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Relationships between Diatom Abundances in Rat Organs and in Environmental Waters

Current Medical Science 2021年第5期41卷 981-986页

作者： Liang REN Yi-qun CHEN Qian-li ZHOU zun-zhong liu Ying LI Quan liu Department of Forensic Medicine Tongji Medical CollegeHuazhon^University of Science and TechnologyWuhan 430030China Hubei Key Laboratory of Forensic Science Hubei University of PoliceWuhan 430034China Guangdong Tongji Forensic Science Institute Foshan 516500China

Objective:A diagnosis of drowning remains one of the most challenging issues in forensic science,especially for decomposed *** analysis is considered as an encouraging method for diagnosing *** this study,we developed a drowned rat model using different diatom densities in ***:A total of 120 adult Sprague-Dawley rats were used and divided into six groups,wherein experimental groups 1-5 were drowned rats(group A)and postmortem submersion rats(group B)that were submerged in water with five different Cyclotella *** densities,while the remaining group was used as a blank *** combination of microwave digestion and vacuum filtration method was used to accomplish efficient tissue digestion and ascertain higher accuracy of diatom determinations within ***:The abundances of diatoms in the lungs,livers,and kidneys were significantly *** diatom abundances in the lungs,livers,and kidneys were directly proportional to the water diatom densities,and specific quantitative relationships could be approximated by separate regression equations for each organ ***,the trends associated with the diatom increases among organs slightly *** addition,the diatom abundances in the lungs,livers,and kidneys were all positively *** were not observed in the postmortem submersion groups nor in the blank control ***:The results of this study provide valuable information for establishing a quantitative diatom framework for informing future forensic medicine efforts.

关键词： drowning diatom test quantitative analysis lungs livers kidneys vacuum filtration

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Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng Zheng Wang Zhou Ying Mo Biao Zheng Miaomiao Han Qin zhong Wenwen Yang Peng Gao Lezhi Yang Jilei liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

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The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling zhong Wenjiao Tai Meng-Lu liu Shuaipeng Ma Tianjin Shen Yuhua Zou Chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

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High‑Entropy Electrode Materials:Synthesis,Properties and Outlook

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Nano-Micro Letters 2025年第1期17卷 472-506页

作者： Dongxiao Li Chang liu Shusheng Tao Jieming Cai Biao zhong Jie Li Wentao Deng Hongshuai Hou Guoqiang Zou Xiaobo Ji College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083People’s Republic of China School of Chemistry and Chemical Engineering Hunan Institute of EngineeringXiangtan 411104People’s Republic of China

High-entropy materials represent a new category of high-performance materials,first proposed in 2004 and extensively investigated by researchers over the past two *** definition of high-entropy materials has continuously *** the last ten years,the discovery of an increasing number of high-entropy materials has led to significant advancements in their utilization in energy storage,electrocatalysis,and related domains,accompanied by a rise in techniques for fabricating high-entropy electrode ***,the research emphasis has shifted from solely improving the performance of high-entropy materials toward exploring their reaction mechanisms and adopting cleaner preparation ***,the current definition of high-entropy materials remains relatively vague,and the preparation method of high-entropy materials is based on the preparation method of single metal/low-or medium-entropy *** should be noted that not all methods applicable to single metal/low-or medium-entropy materials can be directly applied to high-entropy *** this review,the definition and development of high-entropy materials are briefly ***,the classification of high-entropy electrode materials is presented,followed by a discussion of their applications in energy storage and catalysis from the perspective of synthesis ***,an evaluation of the advantages and disadvantages of various synthesis methods in the production process of different high-entropy materials is provided,along with a proposal for potential future development directions for high-entropy materials.

关键词： High-entropy Energy storage Electrode materials

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Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期 46-95页

作者： zhong-Liang Gong Hong-Jie Zhang Yan Cheng Jianxun liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong Yong Chen Chang-Jiang Yao Yuan-Yuan Zhu Liang-Jin Xu Yu-Wu zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

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Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization

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Science China Chemistry 2025年第1期 308-316页

作者： Sili Wang Jiancheng Huang Yanan Du Wei Huang Yufeng Xue Xiaokun Xu Guannan zhong Yuanyuan Shi Bin Hong Xiaoying Bian Wen liu State Key Laboratory of Chemical Biology Shanghai Institute of Organic Chemistry University of Chinese Academy of SciencesChinese Academy of Sciences State Key Laboratory of Microbial Technology Shandong University National Health Commission (NHC) Key Laboratory of Biotechnology for Microbial Drugs Institute of Medicinal BiotechnologyChinese Academy of Medical Science & Peking Union Medical College

