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MicroRNA-320a suppresses tumor progression by targeting PBX3 in gastric cancer and is downregulated by DNA methylation

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 842-856页

作者： Yong-Shuang Li ying zou Dong-Qiu Dai Department of Gastrointestinal Surgery the Fourth Affiliated Hospital of China Medical University

BACKGROUND Ectopic expression of miRNAs promotes tumor development and ***(miR)-320a is downregulated in many cancers,including gastric cancer(GC).However,the mechanism underlying its downregulation and the role of miR-320a in GC are *** To determine expression and biological functions of miR-320a in GC and investigate the underlying molecular *** Quantitative real-time polymerase chain reaction(PCR)was used to determine expression of miR-320a in GC cell lines and ***7.1,miRDB,and *** were used to predict the possible targets of miR-320a,and a dual luciferase assay was used to confirm the *** blotting was used to detect the protein levels of pre-B-cell leukemia homeobox 3(PBX3)in GC cells and tissue *** Counting Kit-8 proliferation,Transwell,wound healing,and apoptosis assays were performed to analyze the biological functions of miR-320a in GC ***-specific PCR was used to analyze the methylation level of the miR-320a promoter CpG islands.5-Aza-2’-deoxycytidine(5-Aza-CdR)and trichostatin A(TSA)were used to treat GC *** miR-320a expression was lower in GC cell lines and tissues than in the normal gastric mucosa cell line GES-1 and matched adjacent normal ***-320a overexpression suppressed GC cell proliferation,invasion and migration,and induced ***3 was a target of miR-320a in *** methylation level of the miR-320a promoter CpG islands was elevated and this was partly reversed by 5-Aza-CdR and *** miR-320a acts as a tumor suppressor and inhibits malignant behavior of GC cells,partly by targeting *** methylation is an important mechanism associated with low expression of miR-320a.

关键词： Gastric cancer miRNA-320a DNA methylation Pre-B-cell leukemia homeobox 3 Tumor suppressor

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Modeling the Adverse Impact of Rainstorms on a Regional Transport Network

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International Journal of Disaster Risk Science 2016年第1期7卷 77-87页

作者： Saini Yang Guofan Yin Xianwu Shi Hao Liu ying zou State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University Academy of Disaster Reduction and Emergency Management Beijing Normal University National Marine Hazard Mitigation Service Beijing Transportation Information Center Beijing Municipal Commission of Transport

Cities are centers of socioeconomic activities,and transport networks carry cargoes and passengers from one city to another. However, transport networks are influenced by meteorological hazards, such as rainstorms,hurricanes, and fog. Adverse weather impacts can easily spread over a network. Existing models evaluating such impacts usually neglect the transdisciplinary nature of approaches for dealing with this problem. In this article, a mesoscopic mathematical model is proposed to quantitatively assess the adverse impact of rainstorms on a regional transport network in northern China by measuring the reduction in traffic volume. The model considers four factors: direct and secondary impacts of rainstorms, interdependency between network components, and recovery abilities of cities. We selected the Beijing-Tianjin-Hebei region as the case study area to verify our ***, precipitation, and traffic volume data in this area were used for model calibration and *** case study highlights the potential of the proposed model for rapid disaster loss assessment and risk reduction planning.

关键词： China Disaster loss assessment Mathematical modeling Rainstorm hazards Recovery Transport networks

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Titanium Dioxide Nanoparticles Promote Root Growth by Interfering with Auxin Pathways in Arabidopsis thaliana

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Phyton-International Journal of Experimental Botany 2020年第4期89卷 883-891页

作者： Jiali Wei ying zou Ping Li Xiaojun Yuan Shanghai Key Laboratory of Bio-Energy Crops Research Center for Natural ProductsPlant Science CenterSchool of Life SciencesShanghai UniversityShanghai200444China

