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新金融评论 2014年第4期 104-108页

作者： zsolt Darvas Bruegel

总体而言,我认为对欧盟区的评论是不正确的,一方面,欧洲经济萧条比我们料想的更严重;另一方面,在欧盟区经常账户还存在赤字,危机之前,其他地区的金融一体化也非常脆弱。我们现在进行结构性改革,不可能一蹴而就,欧元区各个国家的情况也... 详细信息

总体而言,我认为对欧盟区的评论是不正确的,一方面,欧洲经济萧条比我们料想的更严重;另一方面,在欧盟区经常账户还存在赤字,危机之前,其他地区的金融一体化也非常脆弱。我们现在进行结构性改革,不可能一蹴而就,欧元区各个国家的情况也不尽相同。欧洲人民对民主的满意度出现了严重的分化,并由此造成了负面的影响。相应的政策选择包括:一是南欧国家应该调整财政政策,二是建立欧元区的良好环境,三是应该更好地使用欧盟的合作体制。

关键词：萧条经常账户赤字结构性改革民主满意度

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整体解决方案对转速调节控制的冲击

现代制造 2016年第34期 32-34页

作者： zsolt Pekker

在许多生产企业中，产生真空所消耗的能源是能量平衡的重要项目之一。因此，产生真空时的效率高低显得越来越重要，但迄今为止真空泵节能运行的关键技术还没有。

关键词：整体解决方案调节控制转速生产企业能量平衡节能运行真空泵

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酸面团优选组合菌对苦荞麸皮馒头品质的影响

食品与机械 2016年第12期32卷 201-205,223页

作者：王雪婷杜木英廖钰婷何瑞李玉珠 zsolt Zalán 西南大学食品科学学院重庆400715 西南大学重庆市特色食品工程技术研究中心重庆400715 匈牙利国家农业研究和创新中心食品科学研究所匈牙利布达佩斯999024

以安琪酵母和匈牙利酵母发酵苦荞麸皮馒头为对照,通过感官评价和质构分析,同时采用固相微萃取—气相色谱—质谱联用技术,研究酸面团优选组合菌对苦荞麸皮馒头的品质影响。结果表明:3种发酵剂馒头感官评分为:组合菌种(82.2±2.3)>匈牙利... 详细信息

以安琪酵母和匈牙利酵母发酵苦荞麸皮馒头为对照,通过感官评价和质构分析,同时采用固相微萃取—气相色谱—质谱联用技术,研究酸面团优选组合菌对苦荞麸皮馒头的品质影响。结果表明:3种发酵剂馒头感官评分为:组合菌种(82.2±2.3)>匈牙利酵母(80.9±1.3)>安琪酵母(77.1±1.4);在硬度、咀嚼性、胶粘性、内聚性和回复力方面,组合菌组最佳;在弹性方面,匈牙利酵母组最佳,总体上组合菌组的质构特性更佳;在风味物质上,安琪酵母组共检测到44种风味成分,匈牙利酵母组共检测到49种,组合菌组共检测到52种,并且组合菌组的醛类、呋喃类、酯类、酚类以及同类都比安琪酵母组和匈牙利酵母组的相对含量高,还检测到3种特有的酯类物质,说明组合菌种发酵更利于苦荞麸皮馒头风味物质的形成;表明组合菌更有利于发酵苦荞麸皮馒头,更易让消费者接受,为组合菌种的应用提供理论支持。

关键词：苦荞麸皮馒头组合菌风味物质

Genetic update on inflammatory factors in ulcerative colitis: review of the current literature

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World Journal of Gastrointestinal Pathophysiology 2014年第3期5卷 304-321页

作者： Patricia Sarlos Erzsebet Kovesdi Lili Magyari zsolt Banfai Andras Szabo Andras Javorhazy Bela Melegh 1st Department of Internal Medicine University of Pecs Department of Medical Genetics University of Pecs Szentagothai research Centre Department of Urology University of Pecs

Ulcerative colitis(UC) is one of the main types of inflammatory bowel disease, which is caused by dysregulated immune responses in genetically predisposed individuals. Several genetic factors, including interleukin and interleukin receptor gene polymorphisms and other inflammation-related genes play central role in mediating and modulating the inflammation in the human body, thereby these can be the main cause of development of the disease. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but summarized literature is exiguous for challenge health specialist that can used in the clinical practice nowadays. This review summarizes the current literature on inflammationrelated genetic polymorphisms which are associated with UC. We performed an electronic search of Pubmed Database among publications of the last 10 years, using the following medical subject heading terms: UC, ulcerative colitis, inflammation, genes, polymorphisms, and susceptibility.

关键词： Ulcerative colitis Inflammatory factors Genes Polymorphisms Susceptibility

Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis

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World Journal of Gastroenterology 2017年第47期23卷 8415-8425页

作者： roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas zsolt Szakács László Szapáry Péter Hegyi Alexandra Mikó Department of Gastroenterology First Department of MedicineUniversity of Pécs Institute of Bioanalysis University of Pécs Department of Public Health Medicine University of Pécs Department of Pharmacognosy Faculty of PharmacyUniversity of Szeged Institute for Translational Medicine University of Pécs Department of Neurology University of Pécs

AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding *** A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESrD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and Or(odds ratio) were ***1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(Or = 1.786, 95%CI: 1.689-1.888, P rD group(Or = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(Or = 2.510, 95%CI: 1.521-4.144, P red renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P re time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P rD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed.

