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Four new diarylheptanoids and two new terpenoids from the fruits of Alpinia oxyphylla and their anti-inflammatory activities

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Chinese Journal of Natural Medicines 2024年第10期22卷 929-936页

作者： DONG Jie LI Haibo ZHOU Mi yao Xinsheng GENG Jianliang YU yang Institute of Traditional Chinese Medicine & Natural Products College of Pharmacy International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture Jiangsu Kanion Pharmaceutical Co. Ltd. School of Chinese Materia Medica Guangdong Pharmaceutical University

Four previously unreported diarylheptanoids（1a/1b-2a/2b）, one undescribed sesquiterpenoid（8）, one new diterpenoid（12）, and twelve known analogs were isolated from the fruits of Alpinia oxyphylla. The structural elucidation of these compounds was achieved through a comprehensive analysis of spectroscopic data, single-crystal X-ray diffraction, electronic circular dichroism（ECD）,and modified Mosher's method. Enantiomeric mixtures（1a/1b, 2a/2b, 3a/3b, 4a/4b, and 5a/5b） were separated on a chiral column using acetonitrile-water mixtures as eluents. Among them, compounds 3a/3b and 4a/4b were isolated as optically pure enantiomers in the initial chiral separation. Furthermore, most of the isolates were evaluated for their inhibitory effects against the production of nitric oxide（NO） and interleukin-6（IL-6） in lipopolysaccharide（LPS）-induced RAW264.7 macrophages. Interestingly, 2 and 4 showed significant inhibitory activities against NO production with IC50 values of 33.65 and 9.88 μmol·L-1(hydrocortisone: IC5034.26 μmol·L-1),respectively. Additionally, they also partially reduced the secretion of IL-6.

关键词： Alpinia oxyphylla Anti-inflammatory activity Diarylheptanoids Structural elucidation Terpenoids

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Disturbance rejection tube model predictive levitation control of maglev trains

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High-Speed Railway 2024年第1期2卷 57-63页

作者： Yirui Han Xiuming yao Yu yang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing 100044China

Magnetic levitation control technology plays a significant role in maglev *** a controller for the levitation system is challenging due to the strong nonlinearity,open-loop instability,and the need for fast response and *** this paper,we propose a Disturbance-Observe-based Tube Model Predictive Levitation Control(DO-TMPLC)scheme combined with a feedback linearization strategy for the levitation *** proposed strategy incorporates state constraints and control input constraints,i.e.,the air gap,the vertical velocity,and the current applied to the coil.A feedback linearization strategy is used to cancel the nonlinearity of the tracking error ***,a disturbance observer is implemented to actively compensate for disturbances while a TMPLC controller is employed to alleviate the remaining ***,we analyze the recursive feasibility and input-to-state stability of the closed-loop *** simulation results indicate the efficacy of the proposed control strategy.

关键词： Maglev trains Levitation system Constrained control Disturbance observer Model predictive control

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TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway

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Current Medical Science 2024年第3期44卷 519-528页

作者： Jia SONG Dong-lei SUN Chen-yang LI Yu-xin LUO Qian LIU Yue yao Hong ZHANG Ting-ting yang Mei SONG Xin-li BAI Xiao-lan ZHANG Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesShijiazhuang050000China Department of Pediatrics The Second Hospital of Hebei Medical UniversityShijiazhuang050000China

Objective Intestinal fibrosis is a refractory complication of inflammatory bowel disease(IBD).Tumor necrosis factor ligand-related molecule-1A(TL1A)is important for IBD-related intestinal fibrosis in a dextran sodium sulfate(DSS)-induced experimental colitis *** study aimed to explore the effects of TL1A on human colonic *** A trinitrobenzene sulfonic acid(TNBS)-induced experimental colitis model of LCK-CD2-TL1A-GFP transgenic(Tg)or wild-type(WT)mice was established to determine the effect and mechanism of TL1A on intestinal *** human colonic fibroblast CCD-18Co cell line was treated concurrently with TL1A and human peripheral blood mononuclear cell(PBMC)*** proliferation and activation of CCD-18Co cells were detected by BrdU assays,flow cytometry,immunocytochemistry and Western *** metabolism was tested by Western blotting and real-time quantitative polymerase chain reaction(RT-qPCR).Results The level of collagen metabolism in the TNBS+ethyl alcohol(EtOH)/Tg group was greater than that in the TNBS+EtOH/WT *** growth factor-β1(TGF-β1)and p-Smad3 in the TNBS+EtOH/Tg group were upregulated as compared with those in the TNBS+EtOH/WT *** proliferation of CCD-18Co cells was promoted by the addition of human PBMC supernatant supplemented with 20 ng/mL TL1A,and the addition of human PBMC supernatant and TL1A increased CCD-18Co proliferation by 24.4%at 24 ***1A promoted cell activation and increased the levels of COL1A2,COL3A1,and TIMP-1 in CCD-18Co *** of CCD-18Co cells with TL1A increased the expression of TGF-β1 and *** TL1A promotes TGF-β1-mediated intestinal fibroblast activation,proliferation,and collagen deposition and is likely related to an increase in the TGF-β1/Smad3 signaling pathway.

