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Comparison of different lymph node staging systems in prognosis of gastric cancer:a bi-institutional study from Hungary

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Chinese Journal of Cancer Research 2017年第4期29卷 323-332页

作者： Dezso Toth Adrienn Bfra zsolt vargal Miklos Torok Peter peter Akosy Department of General Surgery Kenezy Gyula Teaching Hospital Debrecen 4031 Hungary Department of General Thoracic and Vascular Surgery Kaposi M6r Teaching Hospital Kaposv~r 7400 Hungary Department of Pathology Ken6zy Gyula Teaching Hospital Debrecen 4031 Hungary Department of Oncology Kan6zy Gyula Teaching Hospital Debrecen 4031 Hungary

Objective： The Union for International Cancer Control （UICC） Node （N） classification is the most common used staging method for the prognosis of gastric cancer. It demands adequate, at least 16 lymph nodes （LNs） to be dissected; therefore different staging systems were invented. Methods： Between March 2005 and March 2010, 164 patients were evaluated at the Department of General Surgery in the Ken^zy Gyula Hospital and at the Department of General, Thoracic and Vascular Surgery in the Kaposi M6r Hospital. The 6th, 7th and 8th UICC N-staging systems, the number of examined LNs, the number of harvested negative LNs, the metastatic lymph node ratio （MLR） and the log odds of positive LNs （LODDS） were determined to measure their 5-year survival rates and to compare them to each other. Results： The overall 5year survival rate for all patients was 55.5% with a median overall survival time of 102 months. The tumor stage, gender, UICC N-stages, MLR and the LODDS were significant prognostic factors for the 5-year survival with univariate analysis. The 6th UICC N-stage did not follow the adequate risk in comparing N2 vs. NO and N3 vs. NO with multivariate investigation. Comparison of performances of the residual N classifications proved that the LODDS system was first in the prediction of prognosis during the evaluation of all patients and in cases with less than 16 harvested LNs. The MLR gave the best prognostic prediction when adequate （more than or equal to 16） lymphadenectomy was performed. Conclusions： We suggest the application of LODDS system routinely in western patients and the usage of MLR classification in cases with extended lymphadenectomy.

关键词： Gastric cancer lymph node metastasis prognosis staging system survival

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Current knowledge about pyruvate supplementation:A brief review

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Sports Medicine and Health Science 2024年第4期6卷 295-301页

作者： Robert A.Olek Sylwester Kujach zsolt Radak Department of Athletics Strengthand ConditioningPoznan University of Physical EducationPoznanPoland Department of Neurophysiology Neuropsychology and NeuroinformaticsMedical University of GdanskGdanskPoland Research Institute of Sport Science Hungarian University of Sport ScienceBudapestHungary Faculty of Sport Sciences Waseda UniversityTokorozawaJapan

Pyruvate is a three-carbon ketoacid that occurs naturally in *** is produced through enzymatic reactions in the glycolytic pathway and plays a crucial role in energy *** promising early results,later wellcontrolled studies of physically active people have shown that pyruvate supplementation lasting more than 1 week has no ergogenic ***,some data suggest that ingested pyruvate may be preferentially metabolized without accumulation in the *** exhibits antioxidant activity and can affect the cellular redox state,and exogenous pyruvate can influence metabolism by affecting the acid-base balance of the *** brief review focuses on the potential effects of pyruvate as a supplement for active *** current state of understanding suggests that studies of the effects of pyruvate supplementation should prioritize investigating the timing of pyruvate intake.

