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T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin Ren ying liu Juntang Yan Congai Chen Yanhui He Yuyu Shi Fafeng Cheng Qingguo Wang Changxiang li Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu li Mu Xi Xu Tianyi Huang ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

Distributions and risk assessment of heavy metals in solid waste in lead-zinc mining areas and across the soil, water body, sediment and agricultural product ecosystem in their surrounding areas

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China Geology 2025年第1期8卷 92-106页

作者： Zhi-qiang Wu Hai-ying li liu-yan Lü Guo-jun liang Ting-ting Wu Jiang-xia Zhu No.117 Geological Team Bureau of Geology and Mineral Exploration and Development of Guizhou ProvinceGuiyang 550023China Ecological Environment Monitoring Center of Guizhou Province Guiyang 550023China Guizhou Institute of Geological Survey Guiyang 550081China Environmental Engineering Assessment Center of Anshun City Anshun 561000China Environmental Emergency Center of Anshun City Anshun 561000China

To identify the root causes of heavy metal contamination in soils as well as prevent and control such contamination from its sources,this study explored the accumulation patterns and ecological risks of heavy metals like Cd and Pb in solid waste in mining areas and across the water body,sediment,soil and agricultural product ecosystem surrounding the mining *** on the residual solid waste samples in lead-zinc deposits in a certain area of Guizhou Province,along with samples of topsoils,irrigation water,river sediments,and crops from surrounding *** study analyzed the distributions of eight heavy metals,i.e.,Cd,As,Cr,Hg,Pb,Zn,Cu,and Ni,in the samples through field surveys and sample ***,this study assessed the contamination levels and ecological risks of heavy metals in soils,sediments,and agricultural products using methods such as the single-factor index,Nemerow composite index,and potential ecological risk *** results indicate that heavy metals in the solid waste samples all exhibited concentrations exceeding their risk screening values,with 60%greater than their risk intervention *** soils and sediments demonstrate slight and moderate comprehensive ecological risks of heavy *** single-factor potential ecological risks of heavy metals in both the soil and sediment samples decreased in the order of Hg,Cd,Pb,As,Cu,Zn,Cr,and Ni,suggesting the same sources of heavy metals in the soils and *** of the agricultural product samples exhibited over-limit concentrations of heavy metals dominated by Cd,Pb,Ni,and Cr,excluding Hg and *** agricultural product assessment using the Nemerow composite index reveals that 35%of the agricultural product samples reached the heavy metal contamination level,implying that the agricultural products from farmland around the solid waste dumps have been contaminated with heavy *** eight heavy metals in the soil,sediment,and agricultural product samples manifested hig

关键词： Lead-zinc mining area Solid waste Soil Water body Sediment Agricultural product Nemerow composite index Cd,Pb,Ni,Cr elements Heavy metal contamination Ecological risk assessment Coefficients of variation(CVs) Environmental restoration engineering

Hemispheric asymmetries and network dysfunctions in adolescent depression:A neuroimaging study using resting-state functional magnetic resonance imaging

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World Journal of Psychiatry 2025年第2期15卷 100-108页

作者： ying Xiong Ren-Qiang Yu Xing-Yu Wang Shun-Si liang Jie Ran Xiao li Yi-Zhi Xu Department of Hematology Chongqing General HospitalChongqing UniversityChongqing 401147China Department of Radiology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Currently,adolescent depression is one of the most significant public health concerns,markedly influencing emotional,cognitive,and social *** advancements in distinguish the neurobiological substrates underlying depression,the intricate patterns of disrupted brain network connectivity in adolescents warrant further *** To elucidate the neural correlates of adolescent depression by examining brain network connectivity using resting-state functional magnetic resonance imaging(rs-fMRI).METHODS The study cohort comprised 74 depressed adolescents and 59 healthy controls aged 12 to 17 *** underwent rs-fMRI to evaluate functional connectivity within and across critical brain networks,including the visual,default mode network(DMN),dorsal attention,salience,somatomotor,and frontoparietal control *** Analyses revealed pronounced functional disparities within key neural circuits among adolescents with *** results demonstrated existence of hemispheric asymmetries characterized by enhanced activity in the left visual network,which contrasted the diminished activity in the right *** DMN facilitated increased activity within the left prefrontal cortex and reduced engagement in the right hemisphere,implicating disrupted self-referential and emotional processing ***,an overactive right dorsal attention network and a hypoactive salience network were identified,underscoring significant abnormalities in attentional and emotional regulation in adolescent *** The findings from this study underscore distinct neural connectivity disruptions in adolescent depression,underscoring the critical role of specific neurobiological markers for precise early diagnosis of adolescent *** observed functional asymmetries and network-specific deviations elucidate the complex neurobiological architecture of adolescent depression,supporting the development of targeted the

关键词： Adolescent depression Brain network connectivity Neuroimaging biomarkers Functional magnetic resonance imaging Default mode network Salience network Hemispheric asymmetry

Modulated waveforms for harmonic minimization of far-field signals in amplitude-modulated heating of the ionosphere

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Earth and Planetary Physics 2025年第02期9卷 387-399页

