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Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： lifang Zhao Mingkai Zhang Qimeng li Xuemin Wang Jie Lu ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

Some new acyclic nucleotide analogues as antiviral prodrugs:Synthesis and bioactivities in vitro

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Some new acyclic nucleotide analogues as antiviral prodrugs:...

Musashi orchestrates melanism in Laodelphax striatellus

2007年全国生化与生物技术药物学术年会

作者： TANG Yan-bo~1 PENG zong-gen liU zong-ying li Yah-ping JIANG Jian-dong li Zhuo-rong (Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,PR China)

A series of ester analogues of acyclic nucleotide PMPA and PMEA were synthesized as potent antiviral *** antiviral evaluation results indicated that bis benzyl ester prodrug of PMPA 5f and bis allyl ester prodrug of P... 详细信息

关键词： nucleotide prodrugs antiviral HIV-1 HBV

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Insect Science 2025年第1期32卷 140-150页

作者： Zeping Mao Biyun Wang Youyuan Chen Jinjun ying Haiqiang Wang Junmin li Chuanxi Zhang Jichong Zhuo State Key Laboratory for ManagingBiotic and Chemical Threats to the Quality and Safety of Agro-products Key Laboratory of Biotechnology in Plant Protection of MARA and Institute of Plant VirologyNingbo UniversityNingboZhejiang Province315211China

In insects,melanism,a fundamental pigmentation process,is of significant importance in evolutionary biology due to its complex genetic *** investigated the role of the RNA-binding gene Musashi(msi)in melanism in Laodelphax striatellus,a Hemiptera *** identified a single *** msi homolog,Lsmsi,encoding a 357 amino acid protein with 2 RNA recognition *** interference-mediated knockdown of LsMsi resulted in complete body melanism and increased cuticular ***,we found the involvement of G protein-coupled receptor A42 and tyrosine hydroxylase(Th)in *** *** of LsTh lightened the epidermis,showing dehydration signs,while LsA42 knockdown enhanced LsTh expression,leading to ***,Lsmsi knockdown decreased both LsA42 and LsTh expression,which was expected to cause whitening but resulted in ***,we found that Lsmsi influenced downstream genes like phenoloxidase homolog LsPo and dopa decarboxylase(Ddc)homolog LsDdc in the tyrosine-mediated melanism *** to Nilaparvata lugens and Sogatella furcifera,we demonstrated the conserved role of msi in melanism among *** MSI proteins’roles in cancer and tumors in vertebrates,our study is the first to link msi in insects to Delphacidae body color melanization via the tyrosine-mediated pathway,offering fresh perspectives on the genetic basis of insect melanism and msi functions.

关键词： dopa decarboxylase melanism Musashi phenoloxidase planthopper

Interfacial behaviors between ZG13Cr9Mo1VNbN stainless steel and chromite sand

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Journal of Iron and Steel Research International 2025年第1期32卷 129-143页

作者： Shi-sen li Xi-min Zang Ji-lin Chen Jie Yang Yu-an Jing Zhi-ying Wang ling-zhong Kong School of Materials and Metallurgy University of Science and Technology LiaoningAnshan114051LiaoningChina School of Material Science and Engineering Shenyang University of TechnologyShenyang110870LiaoningChina Central Iron and Steel Research Institute Co. Ltd.Beijing100081China Xingtai Iron and Steel Co. Ltd.Xingtai054027HebeiChina

To elucidate the formation mechanisms of burn-on sand and metal penetration during sand casting,some laboratory experiments were carried out at different temperatures(1813,1833,1853,and 1873 K)and holding time(20,40,60,and 90 min)to simulate the interaction between ZG13Cr9Mo1VNbN stainless steel and chromite *** results demonstrate that the defects primarily consist of a mixture of the liquid phase,chromite,and *** main components of the liquid phase are SiO_(2),MnO,MgO,Cr_(2)O_(3),FeO,and Al_(2)O_(3),and the formation of Cr_(2)O_(3)through interfacial redox reactions has been *** presence of a liquid phase plays a pivotal role in influencing burn-on sand and metal *** reactions are prioritized,with burn-on sand maintaining a predominant *** the liquid phase quantity within the sand escalates,there is a corresponding incremental rise in the incidence of metal *** a minimal presence of the silicon element in steel can impact the liquid phase’s ***,the decomposition or dissolution of chromite sand is a significant factor in the development of burn-on sand and metal ***,a thorough investigation into the conditions and contributing factors of this phenomenon is essential for its effective management and mitigation.