关键词： tumor necrosis factor ligand-related molecule-1A fibrosis inflammatory bowel disease myofibroblasts transforming growth factor-β1

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Efficacy of Danlou tablet(丹蒌片)on myocardial ischemia/reperfusion injury assessed by network pharmacology and experimental verification

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Journal of Traditional Chinese Medicine 2024年第1期44卷 131-144页

作者： yang Ye CHEN Xiaoyang yao Junkai HU Yueyao WANG Wei School of Chinese Medicine Beijing University of Chinese MedicineBeijing 100700China School of Chinese Medicine Guangzhou University of Chinese MedicineGuangzhou 510006China

OBJECTIVE:To investigate the potential pharmacological mechanism of Danlou tablet(丹蒌片,DLT)with a long-term clinical application in the treatment of myocardial ischemia/reperfusion(I/R)injury through network pharmacology,molecular docking and experimental ***:The main chemical ingredients in DLT were retrieved from the Traditional Chinese Medicine(TCM)System Pharmacology Database,the TCM information database,the bioinformatics analysis tool for molecular mechanism of TCM,and HERB *** targets of I/R were accessed from the databases of Online Mendelian Inheritance in Man,Gene Cards,Therapeutic Target Database,and Dis Ge NET *** overlaying genes of DLT and I/R were obtained from the Venny online *** core targets and proteinprotein interaction network were constructed and analyzed via the Search Tool for the Retrieval of Interacting Genes Proteins database and Cytoscape ***,Gene Ontology(GO)analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed by the Metascape *** on the results,the component-target-pathway network was constructed and drafted via the Cytoscape software and the platform of ***,we performed molecular docking to predict the binding information between chemical molecules and target ***,oxygenglucose deprivation/recovery(OGD/R)-induced H9c2 cardiomyocytes were used to validate the results of network pharmacology in ***:A total of 189 active chemical components in DLT and 849 correlative targets of I/R were *** note,133 overlaying genes found from the Venny online platform were concentrated into 28 core ***,the GO and KEGG pathway enrichment analysis presented that DLT might participate in 42 types of GO molecular functions,747 types of GO biological processes,19 types of GO cellular components,and 140 kinds of pathways to treat I/*** the component-targetpathway network,t

关键词： myocardial ischemia reperfusion network pharmacology molecular docking simulation oxygen-glucose deprivation/recovery Danlou tablet

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A MOF built on 8-connected Y3 nodes demonstrates simultaneous reverse adsorptive separation: ethane over ethylene and propane over propylene

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Science China Chemistry 2024年第11期67卷 3657-3661页

作者： Lu-Lu Ma Jiaqi Liu Kang Zhou Zixuan Cao Jiafeng Miao Guo-Ping yang yao-Yu Wang Jing Li Hao Wang Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Shaanxi Key Laboratory of PhysicoInorganic Chemistry College of Chemistry & Materials Science Northwest University Hoffmann Institute of Advanced Materials Shenzhen Polytechnic University Shenzhen Senior High School Department of Chemistry and Chemical Biology Rutgers University

Selective adsorption of paraffins over olefins（mostly C2 and C3） by porous solids could offer tremendous advantages for the purification of olefins, which is, however, challenging as it has stringent requirements on the pore dimensions and pore surface chemistry of the adsorbent. We report here a metal-organic framework（MOF） with novel topology, Y3（μ3-OH）(TCMPB)2(denoted as HIAM-316, TCMPB4-= 1,2,4,5-tetra（4-carboxy-3-methylphenyl）benzene), which shows reversed separation of C2H6/C2H4and C3H8/C3H6simultaneously. The ideal adsorbed solution theory（IAST） selectivities for equimolar binary mixtures of C2H6/C2H4and C3H8/C3H6were calculated to be 1.67 and 1.23 at 1 bar and 298 K for HIAM-316. Its capability of removing paraffines from paraffin/olefin mixtures is validated by breakthrough measurements. Molecular simulations reveal that the preferential adsorption of paraffins over olefins by HIAM-316 may be attributed to the abundant carboxylate oxygen atoms along its channel.

