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Role of Oncostatin M in the prognosis of inflammatory bowel disease: A meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 228-238页

作者： Yue Yang Kan-zuo Fu Gu Pan Department of Gastroenterology III Heilongjiang Provincial HospitalHarbin 150036Heilongjiang ProvinceChina Department of Nursing The Second Hospital of HarbinHarbin 150056Heilongjiang ProvinceChina

BACKGROUND Oncostatin M(OSM)is a pleiotropic cytokine which is implicated in the path-ogenesis of inflammatory bowel disease(IBD).AIM To evaluate the prognostic role of OSM in IBD *** Literature search was conducted in electronic databases(Google Scholar,Embase,PubMed,Science Direct,Springer,and Wiley).Studies were selected if they reported prognostic information about OSM in IBD *** data were synthesized,and meta-analyses were performed to estimate standardized mean differences(SMDs)in OSM levels between treatment responders and non-res-ponders and to seek overall correlations of OSM with other inflammatory *** Sixteen studies(818 Crohn’s disease and 686 ulcerative colitis patients treated with anti-tumor necrosis factor-based therapies)were *** levels were associated with IBD severity.A meta-analysis found significantly higher OSM levels in non-responders than in responders to therapy[SMD 0.80(0.33,1.27);P=0.001],in non-remitters than in remitters[SMD 0.75(95%CI:0.35 to 1.16);P<0.0001]and in patients with no mucosal healing than in those with mucosal heal-ing[SMD 0.63(0.30,0.95);P<0.0001].Area under receiver operator curve values showed considerable variability between studies but in general higher OSM levels were associated with poor *** had significant correlations with Simple Endoscopic Score of Crohn’s disease[r=0.47(95%CI:0.25 to 0.64);P<0.0001],Mayo Endoscopic Score[r=0.35(95%CI:0.28 to 0.41);P<0.0001],fecal calprotectin[r=0.19(95%CI:0.08 to 0.3);P=0.001],C-reactive protein[r=0.25(95%CI:0.11 to 0.39);P<0.0001],and platelet count[r=0.28(95%CI:0.17 to 0.39);P<0.0001].CONCLUSION OSM is a potential candidate for determining the severity of disease and predicting the outcomes of anti-tumor necrosis factor-based therapies in IBD patients.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Oncostatin M Prognosis

铒对Al-4.5Mg-0.7Mn合金组织与性能的影响

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稀有金属 2006年第4期30卷 462-465页

作者：季小兰邢泽丙聂祚仁邹景霞左铁庸北京工业大学材料与工程学院北京100022

采用拉伸性能测试、金相组织观察、扫描电镜与能谱分析以及X射线衍射等方法,研究了单独添加微量Er和Er,Zr复合添加对Al-4.5Mg-0.7Mn合金组织与性能的影响。结果表明,Er能够明显细化该合金的晶粒(枝晶网胞),改善合金铸态组织。微量Er和Z... 详细信息

采用拉伸性能测试、金相组织观察、扫描电镜与能谱分析以及X射线衍射等方法,研究了单独添加微量Er和Er,Zr复合添加对Al-4.5Mg-0.7Mn合金组织与性能的影响。结果表明,Er能够明显细化该合金的晶粒(枝晶网胞),改善合金铸态组织。微量Er和Zr元素的同时加入,使得Al-4.5Mg-0.7Mn合金的抗拉强度σb和屈服强度σ0.2均有所提高,而对合金的伸长率几乎没有影响。微量Er元素除部分固溶于Al基体外,大部分与Al形成具有L12型结构的Al3Er相,这种细小的Al3Er颗粒与Al基体共格,对合金起强化作用。

关键词：铸态组织力学性能铒 Al3Er

A Novel Analysis Approach of Uniform Persistence for an Epidemic Model with Quarantine and Standard Incidence Rate

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 695-707页

作者： Song-bai GUO Yu-ling XUE Xi-liang LI zuo-huan ZHENG School of Science Beijing University of Civil Engineering and ArchitectureBeijing 102616China School of Mathematics and Statistics Hainan Normal UniversityHaikou 571158China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of Mathematics and Information Science Shandong Technology and Business UniversityYantai 264005China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

Inspired by the transmission characteristics of the coronavirus disease 2019(COVID-19),an epidemic model with quarantine and standard incidence rate is first developed,then a novel analysis approach is proposed for finding the ultimate lower bound of the number of infected individuals,which means that the epidemic is uniformly persistent if the control reproduction number R_(c)>*** approach can be applied to the related biomat hem at ical models,and some existing works can be improved by using *** addition,the infection-free equilibrium V^(0)of the model is locally asymptotically stable(LAS)if R_(c)1.

