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Acta Mathematica Sinica,English Series 2014年第12期30卷 2027-2044页

作者： Rong ZHU Guo hua zou Academy of Mathematics and Systems Science Chinese Academy of Sciences

The linear mixed-effects model （LMM） is a very useful tool for analyzing cluster data. In practice, however, the exact values of the variables are often difficult to observe. In this paper, we consider the LMM with measurement errors in the covariates. The empirical BLUP estimator of the linear combination of the fixed and random effects and its approximate conditional MSE are derived. The application to the estimation of small area is provided. Simulation study shows good performance of the proposed estimators.

关键词： BLUP linear mixed-effects models measurement errors small area estimation

Theoretical Research and Experimental Validation of Elastic Dynamic Load Spectra on Bogie Frame of High-speed Train

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Chinese Journal of Mechanical Engineering 2016年第3期29卷 498-506页

作者： ZHU Ning SUN Shouguang LI Qiang zou hua Engineering Research Center of Structure Reliability and Operation Measurement Technology of Rail Guided Vehicles Ministry of Education Beijing Jiaotong University

When a train runs at high speeds, the external exciting frequencies approach the natural frequencies of bogie critical components, thereby inducing strong elastic vibrations. The present international reliability test evaluation standard and design criteria of bogie frames are all based on the quasi-static deformation hypothesis. Structural fatigue damage generated by structural elastic vibrations has not yet been included. In this paper, theoretical research and experimental validation are done on elastic dynamic load spectra on bogie frame of high-speed train. The construction of the load series that correspond to elastic dynamic deformation modes is studied. The simplified form of the load series is obtained. A theory of simplified dynamic load–time histories is then deduced. Measured data from the Beijing–Shanghai Dedicated Passenger Line are introduced to derive the simplified dynamic load–time histories. The simplified dynamic discrete load spectra of bogie frame are established. Based on the damage consistency criterion and a genetic algorithm, damage consistency calibration of the simplified dynamic load spectra is finally performed. The computed result proves that the simplified load series is reasonable. The calibrated damage that corresponds to the elastic dynamic discrete load spectra can cover the actual damage at the operating conditions. The calibrated damage satisfies the safety requirement of damage consistency criterion for bogie frame. This research is helpful for investigating the standardized load spectra of bogie frame of high-speed train.

关键词： elastic dynamic load spectra finite element method modal deformation calibration bogie frame high-speed train

Genome-wide characterization and expression analysis of WRKY family genes during development and resistance to Colletotrichum fructicola in cultivated strawberry(Fragaria×ananassa Duch.)

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Journal of Integrative Agriculture 2022年第6期21卷 1658-1672页

作者： zou Xiao-hua DONG Chao LIU Hai-ting GAO Qing-hua Shanghai Key Laboratory of Protected Horticultural Technology Forestry and Fruit Tree Research InstituteShanghai Academy of Agricultural Sciences(SAAS)Shanghai 201403P.R.China

Based on the recently published whole-genome sequence of cultivated strawberry ’Camarosa’, in this study, 222FaWRKY genes were identified in the ’Camarosa’ genome. Phylogenetic analysis showed that the 222 FaWRKY candidate genes were classified into three groups, of which 41 were in group Ⅰ, 142 were in group Ⅱ, and 39 were in group Ⅲ. The 222 FaWRKY genes were evenly distributed among the seven chromosomes. The exon–intron structures and motifs of the WRKY genes had evolutionary diversity in different cultivated strawberry genomes. Regarding differential expression, the expression of FaWRKY133 was relatively high in leaves, while FaWRKY63 was specifically expressed in roots. FaWRKY207, 59, 46, 182, 156, 58, 39, 62 and 115 were up-regulated during achene development from the green to red fruit transition. FaWRK181, 166 and 211 were highly expressed in receptacles at the ripe fruit stage. One interesting finding was that Fa WRKY179 and 205 were significantly repressed after Colletotrichum fructicola inoculation in both ’Benihoppe’ and ’Sweet Charlie’ compared with Mock. The data reported here provide a foundation for further comparative genomics and analyses of the distinct expression patterns of FaWRKY genes in various tissues and in response to C. fructicola inoculation.

关键词： Fragaria×ananassa FaWRKY Colletotrichum fructicola structure evolution

Theoretical research and experimental validation of quasi-static load spectra on bogie frame structures of high-speed trains

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Acta Mechanica Sinica 2014年第6期30卷 901-909页

作者： Ning Zhu Shou-Guang Sun Qiang Li hua zou Engineering Research Center of Structure Reliability and Operation Measurement Technology of Rail Guided Vehicles Ministry of EducationBeijing Jiaotong University

One of the major problems in structural fatigue life analysis is establishing structural load spectra under actual operating *** study conducts theoretical research and experimental validation of quasi-static load spectra on bogie frame structures of high-speed *** quasistatic load series that corresponds to quasi-static deformation modes are identified according to the structural form and bearing conditions of high-speed train bogie ***,a force-measuring frame is designed and manufactured based on the quasi-static load *** load decoupling model of the quasi-static load series is then established via calibration ***-static load–time histories,together with online tests and decoupling analysis,are obtained for the intermediate range of the Beijing—Shanghai dedicated passenger *** damage consistency calibration of the quasi-static discrete load spectra is performed according to a damage consistency criterion and a genetic *** calibrated damage that corresponds with the quasi-static discrete load spectra satisfies the safety requirements of bogie frames.

