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Phytopharmacological potential of different species of Morus alba and their bioactive phytochemicals:A review

Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 950-956页

作者： Fahad Hussain zohaib rana Hassan Shafique Arif Malik Zahid Hussain Institute of Molecular Biology and Biotechnology(IMBB) The University of LahoreRaiwind Road55150LahorePakistan Department of Pharmaceutics Faculty of PharmacyUniversiti Teknologi MARAPuncak Alam CampusBandar Puncak Alam42300SelangorMalaysia

Medicinal plants of Moraceae family have been well-recognized traditionally due to their versatile applications in various fields including agriculture, cosmetic and food as well as in pharmaceutical industries. Their biomedical and medicinal importance is reflected from their broad range of pharmacological activities for treatment of various inflammatory conditions, cancer, infectious diseases, and gastrointestinal disorders. The present review was aimed to summarize and critically discuss the biomedical implications of Morus species, their bioactive compounds, and phytochemicals. Bioactivity guided fractionation of these medicinal plants revealed that different types of bioactive phytochemicals and secondary metabolites such as steroids, saponins, alkaloids, glycosides and phenolic compounds including terpenoids, flavonoids, anthocyanins and tannins were present. The critical analysis of the literature revealed that the aqueous, methanolic, and ethanolic extracts of Morus species and their bioactive compounds exhibit remarkable anti-oxidative,anti-diabetic, anti-stress, nephroprotective, antimicrobial, anti-mutagenic, anticancer,anxiolytic, hepatoprotective, anthelmintic, antimicrobial, immune-modulatory and cholesterol lowering effects. Based on the literature review and bioactivity guided investigation of Morus species and their phytomedicinal effects, we anticipate that these herbal products hold excellent potential for future research.

关键词： Moraceae Phytochemicals Pharmacological activities Anti-inflammatory Immunomodulatory Anticancer

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Efficient hepatoprotective activity of cranberry extract against CCl_4-induced hepatotoxicity in Wistar albino rat model: Down-regulation of liver enzymes and strong antioxidant activity

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1054-1058页

作者： Fahad Hussain Arif Malik Ujala Ayyaz Hassan Shafique zohaib rana Zahid Hussain Institute of Molecular Biology and Biotechnology (IMBB) The University of Lahore Department of Biochemistry University of AgricultureFaisalabad Department of Pharmaceutics Faculty of Pharmacy Universiti Teknologi MARA Puncak Alam Campus

ObjectiveTo investigate the hepatoprotective efficacy of cranberry extract (CBE) against carbon tetrachloride (CCl4)-induced hepatic injury using in-vivo animal *** hepatoprotective efficacy of CBE (200 and 400 mg/kg) was investigated against CCl4 (4 mL/kg)-induced hepatotoxicity, elevated liver enzymes [ALT (alanine aminotransferase), AST (aspartate aminotransferase), and alkaline phosphatase (ALP)], and total protein (TP) contents in the serum. Moreover, CBE-aided antioxidant defense against hepatotoxic insult of CCl4 was measured by evaluating a number of anti-oxidative biomarkers including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) in the serum by using spectrophotometric *** showed that the exposure of experimental animals to CCl4 did induce significant hepatotoxicity compared to the non-induced (untreated) group. The oral administration of CBE demonstrated a significant dose-dependent alleviation in the liver enzymes (AST, ALT, and ALP), increased antioxidant defense (GSH, SOD, and CAT), and reduced MDA levels in the serum of treated animals compared to the animals without treatment. The resulting data showed that the administration of CBE decreased the serum levels of ALT, AST, and ALP compared to the CCl4-induced *** resulting data evidenced that CBE exhibits promising hepatoprotective potential against the chemical induced hepatotoxicity, maintains homeostasis in liver enzymes, and can provide significant antioxidant defense against free radicals-induced oxidative stress.

关键词： Hepatotoxicity Carbon tetrachloride Oxidative stress Liver enzymes Cranberry extract Hepatoprotective

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Homeostatic relevance of vitamin D in maintaining male fertility in human: Down-regulation of oxidative stress and up-regulation of anti-oxidative defense and steroidal hormones

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Asian pacific Journal of Reproduction 2018年第2期7卷 56-61页

作者： Fahad Hussain Arif Malik Muhammad Saeed Qureshi Muhammad Imran Sulayman Waquar Hassan Shafique zohaib rana Hnin Ei Thu Zahid Hussain Institute of Molecular Biology and Biotechnology The University of LahoreRaiwind Road55150LahorePakistan Department of Biochemistry Akhtar Saeed Medical and Dental CollageLahorePakistan Department of Physiology Nishtar Medical University66000MultanPakistan Department of Biochemistry University of AgricultureFaisalabad38040Pakistan Department of Pharmacology Faculty of MedicineUniversiti Kebangsaan MalaysiaJalan Yaacob LatifBandar Tun Razak56000CherasKualaLumpurMalaysia Department of Pharmaceutics Faculty of PharmacyUniversiti Teknologi MARAPuncak Alam CampusBandar Puncak Alam42300SelangorMalaysia

Objective:To evaluate correlation between the levels of vitamin D and male infertility as well as to determine the efficacy of vitamin D in improving the male fertility by up-regulating the levels of testosterone and ***: In the present study, 130 male patients (aged 25-70 years) having fertility defects were screened and 145 healthy individuals were taken as control. All human subjects were screened for 4-hydroxynonenal, isoprostane-F2α, 8-hydroxy-2′-deoxyguanosine, vitamin D, luteinizing hormone, follicle stimulating hormone, testosterones, malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, and nitric ***: The screening analysis revealed that the levels of luteinizing hormone, follicle stimulating hormone, and testosterone were lower in male infertile subjects compared to healthy subjects. Similarly, the levels of vitamin D [(17.17 ± 2.30) ng/mL] and calcium[(6.29 ± 0.31) mg/dL] were significantly lower in infertile groups compared to the normal healthy groups. Moreover, the study revealed that the levels of superoxide dismutase, catalase, and glutathione peroxidase were significantly higher in healthy subjects compared to the infertile ***:Vitamin D exhibits strong relevance to male fertility by maintaining the levels of sex hormones (luteinizing hormone, follicle stimulating hormone, and testosterone), up-regulating the antioxidant defense (superoxide dismutase, catalase, and glutathione peroxidase), and down-regulating the oxidative stress (malondialdehyde, nitric oxide, and inducible nitric oxide synthase species).

关键词： Vitamin D Male fertility Luteinizing hormone Follicle-stimulating hormone Testosterone Oxidative stress Spermatogenesis

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