关键词： uniform persistence epidemic model control reproduction number quarantine standard incidence rate

Diagenetic evolution and reservoir quality of the Oligocene sandstones in the Baiyun Sag, Pearl River Mouth Basin, South China Sea

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Acta Oceanologica Sinica 2024年第2期43卷 67-82页

作者： Bing Tian Shanshan zuo Youwei Zheng Jie Zhang Jiayu Du Jun Tang Institute of Mining and Coal Inner Mongolia University of Science and TechnologyBaotou 014010China Institute of Science Inner Mongolia University of Science and TechnologyBaotou 014010China

The Oligocene Zhuhai sandstones are significant reservoirs for hydrocarbons in the Baiyun Sag, South China *** effective appraisal, exploration and exploitation of such a deep-water hydrocarbon sandstone, samples of five wells from depths of 850 m to 3 000 m were studied. A series of comprehensive petrographic and geochemical analyses were performed to unravel the diagenetic features and their impact on the reservoir ***, the sandstones are dominated by feldspathic litharenites and lithic arenites with fine to medium grain sizes and moderate to good sorting. The reservoir quality varies greatly with a range of porosity from 0.2% to 36.1% and permeability from 0.016 ×10~(–3) μm~2 to 4 301 ×10~(–3) μm~2, which is attributed to complex diagenetic evolution related to sedimentary facies;these include compaction, cementation of calcite, dolomite, siderite and framboidal pyrite in eogenetic stage;further compaction, feldspar dissolution, precipitation of ferrocalcite and ankerite, quartz cements, formation of kaolinite and its illitization, precipitation of albite and nodular pyrite, as well as hydrocarbon charge in mesogenetic stage. The dissolution of feldspar and illitization of kaolinite provide internal sources for the precipitation of quartz cement, while carbonate cements are derived from external sources related to interbedded mudstones and deep fluid. Compaction is the predominant factor in reducing the total porosity, followed by carbonate cementation that leads to strong heterogeneity. Feldspar dissolution and concomitant quartz and clay cementation barely changes the porosity but significantly reduces the *** high-quality reservoirs can be concluded as medium-grained sandstones lying in the central parts of thick underwater distributary channel sandbodies(>2 m) with a high content of detrital quartz but low cement.

关键词： Baiyun Sag Oligocene Zhuhai Formation diagenesis reservoir quality

Contribution of Surface Waves to Sea Surface Temperatures in the Arctic Ocean

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Journal of Ocean University of China 2024年第5期23卷 1151-1162页

作者： WEI Meng SHAO Weizeng SHEN Wei HU Yuyi ZHANG Yu zuo Juncheng College of Oceanography and Ecological Science Shanghai Ocean University China Waterborne Transport Research Institute Ministry of Transport of the People's Republic of China

The aim of our study was to examine the contribution of surface waves from WAVEWATCH-III(WW3) to the variation in sea surface temperature(SST) in the Arctic Ocean. The simulated significant wave height(SWH) were validated against the products from Haiyang-2B(HY-2B) in 2021, obtaining a root mean squared error(RMSE) of 0.45 with a correlation of 0.96 and scatter index of 0.18. The wave-induced effects, i.e., wave breaking and mixing induced by nonbearing waves resulting in changes in radiation stress and Stokes drift, were calculated from WW3, ERA-5 wind, SST, and salinity data from the National Centers for Environmental Prediction and were taken as forcing fields in the Stony Brook Parallel Ocean Model. The results showed that an RMSE of 0.81℃ with wave-induced effects was less than the RMSE of 1.11℃ achieved without the wave term compared with the simulated SST with the measurements from Argos. Considering the four wave effects and sea ice freezing, the SST in the Arctic Ocean decreased by up to 1℃ in winter. Regression analysis revealed that the SWH was linear in SST(values without subtraction of waves) in summer and autumn, but this behavior was not observed in spring or winter due to the presence of sea ice. The interannual variation also presented a negative relationship between the difference in SST and SWH.

关键词： Arctic Ocean sea surface temperature sea surface wave

Wireless electrical stimulation generated by piezoelectric nanomaterial promotes the dental pulp regeneration via regulating mitochondrial Ca^(2+)/PKA signaling pathway

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Journal of Materials Science & Technology 2024年第1期168卷 24-34页

作者： Jianmao Zheng Jiyuan zuo Cairong Xiao Qining Guo Xiaobin Fu Chengyun Ning Peng Yu Guangdong Provincial Key Laboratory of Stomatology Hospital of StomatologySun Yat-Sen UniversityGuangzhou 510080China School of Materials Science and Engineering National Engineering Research Center for Tissue Restoration and ReconstructionSouth China University of TechnologyGuangzhou 510641China

The induction of dental pulp stem cells(DPSCs)into odontogenic differentiation is a cutting-edge method of dental pulp regeneration ***,it remains a challenge to develop biomaterials and ther-apies that can induce odontogenic ***,we propose a wireless electrical stimulation strat-egy to induce DPSCs odontogenic differentiation via K_(0.5)Na_(0.5)NbO_(3)piezoelectric nanoparticles(KNN)and polarized KNN(PKNN),which can be endocytosed by *** vitro,several odontogenic differentiation indexes were also increased in DPSCs treated with KNN and PKNN,and the increase was more obvious in the PKNN *** wireless electrical field promoted mitochondrial calcium concentration via mitochondrial calcium unidirectional transporter(MCU),increased the production of adenosine triphos-phate(ATP),and induced odontogenic differentiation through the activation of the cAMP-PKA signaling *** vivo,dental pulp-like tissue was induced by electrical stimulation wirelessly with KNN and PKNN,which was more clinically friendly compared with the wired device,and the induction was more obvious in the PKNN group consistent with in vitro *** conclusion,this work demonstrates the potential of PKNN as an effective stimulus that can induce odontogenic differentiation of DPSCs and be applied to dental pulp regeneration treatment.