关键词： Heat-resistant steel Chromite sand Interfacial reaction Burn-on sand Metal penetration Temperature Holding time

Negative efficacy of antidepressants in pharmacotherapy of child and adolescent depression

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World Journal of Psychiatry 2025年第1期15卷 32-36页

作者： Min Xu Hai-ying Jin Feng-li Sun Wei-Dong Jin Department of Psychiatry Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Psychiatry Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Psychiatry Zhejiang Provincial Mental Health CenterHangzhou 311122Zhejiang ProvinceChina

Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent ***,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake *** studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent *** the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side *** review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.

关键词： Child depression Adolescent depression Antidepressant Switch Suicide Non-suicidal self injury

Folding encapsulation toward lindqvist polyoxometalates within adaptive coordination cages for catalysis

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Science China Chemistry 2025年第2期68卷 561-569页

作者： ying-Mei Zhong Jin-Jin Xuan Xujie Qin Han Xiao Zi-Jun Xia li-Peng Zhou Xiao-Qing Guo Yu-Hang Hu Lu Zhang Chunsen li li-Xuan Cai Qing-Fu Sun State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China

In nature,enzymes at specific folded conformations exhibit high substrate complementarity,enabling them to efficiently and selectively catalyze biochemical *** by enzymes,coordination cages with conformational dynamics have been designed and are receiving increasing attention due to their versatile applications in allosteric guest binding and *** present here two enzyme-mimicking adaptive macrocycle-based coordination cages,Pd_(2)L_(2)^(1) and Pd_(2)L_(2)^(2),from macrocycle-based ligands(L^(1) and L^(2))and the encapsulation and stabilization of lindqvist polyoxometalates anions M6O192−(M=W or Mo)in neutral aqueous solution.X-ray crystallographic studies have verified the formation of 1:1 host-guest complexes of two Pd_(2)L_(2) cages and the W6O192−anion,via an induced-fit folding *** with the free host,Pd_(2)L_(2)^(1) exhibited an induced-fit semi-folded conformation in the inclusion complex,while Pd_(2)L_(2)^(2) adopted an induced-fit fully-folded ***,the Mo_(6)O_(19)⊂Pd_(2)L_(2) host-guest complexes demonstrate high yield and selectivity in the oxidative decontamination reaction of the sulfur mustard simulant,2-chloroethyl ethyl *** work not only sheds light on the importance of conformational adaptability in enzyme-like systems but also paves the way for protecting labile POM clusters via host-guest encapsulation toward enhanced catalytic performance in aqueous solution.

关键词： coordination cage induced-fit polyoxometalates host-guest chemistry supramolecular catalysis

Immune cells:potential carriers or agents for drug delivery to the central nervous system

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Military Medical Research 2025年第1期12卷 121-153页

作者： Shan-Shan Zhang Ruo-Qi li Zhong Chen Xiao-ying Wang Aaron S.Dumont Xiang Fan School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province Zhejiang Chinese Medical UniversityHangzhou 310053China Clinical Neuroscience Research Center Department of Neurosurgery and NeurologyTulane University School of MedicineNew OrleansLA 70122USA

Drug delivery systems(DDS)have recently emerged as a promising approach for the unique advantages of drug protection and targeted ***,the access of nanoparticles/drugs to the central nervous system(CNS)remains a challenge mainly due to the obstruction from brain *** cells infiltrating the CNS in the pathological state have inspired the development of strategies for CNS foundation drug ***,we outline the three major brain barriers in the CNS and the mechanisms by which immune cells migrate across the blood–brain *** subsequently review biomimetic strategies utilizing immune cell-based nanoparticles for the delivery of nanoparticles/drugs to the CNS,as well as recent progress in rationally engineering immune cell-based DDS for CNS ***,we discuss the challenges and opportunities of immune cell-based DDS in CNS diseases to promote their clinical development.

