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Plasma Proteome Profiling with Monoclonal Antibody Libraries: A Pilot Biomarker Analysis for nanomedicine-Induced Complement Activation

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Advances in nanoparticles 2013年第2期2卷 133-144页

作者： János Szebeni Zsóka Weiszhár zoltán rozsnyay Todd Martinsky János Kádas József Lázár László Takács István Kurucz Arrayit Corporation Sunnyvale USA Biosystems International Kft. Debrecen Hungary nanomedicine Research and Education Center Semmelweis University Budapest Hungary Seroscience Ltd. Budapest Hungary

Complement (C) activation-related hypersensitivity reactions (HSRs) represent an unsolved adverse immune effect of many i.v. administered “nanomedicines”, such as liposomal doxorubicin (Doxil/Caelyx). Because these pseudoallergic reactions can be severe or even lethal, it is an important clinical objective to find biomarkers for proneness for C activation by reactogenic nanoparticles that will allow the prediction of in vivo reactions by in vitro assays. With this goal in mind we identified a normal human blood donor who consistently showed high sensitivity to Caelyx-induced C activation in vitro, whose plasma (Caelyx sensitive plasma, CSP) was subjected to proteome profiling with a library of human plasma proteome specific mAbs. The chip (PlasmaScan-380TM) contained 380 non redundant (with respect to epitopes) mAbs. The analysis revealed 8 proteins that were differentially represented in CSP in comparison with Caelyx-insensitive control plasma. These proteins were identified by mass spectrometry and Western blot analyses to represent factor H (decreased in CSP), factor H related protein, serum amyloid P component, fibronectin, complement component C4, Apo B100, prothrombin and alpha-2-HS glycoprotein (all increased in CSP). Some of these protein changes are consistent with proneness for increased C activation, suggesting the potential use of this method in the search for biomarkers for liposome-induced or other types of nanomedicine-induced HSRs.

关键词： Hypersensitivity Reactions Complement Factor H Serum Amyloid P Proteome Profiling Biomarkers

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DIRECT LOCAL AnD GLOBAL APPROXIMATIOn THEOREMS FOR SOME LInEAR POSITIVE OPERATORS

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Analysis in Theory and Applications 2004年第4期20卷 307-322页

作者： zoltán Finta Bases-Bolyai University Department of Mathematics and Computer Science M. Kogalniceanu St. 3400 Cluj Romania

In this paper we establish direct local and global approximation theorems for Baskakov type operators and Szasz - Mirakjan type operators, respectively.

关键词： direct approximation theorem Baskakov type operator Szasz-Mirakjan type operator

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Role of ultrasound in colorectal diseases

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World Journal of Gastroenterology 2016年第43期22卷 9477-9487页

作者： Renáta Bor Anna Fábián zoltán Szepes First Department of Medicine University of Szeged

Ultrasound is an undervalued non-invasive examination in the diagnosis of colonic diseases. It has been replaced by the considerably more expensive magnetic resonance imaging and computed tomography, despite the fact that, as first examination, it can usefully supplement the diagnostic process. Transabdominal ultrasound can provide quick information about bowel status and help in the choice of adequate further examinations and treatment. Ultrasonography,as a screening imaging modality in asymptomatic patients can identify several colonic diseases such as diverticulosis, inflammatory bowel disease or cancer. In addition, it is widely available, cheap, non-invasive technique without the use of ionizing radiation, therefore it is safe to use in childhood or during pregnancy, and can be repeated at any time. new ultrasound techniques such as elastography, contrast enhanced and Doppler ultrasound, miniprobes rectal and transperineal ultrasonography have broadened the indication. It gives an overview of the methodology of various ultrasound examinations, presents the morphology of normal bowel wall and the typical changes in different colonic diseases. We will pay particular attention to rectal and transperineal ultrasound because of their outstanding significance in the diagnosis of rectal and perineal disorders. This article seeks to overview the diagnostic impact and correct indications of bowel ultrasound.

关键词： Ultrasound Perineal ultrasound Rectal endosonography Gastrointestinal diseases

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Anthropogenic Pseudokarstic Depressions on Mount Bocskor(Bakony Region, Hungary)

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Journal of Earth Science 2023年第1期34卷 214-231页

作者： Márton Veress zoltán Unger Szilárd Vetési-Foith Department of Geography Savaria University centreEötvös Lóránd UniversitySzombathely9700Hungary Institute of Geography University of PécsPécs7600Hungary

