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一种基于非均匀线性麦克风阵列的窄带声源定向方法及系统

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电子器件 2024年第1期47卷 116-121页

作者：唐洵睿钱晓昱王子源孟桥东南大学吴健雄学院江苏南京211189 东南大学信息科学与工程学院江苏南京210096

提出了一种基于窄带信号相位时延估计的信号定位方法,通过非均匀线性阵列的布放,解决增大阵元孔径带来的相位卷绕问题,提高定位精度。提出了非均匀线性布阵方式情况下,修正卷绕量计算延时量的估计算法,并给出了非均匀阵列间距需要满足... 详细信息

提出了一种基于窄带信号相位时延估计的信号定位方法,通过非均匀线性阵列的布放,解决增大阵元孔径带来的相位卷绕问题,提高定位精度。提出了非均匀线性布阵方式情况下,修正卷绕量计算延时量的估计算法,并给出了非均匀阵列间距需要满足的条件。此方法提高了定位可用基阵孔径,与一般均匀间隔线性阵列相比,大大减少了同孔径下所需的阵元个数,从而降低了对后续信号处理设备的需求。构建了定位系统并进行实际测试。实验表明,所提方法有效地提高了在开放空间中对窄带声源的定位精度。

关键词：窄带声源定向非均匀线性阵列时延估计解相位卷绕

A Review on Metal-Organic Framework-Derived Porous Carbon-Based Novel Microwave Absorption Materials

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Nano-Micro Letters 2021年第4期13卷 1-29页

作者： Zhiwei Zhang Zhihao Cai ziyuan wang Yaling Peng Lun Xia Suping Ma Zhanzhao Yin Yi Huang National Institute for Advanced Materials Tianjin Key Laboratory of Metal and Molecule Based Material Chemistry Key Laboratory of Functional Polymer MaterialsCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)School of Materials Science and EngineeringNankai UniversityTianjin 300350People’s Republic of China

The development of microwave absorption materials(MAMs) is a considerable important topic because our living space is crowed with electromagnetic wave which threatens human’s *** MAMs are also used in radar stealth for protecting the weapons from being *** nanomaterials were studied as MAMs,but not all of them have the satisfactory ***,metal-organic frameworks(MOFs) have attracted tremendous attention owing to their tunable chemical structures,diverse properties,large specific surface area and uniform pore *** can transform to porous carbon(PC) which is decorated with metal species at appropriate pyrolysis ***,the loss mechanism of pure MOF-derived PC is often relatively *** order to further improve the MA performance,the MOFs coupled with other loss materials are a widely studied *** this review,we summarize the theories of MA,the progress of different MOF-derived PC-based MAMs,tunable chemical structures incorporated with dielectric loss or magnetic loss *** different MA performance and mechanisms are discussed in ***,the shortcomings,challenges and perspectives of MOF-derived PC-based MAMs are also *** hope this review could provide a new insight to design and fabricate MOF-derived PC-based MAMs with better fundamental understanding and practical application.

关键词： Metal-organic frameworks Porous carbon Microwave absorption material Reflection loss Effective absorption bandwidth

乡村振兴背景下3类福建乡村文化景观针灸点探索

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山西建筑 2024年第11期50卷 41-45页

作者：贺宇豪王紫媛刘玥婷白霖北京市十三陵林场管理处北京100000 北京市大兴区园林服务中心北区公园管理所北京100000 北京天岳恒房屋经营管理有限公司北京100000 北京市政建设集团有限责任公司北京100000

乡村振兴背景下,如何通过建筑手段参与乡村发展,带动乡村活化是一个值得探索的问题。结合文献与实践梳理福建乡村文化特色,确立了福建乡村针灸点。依托永泰庄寨、向阳民宿等乡村实践案例,针对宗法景观、公共景观、居住景观三种类型进行... 详细信息

乡村振兴背景下,如何通过建筑手段参与乡村发展,带动乡村活化是一个值得探索的问题。结合文献与实践梳理福建乡村文化特色,确立了福建乡村针灸点。依托永泰庄寨、向阳民宿等乡村实践案例,针对宗法景观、公共景观、居住景观三种类型进行实践。通过人类学访谈证实了实践后文化景观对于村民活动和集体意识的正相关作用,验证了针灸点选取的正确性,证明了在乡村振兴中合理的建筑针灸能够实现空间活化和地区激活等基本要求。

关键词：文化景观建筑针灸乡村振兴实践景观人类学

Methods for Shale Gas Play Assessment: A Comparison between Silurian Longmaxi Shale and Mississippian Barnett Shale

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Journal of Earth Science 2015年第2期26卷 285-294页

作者： Songqi Pan Caineng Zou Zhi Yang Dazhong Dong Yuman wang Shufang wang Songtao Wu Jinliang Huang Qun Liu Dule wang ziyuan wang School of Earth and Space Sciences Peking University Research Institute of Petroleum Exploration & Development Petro China Southwest Petroleum University