关键词： Drug delivery systems Immune cells Blood-brain barrier Central nervous system

Coseismic surface ruptures of MW7.8 and MW7.5 earthquakes occurred on February 6,2023,and seismic hazard assessment of the East Anatolian Fault Zone,Southeastern Türkiye

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Science China Earth Sciences 2025年第2期68卷 611-625页

作者： Peng liANG Yueren XU Xiaocheng ZHOU ying li Qinjian TIAN Huiping ZHANG Zhikun REN Jingxing YU Chuanyou li Zheng GONG Shiguang WANG Aixia DOU Zifa MA Junjie li Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake AdministrationBeijing 100036China China Earthquake Disaster Prevention Center Beijing 100029China State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing 100029China Institute of Geophysics China Earthquake AdministrationBeijing 100081China

On February 6,2023,southeastern Türkiye experienced a devastating earthquake doublet along the East Anatolian Fault(EAF),with moment magnitude(MW)values of 7.8 and *** strong earthquakes resulted in at least 50,000 deaths and severe economic *** research on coseismic surface ruptures induced by these events is vital for assessing the cascade rupture behaviors of plate boundary faults and future seismic hazards in the *** of high-resolution post-earthquake satellite images and field investigations yielded the following results:(1)the two strong earthquakes had separate rupture *** first earthquake generated an approximately 280 km coseismic surface rupture along the southwestern segment of the main EAF,with 241 left-lateral displacements reaching up to 6.8±0.68 m,particularly 40 km northeast of the *** second earthquake produced a roughly 110 km surface rupture on an east-west branch of the EAF,with maximum displacements of 7.2±0.72 m.(2)The MW7.8 earthquake resulted in a cascading rupture across multiple segments of the southwestern section of the main EAF,with significantly variable *** northeastern and southwestern parts of the main EAF and Malatya Fault remain at risk of strong earthquakes in the future.(3)The EAF rupture zone is densely populated,and due to the site amplification effect of loose sediments on foreland alluvial fans,foundation failures of buildings in the populated areas are ***,it is crucial to enhance the future seismic fortification capabilities in urban and rural areas along the EAF.

关键词： Double strong earthquakes of Mw7.8 and Mw7.5 in Tirkiye,East Anatolian Fault Surface rupture zone,Strong earthquake hazard

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Artificial sensory neurons and their applications

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Journal of Semiconductors 2025年第1期46卷 108-128页

作者： Jiale Shao Hongwei ying Peihong Cheng lingxiang Hu Xianhua Wei zongxiao li Huanming Lu Zhizhen Ye Fei Zhuge Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China School of Electronic and Information Engineering Ningbo University of TechnologyNingbo 315211China State Key Laboratory of Environment-friendly Energy Materials Southwest University of Science and TechnologyMianyang 621010China Institute of Wenzhou Zhejiang UniversityWenzhou 325006China State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200072China

With the rapid development of artificial intelligence(AI)technology,the demand for high-performance and energyefficient computing is increasingly *** limitations of the traditional von Neumann computing architecture have prompted researchers to explore neuromorphic computing as a *** computing mimics the working principles of the human brain,characterized by high efficiency,low energy consumption,and strong fault tolerance,providing a hardware foundation for the development of new generation AI *** neurons and synapses are the two core components of neuromorphic computing *** perception is a crucial aspect of neuromorphic computing,where artificial sensory neurons play an irreplaceable role thus becoming a frontier and hot topic of *** work reviews recent advances in artificial sensory neurons and their ***,biological sensory neurons are briefly ***,different types of artificial neurons,such as transistor neurons and memristive neurons,are discussed in detail,focusing on their device structures and working ***,the research progress of artificial sensory neurons and their applications in artificial perception systems is systematically elaborated,covering various sensory types,including vision,touch,hearing,taste,and ***,challenges faced by artificial sensory neurons at both device and system levels are summarized.

关键词： artificial sensory neurons artificial perception systems neuromorphic computing artificial intelligence