Surface forms above the mine(ármin mine) of Mount Bocskor(Southern Bakony, Hungary) were examined. We made contour maps, plan maps, morphological maps and atectonic grike(cave) maps of some of the forms and their surroundings. We examined the distribution of the depth, length, elongation ratio in case of some depressions, the relation between the depth and the diameter of some depressions, the relationship between depression group directions and mine cut directions, the standard deviation of the direction differences of depression groups and of their depressions. The forms of the mountain related to surface mining can be separated to open and closed. The former are trenches and stairs, the latter are circular, elongated, and complex depressions. The formation of these forms can be related to the balancing movements of the vault over the mountain’s mine. At thin vault, stairs develop by collapses, while at the atectonic fissures of thicker vault, trenches and depressions are formed at the surface. In areas bordered by sinking(subsidence through) and downwardly cohesive faults, depression groups of diverse features are arranged in the marginal bands. Elongated depressions are formed at atectonic blocks bounded by dispersing faults in non-banded distribution. Where there is a superficial deposit, atectonic fissures can also be inherited directly by collapse to the surface and form depressions. They can also form indirectly over atectonic fissures by compaction, subsequent collapse and/or suffosion of the superficial deposit. The results of the study make it possible to analyse the material loss due to mining on the vault if the atectonic structures of the vault are partly or completely covered by superficial deposit.

关键词： mining pseudokarstic depression atectonic fissure atectonic block collapse suffosion

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Systematic exploration of signal-based indicators for failure diagnosis in the context of cyber-physical systems

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Frontiers of Information Technology & Electronic Engineering 2019年第2期20卷 152-175页

作者： Santiago RUIZ-AREnAS zoltán RUSáK Imre HORVáTH Ricardo MEJí-GUTIERREZ Faculty of Industrial Design Engineering Delft University of Technology Grupo de Investigación en Ingeniería de Diseno Universidad EAFIT

Malfunction or breakdown of certain mission critical systems(MCSs) may cause losses of life, damage the environments, and/or lead to high costs. Therefore, recognition of emerging failures and preventive maintenance are essential for reliable operation of MCSs. There is a practical approach for identifying and forecasting failures based on the indicators obtained from real life processes. We aim to develop means for performing active failure diagnosis and forecasting based on monitoring statistical changes of generic signal features in the specific operation modes of the system. In this paper, we present a new approach for identifying emerging failures based on their manifestations in system signals. Our approach benefits from the dynamic management of the system operation modes and from simultaneous processing and characterization of multiple heterogeneous signal sources. It improves the reliability of failure diagnosis and forecasting by investigating system performance in various operation modes, includes reasoning about failures and forming of failures using a failure indicator matrix which is composed of statistical deviation of signal characteristics between normal and failed operations, and implements a failure indicator concept that can be used as a plug and play failure diagnosis and failure forecasting feature of cyber-physical systems. We demonstrate that our method can automate failure diagnosis in the MCSs and lend the MCSs to the development of decision support systems for preventive maintenance.

关键词： Failure indicators Failure classification Failure detection and diagnosis Complex systems

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Stone–Wales defects in hexagonal boron nitride as ultraviolet emitters

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npj Computational Materials 2020年第1期6卷 169-175页

作者： Hanen Hamdi GergőThiering zoltán Bodrog Viktor Ivády Adam Gali Wigner Research Centre for Physics P.O.Box 49Budapest 1525Hungary Department of Physics Chemistry and BiologyLinköping UniversityLinköping SE-58183Sweden Budapest University of Technology and Economics Budafokiút 8.Budapest 1111Hungary

Many quantum emitters have been measured close or near the grain boundaries of the two-dimensional hexagonal boron nitride where various Stone–Wales defects *** show by means of first principles density functional theory calculations that the pentagon–heptagon Stone–Wales defect is an ultraviolet emitter and its optical properties closely follow the characteristics of a 4.08-eV quantum emitter,often observed in polycrystalline hexagonal boron *** also show that the square–octagon Stone–Wales line defects are optically active in the ultraviolet region with varying gaps depending on their density in hexagonal boron *** results may introduce a paradigm shift in the identification of fluorescent centres in this material.

关键词： Wales boron hexagonal

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Endangered lowland oak forest steppe remnants keep unique bird species richness in Central Hungary

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Journal of Forestry Research 2022年第1期33卷 343-355页

作者： GáborÓnodi zoltán Botta‑Dukát Dániel Winkler Tamás Rédei Institute of Ecology and Botany Centre for Ecological ResearchVácrátótHungary Department of Botany and Biodiversity Research University of ViennaViennaAustria Institute of Wildlife Management and Wildlife Biology University of SopronSopronHungary

The biodiversity of natural or semi-natural native,old oak woodlands have high conservation importance,especially in landscapes of monocultural forest plantations and arable *** a wider variety of microhabitats and foraging sources,such old oak forests can provide essential habitat for native forest bird *** conducted a study using bird point counts to compare the forest bird communities of old pedunculate oak(Quercus robur)remnants with native and non-native plantations in central Hungary in a landscape of mostly arable fields,settlements,and monocultural *** surveys were carried out in old oak forest remnants,middle-aged oak,white poplar(Populus alba),hybrid poplar(Populus×euramericana),black locust(Robinia pseudoacacia),and pine(Pinus spp.)*** has been carried out in nine study sites,where all six habitat types were represented(with a few exceptions),to determine total abundance,species richness,Shannon–Wiener diversity,species evenness,dominant and indicator species,and guild *** found that old oak forest remnants were the most diverse habitats among the studied forest types,while hybrid poplar and pine plantations exhibited the lowest avian *** avian guilds most sensitive to the loss of old oak forest remnants were ground foragers,bark foragers,cavity-nesters,residents,and Mediterranean migratory *** habitats were more diverse than non-native *** results suggest that it is important to conserve all remaining high biodiversity old oak stands and to avoid clear-cutting of monocultural plantations in favour of practices such as mixed-species plantations,longer rotation lengths,or retention forestry.

