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Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis

World Journal of Gastroenterology 2019年第6期25卷 729-743页

作者： Dalma Dobszai Péter Mátrai zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group Institute for Translational Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Clinical Medicine Doctoral School University of SzegedSzeged 6720Hungary Institute for Bioanalysis Medical SchoolUniversity of PécsPécs 7624Hungary Department of Public Health Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Department of Pharmacognosy University of SzegedSzeged 6720Hungary Division of Gastroenterology First Department of MedicineUniversity of PécsMedical SchoolPécs 7624Hungary János Szentágothai Research Center University of PécsPécs 7624 Hungary MTA-SZTE Momentum Translational Gastroenterology Research Group University of SzegedSzeged 6720Hungary 不详

BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the *** To quantify the association between subgroups of BMI and the severity and mortality of *** A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number *** A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality

关键词： Acute pancreatitis Body-mass index Obesity Severity Mortality Prognostic Meta-analysis

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四合屯玄武岩斑晶中单个熔体包裹体元素组成及其对岩浆演化的指示

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地球化学 2011年第2期40卷 109-125页

作者：张春来刘勇胜高山 zoltan ZAJACZ 胡兆初高长贵中国地质大学(武汉)地质过程与矿产资源国家重点实验室湖北武汉430074 Laboratory for Mineral Deposits Research Department of GeologyUniversity of MarylandCollege Park

玄武岩斑晶中熔体包裹体成分特征可以推断玄武岩源区物质组成,反映岩浆形成演化过程。利用LA-ICPMS对四合屯义县组玄武岩橄榄石、单斜辉石斑晶中单个熔体包裹体的元素组成进行了分析测试。研究结果表明,橄榄石、单斜辉石斑晶中的熔体包... 详细信息

玄武岩斑晶中熔体包裹体成分特征可以推断玄武岩源区物质组成,反映岩浆形成演化过程。利用LA-ICPMS对四合屯义县组玄武岩橄榄石、单斜辉石斑晶中单个熔体包裹体的元素组成进行了分析测试。研究结果表明,橄榄石、单斜辉石斑晶中的熔体包裹体在主、微量元素含量上表现出了比全岩更大的变化范围,但微量元素分配特征总体和全岩一致。单斜辉石斑晶中包裹体的CaO含量、CaO/Al2O3比值和Cr2O3含量随着单斜辉石Mg#值的降低而降低,反映了单斜辉石结晶分离的影响,Al2O3与Sr之间的显著相关关系则记录了斜长石结晶分离作用的影响,MgO-Ni和MgO-CaO/Al2O3的变化则反映了橄榄石的分离结晶作用。包裹体元素组成变化总体受橄榄石、单斜辉石和斜长石的结晶分离作用控制。结合前人研究成果,认为四合屯玄武岩在微量元素和同位素组成上的壳源组分特征可能部分地继承自原岩(即橄榄岩+榴辉岩部分熔融体反应形成的(橄榄)辉石岩),而不是岩浆上升过程中受地壳岩石混染的结果。高Mg#值单斜辉石斑晶中少量高Mg#值、高Si含量,低CaO、TiO2、Al2O3和微量元素含量的熔体包裹体反映玄武岩浆上升过程中受到了Si质岩石的混染,这与义县组玄武岩下伏地层为长城系大红裕组石英岩、石英砂岩的地质特征一致。因此,高Fo橄榄石斑晶中的熔体包裹体比采用向全岩中简单添加橄榄石方式计算出的原始熔体可能更能真实反映原始熔体组成。

关键词：熔体包裹体 LA—ICPMS 结晶分异同化混染玄武岩原始熔体

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The Incidence of Late-Onset Pompe Disease in Subjects with Obstructive Sleep Apnea:A Cross-Sectional Study

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Open Journal of Internal Medicine 2014年第3期4卷 64-68页