关键词： Load spectra Quasi-static Bogie frame Calibration High-speed train

Severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-N,3-dimethylbenzamide: A case series

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 186-194页

作者： Meng-Xiao Feng hua zou Yuan-Qiang Lu Department of Emergency Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China Occupational Health and Radiation Protection Institute Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051China

Background:The 2-amino-5-chloro-N,3-dimethylbenzamide is a key intermediate in the synthesis of pesticides and ***,no literature currently exists on 2-amino-5-chloro-N,3-dimethylbenzamide poisoning in *** study aimed to reveal the health hazard of this chemical for humans and summarize the clinical characteristics of patients with occupational 2-amino-5-chloro-N,3-dimethylbenzamide ***:This observational study included four patients with 2-amino-5-chloro-N,3-dimethylbenzamide poisoning from June 2022 to July *** entire course of the incidents was described in *** 2-amino-5-chloro-N,3-dimethylbenzamide concentrations were detected by a mass ***-toxylin and eosin staining was performed to assess liver injury,and immunofluorescence was used to evaluate hepatic ***:The 2-amino-5-chloro-N,3-dimethylbenzamide powder(99%purity)entered the human body mainly via the skin and respiratory tract due to poor personal protective *** typical course of 2-amino-5-chloro-N,3-dimethylbenzamide poisoning was divided into latency,rash,fever,organic dam-age,and recovery phases in accordance with the clinical *** and fever may be the important premonitory symptoms for further organ *** chemical was detected in the blood of all patients and caused multiple organ injuries,predominantly liver injury,including kidney,myocardium,and *** patients recovered smoothly after comprehensive treatments,including artificial liver therapy,continuous renal replacement therapy,glucocorticoids,and other symptomatic and supportive *** patient survived by liver *** postoperative pathological findings of the removed liver showed acute liver failure,and immunofluorescence staining confirmed the abundance of mitophagy in residual ***:This study is the first to elaborate the clinical characteristics of patients with 2-amino-5-chloro-N,

关键词： 2-amino-5-chloro-N,3-dimethylbenzamide Poisoning Clinical characteristics Liver injury

A Practical Group Key Management Algorithm for Cloud Data Sharing with Dynamic Group

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China Communications 2016年第6期13卷 205-216页

作者： Wei Song hua zou Haowen Liu Jun Chen State Key Laboratory of Software Engineering Wuhan University School of Computer Wuhan University International School of Software Wuhan University Lab of Storage and quantum computing University of Pittsburgh

Cloud data sharing service, which allows a group of people to work together to access and modify the shared data, is one of the most popular and efficient working styles in the enterprises. However, the cloud server is not completely trusted, and its security could be compromised by monetary reasons or caused by hacking and hardware errors. Therefore, despite of having advantages of scalability and flexibility, cloud storage service comes with privacy and the security concerns. A straightforward method to protect the user's privacy is to encrypt the data stored at the cloud. To enable the authenticated users to access the encrypted cloud data, a practical group key management algorithm for the cloud data sharing application is highly desired. The existing group key management mechanisms presume that the server is trusted. But, the cloud data service mode does not always meet this condition. How to manage the group keys to support the scenario of the cloud storage with a semi-trusted cloud server is still a challenging task. Moreover, the cloud storage system is a large-scale and open application, in which the user group is dynamic. To address this problem, we propose a practical group key management algorithm based on a proxy re-encryption mechanism in this paper. We use the cloud server to act as a proxy tore-encrypt the group key to allow authorized users to decrypt and get the group key by their private key. To achieve the hierarchical access control policy, our scheme enables the cloud server to convert the encrypted group key of the lower group to the upper group. The numerical analysis and experimental results further validate the high efficiency and security of the proposed scheme.

关键词： proxy re-encryption group key management bilinear map encrypted cloud storage

Web service composition algorithm based on TOPSIS

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The Journal of China Universities of Posts and Telecommunications 2011年第4期18卷 89-97页

作者： ZHANG Long-chang zou hua YANG Fang-Chun School of Marketing Management Liaoning Technical University Huludao 125105 China State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications Beijing 100876 China

Independent quality of service （QoS） registration center is difficult to monitor QoS with lots of requests in Intemet environment with a large number of services and lots of service requests. It is able to reduce the load and decrease the failure rate by using multiple QoS registration centers to monitor QoS of some services with lots of requests. In addition, the heterogeneous QoS data close to user＇s habitual expression and adapts to the environment with complexity and uncertainty. This paper introduces a novel Web service composition algorithm based on technique for order preference by similarity to an ideal solution （TOPSIS）（WSCA TOPSIS） to solve the above difficulties for the fu＇st time. WSCA TOPSIS can support multiple decision-makers and heterogeneous QoS data. It includes three main steps： normalizing decision matrix, evaluating alternatives synthetically and evaluating group alternatives synthetically. Other contributions of the paper include a novel algorithm of aggregating QoS and a set of experiments that demonstrate the benefits and effectiveness of our approach. Experimental results show that the proposed algorithm can better support Web service composition with heterogeneous QoS data and multiple decision-makers.