关键词： Gastrointestinal bleeding Chronic kidney disease Mortality Blood transfusion rebleeding

NKX2-3 and IrGM variants are associated with diseasesu sceptibility to IBD in Eastern European patients

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World Journal of Gastroenterology 2010年第41期16卷 5233-5240页

作者： Nora Meggyesi Lajos S Kiss Magdalena Koszarska Martin Bortlik Dana Duricova Laszlo Lakatos Tamas molnar Martin Lenicek Libor Vítek Istvan Altorjay Maria Papp zsolt Tulassay Pal Miheller Janos Papp Attila Tordai Hajnalka Andrikovics Milan Lukas Peter Laszlo Lakatos Department of Molecular Diagnostics Hun-garian National Blood Transfusion Service H-1113 BudapestHungary 1st Depart-ment of Medicine Semmelweis University H-1083 BudapestHungary IBD Clinicaland research Centre ISCARE IVF and 1st Medical FacultyCharles University 170 04 Prague Czech Republic 1st Department of Medicine Csolnoky F.County Hospital H8200 Veszprem Hungary 1st Department of Medicine University ofSzeged H6720 Szeged Hungary Department of Biochemistry andLaboratory Diagnostics 1st Medical Faculty Charles Univer-sity 170 04 Prague Czech Republic 2nd Department of Medicine University of Debrecen H4032 Debrecen Hungary 2nd Department of Medicine Semmelweis University H1085 Budapest Hungary

AIM: To investigate variants of immunity-related GT-Pase family M (IrGM) and NKX2-3 genes and genotype-phenotype in Eastern European patients with inflammatory bowel disease (IBD).METHODS: We analyzed 1707 Hungarian and Czech subjects with Crohn’s disease (CD) (n = 810, age: 37.1 ± 12.6 years, duration: 10.7 ± 8.4 years) and ulcerative colitis (UC) (n = 428, age: 43.7 ± 15.0 years, duration: 12.6 ± 9.9 years), as well as 469 healthy controls. IrGM rs13361189, NKX2-3 rs10883365 and ECM1 rs13294 polymorphisms were tested by LightCy-cler allele discrimination. Detailed clinical phenotypes were determined by reviewing the medical charts. rESULTS: NKX2-3 rs10883365 variant allele was as-sociated with increased risk for CD (P = 0.009, Or = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, Or = 1.36, 95% CI = 1.13-1.63), whereas variant IrGM allele increased risk for CD (P = 0.029, Or = 1.36, 95% CI = 1.03-1.79). In contrast, ECM1 rs13294 was not associat-ed with either CD or UC. In CD, the variant IrGM allele was associated with a colon-only location (P = 0.02, Or = 1.62, 95% CI = 1.07-2.44), whereas in UC, the ECM1 variant was associated with cutaneous manifestations (P = 0.002, Or = 3.36, 95% CI = 1.48-7.63). Variant alleles did not predict resistance to steroids or azathio-prine, efficacy of infliximab, or need for surgery. CONCLUSION: NKX2-3 and IrGM are susceptibility locifor IBD in Eastern European patients. Further studies are needed to confirm the reported phenotype-genotype associations.

关键词： Crohn’s disease Ulcerative colitis NKX2-3 Immunity-related GTPase family M ECM1 Genotype Phenotype Pharmacogenetics

DNA extraction from paraffin embedded colorectal carcinoma samples: A comparison study of manual vs automated methods,using four commercially kits

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World Journal of Clinical Oncology 2019年第9期10卷 307-317页

作者： zsolt Kovacs Ioan Jung Erzsebet Csernak Zoltan Szentirmay Laura Banias Genoveva rigmanyi Simona Gurzu Department of Pathology University of MedicinePharmacySciences and TechnologyTargu-Mures 530149Romania research Center(CCAMF) University of MedicinePharmacySciences and TechnologyTargu-Mures 540139Romania

