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Chinese Physics B 2018年第3期27卷 410-416页

作者： Jianfei zou and jing Kang College of Science Hohai University Nanjing 210098 China

Based on the tight binding model, we investigate the low energy bandstructures, edge states, and optical absorptions for the silicene nanoribbons （SiNRs） with different terminations under an in-plane exchange field and/or a perpendicular electric field. We find that the zigzag SiNRs are gapped by the exchange field, but they could reenter the metallic state after the application of the electric field. Contrarily, a certain kind of armchair SiNRs remain gapless even if a weak exchange field is present. Furthermore, the combination of the exchange and electric fields could effectively modulate the penetration length and the components of the edge states in the SiNRs. The corresponding optical conductivities for the SiNRs are also calculated, which show remarkable dependence on the edge types of the SiNRs and the two external fields.

关键词： silicene nanoribbon edge state optical conductivity exchange field

Charge transfer interfaces across black phosphorus/Co,N Co-doped carbon heterojunction for enhanced electrocatalytic water splitting

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Journal of Materials Science & Technology 2024年第11期178卷 171-178页

作者： Jizhou Jiang Yongjing Wang jing Wu Hao Wang Arramel Yilun zou jing zou Haitao Wang School of Environmental Ecology and Biological Engineering School of Chemistry and Environmental EngineeringKey Laboratory of Green Chemical Engineering Process of Ministry of EducationEngineering Research Center of Phosphorus Resources Development and Utilization of Ministry of EducationNovel Catalytic Materials of Hubei Engineering Research CenterWuhan Institute of TechnologyWuhan 430205China Key Laboratory of Rare Mineral Ministry of Natural ResourcesGeological Experimental Testing Center of Hubei ProvinceWuhan 430034China Nano Center Indonesia South TangerangBanten 15314Indonesia

The practicality of electrochemical water-splitting technology relies on the development of novel and efficient bifunctional electrocatalysts capable of facilitating both the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).Black phosphorus(BP)holds tremendous promise for HER and OER electrocatalysis owing to its fully exposed atoms and high carrier ***,the elec-trocatalytic performance of BP is still much lower than the expected theoretical limit,presenting an exciting challenge for further ***,we embed electrochemically exfoliated few-layer BP nanosheets in higher Fermi level(EF)of cobalt,nitrogen co-doped carbons to form a new heterojunction(CoNC-BP),as efficient bifunctional electrocatalysts toward HER and OER for the advancement overall water splitting applications.A directed interfacial electron transfer is realized from CoNC to BP,facilitated by the lowering Fermi level(EF).This interfacial electron transfer plays a crucial role in optimizing the adsorption and desorption of active intermediates,while also introducing an abundance of hypervalent Co *** factors collectively contribute to the remarkable electrocatalytic activities of HER and OER performance,leading to the efficient performance of the developed CoNC-BP heterojunction in water-splitting *** work demonstrates a promising breakthrough that can inspire the design of high-efficiency catalysts.

关键词： Directional charge transfer Black phosphorus Co,N co-doped carbon Heterointerface Electrocatalytic water splitting

Missing perilymph but leaking blood-endolymph and vestibulocochlear nerve barriers in idiopathic sudden sensorineural hearing loss:A case study

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Journal of Otology 2020年第4期15卷 171-173页

作者： jing zou Department of Otolaryngology-Head and Neck Surgery Center for Otolaryngology-Head&Neck Surgery of Chinese PLAChanghai HospitalSecond Military Medical UniversityShanghaiChina

Objectives:To evaluate the pathological changes in the blood-perilymph,blood-endolymph,and bloodnerve barriers of a patient with idiopathic sudden sensorineural hearing loss(SSNHL).Methods:Potential ossification or fibrosis in the inner ear was evaluated using temporal bone CT and MRI acquired using the 3-dimensional T2-weighted sampling perfection with application-optimized contrasts using a flip angle evolution *** changes in the barriers were analyzed by MRI obtained 4 h after a single-dose intravenous injection of gadolinium chelate using a medium inversiontime inversion recovery imaging with magnitude reconstruction ***:The perilymph was absent,while significant enhancements of the vestibulocochlear nerve and the endolymphatic compartments were ***:Significant injuries in the blood-endolymph and blood-vestibulocochlear nerve barriers and disabled perilymph production may contribute to the development of SSNHL with poor response to treatments.

关键词： Sensorineural hearing loss MRI Biological barrier Enhancement

Controlled release of dexamethasone from fibrin sealant for intratympanic administration in inner ear therapy

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Journal of Otology 2024年第1期19卷 55-58页

作者： jing zou Department of Otolaryngology-Head and Neck Surgery Changhai HospitalSecond Military Medical UniversityShanghai200433China Faculty of Information Technology and Communication Sciences Tampere UniversityTampereFinland

The aim of the present work was to show the sustainability of fibrin sealant in releasing dexamethasone and adjust the protocol for clinical application of the novel method in the treatment of Meniere’s disease (MD) and sudden sensorineural hearing loss (SSHL).Gelation occurred shortly after mixing dexamethasone-containing fibrinogen with *** was constantly released for at least 16 d at a stable level after 7d in protocol 1 (low-dose),while it was robustly released within 4 d and slowed afterward until 10 d in protocol 2(high-dose).There were significant differences among the time points in Protocol 2 (p<0.01,ANOVA),and the exponential model with the formula y=15.299*e~(-0.483*t) fits the *** estimated concentration of dexamethasone released on 7 d in protocol 2 was slightly lower than that observed in protocol *** fibrin sealant is capable of constantly releasing dexamethasone with adjustable *** and minimally invasive administration of the material can be achieved in the clinic by sequential injections of the fluids using a soft-tipped catheter.

