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Atmospheric and Climate Sciences 2023年第4期13卷 455-465页

作者： zoltán Varga-Haszonits Éva Szalka Dávid Vasas Zsolt Giczi Pál Szakál Tamás Szakál Albert Casimir Faculty at Mosonmagyaróvár Széchenyi István University of Gy&#337r Gy&#337r Hungary

The extent to which specific climatic factors influence evapotranspiration under subhumid conditions in Hungary was investigated. The reference evapotranspiration, calculated with the internationally accepted Penman-Monteith equation proposed by FAO, was considered. The results show that the influence of radiation, which provides energy for evaporation, is the strongest factor and that the influence of global radiation alone is very strong. Taking into account that radiation was measured under rather limited conditions in space and time, global radiation was calculated using the Hargreaves method based on temperature. Accordingly, we have defined a formula based on temperature-based global radiation and verified the data obtained with the Penman-Monteith formula calculated for 14 meteorological stations. The verification gave good results, therefore the method can be used for practical purposes in the subhumid conditions of Hungary based on the data of the nearest meteorological station.

关键词： Effecting Factors Sensitivity Analysis Global Radiation Multilocal Validation Estimation Error

Experiences and Conclusions of the Hungarian Emergency Sepsis Register

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Open Journal of Epidemiology 2017年第1期7卷 44-58页

作者： Péter Kanizsai Tamás Berényi Miklós Pálv?lgyi János Gál zoltán Peto Department of Emergency Medicine Clinical Centre Semmelweis University Budapest Hungary Department of Social Sciences Faculty of Health Sciences Semmelweis University Budapest Hungary Department of Anaesthesia and Intensive Care Division of Emergency Medicine and Oxyology Faculty of Medicine Semmelweis University Budapest Hungary Department of Emergency Medicine Szent-Gyorgyi Science University Faculty of Medicine Szeged Hungary

Objective: Early recognition is a key step in decreasing morbidity and mortality in sepsis. Like in other European countries an ever growing number of septic patients enter hospitals via emergency departments. Our goal was to assess the number and severity of patients with sepsis, severe sepsis and septic shock attending the Hungarian emergency departments. Methods: Two-hundred and ninety-nine patients were entered into the Hungarian Emergency Sepsis Register, focusing on age, disease severity, monitoring and oxygenation. Application and time of administration of antibiotics, use of biomarkers, i.e. lactate and procalcitonin, disposition of patients were assessed using a web-based electronic questionnaire. Results: Data arriving from twenty emergency departments revealed that with severity of the disease oxygen administration and level of monitoring increased, along with antibiotic administration and use of biomarkers. Time spent in the ED did not differ between septic, severely septic and septic shock patients;however higher level of care was provided for the sickest patients. Conclusion: Our register data indicate that sepsis presents a substantial challenge to Hungarian emergency departments. The set standards for timely, adequate treatment are not yet met. The results are however also influenced by characteristics of the Hungarian health care system, most notably the lack of hospice systems. Further studies are needed to separate the subset of patients who would require and of life care.

关键词： Sepsis Register Monitoring Antibiotic Disposition Lactate Procalcitonin

Effect of herpesvirus infection on pancreatic duct cell secretion

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World Journal of Gastroenterology 2005年第38期11卷 5997-6002页

作者： Péter Hegyi Balázs rdg zoltán Rakonczai Jr Tamás Takács János Lonovics Annamária Szabolcs Réka Sári András Tóth Julius G Papp András Varró Mária K Kovács Mike A Gray Barry E Argent Zsolt Boldogki First Department of Medicine Department of Biology Division of Cardiovascular Pharmacology School of Cell and Molecular Biosciences

