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Atmospheric and Oceanic Science Letters 2024年第4期17卷 15-22页

作者： Weikai Jia Botao Zhou ziyi song Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina

评估了20个CMIP6模式对春季北极涛动(AO)与长江流域夏季降水(YRP)关系的模拟能力.结果表明, 4个模式(ACCESS-ESM1-5, CMC-CM2-SR5, MRI-ESM2-0, NorESM2-LM))能合理模拟出1990年代后期AO-YRP关系的减弱. 1980-1998年,当春季AO位于正位相时,夏季东亚急流北移,长江流域为异常下沉运动,同时西太平洋副热带高压减弱,减少向长江流域的水汽输送,结果导致降水减少. 1999-2014年,上述大气环流与春季AO的联系不显著,从而减弱AO-YRP的关系.利用这四个模式进一步预估了RCP4.5情景下2015-2100年期间AO-YRP的关系.两者在2015-2040年为显著负相关关系,随后再次减弱.

关键词：北极涛动降水长江流域年代际变化 CMIP6

场景功能·精神观照·历史书写:电影空间形态的多元样式论

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电影评介 2024年第1期 28-33页

作者：宋姿颐北京电影学院视听传媒学院

作为一门结合时间与空间表现方式的综合艺术,电影以平面化的形式构成容纳各种多元化的“空间”概念,其中既有电影影像与叙事中的地理景观,又有观影者将平面投射为立体、将片段空间投射为连续空间的知觉作用,还有蕴含文化与历史的复杂空... 详细信息

作为一门结合时间与空间表现方式的综合艺术,电影以平面化的形式构成容纳各种多元化的“空间”概念,其中既有电影影像与叙事中的地理景观,又有观影者将平面投射为立体、将片段空间投射为连续空间的知觉作用,还有蕴含文化与历史的复杂空间景观书写等。在早期电影的分析与批评中,视觉本位的信息往往被故事的变化与主题压制,电影空间则作为故事或角色经历的一部分藏于幻想之中。随着近年来多学科研究的空间转向日益凸显,电影的空间形态表述逐渐演变为电影研究的新切入点之一。

关键词：电影空间多学科研究早期电影地理景观空间形态历史书写空间转向连续空间

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基于矿物溶解理论的砂岩化学损伤动态模型

材料导报 2024年第8期38卷 159-165页

作者：梁艳玲霍润科宋战平穆彦虎秋添宋子羿西安建筑科技大学土木工程学院西安710055 西安建筑科技大学陕西省岩土与地下空间工程重点实验室西安710055 中国科学院西北生态环境资源研究院冻土工程国家重点实验室兰州730050

酸腐蚀环境下岩石物理力学性质的劣化本质上由岩石矿物的溶解引发的孔隙微裂隙的扩展贯通所致。为研究酸性环境下砂岩矿物的溶解特性,选择pH=1、3的盐酸溶液为腐蚀环境,借助X射线衍射试验鉴定砂岩矿物成分及含量,测试不同浸泡周期下溶液... 详细信息

酸腐蚀环境下岩石物理力学性质的劣化本质上由岩石矿物的溶解引发的孔隙微裂隙的扩展贯通所致。为研究酸性环境下砂岩矿物的溶解特性,选择pH=1、3的盐酸溶液为腐蚀环境,借助X射线衍射试验鉴定砂岩矿物成分及含量,测试不同浸泡周期下溶液的pH值、阳离子浓度、岩样的质量及其纵波波速,并通过矿物溶解理论与化学动力学原理,建立反映整个腐蚀过程的砂岩化学损伤动态模型。研究结果表明:酸性环境下砂岩的损伤主要由长石和方解石的溶解所致,矿物溶解反应分为界面吸附、界面交换、解吸附三个步骤,且步骤最慢者对整个反应起控制作用。矿物溶解速率与H+浓度的n次幂成正比,且0

关键词：砂岩矿物溶解化学损伤模型孔隙度纵波波速

基于基因表达综合数据库芯片挖掘结合网络药理学与分子对接探讨芒果苷治疗口腔黏膜下纤维化的机制研究

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华西口腔医学杂志 2024年第4期42卷 444-451页

