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Effect of preemptive local injection of ropivocaine with dexmedetomidine on mirror pain in rats and its mechanism

Asian Pacific Journal of Tropical Medicine 2015年第10期8卷 817-822页

作者： Xi-Zhao Huang Wei-Feng Tu Jie Peng Rong-Fang Deng Kai Mo zu-Rong Hu Yi lu Department of Anesthesiology General Hospital of Guangzhou Military CommandSouthern Medical University Department of Anesthesiology Guangdong Women and Children's Hospital

Objective:To observe the effect of preemptive local injection of ropivocaine with dexmedetomidine on activation of glial cells and on the mirror pain in rats and its ***:A total of 48 adult male Sprague-Dawley rats(weighing 180 g-220 g)were included in the study and randomized into 3 groups,Group S,Group R,and Group RD,.A rat model of persistent postoperative pain evoked by skin/muscle incision and retraction was established in the three *** procedures and nerve extraction,Group S(n=16)was injected 0.9%saline locally;Group R(n=16)was injected 0.5%ropivocaine locally,and Group RD,(n=16)was injected 0.5%ropivocaine in combined with 1μg dexmedetomidine *** the model being established in the three groups,8 rats were used for behavior test until 28 d,and dorsal root ganglions(DRGs)of the other 8 rats were harvested on the3 rd day after *** and transmission electron microscopy were used to observe the activation of glial cells in DRG,and the behavior test results in the three groups were ***:The results showed that mechanical pain threshold in ipsilateral hindpaws of the Group S,Group R,Group RD,animals dropped to(3.640±1.963)g,(5.827±1.204)g,(7.482)±1.412 g at 3 d respectively;while in contralateral paws dropped to(7.100±1.789)g,(17.687±1.112)g,(16.213±1.345)g on the 3 d *** showed that the glial cells were activated in bilateral side DRG after surgery in 3 groups,but ipsilateral paws expressed more active glial cells than contralateral *** electron microscopy showed that mitochondria swelling/vacuolization and lysosomes were more obvious in ipsilateral paws than contralateral paws,but Group RD,formula could reduce glial cells activity,mitochondria swelling/vacuolization and the amount of ***:Local injection of ropivocaine and/or dexmedetomidine can effectively inhibit the activation of glial cells in DRG,mitigate the pathological changes of neu

关键词： Mirror-image pain Glial cells Ropivocaine Dexmedet

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Enhancement of Electroluminescence by Low-Temperature Deposition of Organic Thin Solid Films

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Chinese Physics Letters 1997年第2期14卷 141-144页

作者： GU Jian-hua XU Min-hua XIAO Zhong-dang lu zu-hong HUANG Song-yu National Laboratory of Molecular and Bioelectronics Southeast UniversityNanjing 210096 Department of Physics East China University of Science and Technologx Shanghai 200237

The electrical and light-emitting behaviors of electroluminescent cells,which consist of naphthoylimide(NPL)as emitting layer and poly(3-octylthiophene)(P3OT)doped with poly(N-vinylcarbazoe)(PVK)as hole transport layer sandwiched between indium-tin-oxide(ITO)and aluminum electrode,have been *** mixed polymer(P3OT:PVK)layer and the emitting layer were deposited by spin coating and by vacuum deposition *** was found that the visible blue emission could be observed from the cells at low bias *** when the ITO substrate was cooled to near the liquid N_(2) temperature during the deposition of NPL emitting layer,the brightness of the cell *** was confirmed that holes could be easily injected into NPL layer with deposition temperature decreased.

关键词： layer Solid sandwich

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Second-order Nonlinearities of CdS Nanoparticles Studied by Hyper-Rayleigh Scattering Technique

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Chinese Chemical Letters 2000年第4期11卷 375-376页

作者： Yu ZHANG Xin wang De Gang FU Ju Zheng LIU zu Hong lu. (National Laboratory of Molecular and Biomolecular Electronics. Department of Chemistry and Chemical Engineering. Southeast University. Nanjing 210096) Natl. Lab. Molec. Biomol. E. Dept. of Chem. and Chem. Engineering Southeast University Nanjing 210096 China

A series of CdS nanoparticles with different surfaces were prepared by colloidal chemical method and reverse micelle method. Their second-order nonlinear optical (NLO) properties were experimentally studied in solution by newly developed hyper-Rayleigh scattering (HRS) technique. The results show that 'per particle' first-order hyperpolarizability beta values are sensitive To the synthetic method and the surface chemical modification.