关键词： Acidosis Bicarbonate Lactate Nicotinamide adenine dinucleotide Sirtuins

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Effect of Normative and Socioeconomic Power Bases on Japanese Marital Decision-Making Authority

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Management Studies 2019年第2期7卷 139-148页

作者： zsolt varga Wirawan Dony Dahana Sotaro Katsumata Osaka University OsakaJapan

According to normative-resource theory,the balance of marital power is influenced by the effect of socioeconomic resources and subcultural *** purpose of our study is to empirically test the effects of Japanese married individuals’comparative socioeconomic variables—education,age,occupation status,personal income,family income,urban/rural living area,years married,and the presence/number of children;and normative resources—the four dimensions of sex role orientation—on decision-making authority across the stages of automobile *** data of 500 demographically heterogeneous married individuals are analyzed by using a Lasso(least absolute shrinkage and selection operator)regression to select variables and to improve the accuracy of prediction and *** findings reveal that wives’authority is significantly influenced across all stages by their personal income and specific dimensions of their sex role *** the other hand,husbands’authority is not affected by their perception of role norms,but only by their *** to expectations,the effects of education,occupation,and employment status are not significant in any of the cases,opening a discussion for cross-cultural *** findings are interpreted and transformed into actionable items for managerial implications.

关键词： family purchase decision consumer behavior sex role orientation durable product

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Reactive oxygen species promote endurance exercise-induced adaptations in skeletal muscles

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Journal of Sport and Health Science 2024年第6期13卷 780-792页

作者： Scott K.Powers zsolt Radak Li Li Ji Malcolm Jackson Department of Applied Physiology University of FloridaGainesvilleFL 32608USA Research Institute of Sport Science Hungarian University of Sport ScienceBudapest 1123Hungary Department of Kinesiology University of MinnesotaSt.PaulMN 55455USA Department of Musculoskeletal and Ageing Science Institute of Life Course and Medical SciencesUniversity of LiverpoolLiverpool L78TXUK

The discovery that contracting skeletal muscle generates reactive oxygen species(ROS)was first reported over 40 years *** prevailing view in the 1980s was that exercise-induced ROS production promotes oxidation of proteins and lipids resulting in muscle ***,a paradigm shift occurred in the 1990s as growing research revealed that ROS are signaling molecules,capable of activating transcriptional activators/coactivators and promoting exercise-induced muscle *** evidence supports the notion that reduction-oxidation(redox)signaling pathways play an important role in the muscle remodeling that occurs in response to endurance exercise *** review examines the specific role that redox signaling plays in this endurance exercise-induced skeletal muscle *** begin with a discussion of the primary sites of ROS production in contracting muscle fibers followed by a summary of the antioxidant enzymes involved in the regulation of ROS levels in the *** then discuss which redox-sensitive signaling pathways promote endurance exercise-induced muscle adaptation and debate the strength of the evidence supporting the notion that redox signaling plays an essential role in muscle adaptation to endurance exercise *** hopes of stimulating future research,we highlight several important unanswered questions in this field.

关键词： Antioxidants Mitochondrial biogenesis Radicals Redox signaling

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干辣椒复水模型构建及复水后特性和发酵品质研究

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食品与发酵工业 2024年第15期50卷 222-230页

作者：郭美玲姚红黄璐晗武运武亚婷 zsolt Zalan 阚建全杜木英西南大学食品科学学院重庆400715 西南大学中匈食品科学合作研究中心重庆400715 川渝共建特色食品重庆市重点实验室重庆400715 新疆农业大学食品科学与药学学院新疆乌鲁木齐830052 新疆农业科学院农业质量标准与检测技术研究所新疆乌鲁木齐830091 匈牙利农业与生命科学大学食品研究所布达佩斯1022

为探究干辣椒复水后的加工适应性,选取西南地区常见的5个辣椒品种进行复水试验,采用主成分分析筛选综合得分最高的品种并以其为原料制备辣椒酱。结果表明,Peleg模型适用于料液比1:50(g:mL),恒温45℃干辣椒复水过程,复水90 min时5种辣椒... 详细信息