AIM： To examine the effect of acute infection caused by herpesvirus （pseudorabies virus, PRV） on pancreatic ductal secretion. METHODS： The virulent Ba-DupGreen （BDG） and non- virulent Ka-RREp01acgfp （KEG） genetically modified strains of PRV were used in this study and both of them contain the gene for green fluorescent protein （GFP）. Small intra/ interlobular ducts were infected with BDG virus （10^7 PFU/mL for 6 h） or with KEG virus （10^10 PFU/mL for 6 h）, while non-infected ducts were incubated only with the culture media. The ducts were then cultured for a further 18 h. The rate of HCO3 secretion [base efflux -λ（B）] was determined from the buffering capacity of the cells and the initial rate of intracellular acidification （1） after sudden blockage of basolateral base loaders with dihydro-4,4,- diisothiocyanatostilbene-2,2,-disulfonic acid （500 μmol/L） and amiloride （200 μmol/L）, and （2） after alkali loading the ducts by exposure to nH4Cl. All the experiments were performed in HCO3-buffered Ringer solution at 37 ℃ （n = 5 ducts for each experimental condition）. Viral structural proteins were visualized by immunohistochemistry. Virallyencoded GFP and immunofluorescence signals were recorded by a confocal laser scanning microscope.RESULTS： The BDG virus infected the majority of accessible cells of the duct as judged by the appearance of GFP and viral anUgens in the ductal cells. KEG virus caused a similarly high efficiency of infection. After blockage of basolateral base loaders, BDG infection significantly elevated -λB-） 24 h after the infection, compared to the non-infected group. However, KEG infection did not modify -λB-）. After alkali loading the ducts, -λB-） was significantly elevated in the BDG group compared to the control group 24 h after the infection. As we found with the inhibitor stop method, no change was observed in the group KEG compared to the non-infected group. COnCLUSIOn： Incubation with the BDG or KEG strains of PRV results in an effective i

关键词： Pancreas Hypersecretion Ductal cells Infection Pseudorabies virus

实践中的Krashen输入假说和Swain输出假说:设计“i+1”教学技巧

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外语教学理论与实践 1994年第1期 26-28页

作者： zoltán Dǒrnyei 宋孔尧

Stephen Krashen 的语言学习理论引起激烈的争论和学术讨论,但通过对进行实践的教师的思想态度的影响,它无疑把语言学理论和实际语言教学连接了起来。本文着重阐述 Krashen 一部分语言习得概念——输入假说的实践意义。它就是 Krashen... 详细信息

Stephen Krashen 的语言学习理论引起激烈的争论和学术讨论,但通过对进行实践的教师的思想态度的影响,它无疑把语言学理论和实际语言教学连接了起来。本文着重阐述 Krashen 一部分语言习得概念——输入假说的实践意义。它就是 Krashen所认为的“这个理论的最重要的部分”,因为它试图解答语言学习究竟是如何产生的以及用何种方式(课堂内与课堂外)

关键词：输入假说教学技巧输出假说语言学习理论理解性输入语言输入学习者语言教学学生语言习得

KEY ELEMEnTS OF THE AGEInG MAnAGEMEnT OF THE WWER-440/213 TYPE nUCLEAR POWER PLAnTS

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KEY ELEMENTS OF THE AGEING MANAGEMENT OF THE WWER-440/213 TY...

Plasma Proteome Profiling with Monoclonal Antibody Libraries: A Pilot Biomarker Analysis for nanomedicine-Induced Complement Activation

第十八届国际反应堆结构力学大会

作者： Tamás János Katona gnes Jánosiné Bíró Sándor Rátkai zoltán Ferenczi nuclear Power Plant Paks Ltd. PaksHungary Electric Power Research Institute BudapestHungary nuclear Power Plant Paks Ltd. PaksHungary Electric Power Research Institute BudapestHungary

＜正＞ 1 InTRODUCTIOn The owner’s intention of WWER-440/213 units in Central Europe is to keep the generating capacity in operation as long as technically feasible and reasonable from business point of view. The basis of Long Term Operation （LTO） is the safety and good plant condition. The last depends on the past practice of in-service inspection, maintenance, testing and recording the lifetime relevant data as well as on the knowledge of the design basis of the lifetime limiting structures, systems and components （SSC）. In the paper an overall picture of LTO of WWER-440/213 units is given on the examples of Paks nPP.