TiO_(2) nanoparticles(nano-TiO_(2))are widely used in the world,and a considerable amount of nano-TiO_(2) is released into the environment,with toxic effects on *** the various species of higher plants,growth,including seed germination,root elongation,and biomass accumulation,is affected by nano-TiO_(2).However,the underlying molecular mechanisms remain to be *** this study,we observed that nano-TiO_(2) promoted root elongation in a dose-dependent ***,we found that nano-TiO_(2) elevated auxin accumulation in the root tips of the auxin marker lines DII-VENUS and DR5::GUS,and,correspondingly,quantitative real-time PCR analysis revealed that nano-TiO_(2) increased the expression levels of auxin biosynthesis-and transport-related *** fluorescence observation using transgenic PIN2-GFP indicated that nano-TiO_(2) promoted root growth by inducing PIN2 ***,we propose that nano-TiO_(2) promote root growth in Arabidopsis thaliana by altering the expression levels of auxin biosynthesis-and transport-related genes.

关键词： Nanoparticles nano-TiO_(2) root length auxin PIN2 auxin-related genes

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高磷血症与血液透析患者左室重量随时间增加的关系

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哈尔滨医科大学学报 2024年第3期58卷 249-253页

作者：邹慧莹张爱华马捷北京市普仁医院内科北京100062 北京市友谊医院肾内科北京100050

目的探讨高磷血症与血液透析患者左室重量(left ventricular mass,LVM)进行性恶化的关系。方法选取2019年3月~2021年3月104例来自我院血液净化中心的维持性血液透析患者,根据血磷水平分为正常组(23例)及高磷血症组(81例),随访2年。收集... 详细信息

目的探讨高磷血症与血液透析患者左室重量(left ventricular mass,LVM)进行性恶化的关系。方法选取2019年3月~2021年3月104例来自我院血液净化中心的维持性血液透析患者,根据血磷水平分为正常组(23例)及高磷血症组(81例),随访2年。收集患者基本资料、2年内透析记录及相关实验室检查,同时基线及随访结束时分别行超声心动图检查评价LVM及其变化情况。分析不同血磷水平与LVM变化的关系。结果存在高磷血症的患者LVM的增加值和增加百分比均显著高于血磷正常者(P<0.05)。LVM增加者2年内平均的血钙、血磷和超敏C反应蛋白水平显著高于未增加者(P<0.05)。Logistic回归分析显示只有血磷是LVM随时间增加的独立预测因子(P<0.05)。结论高磷血症是血液透析患者LVM进行性增加的独立危险因素。

关键词：血液透析高磷血症左室重量左室肥厚

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Interacted Effect of Arbuscular Mycorrhizal Fungi and Polyamines on Root System Architecture of Citrus Seedlings

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Journal of Integrative Agriculture 2012年第10期11卷 1675-1681页

作者： WU Qiang-sheng zou ying-ning LIU Chun-yan LU Ting College of Horticulture and Gardening Yangtze University

Either arbuscular mycorrhizal fungi （AMF） or polyamines （PAs） may change root system architecture （RSA） of plants, whereas the interaction of AMF and PAs on RSA remains unclear. In the present study, we studied the interaction between AMF （Paraglomus occultum） and exogenous PAs, including putrescine （Put）, spermidine （Spd） and spermine （Spin） on mycorrhizal development of different parts of root system, plant growth, RSA and carbohydrate concentrations of 6-m-old citrus （Citrus tangerine Hort. ex Tanaka） seedlings. After 14 wk of PAs application, PA-treated mycorrhizal seedlings exhibited better mycorrhizal colonization and numbers of vesicles, arbuscules, and entry points, and the best mycorrhizal status of taproot, first-, second-, and third-order lateral roots was respectively found in mycorrhizal seedlings supplied with Put, Spd and Spm, suggesting that PAs might act as a regulated factor of mycorrhizal development through transformation of root sucrose more into glucose for sustaining mycorrhizal development. AMF usually notably increases RSA traits （taproot length, total length, average diameter, projected area, surface area, volume, and number of first-, second-, and third-order lateral roots） of only PA-treated seedlings. Among the three PA species, greater positive effects on RSA change and plant biomass increment of the seedlings generally rank as Spd〉Spm〉Put, irrespective of whether or not AMF colonization. PAs significantly changed the RSA traits in mycorrhizal but not in non-mycorrhizal seedlings. It suggests that the application of PAs （especially Spd） to AMF plants would optimize RSA of citrus seedlings, thus increasing plant growth （shoot and root dry weight）.