为探究干辣椒复水后的加工适应性,选取西南地区常见的5个辣椒品种进行复水试验,采用主成分分析筛选综合得分最高的品种并以其为原料制备辣椒酱。结果表明,Peleg模型适用于料液比1:50(g:mL),恒温45℃干辣椒复水过程,复水90 min时5种辣椒质构特性较好,微观结构最接近新鲜辣椒,其中二荆条为最适宜复水再加工辣椒品种。以鲜二荆条发酵辣椒酱(A)为对照,对比研究复水二荆条发酵辣椒酱(B)和复水二荆条加蔗糖发酵辣椒酱(C),辣椒酱A的总酸、还原糖和氨基酸含量显著高于辣椒酱B和C(P<0.05),但辣椒酱C的必需氨基酸含量占比(38.43%)最接近理想蛋白模式;辣椒酱B的辣度最高,添加蔗糖后辣椒酱C的辣度显著改善;辣椒酱C和A的感官评分最为接近。试验表明复水二荆条添加蔗糖发酵可提升复水辣椒酱的营养价值,感官品质也更接近鲜二荆条发酵辣椒酱。该研究结果可为复水辣椒的高值化应用提供理论参考。

关键词：干辣椒复水 Peleg模型二荆条辣椒酱

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Iterative signal reconstruction of deliberately clipped SMT signals

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Science China(Information Sciences) 2014年第2期57卷 5-17页

作者： KOLLR zsolt GAZDA Juraj HORVTH Pter varga Lajos KOCUR Duan Budapest University of Technology and Economics Technical University of Koice

Staggered MultiTone(SMT)is a modulation technique showing significantly reduced Adjacent Channel Leakage Ratio(ACLR)resulting in a more compact Power Spectrum Density(PSD)for the transmitted signal,than the well-known and already widely adopted Orthogonal Frequency Division Multiple Access(OFDMA)***,the unique spectral properties of an SMT signal could be degraded by a non-linear element(e.g.a Power Amplifier(PA))in the *** baseband clipping can be applied to the transmitted signal,reducing the notable high Peak-to-Average Power Ratio(PAPR).The objective of this paper is to give a brief introduction to the SMT scheme,with a special emphasis on deliberate clipping efects and their *** paper introduces two receiver-oriented iterative methods aiming at the restoration of the baseband Bit Error Rate(BER)performance of a non-clipped *** methods are evaluated and compared based on numerical *** paper concludes with the selection of a possible candidate for use in systems applying deliberately clipped SMT signals.

关键词： clipping SMT iterative decoding nonlinear distortion PAPR

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Genetic background of phenotypic variation

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Progress in Natural Science:Materials International 2007年第10期17卷 1119-1126页

作者： zsolt Boldogki Department of Biology Faculty of Medicine University of Szeged Somogyi Bela st. 4 H-6720 Szeged Hungary

A noteworthy feature of the living world is its bewildering variability. A key issue in several biological disciplines is the achievement of an understanding of the hereditary basis of this variability. Two opposing, but not necessarily irreconcilable conceptions attempt to explain the underlying mechanism. The gene function paradigm postulates that phenotypic variance is generated by the polymorphism in the coding sequences of genes. However, comparisons of a great number of homologous gene and protein sequences have revealed that they predominantly remained functionally conserved even across distantly related phylogenic taxa. Alternatively, the gene regulation paradigm assumes that differences in the cis-regulatory region of genes do account for phenotype variation within species. An extension of this latter concept is that phenotypic variability is generated by the polymorphism in the overall gene expression profiles of gene networks. In other words, the activity of a particular gene is a system property determined both by the cis-regulatory sequences of the given genes and by the other genes of a gene network, whose expressions vary among individuals, too. Novel proponents of gene function paradigm claim that functional genetic variance within the coding sequences of regulatory genes is critical for the generation of morphological polymorphism. Note, however, that these developmental genes play direct regulatory roles in the control of gene expression.

关键词： evolution gene network gene regulation genetic variance phenotype variation.