作者： Jan Stolk Nina Lon Jeannette Gast-Strookman zoltan Lukacs Paulina Nieves Cobos Poul Jennum Department of Pulmonology Leiden University Medical CenterLeidenThe Netherlands Danish Center for Sleep Medicine Department of Clinical NeurophysiologyFaculty of HealthUniversity of CopenhagenGlostrup HospitalGlostrupDenmark Department of Pediatrics and Institute of Clinical Chemistry Hamburg University Medical CenterHamburgGermany

Objectives: Current treatment options for obstructive sleep apnea syndrome often work to the sa-tisfaction of the patient, but in certain cases may not yield the required results for reasons that remain unclear. Late-onset Pompe disease may be a contributing factor in these circumstances. The aim of the present study was to determine the incidence of late-onset Pompe disease in a population diagnosed with obstructive sleep apnea. Material and Methods: The study had a cross-sec- tional, explorative design to assess the prevalence of late-onset Pompe disease in subjects with an established diagnosis of obstructive sleep apnea syndrome. In two different study mid to large size sleep clinics in Europe patients have been asked to donate a blood sample for the detection of ac-id-glucosidase enzyme activity. Results: Of a total of 544 patients with mild to severe obstructive sleep apnea, none had an acid maltase deficiency. Conclusions: Screening for Pompe disease in newly or recently detected OSA patients in mid to large size sleep clinics is not clinically effective. It should be confined to those subjects with OSA when upright forced vital capacity during spirometry is only moderately abnormal, because of the disproportionate diaphragmatic involvement.

关键词： Kidney Transplant Dialysis

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Holographic Raman Tweezers Controlled by Hand Gestures and Voice Commands

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Optics and Photonics Journal 2013年第2期3卷 331-336页

作者： zoltan Tomori Marian Antalik Peter Kesa Jan Kanka Petr Jakl Mojmir Sery Silvie Bernatova Pavel Zemanek 1Department of Biophysics Institute of Experimental Physics SAS Kosice Slovakia 2Department of Biochemistry P. J. Safarik University Kosice Slovakia Department of Biochemistry P. J. Safarik University Kosice Slovakia Department of Biophysics Institute of Experimental Physics SAS Kosice Slovakia Institute of Scientific Instruments of the ASCR v.v.i. Brno Czech Republic

Several attempts have appeared recently to control optical trapping systems via touch tablets and cameras instead of a mouse and joystick. Our approach is based on a modern low-cost hardware combined with fingertips and speech recognition software. Positions of operator's hands or fingertips control the positions of trapping beams in holographic optical tweezers that provide optical manipulation with microobjects. We tested and adapted two systems for hands position detection and gestures recognition – Creative Interactive Gesture Camera and Leap Motion. We further enhanced the system of Holographic Raman tweezers (HRT) by voice commands controlling the micropositioning stage and acquisition of Raman spectra. Interface communicates with HRT either directly by which requires adaptation of HRT firmware, or indirectly by simulating mouse and keyboard messages. Its utilization in real experiments speeded up the operator’s communication with the system cca. Two times in comparison with the traditional control by the mouse and the keyboard.

关键词： Holographic Optical Tweezers Raman Tweezers Natural User Interface Leap Motion Gesture Camera

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Predictors of Spermatic Cord Torsion—Clinical Presentation and Intraoperative Findings

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Open Journal of Urology 2011年第4期1卷 81-85页

作者： Axel Hegele Dirk Wappelhorst zoltan Varga Fabian Brüning Peter Olbert Carsten Frohme Rainer Hofmann 不详

Background: To evaluate aetiology of acute scrotum after surgical exploration suspicious for spermatic cord torsion, to compare surgical with clinical findings and to support the clinician distinguishing spermatic cord torsion from other diseases mimicking this emergency requiring surgical exploration. Methods: All men with the diagnosis of an acute scrotum who underwent emergency scrotal exploration between January 1995 and October 2009 were retrospectively evaluated. Results: 230 patients were analyzed. Torsion of the spermatic cord (53%) was the most common cause followed by torsion of the testis appendages (25%). Patients with spermatic cord torsion were significantly older (15.5 y) and haunted hospital faster than others (p Conclusions: Our data demonstrate that spermatic cord torsion is more common in adolescent. Short pain duration and high intrascrotal position of the testicle are associated with higher probability of spermatic cord torsion. Duplex sonography plays an important role in the diagnostic workup but history and physical examination are the crucial parameters. In nebulous clinical cases emergency surgical exploration has to be recommended.