Based on field work, organic geochemical analyses and experimental testing, a six-property assessment method for shale gas is proposed. These six properties include organic matter properies, lithofacies, petrophysical properties, gas content, brittleness and local stress field. Due to the features of continuous distribution over a large area and low resource abundance in shale plays, a sweet spot should have these following properties：（a） TOC〉2%; （b） brittle minerals content （〉40%） and clay minerals （〈30%）; （c） Ro （〉1.1%）; （d） porosity （〉2%） and permeability （〉0.000 1 mD）, and （e） effective thickness （30-50 m）. Applying these criteria in the Sichuan Basin, the Silurian Longmaxi shale consists of four prospecting sweet spots, including blocks of Changning, Weiyuan, Zhaotong and Fushnn-Yongchuan. Although these four blocks have some similarities, different features were usually observed. After comprehensive analyses using the six-property assessment method, the Fushun-Yongan Block ranks the most favorable sweet spot, followed by the Weiyuan Block. For the other two blocks, the Changning Block is better than the Zbaotong Block. By comparing with the Mississippian Barnett shale, characteristics that are crucial for a high-yielding in the Sichuan Basin include a high content of organic matter （TOC〉2.5%）, a moderate thermal maturity （Ro=0.4%-2%）, a high content of brittle minerals （quartz： 30%-45%）, a high gas content （〉2.5 m^3·t^-1）, and types I and II1 kerogen.

关键词： shale gas play Silurian Longmaxi shale Barnett shale sweet spot six-property assessment.

大叶茜草素对肝癌细胞铁死亡的影响及作用机制研究

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中国中医药信息杂志 2024年第9期31卷 124-130页

作者：姜宇朗余永鑫王子元潘子扬孙明瑜上海中医药大学附属曙光医院上海中医药大学肝病研究所肝肾疾病病证教育部重点实验室上海中医药大学上海201203

目的基于铁死亡通路探究大叶茜草素抑制肝细胞癌的作用机制。方法体外培养肝癌HepG2细胞,根据IC50分为对照组、大叶茜草素低剂量组(10μmol/L)、大叶茜草素中剂量组(20μmol/L)和大叶茜草素高剂量组(40μmol/L),CCK-8法检测细胞活力,... 详细信息

目的基于铁死亡通路探究大叶茜草素抑制肝细胞癌的作用机制。方法体外培养肝癌HepG2细胞,根据IC50分为对照组、大叶茜草素低剂量组(10μmol/L)、大叶茜草素中剂量组(20μmol/L)和大叶茜草素高剂量组(40μmol/L),CCK-8法检测细胞活力,乳酸脱氢酶(LDH)试剂盒检测细胞毒性,克隆形成实验观察细胞克隆能力,检测细胞谷胱甘肽(GSH)、丙二醛(MDA)、活性氧(ROS)、超氧化物歧化酶(SOD)、超氧化物、脂质过氧化物含量及线粒体膜电位(MMP),Western blot检测细胞铁死亡抑制蛋白1(FSP1)、GTP环化水解酶1(GCH1)、二氢乳清酸脱氢酶(DHODH)、谷胱甘肽过氧化物酶(GPX)4蛋白表达,RT-qPCR检测FSP1、DHODH、GCH1、GPX4 mRNA表达。在过表达和沉默GPX4条件下观察大叶茜草素对HepG2细胞活力和GSH、MDA含量的影响。结果中、高剂量大叶茜草素可减少HepG2细胞克隆形成数目,降低细胞GSH含量和SOD活性,升高MDA、超氧化物、脂质过氧化物和ROS含量,降低MMP(P<0.001)。大叶茜草素干预对HepG2细胞FSP1、GCH1、DHODH蛋白和mRNA表达无显著影响,可降低GPX4蛋白和m RNA表达(P<0.001),过表达和沉默实验验证GPX4是大叶茜草素调控铁死亡的核心靶点。结论大叶茜草素主要通过调节GPX4介导的铁死亡发挥抗肝细胞癌作用。

关键词：大叶茜草素肝细胞癌铁死亡 HepG2细胞谷胱甘肽过氧化物酶4

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护生就业意向决策困难现状及影响因素研究

卫生职业教育 2024年第10期42卷 100-103页

作者：王少凯蓝春楚长乐王子源张乔威张伟新齐齐哈尔医学院护理学院黑龙江齐齐哈尔161006

于2023年6月至9月,采用自制就业意向决策调查问卷,便利整群抽样在黑龙江省就读的345名护理本科生作为研究对象,探讨黑龙江省护生就业意向决策困难现状以及影响因素,以减少护理人才的流失,为护生就业相关研究和实践提供参考依据。研究表... 详细信息

于2023年6月至9月,采用自制就业意向决策调查问卷,便利整群抽样在黑龙江省就读的345名护理本科生作为研究对象,探讨黑龙江省护生就业意向决策困难现状以及影响因素,以减少护理人才的流失,为护生就业相关研究和实践提供参考依据。研究表明,需要加强社区护理、护理科研相关培训和宣传,加强就业支持和指导,加强护生的核心竞争力,提高护理行业薪资待遇等,以此来增强护生的职业认同感,加强职业稳定性。

关键词：护生就业意向职业选择就业决策影响因素

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When quantum dots meet blue phase liquid crystal elastomers:visualized full-color and mechanically-switchable circularly polarized luminescence

