TANG Yu-ping Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese MedicineXi'an(712046)China

Chinese medicine cinobufacini is an extract from the dried skin of Bufo bufo gargarizans Cantor,with active ingredients of bufadienolides and indole *** further research and clinical applications,it is found that cinobufacini alone or in combination with other therapeutic methods can play an anti-tumor role by controlling proliferation of tumor cells,promoting apoptosis,inhibiting formation of tumor neovascularization,reversing multidrug resistance,and regulating immune response;it also has the functions of relieving cancer pain and regulating immune *** this paper,the chemical composition,pharmacological effects,clinical applications,and adverse reactions of cinobufacini are ***,the extraction of monomer components of cinobufacini,the relationship between different mechanisms,and the causes of adverse reactions need to be further ***,high-quality clinical studies should be conducted.

关键词： cinobufacini chemical composition Chinese medicine pharmacological effect clinical application adverse effect

Effect of arsenite on the proteome of earthworms Eisenia fetida

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Soil Ecology Letters 2023年第1期5卷 181-194页

作者： Yali Wang Yinsheng Li Hongpei Geng qian zuo Michelle Thunders Jiangping Qiu School of Environmental Engineering Henan University of TechnologyZhengzhou 450001China School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240China State Environmental Protection Key Laboratory of Monitoring for Heavy Metal Pollutants Changsha 410000China Department of Pathology and Molecular Medicine University of OtagoWellington 6242New Zealand

Arsenic(As)is broadly distributed due to natural and anthropogenic sources,and it is toxic to *** study aimed to investigate the proteomic response in earthworm exposed to As^(3+).Earthworms were exposed to As^(3+)in soil at 5-80 mg kg1,and samples were collected after 60 days ***-dimensional electrophoresis(2-DE)was used to separate the proteins in earthworm homogenate,then differentially expressed proteins(DEPs)were identified using MALDI-TOF/TOF-MS *** 2-DE,36 DEPs were found and 24 of them were successfully identified.79.2%of DEPs were upregulated compared to the control *** maximum fold change reached 53.8 in spot 3108 in the 80 mg kg^(-1)As *** proteins were not found in the control group but found in the As treated *** were grouped into metabolism,signal transduction,stress-related,transport,regulation,and predicted/hypothetical protein categories based on their *** protein-protein interaction between the DEPs indicated that serum albumin(ALB)is very important,related to 6 other *** were then verified by western blot,the results were in agreement with the proteomic *** identification of induced or repressed proteins because of As^(3+)in earthworms is helpful to explore the underlying mechanisms of soil arsenic ecotoxicity.

关键词： Earthworm As^(3+) Two dimensional electrophoresis MALDI-TOF/TOF-MS Proteomics

Trade-offs/Synergies in Land-use Function Changes in Central China from 2000 to 2015

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Chinese Geographical Science 2021年第4期31卷 711-726页

作者： LI Qing ZHOU Yong XU Tao WANG Li zuo qian LIU Jingyi SU Xueping HE Nan WU Zhengxiang The College of Urban&Environmental Sciences Central China Normal UniversityWuhan 430079China Key Laboratory for Geographical Process Analysis&Simulation of Hubei Province Central China Normal UniversityWuhan 430079China

To solve the problems caused by irrational land-use, studying the functions of land-use, its changing characteristics, and the relationship between each land-use function will be beneficial for achieving sustainable land development. In this research, we constructed an evaluation framework of multiple land-use functions(LUFs) based on sustainable land-use theory. Specifically,, we classified the multiple LUFs into three types: agricultural production function(APF), living function(LVF), and ecological service function(ESF).We then spatialized the economic and social data, and implemented the InVEST(Integrated Valuation of Ecosystem Services and Tradeoffs) model and RUSLE(Revised Universal Soil Loss Equation) model to evaluate each sub-LUF(crop production, aquatic production, woodlands production, livestock production, living space, life quality, water supply, soil conservation, climate regulation, biological conservation) in central China in 2000 and again in 2015. Moreover, by analyzing the changes to LUFs and the relationships between each LUF change, we were able to discern patterns of LUF change in central China. The results show that: (1)42.12% of total territory in the study area increased their APF from 2000 to 2015, while 43.41% of the lands increased their ESF yet only 8.98% of the lands increased their LVF;(2) in Hubei and Hunan, there was more land with an increase of APF than in Anhui or Jiangxi. The APF in Jiangxi exhibited the greatest decline over time period, the LVF increased more in the provincial capital cities than in other regions, and the ESF expanded more in Jiangxi than in the other provinces;and (3) the changes in APF were significantly and positively correlated with changes in LVF. Additionally, changes in ESF were negatively but non-significantly correlated with changes in APF and LVF.

