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Fundamental Research 2024年第2期4卷 353-361页

作者： Lu yang yao Ni Chengpeng Jiang Lu Liu Song Zhang Jiaqi Liu Lin Sun Wentao Xu Institute of Photoelectronic Thin Film Devices and Technology Key Laboratory of Optoelectronic Thin Film Devices and Technology of TianjinEngineering Research Center of Thin Film Photoelectronic TechnologyMinistry of EducationNankai UniversityTianjin 300350China Shenzhen Research Institute of Nankai University Shenzhen 518000China

The ionic environment of body fluids influences nervous functions for maintaining homeostasis in organisms and ensures normal perceptual abilities and reflex *** reflex activities,such as limb movements,are closely associated with potassium ions(K+).In this study,we developed artificial synaptic devices based on ion concentration-adjustable gels for emulating various synaptic plasticities under different K+concentrations in body *** addition to performing essential synaptic functions,potential applications in information processing and associative learning using short-and long-term plasticity realized using ion concentration-adjustable gels are *** synaptic devices can be used for constructing an artificial neural pathway that controls artificial muscle reflex activities and can be used for image pattern *** tests show a strong relationship with ion *** devices could be applied to neuromorphic robots and human-machine interfaces.

关键词： Nervous regulation Artificial synaptic device Ion gel Ion homeostasis Artificial reflex pathway

Human Placental Mesenchymal Stem Cells Relieve Primary Sclerosing Cholangitis via Upregulation of TGR5 in Mdr2^(-/-)Mice and Human Intrahepatic Cholangiocyte Organoid Models

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Research 2024年第2期2023卷 355-372页

作者： Qigu yao Wenyi Chen Yingduo Yu Feiqiong Gao Jiahang Zhou Jian Wu Qiaoling Pan Jinfeng yang Lingling Zhou Jiong Yu Hongcui Cao Lanjuan Li State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases Cllaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affliated HospitalZhejang University School of Medicine79 Qingchun Rd.Hangzhou 310003China National Clinical Research Center for Infectious Diseases HangzhouChina Key Laboratory of Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province 79 Qingchun Rd.Hangzhou 310003China Jjinan Microecological Biomedicine Shandong Laboratory Jinan 250117China

Primary sclerosing cholangitis(PSC)is a biliary disease accompanied by chronic inflammation of the liver and biliary *** stem cells(MSCs)are used to treat liver diseases because of their immune regulation and regeneration-promoting *** study was performed to explore the therapeutic potential of human placental MSCs(hP-MSCs)in PSC through the Takeda G protein-coupled receptor 5(TGR5)receptor *** tissues were collected from patients with PSC and healthy donors(n=4)for RNA sequencing and intrahepatic cholangiocyte organoid ***-MSCs were injected via the tail vein into Mdr2^(-/-),bile duct ligation(BDL),and 3,5-diethoxycarbonyl-1,4-dihydrocollidine(DDC)mouse models or co-cultured with organoids to confirm their therapeutic effect on biliary *** in bile acid metabolic profile were analyzed by liquid chromatography/tandem mass spectrometry(LC-MS/MS).Compared with healthy controls,liver tissues and intrahepatic cholangiocyte organoids from PSC patients were characterized by inflammation and cholestasis,and marked downregulation of bile acid receptor TGR5 ***-MSC treatment apparently reduced the inflammation,cholestasis,and fibrosis in Mdr2^(-/-),BDL,and DDC model *** activating the phosphatidylinositol 3 kinase/extracellular signal-regulated protein kinase pathway,hP-MSC treatment promoted the proliferation of cholangiocytes,and affected the transcription of downstream nuclear factorκB through regulation of the binding of TGR5 and Pellino3,thereby affecting the cholangiocyte inflammatory phenotype.