关键词： Acute Scrotum Spermatic Cord Torsion Emergency Clinical Predictor

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小鼠自身抗独特型抗体的免疫抑制作用

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北京大学学报(医学版) 1988年第3期 171-174页

作者：殷金珠,zoltan Ovary 北京医科大学免疫学教研室纽约大学医学院病理系

排斥杂交瘤B53（分泌抗DNP IgE）的BALB/C小鼠（Hy·Rej·mice）,注射DNP蛋白质抗原后,几乎不形成抗DNP抗体。用PFC抑制试验证明,该小鼠血清中含有抑制抗DNP PFC形成的物质,此物质能被抗小鼠Ig或小鼠抗DNP IgG2a的免疫吸附柱吸收。DNP-E... 详细信息

排斥杂交瘤B53（分泌抗DNP IgE）的BALB/C小鼠（Hy·Rej·mice）,注射DNP蛋白质抗原后,几乎不形成抗DNP抗体。用PFC抑制试验证明,该小鼠血清中含有抑制抗DNP PFC形成的物质,此物质能被抗小鼠Ig或小鼠抗DNP IgG2a的免疫吸附柱吸收。DNP-EACA可逆转Hy·Rej小鼠血清对DNP PFC形成的抑制作用,免疫印染技术证明,抑制物的分子量及免疫学特性与抗DNP IgE的抗独特型抗体完全一致。说明抑制物的本质是自身抗DNP IgE的抗独特型抗体。

关键词：小鼠 IgE 小家鼠抗独特型抗体 DNP 小鼠血清

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БТР-80装甲输送车

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国外坦克 1996年第10期 15-18页

作者： zoltan Roth 徐晓前上尉

迄今为止,步兵所扮演的角色始终没有变。在任何时候,他们作战的主要目标都是占领和固守预定的区域(地段、地域、目标),原则上讲步兵具有这种能力。其他所有兵种和支援部队。

关键词：装甲输送车步兵部队兵器武器发动机兵种传动装置地段驾驶员

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Mixed adenoneuroendocrine carcinoma of gastrointestinal tract: Report of two cases

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World Journal of Gastroenterology 2015年第4期21卷 1329-1333页

作者： Simona Gurzu zoltan Kadar Tivadar Bara Tivadar Jr. Bara Adrian Tamasi Leonard Azamfirei Ioan Jung Department of Pathology University of Medicine and Pharmacy540139 Tirgu MuresRomania Department of Surgery University of Medicine and Pharmacy 540139 Tirgu Mures Romania Intensive Care Unit University of Medicine and Pharmacy540139 Tirgu MuresRomania

Mixed adenoneuroendocrine carcinoma(MANEC) is a rare tumor of the gastrointestinal tract that consists of a dual adenocarcinomatous and neuroendocrine differentiation, each component representing at least 30% of the tumor. To date, only seven cases have been reported in the cecum, and less than 40 in the stomach. Our first case was diagnosed in a 74-years-old female as a polypoid lesion of the cecum with direct invasion in the transverse colon, without lymph node metastases. The second case was diagnosed in the stomach of a 46-years-old male as a polypoid tumor of the antral region that invaded the pancreas and presented metastases in 22 regional lymph nodes. The metastatic tissue was represented by the glandular component. In both cases, the tumor consisted of a moderately-differentiated tubular adenocarcinoma(with mucinous component in Case 1) intermingled with neuroendocrine carcinoma. Ki67 index was lower than 20% in Case 1, respectively higher than 20% in Case 2. The neuroendocrine component was marked by synaptophysin and neuron specific enolase, being negative for Keratins 7/20. The neuroendocrine component represented 60% in Case 1, and 40% in Case 2, respectively. The glandular components were marked by carcinoembryonic antigen, maspin and keratin 20/7(Case 1/2). Both cases were proved to be microsatellite stable. Independently by the localization and tumor stage, MANECs appear to be highly malignant tumors, with high risk for distant metastases. The aggressiveness seems to depend on the endocrine component, independent of its proportion. The neuroendocrine component could be a dedifferentiated adenocarcinoma with a neuroendocrine phenotype.