BACKGrOUND Nucleic acid isolation from formalin-fixed, paraffin-embedded tissue(FFPET)samples is a daily routine in molecular pathology laboratories, but extraction from FFPET is not always easily achieved. Choosing the right extraction technique is key for further *** To compare the performance of four commercially available kits used for DNA extraction in routine *** DNA isolation was performed on 46 randomly selected formalin-fixed, paraffinembedded(FFPE) colorectal adenocarcinoma(CrC) surgical specimens. Four commercially available extraction kits were used: two for manual DNA extraction(the Pure Link Genomic DNA Mini Kit from Invitrogen and the High Pure FFPE DNA Isolation Kit from roche) and two for automated DNA extraction(the i Prep Genomic DNA Kit from Invitrogen and the Magna Pure LC DNA Isolation Kit from roche). The DNA concentration and quality(odds ratio) among the four systems were compared. The results were correlated with the clinicopathological aspects of CrC cases: age, gender, localization, macro-and microscopic features,lymph node metastases, and the lymph node *** The highest DNA concentration was obtained using the manual kits: 157.24 ±62.99 ng/μL for the Pure Link Genomic DNA Mini Kit and 86.64 ng/μL± 43.84 for the High Pure FFPE DNA Isolation Kit(P r concentrations were obtained with automated systems: 20.39 ± 21.19 ng/μL for the Magna Pure LC DNA Isolation Kit and 8.722 ± 6.408 ng/μL for the i Prep Genomic DNA Kit,with differences between the systems used(P rison between age, gender, tumor localization, pT or pN stage and the lymph node ratio indicated no statistically significant difference in DNA concentration using any of the nucleic acid isolation kits. DNA concentration was influenced by the macroscopic features and grade of differentiation. A higher DNA concentration was obtained for well-differentiated polypoid colorectal adenocarcinomas(CrCs), compared with undif

关键词： DNA isolation Colorectal cancer Paraffin-embedded PureLink Genomic DNA Mini Kit High Pure FFPE DNA Isolation Kit iPrep Genomic DNA Kit MagnaPure LC DNA Isolation Kit

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荧光假单胞菌ZX对葡萄采后灰霉病的防治

食品工业科技 2021年第22期42卷 125-132页

作者：魏雪江孟遥钟涛张曼王智荣 zsolt Zalan FErENC Hegyi KrISZTINA Takacs 杜木英西南大学食品科学学院重庆400715 中匈食品科学联合研究中心重庆400715 匈牙利国家农业创新研究中心匈牙利布达佩斯1022 农业部农产品贮藏保鲜质量安全风险评估实验室(重庆) 重庆400715

研究荧光假单胞菌(Pseudomonas fluorescens)ZX对葡萄采后灰霉病的防治效果。以“巨峰”葡萄为试材,测定*** ZX的控病效果和生长动态,在离体条件下通过孢子萌发观察、挥发性物质抑菌测试、扫描电镜探究其对灰葡萄孢霉(Botrytis cinerea... 详细信息

研究荧光假单胞菌(Pseudomonas fluorescens)ZX对葡萄采后灰霉病的防治效果。以“巨峰”葡萄为试材,测定*** ZX的控病效果和生长动态,在离体条件下通过孢子萌发观察、挥发性物质抑菌测试、扫描电镜探究其对灰葡萄孢霉(Botrytis cinerea)的防治。结果表明,使用*** ZX处理,葡萄果实的发病率仅为24.8%,明显低于对照组(发病率64.67%),病斑直径最小,可以明显抑制***孢子萌发、芽管伸长。*** ZX产生的挥发性物质具有较强的抑菌效果,并且能对***有重寄生作用,破坏菌丝的正常形态。另外,无论是浸泡还是接种处理,*** ZX都能在葡萄果实上快速地定殖生长。由此表明,*** ZX通过抑制***生长来控制葡萄采后灰霉病,为果实采后防腐保鲜提供一种新的选择。

关键词：荧光假单胞菌生物防治葡萄采后病害

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复合菌发酵苦荞麸皮馒头的工艺优化

食品工业科技 2017年第5期38卷 238-245页

作者：何瑞廖钰婷王雪婷李玉珠 zsolt Zalan 杜木英西南大学食品科学学院重庆400715 重庆啤酒股份有限公司重庆400080 匈牙利国家农业研究与创新中心

选取从酸面团筛选的酵母YCY5-2,ZKY7-1及乳酸菌YCL7-3,ZKL10-4进行组合发酵苦荞麸皮馒头,以馒头黄酮含量和感官评定分数作为指标,筛选出发酵苦荞麸皮馒头的最适菌种组合。实验采用响应面法对菌株比例,菌株接种量,发酵时间和醒发时间进... 详细信息

选取从酸面团筛选的酵母YCY5-2,ZKY7-1及乳酸菌YCL7-3,ZKL10-4进行组合发酵苦荞麸皮馒头,以馒头黄酮含量和感官评定分数作为指标,筛选出发酵苦荞麸皮馒头的最适菌种组合。实验采用响应面法对菌株比例,菌株接种量,发酵时间和醒发时间进行了优化。结果表明:最佳组合菌种为YCY5-2和ZKL10-4,苦荞麸皮添加量为20%,最佳工艺条件为YCY5-2∶ZKL10-4=2∶1,菌种添加量为3%,发酵时间为5 h、醒发时间40 min。此条件下苦荞麸皮馒头黄酮含量为(211.33±1.34)mg rutin/100 g,感官评分为(82.2±2.30)。与安琪酵母发酵的苦荞麸皮馒头的黄酮含量((189.70±3.66 mg)rutin/100 g),感官评价(77.1±1.4)及质构相比可知,复合菌馒头的功能和品质均比安琪酵母的好。结论:复合菌发酵的苦荞麸皮馒头具有开发利用的价值。

关键词：乳酸菌酵母菌苦荞麸皮馒头黄酮含量优化