关键词： second-order nonlinear optical properties hyper-Rayleigh scattering (HRS) first-order hyperpolarizability CdS nanoparticles surface-modification

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Chemo-Enzymic Synthesis of a Four-Chiral-Center Portion of A-23187(Calcimycin)

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Chinese Chemical Letters 1997年第2期8卷 111-113页

作者： Jian Wen Fang zu Yi LI(Shanghai Institute of Organic Chemistry.Academic Sinica354 Fenglin lu. Shanghai 200032) Shanghai Inst. of Organic Chemistry Academic Sinica Shanghai 200032 354 Fenglin Lu China

A four-chiral-center portion of A-23187 was synthesized from a chiral synthon which was obtained from lipase-catalyzed resolution.

关键词： HRMS cm Four Calcimycin Chemo-Enzymic Synthesis of a Four-Chiral-Center Portion of A-23187

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Nanocavities:an Effective Gettering Method for Silicon-on-Insulator Wafers

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Chinese Physics Letters 1998年第7期15卷 516-518页

作者： ZHANG Miao ZENG Jian-min HUANG Ji-po LIN Zi-xin ZHOU zu-yao LIN Cheng-lu State Key Laboratory of Functional Materials for Informatics Ion Beam Laboratory Shanghai Institute of MetallurgyChinese Academy of SciencesShanghai 200050

The 4×10^(16)/cm^(2) H+and 9×10^(16)/cm^(2) He+have been implanted into the silicon substrate of separation-by-implantation-of oxygen(SIMOX)wafers,respectively,followed by a 700℃ annealing to form nanocavities beneath the buried oxide(BOX)*** SIMOX wafers were intentionally contaminated with Cu impurities by implanting different doses of Cu in the top Si *** ion mass spectroscopy and cross-sectional transmission electron microscopy technologies have been employed to investigate the gettering effect of nanocavities to the Cu *** cavities induced either by H^(+) or He^(+) implantation are effective gettering centers for Cu in SIMOX *** annealing at 1000℃ for 90 min,up to 4×10^(15)/cm^(2) Cu has diffused through the BOX layer and been captured by the *** gettering efficiency of cavities increases with the decrease of Cu implantation *** nanocavities provide an attractive method for gettering transition metal impurities in SIMOX materials.

关键词： implantation annealing doses

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Saponins from Paris forrestii(Takht.) H. Li displays potent activity against acute myeloid leukemia by suppressing RNF6/AKT/mTOR signaling pathway

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中国药理学与毒理学杂志 2018年第4期32卷 260-261页

作者： Qin lu Yuan-ming HE Yue-hu wang Li GAO Yun-jing ZHENG zu-bin ZHANG Bi-yin CAO Qi wang Xin-liang MAO Shao-yan HU Department of Hematology & Oncology Children's Hospital of Soochow University Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow University Kunming Institute of Botany Chinese Academy of Sciences Institute of Clinical Pharmacology Guangzhou University of Chinese Medicine

Acute myeloid leukemia(AML) is a heterogeneous disease characterized by the *** of immature myeloid progenitor cells in the bone marrow,compromising of normal *** and ultimately resulting in bone marrow *** is the mainstay treatment for all AML patients,however,drug resistance and clinical relapse limits its *** 5-year survival rate of AML patients is only 26.6%.Survival rates are even lower among patients ages 65 to 74 years(5.3%) and 75 years or older(1.6%).Therefore,exploring novel therapeutic agents is urgent for improving the outcome of patients with *** are amphipathic glycosides found in traditional Chinese *** the present study,we isolated a panel of saponins from Paris forrestii(Takht.) ***,a unique plant found in Tibet and Yunnan provinces,*** examining their activities in suppressing acute myeloid leukemia cell proliferation,total saponins from Paris forrestii(TSPf) displayed more potent activity than individual *** induced more than 40% AML cell apoptosis within 24 h and decreased the viability of all leukemia cell ***-induced apoptosis was confirmed by both Annexin V staining and caspase-3 *** downregulated pro-survival proteins Mcl-1,Bcl-xL and Bcl-2,but *** the expression of tumor suppressor proteins p53,p27,Bax and Beclin *** AKT/mTOR signaling pathway is frequently over activated in various AML cells,and TSPf was found to suppress the *** of both AKT and mTOR,but had no effects on their total protein *** was further *** by the inactivation of 4 EBP-1 and p70 S6 K,two typical downstream signal molecules in the AKT/mTOR *** specifically,TSPf-inactivated AKT/mTOR signaling was found to be associated with downregulated RNF6,a recently identified oncogene in ***6 activated AKT/mTOR,and consistently,knockdown of RNF6 led to inactivation of the AKT/mTOR ***,TSPf suppressed the growth of AML xenog

关键词：急性髓系白血病骨髓衰竭治疗方法临床分析

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RESEARCH ON HYDRODYNAMIC AND WATER QUALITY MODEL FOR TIDAL RIVER NETWORKS