关键词： citrus lateral root mycorrhiza putrescine root system architecture spermidine spermine

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Continuous applications of biochar to rice: Effects on grain yield and yield attributes

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Journal of Integrative Agriculture 2019年第3期18卷 563-570页

作者： HUANG Min FAN Long JIANG Li-geng YANG Shu-ying zou ying-bin Norman Uphoff Southern Regional Collaborative Innovation Center for Grain and Oil Crops(CICGO) Hunan Agricultural UniversityChangsha 410128P.R.China International Programs-College of Agriculture and Life Sciences(IP-CALS) Cornell UniversityIthaca 14853USA Key Laboratory of Crop Cultivation and Farming System Guangxi UniversityNanning 530004P.R.China

Biochar is considered as a beneficial soil amendment for crop production. However, limited information is available on the effects of continuous applications of biochar on rice. In this study, a fixed field experiment was conducted in the early and late rice-growing seasons from 2015 to 2017. Grain yield and yield attributes with a widely-grown rice cultivar Zhongzao 39 were compared, with and without applications of biochar in each season. The results showed that grain yield initially decreased with biochar applications in the first three seasons due to decreases in grain weight and harvest index. Although there were further relative decreases in grain weight and harvest index for rice that was supplied with biochar in the fourth to sixth seasons, grain yield was increased(by 4–10%) because of increases in sink size(spikelets per m2) and total biomass. The increased sink size in rice whose soil had been supplied with biochar in the fourth to sixth seasons was achieved by increasing panicle size(spikelets per panicle) or number of panicles, or both. Our study suggests that the positive effects of biochar application on rice yield and yield attributes depend on the duration of biochar application. Further investigations are needed to determine what are the soil and physiological processes for producing yield responses associated with ongoing applications of biochar. Also, it should be evaluated the performance of biochar application combined with other management practices, especially those can increase the grain weight and harvest index in rice production.

关键词： biochar grain yield rice yield attributes

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鼻内镜下泪囊鼻腔造口术与泪道逆行置管术治疗鼻泪管阻塞的临床对比研究

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中国实用医药 2024年第11期19卷 71-74页

作者：张芳邹莹王亚乐彭树文刘洁梅广州市番禺区中医院耳鼻咽喉头颈外科 511400

目的对比鼻内镜下泪囊鼻腔造口术与泪道逆行置管术治疗鼻泪管阻塞(NLDO)的临床效果。方法 50例鼻泪管阻塞患者,按就诊天数的单双号分为A组(单号日期, 25例)、B组(双号日期,25例)。A组实施鼻内镜下泪道逆行置管术, B组实施鼻内镜下泪囊... 详细信息

目的对比鼻内镜下泪囊鼻腔造口术与泪道逆行置管术治疗鼻泪管阻塞(NLDO)的临床效果。方法 50例鼻泪管阻塞患者,按就诊天数的单双号分为A组(单号日期, 25例)、B组(双号日期,25例)。A组实施鼻内镜下泪道逆行置管术, B组实施鼻内镜下泪囊鼻腔造口术。对比两组手术相关指标、并发症发生率、复发率。结果 A组手术时间(29.25±3.18)min、在院时间(0.85±0.23)d明显短于B组的(51.74±3.26)min、(4.47±1.26)d,出血量(5.03±1.06)ml少于B组的(46.45±11.12)ml(P<0.05)。A组并发症发生率(4.00%)低于B组(24.00%),但术后1年复发率(28.00%)高于B组(4.00%)(P<0.05)。结论鼻内镜下泪道逆行置管术治疗鼻泪管阻塞较泪囊鼻腔造口术具有手术时间短、操作较容易、出血量少等优势,而鼻内镜下泪囊鼻腔造口术较泪道逆行置管术则更有利于预防术后复发。