关键词： land planning land-use function(LUF) trade-offs synergies central China

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数字技术与新零售商业模式融合策略研究

科技创新与生产力 2025年第1期46卷 79-81页

作者：左芊湖南开放大学经济管理学院湖南长沙410004

文章介绍了数字技术与新零售商业模式融合可从帮助企业实现精准营销、提升生产效率和创新管理模式的技术。本文通过数字技术与新零售商业模式相互关系的角度出发,分析了数字技术在新零售商业模式构建中的作用,运用数字技术与新零售商业... 详细信息

文章介绍了数字技术与新零售商业模式融合可从帮助企业实现精准营销、提升生产效率和创新管理模式的技术。本文通过数字技术与新零售商业模式相互关系的角度出发,分析了数字技术在新零售商业模式构建中的作用,运用数字技术与新零售商业模式融合策略,为数字技术在新零售商业模式构建体现重要意义。

关键词：数字技术新零售模式融合

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PAHs in surface soils from the western watershed of Bohai Sea

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Chinese Journal Of Geochemistry 2006年第B8期25卷 190-191页

作者： qian zuo Shu TAO Wenxin LIU Laboratory for Earth Surface Processes College of Environmental Sciences Peking University Beijing 10087 China

A Multi-Attribute Decision Making for Investment Decision Based on D Numbers Methods

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Advances in Pure Mathematics 2016年第12期6卷 765-775页

作者： qian zuo Xuanhua Qin Youzhen Tian Daijun Wei School of Science Hubei University for Nationalities Enshi China

Investment decision is a traditional multi-attribute decision making (MADM) problem since it has many uncertainty factors and incomplete information such as investment value, cost, sales, etc. D numbers theory is a useful tool to deal with uncertainty factors and incomplete information. In this paper, interval number and D numbers theory are revealed in the uncertain factor and incomplete information of investment decision. The weights of uncertain factors are calculated using entropy weight method. Thus, a new MADM model for investment decision based on D numbers theory is proposed. Numerical example is used to illustrate the efficiency of the proposed method.

关键词： Uncertainty MADM Investment Decision D Numbers Entropy Weight

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我国环保产业发展历程与新常态下的创新体系

科技管理研究 2016年第21期36卷 263-266页

作者：左茜江苏省科学技术发展战略研究院江苏南京210042

发展环保产业对于促进经济发展与环境保护的双赢具有重要意义。迄今为止,我国环保产业经历了4个发展阶段,即理念构建阶段、初步发展阶段、快速发展阶段和产业升级阶段。环保产业虽然取得了较为快速的发展,但还没有形成体系。在经济新常... 详细信息

发展环保产业对于促进经济发展与环境保护的双赢具有重要意义。迄今为止,我国环保产业经历了4个发展阶段,即理念构建阶段、初步发展阶段、快速发展阶段和产业升级阶段。环保产业虽然取得了较为快速的发展,但还没有形成体系。在经济新常态下,亟待构建环保产业创新体系。从技术合作创新体系、产业服务创新体系和投融资创新体系等维度探讨环保产业创新体系。

关键词：新常态环保产业发展历程创新体系

Linguistic Valued Association Rules

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Systems Science and Systems Engineering 2002年第4期11卷 409-413页

作者： LU Jian-jiang, qian zuo-pingInstitute of Communications Engineering, PLA University of Science & Technology, Nanjing 210016, China Institute of Communications Engineering PLA University of Science & Technology Nanjing 210016 China

Association rules discovering and prediction with data mining method are two topics in the field of information processing. In this paper, the records in database are divided into many linguistic values expressed with normal fuzzy numbers by fuzzy c-means algorithm, and a series of linguistic valued association rules are generated. Then the records in database are mapped onto the linguistic values according to largest subject principle, and the support and confidence definitions of linguistic valued association rules are also provided. The discovering and prediction methods of the linguistic valued association rules are discussed through a weather example last.

关键词： data mining fuzzy c-means algorithm linguistic valued association rules

The effects of 17β-trenbolone and bisphenol A on sexual behavior and social dominance via the hypothalamic-pituitary-gonadal axis in male mice

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Journal of Environmental Sciences 2025年第5期151卷 54-67页

作者： Xiang zuo Minghe Sun Huijuan Bai Shuhui Zhang Jialu Luan qian Yu Zhenhua Fu Qili Zhao Mingzhu Sun Xin Zhao Xizeng Feng College of Life Science State Key Laboratory of Medicinal Chemical BiologyThe Key Laboratory of Bioactive MaterialsMinistry of EducationNankai UniversityTianjin 300071China Institute of Robotics&Automatic Information System College of Artificial IntelligenceNankai UniversityTianjin 300071China

17β-Trenbolone(17-TB)is well documented as an environmental endocrine disruptor in aquatic biological studies,but its effects on mammals remain poorly ***,17-TB acts as a hormone with properties similar to testosterone,and the consequences of juvenile exposure on adult social behavior remain *** A(BPA)acts as an estrogen-like hormone,compared to ***-week-old male Balb/c mice were exposed orally to 17-TB(100μg/(kg·day))and BPA(4 mg/(kg·day))for 28 *** of social interactions and a three-chamber test showed that 17-TB increased virility in male mice,intensified both male and female sexual behavior,and attracted and accepted female *** also increased social dominance through tube tests inmalemice and markedly activated the c-Fos^(+)immune response in themedial prefrontal cortex(mPFC)and basal amygdala(BLA).ELISA data showed that 17-TB and BPA exposure significantly affected serum gonadotropin-releasing hormone(GnRH),growth hormone(GH),estradiol(E2),and luteinizing hormone(LH)levels,as well as testicular lesions and androgen receptor(ARβ)and estrogen receptor(ERα)*** transcriptomic analysis further confirmed that could disrupt steroid synthesis and linoleic acid-related biometabolic *** findings suggest the influence of 17-TB and BPA exposure on sexual behavior and fertility in male mice,possibly through modulation of the hypothalamic-pituitary-gonadal *** study provides insights relevant to human reproductive health and neuro-social behavioral research,and the potential risk of environmental disturbances should not be overlooked.

关键词： 17β-Trenbolone(17-TB) Bisphenol A(BPA) hypothalamic-pituitary-gonadal axis(HPG) Sex hormones Social dominance Sexual behavior