作者： ZhiJian Lu Yong li Hui li Jian Wu JingFeng Yao XingBao Lyu ChengXun Yuan ZhongXiang Zhou ying Wang School of Physics Harbin Institute of Technology China Research Institute of Radio Waves Propagation Heilongjiang Provincial Key Laboratory of Plasma Physics and Application Technology Heilongjiang Provincial Innovation Research Center for Plasma Physics and Application Technology (International Cooperation)

This paper establishes an amplitude modulation heating model, simulating the far-field radiation of ELF/VLF signals generated by modulation heating, as well as the specific location and longitudinal extent of the radiation source. We consider various modulation waveforms and find that square-wave modulation has the highest excitation efficiency for ELF/VLF signals, and that square-wave modulation with a smaller duty cycle(litude of the second harmonic generated by the sin2t waveform is less than one-tenth that of the fundamental frequency, and the energy of higher-frequency harmonics can be negligibly small compared with those of the fundamental wave. It is a challenging task to achieve a balance between enhancing the excitation efficiency of ELF/VLF signals and also suppressing harmonics generated by the modulated heating process. This is because the harmonics are correspondingly enhanced as the excitation efficiency of the signals is increased. However, we find that under conditions of varying effective radiant power and modulation frequency, as long as the modulation waveform is unchanged, the energy ratio between the fundamental frequency signal generated by modulated heating and each harmonic is relatively fixed, with changes only in signal intensity and the location of the radiation source zone. This implies that one can first select modulation waveforms that make the signal less prone to distortion, then increase the effective radiated power to enhance the signal strength, without concern for harmonic interference of the fundamental signal.

关键词： ELF/VLF harmonic amplitude-modulated heating modulated waveforms

Conjunctival microbiota variations in a subset of middleaged and elderly individuals from Beijing,China

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 237-243页

作者： Tian-Yao Zhao Yu-Chen Wang ying-Juan Sun Jun-Yue Wang Xiao-Dan Jiang Xue-Min li Ai-Hua Deng Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NerveBeijing 100191China Fangshan Hospital Beijing University of Chinese Medicine Beijing 102400China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Animal Nutrition and Feeding Ministry of Agriculture and Rural Affairs Feed Industry CentreAgricultural UniversityBeijing 100193China

AIM:To isolate and identify the conjunctival microbiota of cataract patients and analyze the associated influencing ***:This study recruited 216 participants(216 eyes)from April 2022 to July *** the condition of no antibiotic use prior to cataract surgery,sterile swabs were used to collect samples from the lower conjunctival *** cultures were then conducted,followed by species identification through 16S rDNA gene *** factors associated with positive or negative bacterial isolation rates were analyzed,including age,gender,meibomian gland dysfunction(MGD),history of hypertension,history of diabetes,history of cancer,history of infectious diseases and the habit of wearing ***:Among the 216 eyes,78 eyes yielded isolates,with an isolation rate of 36.11%,detecting a total of 122 ***-positive rods accounted for 49.18%(60 strains),gram-positive cocci accounted for 45.08%(55 strains),gram-negative bacteria accounted for 4.92%(6 strains),and fungi accounted for 0.82%(1 strain).This study found that the most abundant genera in the conjunctival sac were Corynebacterium(42.62%),Staphylococcus(31.15%),Micrococcus(9.84%),Acinetobacter(4.10%),and Bacillus(3.28%).Furthermore,age(P=0.006),gender(P=0.039),diabetes(P=0.003),history of infectious diseases(P=0.02),and duration of mask replacement(P<0.001)were important factors influencing the positive bacterial culture of the conjunctival *** hypertensive patients exhibited a higher isolation rate of conjunctival bacteria,it did not reach statistical significance,and the history of cancer did not affect the isolation rate of the conjunctival microbial community in cataract patients before ***:Potential changes are observed in the conjunctival microbiota among a sample of middleaged and elderly individuals from Beijing,***,an increased isolation rate of Corynebacterium and Micrococcus is detected,suggesting a possible change in the mic

关键词： conjunctival microbiota 16S rDNA middle-aged and elderly population mask cataract surgery

Sympathetic Solar Eruption on 2024 February 9

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Research in Astronomy and Astrophysics 2025年第1期25卷 184-193页

作者： Shu-Yue li Qing-Min Zhang Bei-li ying li Feng ying-Na Su Mu-Sheng lin Yan-Jie Zhang School of Science Nanjing University of Posts and Telecommunications Key Laboratory of Dark Matter and Space Astronomy Purple Mountain Observatory School of Astronomy and Space Science University of Science and Technology of China

In this paper,we perform a follow-up investigation of the solar eruption originating from active region 13575 on2024 February *** primary eruption of a hot channel generates an X3.4 class flare,a full-halo coronal mass ejection （CME）,and an extreme-ultraviolet （EUV） *** between the wave and a quiescent prominence（QP） leads to a large-amplitude,transverse oscillation of *** the transverse oscillation,QP loses equilibrium and rises *** ascending motion of the prominence is coherently detected and tracked up to～1.68 R⊙by the Solar Ultra Violet Imager onboard the GOES-16 spacecraft and up to～2.2 R⊙by the Solar Corona Imager（SCI＿UV） of the Lyα Solar Telescope onboard the ASO-S *** velocity increases linearly from 12.3 to68.5 km s-1at 18:30 *** sympathetic eruption of QP drives the second CME with a typical three-part *** bright core comes from the eruptive prominence,which could be further observed up to～3.3 R⊙by the Large Angle Spectroscopic Coronagraph onboard the Solar and Heliospheric Observatory *** leading edge of the second CME accelerates continuously from～120 to～277 km *** EUV wave plays an important role in linking the primary eruption with the sympathetic eruption.