关键词：鼻泪管阻塞鼻内镜泪囊鼻腔造口术泪道逆行置管术临床疗效对比

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Influence of Si,Ce,Sb and Sn on chunky graphite formation

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China Foundry 2011年第1期8卷 96-100页

作者： Hideo Nakae Masayuki Fukami Takayuki Kitazawa ying zou Lab. for Mater. Sci. and Tech. Waseda Univ. Tokyo Japan JFE Steel Corp. Japan Nippon Steel Corp. Japan Appl. Mech. and Eng. Waseda Univ. Tokyo Japan

The thirteen mother alloys,C%+1/3Si%=4.45%,differing in their Si,Ce,Sb and Sn contents,were *** grams of these alloys was remelted in a high purity alumina crucible at 1,450oC under an Ar atmosphere,and then cooled at 30 K/min for obtaining their cooling *** graphite morphologies were observed using an optical microscope and an *** three-dimensional graphite shapes were observed by the SEM using the samples whose matrices were etched off with an acid-aqua solution,to confirm the chunky *** discussing the influence of the Si and Ce contents on the chunky graphite formation,two experiments were carried *** the first one,the Si contents were changed from 0 to 4% in the 0.15%Ce alloys,and for the second one,the 3.5%Si and 4%Si samples that differed in the Ce contents of 0.1 and 0.2% were *** the third experiment,the influence of Sb and Sn on the chunky graphite formation was investigated by using the 4%Si and 0.1%Ce *** results showed that with the increase of the Si content,the volume fraction of the chunky graphite increases,while the volume fraction of the ledeburite decreases,and the chunky graphite volume fraction in the 0.2%Ce samples is higher than that of the 0.1%Ce *** effect of the Sb and Sn additions on the prevention of chunky graphite formation cannot be confirmed due to their high Si ***,further studies will be needed in this field.

关键词： chunky graphite spheroidal graphite graphite morphology solidification of cast iron

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Correction to"MicroRNA-320a suppresses tumor progression by targeting PBX3 in gastric cancer and is downregulated by DNA methylation"

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1216-1217页

作者： Yong-Shuang Li ying zou Dong-Qiu Dai Department of Gastrointestinal Surgery The Fourth Affiliated Hospital of China Medical UniversityShenyang 110032Liaoning ProvinceChina

We rechecked the original data of Figure 3,Part.B,and found that 0 h group in the BGC-823 cell wound scratch assay was ***,we are writing to apply for the modification of Figure 3,Part.B.

关键词： Correction Gastric cancer miRNA-320a DNA methylation

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Yield potential and stability in super hybrid rice and its production strategies

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Journal of Integrative Agriculture 2017年第5期16卷 1009-1017页

作者： HUANG Min TANG Qi-yuan AO He-jun zou ying-bin Southern Regional Collaborative Innovation Center for Grain and Oil Crops(CICGO) Hunan Agricultural UniversityChangsha 410128P.R.China

China＇s Super Hybrid Rice Breeding Program has made significant progress over the past two decades. In this paper, we reviewed our studies on the yield potential and stability in super hybrid rice and discussed the strategies for super hybrid rice production. The results of our studies show that rice yield potential has been increased by 12% in super hybrid cultivars as compared with ordinary hybrid and inbred cultivars. The higher grain yields in super hybrid rice cultivars are attributed to larger panicle size coupled with higher biomass production or higher harvest index. However, grain yields in super hybrid rice cultivars vary widely among locations depending on soil and climatic factors. Therefore, it is important to tailor target yield to local conditions in super hybrid rice production. The target yield for super hybrid rice production can be determined by the average yield method or the regression model method. Improving soil quality is critical to achieving the target yield in super hybrid rice production. Favorable crop rotations such as rice-oilseed rape and novel soil management practices, such as biochar addition, are effective approaches to improve soil quality. It is needed to develop simplified cultivation tech- nologies for super hybrid rice to meet the changes in socioeconomic environments during the period of transition. There are such technologies as no-tillage direct seeding and mechanized transplanting at high hill density with single seedling per hill.

关键词： mechanized transplanting no-tillage direct seeding super hybrid rice target yield yield potential yield stability

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