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Advances in nanoparticles 2013年第2期2卷 133-144页

作者： János Szebeni Zsóka Weiszhár zoltán Rozsnyay Todd Martinsky János Kádas József Lázár László Takács István Kurucz Arrayit Corporation Sunnyvale USA Biosystems International Kft. Debrecen Hungary nanomedicine Research and Education Center Semmelweis University Budapest Hungary Seroscience Ltd. Budapest Hungary

Complement (C) activation-related hypersensitivity reactions (HSRs) represent an unsolved adverse immune effect of many i.v. administered “nanomedicines”, such as liposomal doxorubicin (Doxil/Caelyx). Because these pseudoallergic reactions can be severe or even lethal, it is an important clinical objective to find biomarkers for proneness for C activation by reactogenic nanoparticles that will allow the prediction of in vivo reactions by in vitro assays. With this goal in mind we identified a normal human blood donor who consistently showed high sensitivity to Caelyx-induced C activation in vitro, whose plasma (Caelyx sensitive plasma, CSP) was subjected to proteome profiling with a library of human plasma proteome specific mAbs. The chip (PlasmaScan-380TM) contained 380 non redundant (with respect to epitopes) mAbs. The analysis revealed 8 proteins that were differentially represented in CSP in comparison with Caelyx-insensitive control plasma. These proteins were identified by mass spectrometry and Western blot analyses to represent factor H (decreased in CSP), factor H related protein, serum amyloid P component, fibronectin, complement component C4, Apo B100, prothrombin and alpha-2-HS glycoprotein (all increased in CSP). Some of these protein changes are consistent with proneness for increased C activation, suggesting the potential use of this method in the search for biomarkers for liposome-induced or other types of nanomedicine-induced HSRs.

关键词： Hypersensitivity Reactions Complement Factor H Serum Amyloid P Proteome Profiling Biomarkers

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前所未有之变革时代的历史理论

史学理论研究 2021年第6期 17-24页

作者：佐尔坦·西蒙张旭鹏(译) 德国比勒费尔德大学历史系不详

一历史理论是对人类以及与人类有关的事务随时间变化的解释与描述。自启蒙运动晚期以来,各种古典历史哲学所阐述的非常现代的历史观念,都是从概念上去表达这种变化,而这种变化创造了将每一个特定主题“历史化”的可能性。然而,到20世纪... 详细信息

一历史理论是对人类以及与人类有关的事务随时间变化的解释与描述。自启蒙运动晚期以来,各种古典历史哲学所阐述的非常现代的历史观念,都是从概念上去表达这种变化,而这种变化创造了将每一个特定主题“历史化”的可能性。然而,到20世纪中叶,历史理论的进展变得寸步难行,它对历史变化的解释也变得声名不佳。

关键词：变革时代特定主题 20世纪中叶启蒙运动可能性

Visceral leishmaniasis in an immunocompetent Hungarian adult patient

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Health 2011年第1期3卷 1-5页

作者： zoltán Péterfi Zsuzsanna nemes Szabolcs Vigvári árpád Szomor László Kereskai István Kucsera Balázs Tánczos Gábor Ternák 不详

Visceral leishmaniasis caused by L. infantum nicolle 1908 (Kinetoplastida, Trypanosomatidae) is very rare in immunocompetent adults. Clinical manifestation of the infection occurs in children and immune-compromised patients associated with AIDS, haemopoietic malignancies or after renal, liver, and heart transplantations in Europe. Hungary is regarded free of leishmaniasis. Except for a single infection in a small girl without a travel history, only a few imported cases have been recorded among Hungarians returning from endemic areas. Case presentation: Visceral leishmaniasis was diagnosed in a 32 years old immumocompetent Hungarian man who had spent his holidays during the previous 3 years in Dalmatian territories (Dubrovnik, Makarska and Trogir) of Croatia. He had two months history of fever, chills, and night sweating associated with weight loss. Physical examination showed mild hepatomegaly and extreme splenomegaly. The protozoon infection was confirmed by parasitological, serological and molecular biological methods. Clinical recovery of the patient was observed after treatment with amphotericin B. Conclusion: We want to highlight the effects of climate changes and to call attention of health care professionals in Central and Eastern European countries to consider the possibility of leishmaniasis as an emerging disease of tourists returned from endemic re-gions.

关键词： Visceral Leishmaniasis Immunocompetent Human Imported Hungary Amphotericin B