关键词： Sun: coronal mass ejections (CMEs) Sun: filaments, prominences Sun: flares

Advances in gastrointestinal vascular bleeding disorders:Successful sirolimus treatment in colonic angioectasia

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World Journal of Gastroenterology 2025年第4期31卷 123-136页

作者： Qi Sun Xiao-ying Wang Dong-Hao li Bai-Rong li Xin-Zhuo Tu Zhi-Meng Jiang Shou-Bin Ning Tao Sun Department of Gastroenterology Air Force Medical CenterBeijing 100142China College of life Science Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Pathology Air Force Medical CenterBeijing 100142China

BACKGROUND Gastrointestinal(GI)vascular bleeding disorders pose significant clinical challenges due to their complex pathogenesis and varied treatment *** advancements in diagnostic and therapeutic techniques,optimal mana-gement strategies remain elusive,necessitating further *** To assess research trends and clinical advancements in GI vascular bleeding disorders,highlighting key themes and therapeutic *** A bibliometric analysis was conducted using the Web of Science Core Collection database,reviewing publications from 2000 to 2024 to identify trends,highfrequency keywords,and key contributions from leading research *** addition,a case study highlighted the effective application of sirolimus in managing colonic angioectasia in a patient with recurrent GI bleeding who had not responded to previous *** The analysis reviewed 470 scholarly articles from 203 countries,involving 2817 authors across 1502 *** United States led in publication contributions,with strong collaborations with countries like China,England,and Germany.A significant trend was observed in the shift from traditional endoscopic interventions to pharmacological therapies,particularly highlighting the successful use of sirolimus in treating colonic angioectasia. High-frequency keywords such as “angiodysplasia”,“colon”, and “management” were identified, indicating key research themes. The study also noted a growinginterest in drug therapies, as evidenced by the increasing prominence of keywords like “thalidomide” since *** study links bibliometric analysis and clinical insights, highlighting the shift to pharmacological managementin GI vascular bleeding disorders to improve patient outcomes.

关键词： Gastrointestinal bleeding Vascular anomalies Angioectasia Pharmacological Sirolimus

Activation of zona incerta gamma-aminobutyric acid-ergic neurons alleviates depression-like and anxiety-like behaviors induced by chronic restraint stress

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World Journal of Psychiatry 2025年第2期15卷 209-221页

作者： Si-Hai Chen Bo Lan ying-ying Zhang Guo-Hui li Yu-Long Qian Ming-Xing Hu Yin-lin Tian Wei-Dong Zang Jing Cao Guang-Hai Wang Yi-Gang Wang Department of Psychiatry Xiaogan Rehabilitation HospitalXiaogan 432000Hubei ProvinceChina School of Basic Medical Sciences Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina School of Nursing and Health Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina

BACKGROUND Depression is a prevalent affective disorder,but its pathophysiology remains *** in the gamma-aminobutyric acid(GABA)-ergic system may contribute to its ***,antidepressants(e.g.,brexanolone,zuranolone)targeting the GABA-A receptor were *** zona incerta(ZI),an inhibitory subthalamic region mainly composed of GABAergic neurons,has been implicated in emotional *** brain stimulation of the ZI in humans affects anxiety and depression symptoms,while activation of ZI neurons in mice can either worsen or alleviate ***,there is no direct evidence linking GABAergic neurons in the ZI to depression-like behaviors in *** To explore the relationship between GABAergic neurons in the ZI and depression-like behaviors in *** A chronic restraint stress(CRS)model was utilized to induce depression in ***-cell patch-clamp recordings assessed the excitability changes of GABAergic neurons in the ***,chemogenetic techniques were employed to modulate ZI GABAergic *** performance of the mice in behavioral tests for depression and anxiety was *** The findings indicated that GABAergic neurons in the ZI were closely associated with depression-like behaviors in ***-eight days after the CRS model was established,depression-like and anxiety-like behaviors were observed in the *** excitability of GABAergic neurons in the ZI was *** activation of these neurons alleviated CRS-induced depression-like and anxiety-like ***,inhibition of GABAergic neurons in the ZI led to changes in emotion-related behavioral outcomes in *** Activity of GABAergic neurons in the ZI was closely associated with depression-like phenotypes in mice,suggesting that these neurons could be a potential therapeutic target for treating depression.

关键词： Zona incerta Gamma-aminobutyric acid-ergic Depression Anxiety Animal behavior studies Whole-cell patchclamp