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Light(Science & Applications) 2024年第6期13卷 1210-1220页

作者： Shan Li Yuqi Tang Qingyan Fan ziyuan Li Xinfang Zhang Jingxia wang Jinbao Guo Quan Li Key Laboratory of Carbon Fibers and Functional Polymers Ministry of Educationand College of Materials Science and EngineeringBeijing University of Chemical Technology100029BeijingChina Institute of Advanced Materials and School of Chemistry and Chemical Engineering Southeast UniversityNanjing211189China Materials Science Graduate Program Kent State UniversityKentOH44242USA CAS Key Laboratory of Bio-Inspired Materials and Interfacial Sciences Technical Institute of Physics and ChemistryChinese Academy of Sciences100190BeijingChina

Polymer-based circularly polarized luminescence(CPL)materials with the advantage of diversified structure,easy fabrication,high thermal stability,and tunable properties have garnered considerable ***,adequate and precise tuning over CPL in polymer-based materials remains challenging due to the difficulty in regulating chiral ***,visualized full-color CPL is achieved by doping red,green,and blue quantum dots(QDs)into reconfigurable blue phase liquid crystal elastomers(BPLCEs).In contrast to the CPL signal observed in cholesteric liquid crystal elastomers(CLCEs),the chiral 3D cubic superstructure of BPLCEs induces an opposite CPL ***,this effect is entirely independent of photonic bandgaps(PBGs)and results in a high glum value,even without matching between PBGs and the emission bands of ***,the lattice structure of the BPLCEs can be reversibly switched via mechanical stretching force,inducing on-off switching of the CPL signals,and these variations can be further fixed using dynamic disulfide bonds in the ***,the smart polymer-based CPL systems using the BPLCEs for anti-counterfeiting and information encryption have been demonstrated,suggesting the great potential of the BPLCEs-based CPL active materials.

关键词： circular quantum crystal

血管内皮Krüppel样因子2的抗动脉粥样硬化作用及相关治疗药物研究进展

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药学进展 2024年第7期48卷 536-547页

作者：滕媛赵志伟黄亚萍牟龙王子元张健殷志琦中国药科大学中药学院中药制剂系江苏南京211198 江苏省中医药研究院转化医学实验室江苏南京210046

Krüppel样因子2(KLF2)是一种锌指转录因子,通过与目标基因的顺式作用元件结合,正向或负向调控目标基因转录过程。已有研究发现,KLF2高表达于内皮细胞,参与调控涉及细胞分化、炎症反应、氧化应激等多种生物学过程的信号通路,从而缓解血... 详细信息

Krüppel样因子2(KLF2)是一种锌指转录因子,通过与目标基因的顺式作用元件结合,正向或负向调控目标基因转录过程。已有研究发现,KLF2高表达于内皮细胞,参与调控涉及细胞分化、炎症反应、氧化应激等多种生物学过程的信号通路,从而缓解血管内皮功能障碍,发挥良好的抗动脉粥样硬化作用。对KLF2抗动脉粥样硬化的功能与机制进行总结,并介绍调控KLF2相关信号通路药物的最新研究进展,旨在为抗动脉粥样硬化药物的开发提供新的策略。

关键词： Krüppel样因子2 内皮功能障碍动脉粥样硬化治疗靶标

Single-cell transcriptomic atlas of goat ovarian aging

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Journal of Animal Science and Biotechnology 2024年第1期15卷 146-161页

作者： Dejun Xu Shuaifei Song Fuguo wang Yawen Li ziyuan Li Hui Yao Yongju Zhao Zhongquan Zhao Chongqing Key Laboratory of Herbivore Science College of Animal Science and TechnologySouthwest UniversityChongqing 400715China

Background The ovaries are one of the first organs that undergo degenerative changes earlier in the aging process,and ovarian aging is shown by a decrease in the number and quality of ***,little is known about the molecular mechanisms of female age-related fertility decline in different types of ovarian cells during aging,especially in ***,the aim of this study was to reveal the mechanisms driving ovarian aging in goats at single-cell *** For the first time,we surveyed the single-cell transcriptomic landscape of over 27,000 ovarian cells from newborn,young and aging goats,and identified nine ovarian cell types with distinct gene-expression *** enrichment analysis showed that ovarian cell types were involved in their own unique biological processes,such as Wnt beta-catenin signalling was enriched in germ cells,whereas ovarian steroidogenesis was enriched in granulosa cells(GCs).Further analysis showed that ovarian aging was linked to GCs-specific changes in the antioxidant system,oxidative phosphorylation,and ***,we identified a series of dynamic genes,such as AMH,CRABP2,THBS1 and TIMP1,which determined the fate of ***,FOXO1,SOX4,and HIF1A were identified as significant regulons that instructed the differentiation of GCs in a distinct manner during ovarian *** This study revealed a comprehensive aging-associated transcriptomic atlas characterizing the cell typespecific mechanisms during ovarian aging at the single-cell level and offers new diagnostic biomarkers and potential therapeutic targets for age-related goat ovarian diseases.

关键词： Goat Granulosa cells Ovarian aging Single-cell transcriptomic