关键词： inflammation TGR5 Human

Vibration properties of Paulownia wood for Ruan sound quality using machine learning methods

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Journal of Forestry Research 2024年第5期35卷 216-222页

作者： yang yang College of Art and Design Harbin UniversityHarbin 150076People’s Republic of China College of Mechanical and Electrical Engineering Northeast Forestry UniversityHarbin 150040People’s Republic of China

As an important material for manufacturing resonant components of musical instruments,Paulownia has an important influence on the sound quality of *** this paper,a model for evaluating the sound quality of Ruan based on the vibration characteristics of wood is developed using machine learning ***,the selection of materials for Ruan manufacturing relies primarily on manually weighing,observing,striking,and listening by the instrument *** in scientific theory have hindered the quality of the finished *** this study,nine Ruans were manufactured,and a prediction model of Ruan sound quality was proposed based on the raw material information of *** of a total of 180 data sets,145 and 45 sets were chosen for training and validation,*** this paper,typical correlation analysis was used to determine the correlation between two single indicators in two adjacent pairwise combinations of the measured objects in each stage of the production process in *** vibra-tion characteristics of the wood were tested,and a model for predicting the evaluation of Ruan’s acoustic qualities was developed by measuring the vibration characteristics of the resonating plate *** acoustic quality of the Ruan sound board wood was evaluated and predicted using machine learning model generalized regression neural *** results show that the prediction of Ruan sound quality can be achieved using Matlab simulation based on the vibration characteristics of the soundboard *** the model-predicted values were compared with the tradi-tional predicted results,it was found that the generalized regression neural network had good performance,achieving an accuracy of 93.8%which was highly consistent with the experimental *** was concluded that the model can accurately predict the acoustic quality of the Ruan based on the vibration performance of the soundboards.

关键词： Sound quality Wood vibration performance Paulownia wood Machine learning methods

New Raw Materials Ignite the Singularity of Cosmetic Innovation

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China Detergent & Cosmetics 2024年第3期9卷 6-8页

作者： Yi yao yang Xiaofeng Wuhan Pinguan Media Co. Ltd.China

As traced by the Big Bang theory,the starting point of the universe,is called the“Singularity”in Da Ci Hai,an unabridged,comprehensive *** to cosmological reasoning,the singularity has an infinite density of matter,an infinite curvature of space and time,and it is invisible and *** characteristics are analogous to the human imagination at the level of *** the innovation of cosmetic raw materials,there is also the possibility of infinite *** example,in recent years,the scientific research in cosmetic industry the for promoting upgrade in raw materials is quite *** the raw material enterprises,down to the brand company,the investment in raw material innovation is also strengthened at a visible rate.

关键词： infinite visible singularity

Erratum to:Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第9期25卷 801-802页

作者： Weihao ZHENG Qin ZHANG Ziyang ZHAO Pengfei ZHANG Leilei ZHAO Xiaomin WANG Songyu yang Jing ZHANG Zhijun yao Bin HU Gansu Provincial Key Laboratory of Wearable Computing School of Information Science and EngineeringLanzhou UniversityLanzhou730000China Second Clinical School Lanzhou UniversityLanzhou730030China Department of Magnetic Resonance Lanzhou University Second HospitalLanzhou730030China Gansu Province Clinical Research Center for Functional and Molecular Imaging Lanzhou730030China School of Medical Technology Beijing Institute of TechnologyBeijing100081China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai200031China Joint Research Center for Cognitive Neurosensor Technology of Lanzhou University&Institute of Semiconductors Chinese Academy of SciencesLanzhou730000China

The article(Zheng et al.,2024)unfortunately contained a mistake:in Table 3,four"I"elements in the last"LF in thalamus"column are *** four arrows should be"↑"in the following correctversion of Table3.

关键词： connectivity mistake dynamic

Elaborately engineering of lipid nanoparticle for targeting delivery of siRNA and suppressing acute liver injury

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Chinese Chemical Letters 2024年第2期35卷 323-328页

作者： Qiu Wang Qikun Jiang Dan Li Zimeng yang Lin Gao Fan Liu Chang Li yao Feng Zhonggui He Cong Luo Jin Sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Kangya of Ningxia Pharmaceutical Co.Ltd. Yinchuan 750000China

Small interfering RNA(siRNA)-based gene silencing has been considered as a potential therapy modality against inflammatory ***,the effective delivery of siRNA to desired destination still remains challenging due to poor stability,high molecular weight and negative ***,ionizable lipid nanoparticle(LNP)has been extensively used as vector for effective delivery of ***,we report a mannose-modified LNP(M-MC_(3) LNP@TNFα)loading tumor necrosis factorα(TNFα)siRNA for targeting liver macrophages,achieving effectively inhibit acute liver *** M-MC_(3) LNP@TNFαnot only increases the internalization of LNP by macrophages,but also enhances the gene silencing efficiency of TNFαin ***,the M-MC_(3) LNP@TNFαexhibits higher accumulation in liver of healthy mice than that of MC_(3) LNP@TNFα(un-modified LNP)owing to the targeting effect of *** expected,the M-MC_(3) LNP@TNFαsignificantly suppresses the expression of TNFαand ameliorates liver damage in acute liver injury *** a LNP targeting siRNA delivery holds great potential for the treatment of diseases associated with liver in the future.