作者：宋子毅杨超张云龙张柱江任天娇张欣悦李雪齐齐哈尔医学院口腔医学院齐齐哈尔161006 齐齐哈尔医学院医学技术学院齐齐哈尔161006 齐齐哈尔医学院公共卫生学院齐齐哈尔161006 齐齐哈尔医学院基础医学院齐齐哈尔161006

目的基于基因表达综合(GEO)数据库芯片挖掘、网络药理学及分子对接技术探讨芒果苷(MF)治疗口腔黏膜下纤维化(OSF)的核心作用靶标及潜在作用机制。方法基于GEO芯片挖掘OSF的潜在治疗靶点,利用数据库预测MF潜在作用靶标和收集OSF疾病靶标... 详细信息

目的基于基因表达综合(GEO)数据库芯片挖掘、网络药理学及分子对接技术探讨芒果苷(MF)治疗口腔黏膜下纤维化(OSF)的核心作用靶标及潜在作用机制。方法基于GEO芯片挖掘OSF的潜在治疗靶点,利用数据库预测MF潜在作用靶标和收集OSF疾病靶标,使用EVenn平台绘制维恩图,STRING数据库绘制蛋白质互作(PPI)网络,DAVID平台进行基因本体论(GO)和京都基因与基因组百科全书(KEGG)富集分析,Cytoscape 3.10.1软件绘制药物—靶标—通路—疾病网络图,AutoDocktools 1.5.6软件进行分子对接分析及可视化。结果从多种数据库挖掘得到MF潜在靶标356个,OSF疾病靶标360个,选取PPI网络中排名前15个关键靶蛋白,GO功能及KEGG通路富集分析结果显示,MF治疗OSF主要涉及高级糖基化终末产物-受体(AGE-RAGE)、表皮生长因子受体(EGFR)等信号通路。分子对接显示,MF与丝氨酸蛋白激酶(AKT1)、肿瘤坏死因子(TNF)等核心靶点有较佳结合活性。结论MF可能通过多靶点、多途径的方式对OSF发挥治疗作用。

关键词：口腔黏膜下纤维化芒果苷基因表达综合数据库网络药理学分子对接

Quantitative Architectural Anatomy of the Meandering Fluvial Deposits of the Neogene Upper Guantao Formation in Zhanhua Sag,Bohai Bay Basin,China

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Journal of Earth Science 2023年第6期34卷 1861-1872页

作者： Yupeng Qiao Longwei Qiu Jun Wang Fan song ziyi song Abigail Kuttin Colloge of Petroleum&Gas Engineering Liaoning Petrochemical UniversityFushun 113001China School of Geosciences China University of PetroleumQingdao 266580China Exploration and Development Research Institute Shengli Oilfield CompanySINOPECDongying 257015China

The residual oil in the fluvial reservoir of Gudong Oilfield is still widely developed even after decades of *** order to explore the remaining oil in the subsurface fluvial reservoir,we need to have a better understanding on fluvial sandbody *** paper aims to demonstrate how to quantify anatomy on meandering fluvial *** data from core descriptions of Guantao Formation in Gudong Oilfield were used to identify architectural *** upper Guantao Formation consists of ten lithofacies composing five different types of architectural *** integrating the available core,well logs,and seismic data,the fluvial sandbody distribution was *** characterize the fluvial channel geomorphology,we used seismic inversion to explore the stratigraphic correlation and stacking patterns of different channels,and the sandbody isopach map was obtained by the sandbody thickness in each *** architectural elements distribution in the plane was mapped by the sandbody isopach map and its profile *** to the investigation of meandering fluvial outcrops,subsurface meandering fluvial seismic geomorphology,and modern river morphology,the upstream-bar portions are always eroded because of the downstream channel *** on the morphometric parameters(bar width/looplength,upstream deflection angle,downstream deflection angle,etc.)of modern meandering river(Ob River)were obtained from the Google *** is found that the bar width/looplength and upstream deflection angle,upstream deflection angle and downstream deflection angle in modern meandering river have a good relationship,and we can have a quantitative architectural characterization on the point *** study quantified lithofacies thickness and proportion in different architectural elements of Guantao Formation,which ensures a high resolution anatomy on the small scale *** using this method,the lithofacies proportion in

