检索结果-南通市图书馆

Hippo-YAP/TAZ signaling in breast cancer:Reciprocal regulation of microRNAs and implications in precision medicine

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第2期11卷 760-771页

作者： Farzad Sadri Seyede fatemeh Hosseini zohreh Rezaei Mohammad Fereidouni Student Research Committee Birjand University of Medical SciencesBirjand ***Iran Tabas School of Nursing Birjand University of Medical SciencesBirjand ***Iran Department of Biology University of Sistan and BaluchestanZahedan ***Iran Cellular and Molecular Research Center Birjand University of Medical SciencesBirjand ***Iran

Breast cancer is a molecularly heterogeneous disease and the most common female *** recent years,therapy approaches have evolved to accommodate molecular diversity,with a focus on more biologically based therapies to minimize negative *** regulate cell fate in human breast cells,the Hippo signaling pathway has been associated with the alpha subtype of estrogen *** pathway regulates tissue size,regeneration,and healing,as well as the survival of tissue-specific stem cells,proliferation,and apoptosis in a variety of organs,allowing for cell *** signaling is mediated by the kinases MST1,MST2,LATS1,and LATS2,as well as the adaptor proteins SAV1 and *** kinases phosphorylate the downstream effectors of the Hippo pathway,yes-associated protein(YAP),and transcriptional coactivator with PDZ-binding motif(TAZ),suppressing the expression of their downstream target *** Hippo signaling pathway kinase cascade plays a significant role in all *** the principles of this kinase cascade would prevent the occurrence of breast *** recent years,small noncoding RNAs,or microRNAs,have been implicated in the development of several malignancies,including breast *** interconnections between miRNAs and Hippo signaling pathway core proteins in the breast,on the other hand,remain poorly *** this review,we focused on highlighting the Hippo signaling system,its key parts,its importance in breast cancer,and its regulation by miRNAs and other related pathways.

关键词： Breast cancer Hippo signaling Large tumor suppressor kinase 1 microRNAs PDZ-binding motif Yes-associated protein

Histologic Types of Chest Wall Tumors—Nine Years’ Single Center Experience

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Pathology 2014年第1期4卷 13-19页

作者： zohreh mohammadtaheri Atosa Dorudinia Abolghasem Daneshvar Pegah Akhavan Azar Foruzan Mohammadi Chronic Respiratory Diseases Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran Mycobacteriology Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran Pediatric Respiratory Diseases Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran Tracheal Diseases Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran Virology Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran

Background: Chest wall tumors are rare and mostly malignant. More than half of the malignancies are primary and the remainder are metastatic. Many studies have reported that metastatic lesions occur with about the same frequency as primary tumor. We evaluate common histological types of chest wall tumors in a tertiary center for respiratory and thoracic diseases (National Research Institute of Tuberculosis and Lung Disease). Method: We performed a retrospective study of chest wall tumors at National Research Institute of Tuberculosis and Lung Disease (NRITLD) from April 2001 to March 2010. The pathology slides of patients were retrieved from the pathology archive of NRITLD and reviewed by two pathologists. The lesions were classified as primary or metastatic according to the relevant clinical data and imaging findings. Result: A total of 124 chest wall tumors were identified in patients with a mean age of 47.7 years (range 4-90 years). The male/female ratio was 2:1. The most commonly affected side was the right (42.7%). There were 105 malignant tumors (84.7%), out of which 49 (46.2%) were primary and 57 (53.8%) were metastatic in origin. The majority of the metastatic lesions were epithelial tumors (36/57) (63.1%). The metastatic origin was clear in 51 cases, mostly arising from the lungs (35.7%). The most common types of primary chest wall tumors were primitive neuroectodermal tumor (15/49, 30.6%), chondrosarcoma (7/49, 14.3%), and malignant fibrous histiocytoma, undifferentiated pleomorphic sarcoma (5/49, 10.2%). The most common benign tumor was lipoma (5/18, 35.7%). Conclusion: Most common tumors of chest wall in this study were malignant, mostly metastatic epithelial neoplasms.

关键词： Chest Wall Histology Immunohistochemistry Primary Metastatic Tumor

Late infection after peri-orbital autologous micro-fat graft:a case presentation and literature review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第3期17卷 603-606页

作者： Farzad Pakdel Hassan Asadigandomani Melika Arab Bafrani zohreh Nozarian Zohre Abedinifar Niloofar Pirmarzdashti Behzad Jafari Zaynab Siami Department of Oculofacial Plastic Surgery Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Craniomaxillofacial Research Center Tehran University of Medical SciencesTehran ***Iran Department of Ophthalmology School of MedicineTehran University of Medical SciencesTehran ***Iran Department of Pathology Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Department of Microbiology Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Pediatric Cell and Gene Therapy Research Center Children’s Medical CenterSchool of MedicineTehran University of Medical SciencesTehran ***Iran