关键词： Intratympanic drug delivery Controlled release Corticosteroids Meniere's disease Sudden sensorineural hearing loss

Autoinflammatory characteristics and short-term effects of delivering high-dose steroids to the surface of the intact endolymphatic sac and incus in refractory Ménière’s disease

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Journal of Otology 2019年第2期14卷 40-50页

作者： jing zou Department of Otolaryngology-Head and Neck Surgery Center for Otolaryngology-Head & Neck Surgery of Chinese PLA Changhai Hospital Second Military Medical University

Objective:To investigate immune-related genetic background in intractable Meniere’s disease(MD)and the immediate results of a novel therapy by delivering steroids to the surface of the intact endolymphatic sac(ES)and incus in a sustainable *** report and methods:Candidate genes involved in immune regulation were sequenced using a nextgeneration sequencing method in a patient with intractable *** were confirmed using the Sanger sequencing *** ES was exposed,and gelatin sponge particles were immersed in highdose methylprednisolone solution and placed onto the surface of ES.“L”-shaped gelatin sponge strips were immersed in dexamethasone solution and served as a guiding device for the steroids by touching the incus and gelatin sponge particles on the surface of the *** sponge particles immersed in dexamethasone solution were placed around the gelatin sponge strips and sealed using fibrin ***:Autoinflammation in the refractory MD case was indicated by genotype,including novel heterozygous mutations of PRF1,UNC13D,SLC29A3,ITCH,and JAK3,as well as *** vertigo was fully relieved immediately after *** and aural fullness were resolved 3 weeks after operation,whereas hearing improved in 2 mon *** recurrence was noted during the 5-monfollow-up,and the final MRI supported the novel therapeutic ***:Autoinflammation was involved in a refractory *** novel therapy,which involves the delivery of steroids to the surface of the intact ES and incus,is effective in relieving vertigo and tinnitus and improves hearing function of refractory MD.

关键词： Vestibular function Tinnitus Genetic disorders Hearing

Postaurical injection is a systemic delivery supported by symmetric distribution of Gd-DOTA in both the ipsilateral and contralateral ears

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Journal of Otology 2015年第4期10卷 136-142页

作者： jing zou Department of Otolaryngology-Head and Neck Surgery Center for Otolaryngology-Head&Neck Surgery of Chinese PLA Changhai Hospital Second Military Medical University Hearing and Balance Research Unit Field of Oto-laryngology School of Medicine University of Tampere

Postaurical injection of therapeutics was recently applied in clinical practice to treat inner ear diseases based on supposed existence of a direct channel from the postaurical area to the inner ear. Doubting on the associated reports and aiming to provide evidence on the inner ear uptake mechanism, the present study tracked the dynamic distribution of gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid (Gd-DOTA) in rat inner ears after postaurical injection using MRI. A targeted tympanic medial wall delivery was utilized as control. The results showed that, at the early time points after postaurical injection, Gd-DOTA distributed mainly in tissues surrounding the bulla, temporal bone and skull and neck space. In the inner ear, there was gradual uptake of Gd-DOTA on both the ipsilateral and contralateral sides with equal signal intensities. There was no sign of direct channel carrying the agent from the postaurical area to the inner ear. Targeted tympanic medial wall delivery induced significantly greater uptake of Gd-DOTA in the inner ear than did postaurical injection. At 30 min post-administration, targeted tympanic medial wall delivery yielded 4.6-folds higher signal intensity than did postaurical injection. The total dose of Gd-DOTA delivered by the targeted tympanic medial wall approach was only 0.1% of that delivered by postaurical injection. In conclusion, postaurical injection is a systemic administration, which is similar to hypodermic injection, rather than a focal delivery method. By contraries, targeted tympanic medial wall delivery induces fast and abundant uptake of Gd-DOTA in the ipsilateral inner ear without significant distribution in unwanted areas.

关键词： Focal drug delivery Inner ear Intratympanic delivery Hypodermic injection Magnetic resonance imaging

High-resolution spatiotemporal mapping:a comprehensive view of eukaryotic cell cycle proteome dynamics

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2354-2356页

作者： jing zou Ziran Qin Long Zhang Life Sciences Institute Second Affiliated Hospital of the Zhejiang University School of MedicineThe MOE Key Laboratory of Biosystems Homeostasis&Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell BiologyZhejiang UniversityHangzhouZhejiangChina The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchangChina Cancer Center Zhejiang UniversityHangzhouZhejiangChina

In a recent study published in Cell,Litsios et *** a highresolution spatiotemporal map of the eukaryotic cell cycle proteome.1 They identified proteome-level changes in both abundance and spatial distribution throughout the cell cycle and provided a valuable resource for future exploration into the global proteome dynamics that drive cell cycle progression(https://***/cellcycle).