关键词： Mixed adenoneuroendocrine carcinoma Composite tumo

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Deuterium Depletion May Delay the Progression of Prostate Cancer

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Journal of Cancer Therapy 2011年第4期2卷 548-556页

作者： Andras Kovacs Imre Guller Krisztina Krempels Ildiko Somlyai Istvan Janosi zoltan Gyongyi Istvan Szabo Istvan Ember Gabor Somlyai Saint John’s Hospital BudapestHungary HYD LLC.for Cancer Research and Drug Development BudapestHungary Planimeter Ltd. BudapestHungary University of Pecs Medical SchoolInstitute of Public HealthPecsHungary.

Deuterium-depleted water (DDW) is a new promising agent in cancer therapy. The efficiency of the method is based on the discovery, that cancer cells are extremely sensitive to depletion of deuterium (D) and might cause necrosis of the tumour. The purpose of this study was to show the efficacy of D-depletion in prostate cancer (PC) patients. In the double blind, four-month-long, randomized Phase II clinical trial the daily water intake was replaced with DDW in 22 PC patients. Other 22 PC patients took normal water while both groups received the same forms of conventional treatment. In the retrospective study, 91 DDW-treated PC patients were evaluated and median survival time (MST) in the subgroups was calculated. The time course of changes in DDW dose and PSA is presented in two cases. In the prospective trial seven patients in the treated group and one patient in the placebo group achieved partial response (p = 0.046). In the treated group, the net decrease in the prostate volume was three times higher (160.3 cm3 vs. 54.0 cm3;p = 0.0019), urination complaints ceased at a higher rate (8 vs. 0 patients, p = 0.0041), and the one-year survival rate was also higher (2 vs. 9 deaths;p = 0.034). The 91 retrospectively evaluated patients achieved an MST of 11.02 years, despite the fact that 46 of them suffered from distant metastasis. In the two monitored patients, drop of PSA level correlated with the DDW intake. In summary, D-depletion prolonged MST in patients with PC. The method proved to be safe thus its integration in the PC cure as an adjuvant or complementary therapy would be considered.

关键词： Deuterium Depletion DDW Prostate Cancer Phase II Clinical Trial Retrospective Evaluation Median Survival

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语言策略能力及其培养

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外语教学理论与实践 1992年第3期 29-32页

作者： zoltan Dornyei Sarah Thurrell 陈健沪州教育学院

引言当今交际法语言教学已经在很多国家流行,然而,恰如纳南(Nunan)所言,尽管有卷帙浩繁的专著载述其理论与实践,而对交际语本身的应用却很少有研究者问津。纳南因而极力提倡语言课堂的“交际性”,并要求加强研究,以促进交际语的实际应... 详细信息

引言当今交际法语言教学已经在很多国家流行,然而,恰如纳南(Nunan)所言,尽管有卷帙浩繁的专著载述其理论与实践,而对交际语本身的应用却很少有研究者问津。纳南因而极力提倡语言课堂的“交际性”,并要求加强研究,以促进交际语的实际应用。本文正是如纳南所言,旨在对交际语技巧的一个十分关键,而又为多数人忽略的方面——策略能力(Strategic Competence)一一作一概述。

关键词：策略能力交际语交际性语言策略语言教学语言课堂 Competence 语言知识理论与实践 thinking

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