Citation:Pakdel F,Asadigandomani H,Arab Bafrani M,Nozarian Z,Abedinifar Z,Pirmarzdashti N,Jafari B,Siami *** infection after peri-orbital autologous micro-fat graft:a case presentation and literature *** J Ophthalmol ... 详细信息

关键词： graft orbital after

Assessment of groundwater potential using multi-criteria decision analysis and geoelectrical surveying

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geo-Spatial Information Science 2022年第4期25卷 600-618页

作者： Marzieh Shabani zohreh Masoumi Abolfazl Rezaei Department of Earth Sciences Institute for Advanced Studies in Basic Sciences(IASBS)ZanjanIran Center for Research in Climate Change and Global Warming(CRCC) Institute for Advanced Studies in Basic Sciences(IASBS)ZanjanIran

A precise map of the dispersion of the groundwater potential across each watershed can help decision-makers to exert optimal water management in each *** this research,the potential of groundwater resources in both the Zanjanrood Catchment and the Tarom Region,located in the northwest of Iran,has been *** effective criteria including slope,land-use,drainage density,spring density,lithology,lineament density,and rainfall are *** were first weighted using the Analytical Hierarchical Process(AHP)method and then overlaid by the Technique for Order Preferences by Similarity to Ideal(TOPSIS)***,the spatial zoning map of groundwater potential was obtained in four categories.A sensitivity analysis was performed to determine the influence of each criterion on the obtained *** model was verified using both the spatial distribution of the high-discharged production wells and the geophysical-based geoelectric field *** results indicate that the high-discharged wells(>40 l/s)in both regions are dispersed predominantly in the very good zone and,in several cases,in the good ***,the results from the two-dimensional models of resistivity and induced polarization of geoelectrical field survey are inappropriate agreement with those from the TOPSIS ***,there is no suitable potential zone of groundwater in the surrounding highlands to be used in the future for drinking purposes since the highlands water supply is a strategic supply for *** strategies employed in this study,the results of GIS modeling,and the geoelectrical analysis can be considered for sustainable development of similar arid and semi-arid areas since groundwater is considered as the main supplier of water in such regions.

关键词： Spatial Information System(GIS) Remote Sensing(RS) groundwater potential TOPSIS geoelectrical field survey sustainable development

Effects of Annealing on the Fabrication of Al-TiAl3 Nanocomposites Before and After Accumulative Roll Bonding and Evaluation of Strengthening Mechanisms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2022年第4期35卷 636-650页

作者： zohreh Yazdani Mohammad Reza Toroghinejad Hossein Edris Department of Materials Engineering Isfahan University of Technology84156-83111 IsfahanIran

The strengthening mechanisms of Al-TiAl_(3) nanocomposite, fabricated using cold roll bonding, annealing, and accumulative roll bonding(ARB) on Al sheets sandwiching with pure Ti powder were investigated in the present study. With annealing at 590 ℃ for 2 h, TiAl_(3) intermetallic compound was formed. After subsequent ARB process up to 5 cycles, final composite consists of ultrafine Al grains of less than 500 nm with TiAl_(3) particles larger than 200 nm. The strength and hardness of the final composite are 2.5 and 3.5 times the initial values, with an ultimate tensile strength of 400 MPa, which is dominated by grain-boundary strengthening due to the ultrafine Al grains, and Orowan strengthening due to the small TiAl_(3) particles. For comparison, an alternative fabrication route of cold roll bonding–ARB–annealing was also studied. This study showed that annealing before ARB is a critical factor in producing an ultrafine grain structure containing TiAl_(3) particles.

关键词： Composite Annealing Strength Microstructure Al

Effect of copper nanoparticles on thermal behavior of two-phase argon-copper nanofluid flow in rough nanochannels with focusing on the interface properties and heat transfer using molecular dynamics simulation

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2022年第2期35卷 344-350页

作者： Shabnam Ghahremanian Abbas Abbassi zohreh Mansoori Davood Toghraie Department of Mechanical Engineering Amirkabir University of TechnologyTehranIran Department of Mechanical Engineering Amirkabir University of TechnologyHafez Ave.P.O.Box 15916-34311TehranIran Energy Research Center Amirkabir University of TechnologyHafez Ave.P.O.Box 15916-34311TehranIran Department of Mechanical Engineering Khomeinishahr BranchIslamic Azad UniversityKhomeinishahrIran

A comparison between the efficacy of surface boundary structure and presence of nanoparticles on the condensation two-phase flow inside rough nanochannels has been accomplished by applying molecular dynamics procedure to evaluate the thermal conductivity and flow *** is performed in a computational region with two copper walls containing rectangular rough elements under different saturated *** main properties of liquid–vapor interface including density and the number of liquid atoms,are *** is observed that the density profile is more affected by nanoparticles than the ***,compared to the condensation of nanofluid in a smooth nanochannel,the rough wall causes a greater drop in the temperature at the early time steps and by development of liquid films,effects of the wall roughness *** the first of the condensation process,adding nanoparticle causes that transferring argon particles to the liquid phase increases with a steeper ***,heat current autocorrelation function(HCACF)for nanofluid condensation flow over considered correlation time is analyzed and following that the thermal conductivity for different saturated conditions is *** has been represented that at lower temperatures the roughness makes more significant influence on the heat transfer of two-phase flow,while at higher temperatures the importance of nanoparticles prevails.