关键词： metal-organic framework adsorption separation

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Genome-Wide Identification of ABCC Gene Subfamily Members and Functional Analysis of CsABCC11 in Camellia sinensis

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 2019-2036页

作者： Mingyuan Luo Shiyu Tian Xinzhuan yao Yue Wan Zhouzhuoer Chen Zifan yang Huagen Hao Fei Liu Hu Tang Litang Lu The Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education) College of Life ScienceGuizhou UniversityGuiyang550025China College of Tea Science Institute of Plant Health&MedicineGuizhou UniversityGuiyang550025China Wengfu Group Guiyang550025China Huaneng Clean Energy Research Institute Guiyang550000China

The ATP-binding cassette(ABC)transporter is a gene superfamily in ***-binding cassette subfamily C(ABCC)protein is a multidrug resistance-associated(MRP)*** play various roles in plant growth,development,and secondary metabolite ***,there are few studies on ABCC transporters in tea *** this study,genome-wide association study(GWAS)analysis of epigallocatechin gallate(EGCG)content in 108 strains of Kingbird revealed that CsABCCs may be involved in EGCG *** identified 25 CsABCC genes at the genomic level of the tea plant,their phylogenetic tree,gene structure,targeted miRNA and other bioinformatics were *** expression patterns of CsABCCs in eight different tissues and abiotic stress indicate that they have potential roles in regulating the growth,development,and defense of tea *** correlation analysis revealed that the expression of the CsABCC11 gene was closely related to the EGCG content in tea buds of 108 strains of the Kingbird,and the subcellular localization experiments in tobacco showed that CsABCC11 protein was localized on the plasma *** virus-induced gene silencing(VIGS)strategy in tea plants further verified that CsABCC11 was involved in EGCG *** study laid a foundation for studying the biological function of CsABCC and provided a new candidate molecular marker gene for further EGCG-related variety breeding,which will be of great interest to breeders.

关键词： Camellia sinensis ABCC gene subfamily EGCG VIGS guizhou local variety Kingbird

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An organic visible-photocatalytic-adsorbence mechanism to high-efficient removal of heavy metal antimony ions

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Materials Reports(Energy) 2024年第3期4卷 49-59页

作者： Linji yang Ke Sun Tao Liu Ciyuan Huang Libin Zhang yang Zhou Kai Chen Shangfei yao Ziyang Zhang Chenfu Zhao Hongxiang Zhu Bingsuo Zou Shuangfei Wang Dongfeng Xue School of Chemistry and Chemical Engineering Guangxi Key Laboratory of Processing for Non-ferrous Metals and Featured MaterialsState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite StructuresSchool of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China Department of Biochemistry and Cell Biology YouJiang Medical University for NationalitiesBaise CityGuangxi Zhuang Autonomous Region 533000China Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhen 518110China

Purification of emerging heavy metal antimony contaminated water based on advanced ingenious *** activated modified coconut shell charcoal(CSC)was synthesized and evaluated as a substrate-supported loaded organic photovoltaic material,PM6:PYIT:PM6-b-PYIT,to prepare a surprisingly highly efficient,stable,environmentally friendly,and recyclable organic photocatalyst(CSC–N–P.P.P),which showed excellent effects on the simultaneous removal of Sb(Ⅲ)and Sb(Ⅴ).The removal efficiency of CSC-N-P.P.P on Sb(Ⅲ)and Sb(Ⅴ)reached an amazing 99.9%in quite a short duration of 15 *** the same time,under ppb level and indoor visible light(~1 W m^(2)),it can be treated to meet the drinking water standards set by the European Union and the *** Environmental Protection Agency in 5 min,and even after 25 cycles of recycling,the efficiency is still maintained at about 80%,in addition to the removal of As(Ⅲ),Cd(Ⅱ),Cr(Ⅵ),and Pb(Ⅱ)can also be *** catalyst not only solves the problems of low reuse rate,difficult structure adjustment and high energy consumption of traditional photocatalysts but also has strong applicability and practical *** pioneering approach provides a much-needed solution strategy for removing highly toxic heavy metal antimony pollution from the environment.

关键词： Organic photocatalyst Photocatalysis Purification Indoor visible light

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管电极耦合激光电解复合加工的理论分析与实验研究

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中国激光 2024年第16期51卷 253-267页

作者：杨雪杨成娟佟浩戚慧敏姚尧杨振天津大学机械工程学院天津300072 天津大学机械工程学院机构理论与装备设计教育部重点实验室天津300072 清华大学机械工程系摩擦学国家重点实验室北京100084 清华大学精密/超精密制造装备与控制北京市重点实验室北京100084

激光电解复合加工是将激光加工与电化学加工相结合的复合加工方法,可用于加工硬质导电材料,具有加快电化学溶解速率、避免重铸层和提高表面质量等优势。笔者提出了一种管电极耦合激光电解复合加工工艺,利用设计的管电极实现了激光能量... 详细信息