关键词： Web service service composition TOPSIS QoS multiple decision-makers

Analysis of the Load-Stress Response Characteristics of the Bogie Frame in Intercity Electric Multiple Unit

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Chinese Journal of Mechanical Engineering 2018年第2期31卷 227-237页

作者： hua zou Shou-Guang Sun Qiang Li Zun-Song Ren Engineering Research Center of Structure Reliability and Operation Measurement Technology of Rail Guided Vehicles of Ministry of Education Beijing Jiaotong University

Load spectra research for bogie frame requires establishing the load?stress relationship on working condition, which has been omitted by the researchers. With the load?stress of the bogie frame of an intercity Electric Multiple Unit(Hereinafter referred to as EMU) as the research object, an optimization model of the load?stress transfer relationship is established. The load?stress coe cient for EMU bogie frame was calibrated in the laboratory bench and online test was arranged on Dazhou?Chengdu line. Comparison of nonlinear and linear neural networks proves that the linear transitive relation between the load and stress of the bogie frame in the operating process is highly suitable. An optimization model of the load?stress transfer coe cient is obtained. The data calculated with the modified coe cient are closer to the dynamic stress results in the actual operating process than the data calculated with the calibration coe cient. The coe cient of the modified transitive relation is una ected by operating area, empty load, heavy load, or other conditions in the operating process of the intercity EMU. The real loads in actual situations are obtained. The model of online load?stress relationship that is highly suitable for line stress calculation is finally established. The research is helpful for further damage calculation and inferring the time history signal of the load in load spectra research.

关键词： Bogie frame Load Stress Transitive relation Neural network

The small and large subunits of carbamoyl-phosphate synthase exhibit diverse contributions to pathogenicity in Xanthomonas citri ***

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Journal of Integrative Agriculture 2015年第7期14卷 1338-1347页

作者： GUO Jing SONG Xue zou Li-fang zou hua-song CHEN Gong-you School of Agriculture and Biology Shanghai Jiao Tong University

Carbamoyl-phosphate synthase plays a vital role in the carbon and nitrogen metabolism cycles. In Xanthomonas citrisubsp. citri, carA and carB encode the small and large subunits of carbamoyl-phosphate synthase, respectively. The deletion mutation of the coding regions revealed that carA did not affect any of the phenotypes, while carB played multiple roles in pathogenicity. The deletion of carB rendered the loss of pathogenicity in host plants and the ability to induce a hyper- sensitive reaction in the non-hosts. Quantitative reverse transcription-PCR assays indicated that 11 hrp genes coding the type Ill secretion system were suppressed when interacting with citrus plants. The mutation in carB also affected bacterial utilization of several carbon and nitrogen resources in minimal medium MMX and extracellular enzyme activities. These data demonstrated that only the large subunit of carbamoyl-phosphate synthase was essential for canker development by X. citri subsp, citri.

关键词： Xanthomonas citri subsp citri carbamoyl-phosphate synthase pathogenicity citrus canker hrp gene

Land cover change in Ningbo and its surrounding area of Zhejiang Province, 1987~2000

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第4期7卷 633-640页

作者： LU Shan-long SHEN Xiao-hua zou Le-jun Department of Earth Sciences Zhejiang University Hangzhou 310027 China

Ningbo and its surrounding area is the forefront in the rapid economic development in the Yangtse delta, and the main production area for food supplies, cotton, edible oil and hemp; and at the same time, is the main area for wetland protection in Zhejiang Province. Our objectives were to quantify land cover change in Ningbo and its surrounding area from 1987 to 2000 and to analyze the causative factors of the change. Using 30-m resolution Landsat TM/ETM+ data and maximum likelihood classifica- tion method, we classified the study area into six land cover types: forest, agriculture, urban, freshwater, seawater and bottomland. The research results showed that significant changes in land cover occurred in the study area, and that agriculture and urban land cover change dominated most of the land cover change and were main causes for the changes of other types with human activities, such as urbanization, industrialization, etc. being the main factor while it was not very obvious whether climatic conditions have any role in the land cover changes. Agriculture, bottomland and other nature dominated land cover types are undergoing signifi- cant changes due to industrialization and urbanization, which threaten the stabilization of the environment. The study conclusion called for finding reasonable ways to solve the problems between land cover change and land use.

关键词： Land cover change Maximum likelihood classification Landsat TM/ETM+ Remote sensing Ningbo