关键词： Forest bird community Bird conservation Old oak forest-steppe remnant Plantation forestry Forest conservation non-native plantation

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Acyclic Complexes and Gorenstein Rings

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Algebra Colloquium 2020年第3期27卷 575-586页

作者： Sergio Estrada Alina Iacob Holly zolt Departamento de Matematicas Universidad de MurciaMurcia 30100Spain Department of Mathematical Sciences Georgia Southern University StatesboroGA 30460-8093USA

For a given class of modules A,let A be the class of exact complexes having all cycles in A,and dw(A)the class of complexes with all components in *** by GL the class of Gorenstein injective *** prove that the following are equivalent over any ring R:every exact complex of injective modules is totally acyclic;every exact complex of Gorenstein injective modules is in every complex in dw(GL)is dg-Gorenstein *** analogous result for complexes of flat and Gorenstein flat modules also holds over arb计rary *** the ring is n-perfect for some integer n≥0,the three equivalent statements for flat and Gorenstein flat modules are equivalent with their counterparts for projective and projectively coresolved Gorenstein flat *** also prove the following characterization of Gorenstein *** R be a commutative coherent ring;then the following are equivalent:(1)every exact complex of FP-injective modules has all its cycles Ding injective modules;(2)every exact complex of flat modules is F-totally acyclic,and every R-modulc M such that M^(+)is Gorenstein flat is Ding injective;(3)every exact complex of injectives has all its cycles Ding injective modules and every R-module M such that is Gorenstein flat is Ding *** R has finite Krull dimension,statements(1)-(3)are equivalent to(4)R is a Gorenstein ring(in the sense of Iwanaga).

关键词： totally acyclic complex Gorenstein injective module Gorenstein projective module Gorenstein flat module Ding injective module

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Prevalence of refractive errors in Hungary reveals three-fold increase in myopia

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1174-1179页

作者： János németh TennóDaiki Gergely Dankovics István Barna Hans Limburg zoltán Zsolt nagy Department of Ophthalmology Semmelweis UniversityBudapest 1085Hungary Comprehensive Health Test Program of Hungary Szentendre 2000Hungary Department of Media and Education Informatics Eötvös Loránd UniversityBudapest 1053Hungary 1st Department of Internal Medicine Semmelweis UniversityBudapest 1083Hungary Health Information Services Grootebroek 1613LCThe Netherlands

AIM:To examine the prevalence and composition of refractive errors in ***:nationwide cross-sectional data collected between 2014 and 2019 were analysed from the Comprehensive Health Screening Program of Hungary,which provided spectacle dioptric power and autorefractometry data for 68227 people(35850 women and 32377 men).Their age distribution,18-99y,was similar to the national demographic ***:Of the total population,16.50%of the refractive errors exhibited hyperopia,40.05%emmetropia,and 43.45%*** was 3 times more frequent(58.7%)in younger ages(18-35y of age)compared to older age groups(19.4%of those 56-70y of age;Pnce(0.21%),and an increase parallel with ageing(r=0.716;P=0.009).COnCLUSIOn:Myopia is the most frequent refractive error in *** prevalence of myopia is especially increased,up to 2-3 times,in the younger age *** actions need to be taken to reduce the onset of myopia and its associated consequences.

关键词： refractive errors myopia hyperopia emmetropia Hungary

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Is rectal indomethacin effective in preventing of post-endoscopic retrograde cholangiopancreatography pancreatitis?

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World Journal of Gastroenterology 2014年第29期20卷 10151-10157页

作者： zoltán Dbrnte zoltán Szepes Ferenc Izbéki Judit Gervain László Lakatos Gyula Pécsi Miklós Ihász Lilla Lakner Erzsébet Toldy László Czakó Department of Gastroenterology and Internal Medicine Markusovszky Teaching Hospital 1st Department of Medicine University of Szeged 1st Department of Internal Medicine Szent Gyrgy Regional Hospital Department of Internal Medicine Csolnoky Ferenc Regional Hospital Department of Gastroenterology Karolina Hospital Central Laboratory Markusovszky Teaching Hospital Institute of Diagnostics Faculty of Health SciencesUniversity of Pécs

AIM: To investigate the effectiveness of rectally administered indomethacin in the prophylaxis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and hyperamylasaemia in a multicentre study.

关键词： Endoscopic retrograde cholangiopancreatography Post-endoscopic retrograde cholangiopancreatography pancreatitis Hyperamylasaemia nonsteroidal anti-inflammatory drugs Indomethacin

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