关键词： Lipid nanoparticle Targeting siRNA delivery Acute liver injury Gene silencing Tumor necrosis factorα

Enhanced fatigue resistance of ferroelectric Al0.65Sc0.35N deposited by physical vapor deposition

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Science China(Information Sciences) 2024年第5期67卷 335-336页

作者： yang LI Danyang yao Yan LIU Zhi JIANG Ruiqing WANG Xu RAN Jiuren ZHOU Qikun WANG Guoqiang WU Genquan HAN School of Microelectronics Xidian University Hangzhou Institute of Technology Xidian University Ultratrend Technologies Inc. Emerging Device and Chip Laboratory Institute of Technological Sciences Wuhan University

Aluminum scandium nitride(AlScN), a Ⅲ-Ⅴ ternary semiconductor, has been recognized as an innovative and promising ferroelectric material in emerging research. Among the characteristics of ferroelectric material, fatigue resistance is a critical measure of the endurance of ferroelectric films and represents an inherent challenge in the pursuit of practical applications.

关键词： Physical vapor deposition

Combining anodic alcohol oxidative coupling for C-C bond formation with cathodic ammonia production

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National Science Review 2024年第5期11卷 217-226页

作者： Leitao Xu Wei Chen Cairong Wang Wenjie Wu Yelin yao Zhifeng Huang Jingcheng Wu Ming yang Yandong Wu Dianke Xie Yuqin Zou Shuangyin Wang State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringAdvanced Catalytic Engineering Research Center of the Ministry of Education Hunan University

Electrocatalytic oxidation of alcohols using heterogeneous catalysts is a promising aqueous, energy-efficient and environmentally friendly approach, especially for coupling different alcohols to prolong the carbon chain via co-oxidation. Precisely regulating critical steps to tailor electrode materials and electrolyte composition is key to selectively coupling alcohols for targeted synthesis. However, selectively coupling different alcohols remains challenging due to the lack of effective catalyst and electrolyte design promoting specific pathways. Herein, we demonstrate a paired electrolysis strategy for combining anodic oxidative coupling of ethanol（EtOH） and benzyl alcohol（PhCH2OH） to synthesize cinnamaldehyde（CAL） and cathodic ammonia production. The strategies involve:（i） utilizing the salt-out effect to balance selective oxidation and coupling rates;（ii） developing platinum-loaded nickel hydroxide electrocatalysts to accelerate intermediate coupling kinetics;（iii） introducing thermodynamically favorable nitrate reduction at the cathode to improve coupling selectivity by avoiding hydrogenation of products while generating valuable ammonia instead of hydrogen. We achieved 85% coupling selectivity and 278 μmol/h NH3productive rate at 100 m A/cm2with a low energy input（～1.63 V）. The membrane-free, low energy, scalable approach with a wide substrate scope highlights promising applications of this methodology. This work advances heterogeneous electrocatalytic synthesis through rational design principles that integrate anodic oxidative coupling with cathodic nitrate reduction reactions, having synergistic effects on efficiency and selectivity.