Cobalamin(Cbl)-dependent radical S-adenosyl-L-methionine(SAM) proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual members. Many of these proteins are involved in the biosynthesis of pharmaceutically important natural products to catalyze chemically demanding reactions. In the biosynthetic pathway of chuangxinmycin(CXM), a unique indole alkaloid antibiotic with potent anti-infective activity, functionalization of the characteristic thiopyrano[4,3,2-cd]indole scaffold by regio-and stereoselective C3-methylation is believed to rely on a Cbl-dependent radical process, which, however, remained to be reconstituted biochemically. We here report the dissection of this enzymatic process, which requires the incorporation of Cxm8, a Cbl-dependent radical SAM protein, with Cxm9, a DUF5825family protein that shares no homology to any proteins of known functions. Cxm8 and Cxm9 function together by forming an unexpected heterodimeric complex that selectively catalyzes C3-methylation of the tricyclic indole-S-hetero ring system in a successive manner, achieving CXM and a recently identified, C3-dimethylated congener. Detailed biochemical characterization,isotope labeling, structural simulation and bioinformatics analysis rationalized the catalysis of the Cxm8/Cxm9 complex and particularly the necessity of the DUF5825 protein for C3-methylase activity. This is the first example that a Cbl-dependent protein acts with a partner to exhibit radical SAM activity.

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong zhong Qiang liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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Measurement and Evolution of High-quality Development Level of Marine Fishery in China

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Chinese Geographical Science 2022年第2期32卷 251-267页

作者： LI Bo liu zun Institute of Marine Sustainable Development Liaoning Normal UniversityDalian 116029China

High-quality development of marine fisheries provides an important advantage for China to build itself into a maritime power and implement the Blue Granary Plan *** on the concepts of‘new development’,‘food security’,and the six dimensions of‘openness,innovation,coordination,green,sharing,and security’,in this study,we established an evaluation index system for the high-quality development of China’s marine fishery *** applied the entropy method to evaluate the high-quality development level of China’s marine fishery sector from 2000 to 2016 and explored its spatial and temporal evolution *** results indicated that:1)from 2000 to 2016,China’s marine fishery sector was in the primary stage of high-quality development;2)spatially,the highquality development of marine fisheries showed an upward trend in all provinces,autonomous regions,and municipalities in the country(not including Hong Kong,Macao and Taiwan of China),and with time,the distribution pattern changed from single to multi-polarization;3)temporally,the development level of high-quality marine fisheries fluctuated during the study *** 2000 to 2010,the growth rate in openness was relatively slow,but after 2010,it increased ***,innovation is the driving force for high-quality *** green and security factors provide a solid guarantee for high-quality *** the high-quality development of a region,economic development is better coordinated,and the distribution of benefits is more *** study provides a theoretical basis to formulate effective marine fishery policies for the high-quality development of the marine fishery sector in *** the high-quality development and evolution process of marine fishery is conducive to promoting the sustainable development of marine fishery industry,ensuring marine fishery food security,and alleviating global food crisis.

关键词： marine fisheries high-quality development new development concept food security spatiotemporal evolution comprehensive measurement

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Background dominant colors extraction method based on color image quick fuzzy c-means clustering algorithm

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Defence Technology（防务技术） 2021年第5期17卷 1782-1790页

作者： zun-yang liu Feng Ding Ying Xu Xu Han College of Electronic Engineering National University of Defense TechnologyNo.460Huangshan RoadShushan DistrictHefeiAnhui230037China

A quick and accurate extraction of dominant colors of background images is the basis of adaptive camouflage *** paper proposes a Color Image Quick Fuzzy C-Means(CIQFCM)clustering algorithm based on clustering spatial ***,the clustering sample space was mapped from the image pixels to the quantized color space,and several methods were adopted to compress the amount of clustering ***,an improved pedigree clustering algorithm was applied to obtain the initial class ***,CIQFCM clustering algorithm was used for quick extraction of dominant colors of background *** theoretical analysis of the effect and efficiency of the CIQFCM algorithm,several experiments were carried out to discuss the selection of proper quantization intervals and to verify the effect and efficiency of the CIQFCM *** results indicated that the value of quantization intervals should be set to 4,and the proposed algorithm could improve the clustering efficiency while maintaining the clustering *** addition,as the image size increased from 128×128 to 1024×1024,the efficiency improvement of CIQFCM algorithm was increased from 6.44 times to 36.42 times,which demonstrated the significant advantage of CIQFCM algorithm in dominant colors extraction of large-size images.

关键词： Dominant colors extraction Quick clustering algorithm Clustering spatial mapping Background image Camouflage design

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Exact Jacobian Elliptic Function Solutions to sinh-Gordon Equation

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Communications in Theoretical Physics 2006年第1期45卷 55-60页

作者： FU zun-Tao liu Shi-Kuo liu Shi-Da School of Physics Peking University Beijing 100871 China State Key Laboratory for Turbulence and Complex Systems Peking University Beijing 100871 China

In this paper, two transformations are introduced to solve sinh-Gordon equation by using the knowledge of elliptic equation and Jacobian elliptic functions. It is shown that different transformations are required in o... 详细信息

关键词： Jacobian elliptic function transformation sinh-Gordon equation

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