关键词： Piezoelectric nanoparticles Dental pulp stem cells Odontogenic differentiation

Analysis of explosion wave interactions and rock breaking effects during dual initiation

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1788-1798页

作者： Renshu Yang Jinjing zuo Liwei Ma Yong Zhao Zhen Liu Quanmin Xie School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Research Institute of Macro-Safety Science University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Precision Blasting Jianghan UniversityWuhan 430056China

In blasting engineering, the location and number of detonation points, to a certain degree, regulate the propagation direction ofthe explosion stress wave and blasting effect. Herein, we examine the explosion wave field and rock breaking effect in terms of shockwave collision, stress change of the blast hole wall in the collision zone, and crack propagation in the collision zone. The produced shockwave on the collision surface has an intensity surpassing the sum of the intensities of the two colliding explosion shock waves. At the collisionlocation, the kinetic energy is transformed into potential energy with a reduction in particle velocity at the wave front and the wavefront pressure increases. The expansion form of the superposed shock wave is dumbbell-shaped, the shock wave velocity in the collisionarea is greater than the radial shock wave velocity, and the average propagation angle of the explosion shock waves is approximately 60°.Accordingly, a fitted relationship between blast hole wall stress and explosion wave propagation angle in the superposition area is *** the experimental conditions, the superimposed explosion wave stress of the blast hole wall is approximately 1.73 times the singleexplosionwave incident stress. The results of the model test and numerical simulations reveal that large-scale radial fracture cracks weregenerated on the blast hole wall in the superimposed area, and the width of the crack increased. The width of the large-scale radial fracturecracks formed by a strong impact is approximately 5% of the blast hole length. According to the characteristics of blast hole wallcompression, the mean peak pressures of the strongly superimposed area are approximately 1.48 and 1.84 times those of the weakly superimposedand nonsuperimposed areas, respectively.

关键词： blasting shock wave collision high-speed schlieren system crack fracture characteristic explosion wave

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钢铁生产流程CO_2编目分析评价

广州环境科学 2002年第1期17卷 21-24页

作者：周和敏聂祚仁左铁镛北京工业大学材料科学与工程学院北京100022

对钢铁生产的几种流程在研究的系统边界内进行编目分析,结果表明:吨铁产品累计CO_2排放量,直接还原海绵铁>高炉铁;吨钢产品累计CO_2排放量,BF-BOF流程的粗钢CO_2排放量最大,DRI-EAF次之,EAF最小,吨粗钢累计CO_2排放量BF-BOF流程高于EAF... 详细信息

对钢铁生产的几种流程在研究的系统边界内进行编目分析,结果表明:吨铁产品累计CO_2排放量,直接还原海绵铁>高炉铁;吨钢产品累计CO_2排放量,BF-BOF流程的粗钢CO_2排放量最大,DRI-EAF次之,EAF最小,吨粗钢累计CO_2排放量BF-BOF流程高于EAF流程18%;CO_2排放主要在铁前工序,铁后工序CO_2排放量相对较少,因此减少铁前工序能耗是减少CO_2排放量的主要矛盾;由于我国吨钢能耗大于国外先进水平,导致CO_2排放量高于国外35%左右。

关键词： CO2排放环境负荷编目分析钢铁生产流程评价冶金行业二氧化碳

Oxidation Resistance of In Situ Reaction/Hot Pressing Synthesized Ti_(2)AlC-20%TiB_(2) Composite at 600-900℃in Air

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 739-748页

作者： Wenting Wang Jingjun Xu Jun zuo Ke Ma Yang Li Guangqi He Meishuan Li Shengyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China

The oxidation behavior and kinetics of Ti_(2)AlC-20vol.%TiB_(2) composite at 600-900℃ in air were *** results showed that the oxidation kinetics of the composite followed a logarithmic law within the given temperature range,which indicated that the composites had excellent oxidation *** selective oxidation of Al in Ti_(2)AlC was greatly enhanced,which facilitated the formation of a continuous and dense protective layer of Al_(2)O_(3).Meanwhile,the existence of molten B_(2)O_(3) inhibited the outward diffusion of Ti and inward diffusion of oxygen,which prevented the growth of anatase TiO_(2) at 600℃ and rutile TiO_(2) at 700-900℃.Therefore,the incorporation of TiB_(2) completely inhibited the abnormally rapid oxidation of bulk Ti_(2)AlC at 600℃ and improved its oxidation resistance at 700-900℃.

关键词： MAX phase Ti_(2)AlC-TiB_(2)composite Intermediate temperature oxidation Oxidation kinetics