关键词： anodic alcohol oxidative coupling C–C bond formation cinnamaldehyde cathodic ammonia production

An early scoring system to predict mechanical ventilation for botulism: a single-center-based study

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World Journal of Emergency Medicine 2024年第5期15卷 365-371页

作者： Yaqing An Tuokang Zheng Yanling Dong yang Wu Yu Gong Yu Ma Hao Xiao Hengbo Gao Yingping Tian Dongqi yao Emergency Department the Second Hospital of Hebei Medical UniversityShijiazhuang 050051China

BACKGROUND: Early identification of patients requiring ventilator support will be beneficial for the outcomes of botulism. The present study aimed to establish a new scoring system to predict mechanical ventilation(MV) for botulism ***: A single-center retrospective study was conducted to identify risk factors associated with MV in botulism patients from 2007 to 2022. Univariate analysis and multivariate logistic regression analysis were used to screen out risk factors for constructing a prognostic scoring system. The area under the receiver operating characteristic(ROC) curve was ***: A total of 153 patients with botulism(66 males and 87 females, with an average age of 43 years) were included. Of these, 49 patients(32.0%) required MV, including 21(13.7%) with invasive ventilation and 28(18.3%) with non-invasive ventilation. Multivariate analysis revealed that botulinum toxin type, pneumonia, incubation period, degree of hypoxia, and severity of muscle involvement were independent risk factors for MV. These risk factors were incorporated into a multivariate logistic regression analysis to establish a prognostic scoring system. Each risk factor was scored by allocating a weight based on its regression coefficient and rounded to whole numbers for practical utilization([botulinum toxin type A: 1], [pneumonia: 2], [incubation period ≤1 day: 2], [hypoxia <90%: 2], [severity of muscle involvement: grade Ⅱ, 3;gradeⅢ, 7;grade IV, 11]). The scoring system achieved an area under the ROC curve of 0.82(95% CI 0.75–0.89, P<0.001). At the optimal threshold of 9, the scoring system achieved a sensitivity of 83.7% and a specificity of 70.2%.CONCLUSION: Our study identified botulinum toxin type, pneumonia, incubation period, degree of hypoxia, and severity of muscle involvement as independent risk factors for MV in botulism patients. A score ≥9 in our scoring system is associated with a higher likelihood of requiring MV in botulism patients. This scoring

关键词： Botulism Scoring system Botulinum toxin type Incubation period Hypoxia Pneumonia Severity of muscle involvement

Effect and mechanism of Qingre Huashi decoction on drug-resistant Helicobacter pylori

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World Journal of Gastroenterology 2024年第24期30卷 3086-3105页

作者： Miao-Miao Lin Shan-Shan yang Qiu-Yue Huang Guang-Hui Cui Xiao-Fen Jia yao yang Zong-Ming Shi Hui Ye Xue-Zhi Zhang Department of Integrated Traditional Chinese and Western Medicine Peking University First HospitalBeijing 100034China Institute of Integrated Traditional Chinese and Western Medicine Peking UniversityBeijing 100034China

BACKGROUND Helicobacter pylori(HP),the most common pathogenic microorganism in stomach,can induce inflammatory reactions in the gastric mucosa,causing chronic gastritis and even gastric *** infection affects over 4.4 billion people globally,with a worldwide infection rate of up to 50%.The multidrug resistance of HP poses a serious challenge to *** has been monstrated that compared to bismuth quadruple therapy,Qingre Huashi decoction(QHD)combined with triple therapy exhibits comparable eradication rates but with a lower incidence of adverse reactions;in addition,QHD directly inhibit and kill HP in *** In this study,12 HP strains were isolated in vitro after biopsy during gastroscopy of HP-infected *** vitro,the minimum inhibitory concentration(MIC)values for clinical HP strains and biofilm quantification were determined through the E-test method and crystal violet staining,*** most robust biofilm-forming strain of HP was selected,and QHD was evaluated for its inhibitory and bactericidal effects on the strain with strong biofilm *** assessment was performed using agar dilution,E-test,killing dynamics,and transmission electron microscopy(TEM).The study also explored the impact of QHD on antibiotic resistance in these HP strains with strong biofilm *** violet method,scanning electron microscopy,laser confocal scanning microscopy,and(p)ppGpp chromatographic identification were employed to evaluate the effect of QHD on biofilm in strong biofilm-forming HP *** effect of QHD on biofilm and efflux pump-related gene expression was evaluated by quantitative polymerase chain ***-targeted metabolomics with UHPLC-MS/MS was used to identify potential metabolic pathways and biomarkers which were different between the NC and QHD *** HP could form biofilms of different degrees in vitro,and the intensity of formation was associated with the drug resistance of the *** had str

关键词： Qingre Huashi decoction Helicobacter pylori Drug resistance Biofilm Metabolomics