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Journal of Hydrodynamics 2003年第2期15卷 64-70页

作者： Xu zu xin, lu Shi qiang School of Environment Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai 200092, China Lab. of Pollution Control Sch. of Environ. Sci. and Eng. Tongji Univ. Shanghai 200092 China

Hydrodynamic and water quality model for tidal river network is set up withMIKE11 modeling system, according to the features of tidal river networks in plain area. The modelwas calibrated using the hydrological and water quality data of 1999, and the results show that thesimulated values agree with the measured data very well. This model is used to numerically analyzethe effects of low flow augmentation on hydrodynamic and water quality conditions of Suzhou *** simulation results show that the flow augmentation can increase net discharge of Suzhou Creekand improve its ability of re-aeration; and its concentration of dissolved oxygen in the rivernetworks can also increase correspondingly.

关键词： tidal river network water quality model suzhou creek low flow augmentation

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A New Quaternary Ammonium Heteropolyoxotungstate Catalyst for Propylene Epoxidation to Propylene Oxide

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Chinese Chemical Letters 2004年第12期15卷 1491-1493页

作者： Ying lu Meng LI Rong Hua ZHANG zu Wei XI Shuang GAOf Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

A new quatemary ammonium heteropolyoxotungstant (cat.C) is prepared andcharacterized. And the cat.C also is an reaction-controlled phase-transfer catalyst The catalyticsystem of O_2/EAHQ (2-ethylanthrahydroquinone)/cat.c is used for the epoxidation of propylene.Under the optimal conditions, the yield of propylene oxide based on EAHQ is 84.1%, theselectivity for propylene oxide based on propylene is 99.8% and the conversion of propylene basedon EAHQ is 84.3%. The cat.c precipitates after the epoxidation reaction for easy separation.The cat C is stable enough to be recycled three times without any loss in selectivity.

关键词： Epoxidation propylene reaction-controlled phase-transfer catalyst.

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基于知识网格的知识供应模型

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上海交通大学学报 2007年第1期41卷 45-50页

作者：镇璐蒋祖华上海交通大学机械与动力工程学院上海200240

探索了如何在知识网格环境下实现知识供应;提出了基于知识网格的知识供应系统层次图以及各个层次的服务模型;构建了具体的知识网格拓扑结构.在此基础上,分别针对知识网格环境下企业内部的知识生产、企业之间的知识供应进行建模,使知识... 详细信息

探索了如何在知识网格环境下实现知识供应;提出了基于知识网格的知识供应系统层次图以及各个层次的服务模型;构建了具体的知识网格拓扑结构.在此基础上,分别针对知识网格环境下企业内部的知识生产、企业之间的知识供应进行建模,使知识网格能够高效率、智能化地支持在产品创新设计中知识的快速获取和利用.

关键词：知识供应知识网格知识管理

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Effects of Fertilizer Placement and Nitrogen Forms on Soil Nitrogen Diffusion and Migration of Red-Yellow Soil in China

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Agricultural Sciences 2017年第11期8卷 1227-1238页

作者： Chaoqiang Jiang Huoyan wang Dianjun lu Jianmin Zhou Decheng Li Chaolong zu Tobacco Research Institute/Maize Research Institute Anhui Academy of Agricultural Sciences Hefei China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing China

A better understanding of nitrogen (N) diffusion and transformation in soils could reveal the capacity of the biological inorganic N and improve the efficiency of N fertilizers. A field micro-plot experiment was carried out to study the effects of fertilization methods (mixed uniformly with 12 cm top soil, placed in holes at a 12-cm depth, or placed in furrows at a 12-cm depth) and forms of N fertilizers (urea and ammonium phosphate) on the dynamics of soil N’s vertical diffusion and horizontal migration in red-yellow soil. The soil inorganic N ( NH4+-N and NH3--N) content following point deep placement was greater than that from mixed or furrow applications. Under point placement, the migration of soil inorganic N in urea and ammonium phosphate treatments occurred in the 6 - 15 cm layer at a horizontal distance of 0 - 9 cm. However, the nutrient preservation capability of the soil receiving ammonium phosphate was greater than that receiving urea under point deep placement. Thus, point deep placement had a tendency to increase the inorganic N in the soil and reduce inorganic N loss, which probably occurred due to the reduced soil volume with which the N fertilizer was mixed. According to crop growth and fertilizer requirements, the optimized fertilizer placement and N species resulted in a continuously high nutrient supply to crops for 90 d. However, the effects of point deep placement on increasing the N-use efficiency and reducing N loss have to be evaluated under natural field conditions.

关键词： Fertilization Method Nitrogen Fertilizer Point Deep Placement Migration Transformation

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