激光电解复合加工是将激光加工与电化学加工相结合的复合加工方法,可用于加工硬质导电材料,具有加快电化学溶解速率、避免重铸层和提高表面质量等优势。笔者提出了一种管电极耦合激光电解复合加工工艺,利用设计的管电极实现了激光能量与电化学能量在管电极内部的同轴传导以及在加工间隙处的可控耦合,所提工艺适用于高品质超大深径比小孔的加工。基于激光与电化学能量在加工间隙处的可控调节,提出了以激光加工为主导和以电化学加工为主导的耦合作用机制。通过分析激光辐照区温升对电解质电导率、电流密度、液相传质和电化学溶解速率的影响,以及电解产生的气泡和杂质等对激光能量的影响,建立了激光电解复合加工的材料去除模型,并进行了初步的激光电解复合加工仿真分析与实验研究。

关键词：激光技术电解加工理论模型耦合机制高深径比深孔

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Advancing flood susceptibility modeling using stacking ensemble machine learning: A multi-model approach

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Journal of Geographical Sciences 2024年第8期34卷 1513-1536页

作者： yang Huilin yao Rui DONG Linyao SUN Peng ZHANG Qiang WEI Yongqiang SUN Shao AGHAKOUCHAK Amir School of Geography and Tourism Anhui Normal UniversityWuhu 241002AnhuiChina Changjiang River Scientific Research Institute Wuhan 430015China Advanced Interdisciplinary Institute of Environment and Ecology Beijing Normal UniversityZhuhai 519087GuangdongChina Hunan Institute of Water Resources and Hydropower Research Changsha 410007China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Department of Civil and Environmental Engineering University of California IrvineIrvineCA 92697USA

Flood susceptibility modeling is crucial for rapid flood forecasting, disaster reduction strategies, evacuation planning, and decision-making. Machine learning(ML) models have proven to be effective tools for assessing flood susceptibility. However, most previous studies have focused on individual models or comparative performance, underscoring the unique strengths and weaknesses of each model. In this study, we propose a stacking ensemble learning algorithm that harnesses the strengths of a diverse range of machine learning models. The findings reveal the following:(1) The stacking ensemble learning, using RF-XGBCB-LR model, significantly enhances flood susceptibility simulation.(2) In addition to rainfall,key flood drivers in the study area include NDVI, and impervious surfaces. Over 40% of the study area, primarily in the northeast and southeast, exhibits high flood susceptibility, with higher risks for populations compared to cropland.(3) In the northeast of the study area,heavy precipitation, low terrain, and NDVI values are key indicators contributing to high flood susceptibility, while long-duration precipitation, mountainous topography, and upper reach vegetation are the main drivers in the southeast. This study underscores the effectiveness of ML, particularly ensemble learning, in flood modeling. It identifies vulnerable areas and contributes to improved flood risk management.

关键词： flood susceptibility assessment machine learning stacking ensemble learning flood drivers XiangjiangRiverBasin

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Layered oxide cathodes for sodium-ion batteries:microstructure design,local chemistry and structural unit

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Science China Chemistry 2024年第1期67卷 191-213页

作者： Ling-Yi Kong Han-Xiao Liu Yan-Fang Zhu Jia-yang Li Yu Su Hong-Wei Li Hai-Yan Hu Yi-Feng Liu Ming-Jing yang Zhuang-Chun Jian Xin-Bei Jia Shu-Lei Chou yao Xiao Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Because of the low price and abundant reserves of sodium compared with lithium,the research of sodium-ion batteries(SIBs)in the field of large-scale energy storage has returned to the research *** oxides distinguish themselves from the mains cathode materials of SIBs owing to their advantages such as high specific capacity,simple synthesis route,and environmental ***,the commercial development of the layered oxides is limited by sluggish kinetics,complex phase transition and poor air *** on the research ideas from macro-to micro-scale,this review systematically summarizes the current optimization strategies of sodium-ion layered oxide cathodes(SLOC)from different dimensions:microstructure design,local chemistry regulation and structural unit *** the dimension of microstructure design,the various structures such as the microspheres,nanoplates,nanowires and exposed active facets are prepared to improve the slow kinetics and electrochemical ***,from the view of local chemistry regulation by chemical element substitution,the intrinsic electron/ion properties of SLOC have been enhanced to strengthen the structural ***,the optimization idea of endeavors to regulate the physical and chemical properties of cathode materials essentially is put forward from the dimension of structural unit *** opinions and strategies proposed in this review will provide some inspirations for the design of new SLOC in the future.

关键词： sodium-ion batteries layered oxide cathodes microstructure design local chemistry structural unit

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