关键词： Two-phase flow Nanofluid Roughness element Thermal conductivity

A comparison of three surface roughness characterization techniques:photogrammetry,pin profiler,and smartphone-based LiDAR

在线全文

学校读者我要写书评

暂无评论

International Journal of Digital Earth 2022年第1期15卷 2422-2439页

作者： zohreh Alijani Julien Meloche Alexander McLaren John Lindsay Alexandre Roy Aaron Berg Department of Geography Environment and GeomaticsUniversity of GuelphGuelphCanada Département de Géomatique Appliquée Université de SherbrookeSherbrookeCanada Département des Sciences de l’Environment Université du Québec à Trois-RivièresTrois-RivièresCanada

Surface roughness plays an important role in microwave remote *** the agricultural domain,surface roughness is crucial for soil moisture retrieval methods that use electromagnetic surface scattering or microwave radiative transfer ***,improved characterization of Soil Surface Roughness(SSR)is of considerable *** this study,three approaches,including a standard pin profiler,a LiDAR point cloud generated from an iPhone 12 Pro,and a Structure from Motion(SfM)photogrammetric point cloud,were applied over 24 surface profiles with different roughness variations to measure surface *** objective of this study was to evaluate the capability of smartphone-based LiDAR technology to measure surface roughness parameters and compare the results of this technique with the more common *** showed that the iPhone LiDAR technology,when point cloud data is captured in a fine-resolution mode,has a significant correlation with SfM photogrammetry(R2=0.70)and a relatively close agreement with pin profiler(R2=0.60).However,this accuracy tends to be greater for random surfaces and rough profiles with row structure *** results of this study confirm that smartphone-based LiDAR can be used as a cost-effective,fast,and time-efficient alternative tool for measuring surface roughness,especially for rough,wide,and inaccessible areas.

关键词： LiDAR surface roughness structure from motion iPhone pin profiler

The effect of climate factors on the size of forest wildfires(case study:Prague-East district,Czech Republic)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2022年第4期33卷 1291-1300页

作者： zohreh Mohammadi Peter Lohmander Jan Kašpar Roman Berčák Jaroslav Holuša Robert Marušák Faculty of Forestry and Wood Sciences Czech University of Life Sciences PragueKamýcká12916500 Praha-SuchdolCzech Republic Optimal Solutions in Cooperation with Linnaeus University UmeaSweden

This paper presents a new approach to identifying the climate variables that influence the size of the area burned by forest *** linear regression was used in combination with nonlinear variable transformations to determine relevant nonlinear forest wildfire size *** from the Prague-East District of the Czech Republic was used for model *** burned forest area was hypothesized as a function of water vapor pressure,air temperature and wind *** speed was added to enhance predictions of the size of forest wildfires,and further improvements to the utility of prediction methods were added to the regression *** results show that if the air temperature increases,it may contain less water and the fuel will become *** size of the burned area then *** the relative humidity in the air increases and the wind speed decreases,the size of the burned area is *** model suggests that changes in the climate factors caused by ongoing climate change could cause significant changes in the size of wildfire in forests.

关键词： Climatic variables Burned forest area Climate change Multiple linear regression

Analytical solution of the low Reynolds third-grade non-Newtonian fluids flow inside rough circular pipes

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2020年第5期36卷 1018-1030,I0001页

作者： zohreh Sheidaei Pooria Akbarzadeh Faculty of Mechanical and Mechatronics Engineering Shahrood University of TechnologyShahroodIran

The present paper focuses on finding an analytical solution for fully developed third-grade non-Newtonian fluids flows inside rough circular pipes at low Reynolds numbers(Stokes flows).The wall roughness is modeled by two different periodic morphologies based on sinusoidal and triangular *** this study,the relative roughness(ratio of the roughness amplitude to the pipe hydraulic diameter)is selected to be a small value,which is appropriate for the perturbation *** governing parameters including the axial and radial velocity profiles,stream function,wall shear stress,pressure gradient,and friction factor are expressed in analytical formulas and they are compared to the smooth *** effect of the relative roughness,the wall wave number,and the non-Newtonian parameter on the governing parameters are *** results show that modeling the roughness by triangular geometry has a better prediction of pressure drop regarding the basic solution of the smooth pipe.

关键词： Relative roughness Third-grade non-Newtonian fluid Perturbation method Low Reynolds number