关键词： al. cycle dynamics

High temperature thermo-photocatalysis driven carbon removal in direct biogas fueled solid oxide fuel cells

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Chinese Chemical Letters 2021年第11期32卷 3548-3552页

作者： Doudou Gu Guan Zhang jing zou Institute of Hydrogen and Fuel Cell Harbin Institute of TechnologyShenzhenShenzhen 518055China General Education Division School of Humanities Social ScienceThe Chinese University of Hong KongShenzhenShenzhen 518172China School of Civil and Environmental Engineering Harbin Institute of TechnologyShenzhenShenzhen 518055China

Solid oxide fuel cells(SOFCs)can directly convert renewable biogas into electricity with high efficiency at high temperature,however the long-term stability of SOFCs is significantly affected by the carbon deposition on the anode during cell ***,we report a novel carbon removal approach by high temperature infrared light driven photocatalytic *** the comparison of electrochemical performance of Ni-YSZ anode and TiO_(2)modified Ni-YSZ anode in the state-of-the-art single cell(Ni-YSZ/YSZ/LSCM),the modified anodes exhibit markedly improved peak powder density with simulated biogas fuel(70%CH_(4)+30%CO_(2))at 850℃with less coking after 40 h *** high activity and carbon deposition resistance of the modified anode is possibly attributed to the in situ generated hydroxyl radical from the reduced TiO_(x)powder under high temperature infrared light excitation,which is supported by detailed analysis of microstructural information of anodes and the powder-based thermo-photocatalytic experiments.

关键词： Thermo-photocatalysis Infrared light excitation Carbon removal Biogas utilization Solid oxide fuel cells

DNA N^6-methyladenine demethylase ALKBH1 enhances osteogenic differentiation of human MSCs

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Bone Research 2016年第3期4卷 174-182页

作者： Chenchen Zhou Yuting Liu Xiaobing Li jing zou Shujuan zou State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan University

ALKBH1 was recently discovered as a demethylase for DNA N6-methyladenine （N6-mA）, a new epigenetic modification, and interacts with the core transcriptional pluripotency network of embryonic stem cells. However, the role of ALKBH1 and DNA N6-mA in regulating osteogenic differentiation is largely unknown. In this study, we demonstrated that the expression of ALKBH1 in human mesenchymal stem cells （MSCs） was upregulated during osteogenic induction. Knockdown of ALKBH1 increased the genomic DNA N6-mA levels and significantly reduced the expression of osteogenic-related genes, alkaline phosphatase activity, and mineralization. ALKBHl-depleted MSCs also exhibited a restricted capacity for bone formation in vivo. By contrast, the ectopic overexpression of ALKBH1 enhanced osteoblastic differentiation. Mechanically, we found that the depletion of ALKBH1 resulted in the accumulation of N6-mA on the promoter region of ATF4, which subsequently silenced ATF4 transcription. In addition, restoring the expression of ATP by adenovirus-mediated transduction successfully rescued osteogenic differentiation. Taken together, our results demonstrate that ALKBH1 is indispensable for the osteogenic differentiation of MSCs and indicate that DNA N6-mA modifications area new mechanism for the epigenetic regulation of stem cell differentiation.

关键词： ATF Figure MSCs DNA N~6-methyladenine demethylase ALKBH1 enhances osteogenic differentiation of human MSCs

Evaluation indicators for open-source software:a review

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Cybersecurity 2021年第1期4卷 292-315页

作者： Yuhang Zhao Ruigang Liang Xiang Chen jing zou SKLOIS Institute of Information EngineeringChinese Academy of SciencesBeijing 100093China School of Cyber Security University of Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Nantong UniversityNantong 226019China State Grid Economic and Technological Research Institute Co.Ltd. Beijing 102209China

In recent years,the widespread applications of open-source software(OSS)have brought great convenience for software ***,it is always facing unavoidable security risks,such as open-source code defects and security *** find out the OSS risks in time,we carry out an empirical study to identify the indicators for evaluating the *** achieve a comprehensive understanding of the OSS assessment,we collect 56 papers from prestigious academic venues(such as IEEE Xplore,ACM Digital Library,DBLP,and Google Scholar)in the past 21 *** the process of the investigation,we first identify the main concerns for selecting OSS and distill five types of commonly used indicators to assess *** then conduct a comparative analysis to discuss how these indicators are used in each surveyed study and their ***,we further undertake a correlation analysis between these indicators and uncover 13 confirmed conclusions and four cases with controversy occurring in these ***,we discuss several possible applications of these conclusions,which are insightful for the research on OSS and software supply chain.

关键词： Open-source Software Evaluation Indicator Correlation Vulnerability License