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Formability Investigations of High-Strength Dual-Phase Steels

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Acta Metallurgica Sinica(English Letters) 2015年第12期28卷 1471-1481页

作者： Miklós Tisza zsolt Lukács Department of Materials Processing Technology Institute of Materials Science and Technology University of Miskolc

Car manufacturing is always regarded as the key industry behind sheet metal forming, and thus, the requirements of and developments in car manufacturing play a decisive role in the development of sheet metal forming. The automotive industry is faced with contradictory demands and requirements： better performance with lower consumption and less harmful emissions, more safety and comfort; these are extremely difficult to supply simultaneously with conventional materials and conventional manufacturing processes. The fulfillment of these often contradictory requirements is one of the main driving forces in the automotive industry and thus in the material and process developments in sheet metal forming, as well. In recent years, significant developments can be observed in the application of high-strength steels. In this respect, the application of various dual-phase steels is one of the best examples. However, the application of these highstrength steels often leads to formability and manufacturing problems. One formability problem is the springback occurring after sheet metal forming. In the current research, we have dealt mainly with advanced high-strength steels, primarily with dual-phase steels. When applying them, the springback phenomenon is one of the most critical issues. To reduce the tremendous amount of experimental work needed, we also applied numerical simulation using isotropic–kinematic hardening rules. The isotropic–kinematic hardening behavior of a given material in the applied Auto Form numerical package may be characterized with three independent material parameters c, v and K（a detailed explanation of their meaning will be given in the main part of this paper）. However, we found that the material data included in simulation packages for these new high-strength steels are not fully adequate. For the determination of more reliable material parameters and to achieve better simulation results, a new testing device was developed. Numerical simulations were

关键词： Springback Large-strain cyclic deformation High-strength dual-phase steels

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Effect of ageing on colonic mucosal regeneration

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World Journal of Gastroenterology 2011年第25期17卷 2981-2986页

作者： Ferenc Sipos Katalin Leiszter zsolt Tulassay 2nd Department of Internal Medicine Semmelweis University Molecular Medicine Research Unit Hungarian Academy of Sciences

The physiologic and pathologic cellular and molecular changes occurring with age in the human colon affect both the inflammatory process leading to mucosal injury and the regenerative capacity of the *** the one hand,age-related telomere shortening and inflamm-ageing may lead to the development of colonic inflammation,which results in epithelial *** the other hand,the altered migration and function of regenerative stem cells,the age-related methylation of mucosal healing-associated genes,together with the alterations of growth factor signaling with age,may be involved in delayed mucosal *** connections of these alterations to the process of ageing are not fully *** understanding and customtailored modification of these mechanisms are of great clinical importance with regard to disease prevention and modern therapeutic ***,we aim to summarize the age-related microscopic and molecular changes of the human colon,as well as their role in altered mucosal healing.

关键词： Colon Mucosal repair Ageing Colorectalcancer Telomere shortening DNA methylation

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Helicobacter pylori infection: New pathogenetic and clinical aspects

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World Journal of Gastroenterology 2014年第21期20卷 6386-6399页

作者： Krisztina Hagymási zsolt Tulassay 2~(nd) Department of Internal Medicine Semmelweis UniversityH-1088 BudapestHungary

Helicobacter pylori (H. pylori) infects more than half of the world’s human population, but only 1% to 3% of infected people consequently develop gastric adenocarcinomas. The clinical outcome of the infection is determined by host genetic predisposition, bacterial virulence factors, and environmental factors. The association between H. pylori infection and chronic active gastritis, peptic ulcer disease, gastric cell carcinoma, and B cell mucosa-associated lymphoid tissue lymphoma has been well established. With the exception of unexplained iron deficiency anemia and idiopathic thrombocytopenic purpura, H. pylori infection has no proven role in extraintestinal diseases. On the other hand, there is data showing that H. pylori infection could be beneficial for some human diseases. The unpredictability of the long-term consequences of H. pylori infection and the economic challenge in eradicating it is why identification of high-risk individuals is crucial.

关键词： Helicobacter pylori Virulence factor Host factors Gastroduodenal diseases Extraintestinal disorders

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