关键词： meandering fluvial architectural characteristics point bar migration quantitative architectural anatomy Guantao Formation Zhanhua sag stratigraphy petroleum industry

中药通过PI3K/Akt信号通路干预肾间质纤维化的研究进展

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中国药房 2024年第14期35卷 1795-1800页

作者：李雪张云龙宋子毅张柱江杨超任天娇贾淋珍齐齐哈尔医学院基础医学院黑龙江齐齐哈尔161006 黑龙江省药食同源资源与代谢性疾病防治重点实验室黑龙江齐齐哈尔161006 齐齐哈尔医学院公共卫生学院黑龙江齐齐哈尔161006 齐齐哈尔医学院口腔医学院黑龙江齐齐哈尔161006 齐齐哈尔医学院医学技术学院黑龙江齐齐哈尔161006 齐齐哈尔医学院药学院黑龙江齐齐哈尔161006

肾间质纤维化(RIF)是慢性肾病的主要病理表现结果,由于其发生机制复杂,临床上尚无特效治疗措施。磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)信号通路的异常激活及其下游靶基因的活化是RIF发生进展的关键诱因。中药具有药效确切、毒副作用... 详细信息

肾间质纤维化(RIF)是慢性肾病的主要病理表现结果,由于其发生机制复杂,临床上尚无特效治疗措施。磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)信号通路的异常激活及其下游靶基因的活化是RIF发生进展的关键诱因。中药具有药效确切、毒副作用小等特点,可多靶点、多途径协同调控RIF的发生进展。本文以PI3K/Akt信号通路为核心,对中药在RIF治疗中的作用靶点及调控机制进行归纳,发现多种中药有效成分(如青藤碱、芒果苷、圆锥绣球提取物等)以及复方(如复肾功方、气邦益肾方等)可通过该通路抑制成纤维细胞增殖、改善炎症反应与氧化应激、维持线粒体稳态、减缓铁死亡发生等,从而延缓RIF的发生进展。

关键词：中药 PI3K/Akt信号通路肾间质纤维化作用机制

Dietary calcium supplementation promotes the accumulation of intramuscular fat

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Journal of Animal Science and Biotechnology 2022年第2期13卷 536-550页

作者： Zhiwang Zhang Tingli Pan Yu Sun Siqi Liu ziyi song Haojie Zhang Yixing Li Lei Zhou State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Animal Science and TechnologyGuangxi UniversityGuangxi Zhuang Autonomous RegionNanning 530004People’s Republic of China

Background:In the livestock industry,intramuscular fat content is a key factor affecting meat *** studies have shown that dietary calcium supplementation is closely related to lipid ***,few studies have examined the relationship between dietary calcium supplementation and intramuscular fat ***:Here,we used C2C12 cells,C57BL/6 mice(n=8)and three-way cross-breeding pigs(Duroc×Landrace×Large white)(n=10)to study the effect of calcium addition on intramuscular fat *** vitro,we used calcium chloride to adjust the calcium levels in the medium(2 mmol/L or 3 mmol/L).Then we measured various *** vivo,calcium carbonate was used to regulate calcium levels in feeds(Mice:0.5%calcium or 1.2%calcium)(Pigs:0.9%calcium or 1.5%calcium).Then we tested the mice gastrocnemius muscle triglyceride content,pig longissimus dorsi muscle meat quality and ***:In vitro,calcium addition(3 mmol/L)had no significant effect on cell proliferation,but promoted the differentiation of C2C12 cells into slow-twitch *** supplementation increased triglyceride accumulation in C2C12 *** addition increased the number of mitochondria and also increased the calcium level in the mitochondria and reduced the of key enzymes activity involved inβ-oxidation such as acyl-coenzyme A *** mitochondrial calcium level can alleviate lipid accumulation induced by calcium *** addition,calcium addition also reduced the glycolytic capacity and glycolytic conversion rate of C2C12 *** vivo,dietary calcium supplementation(1.2%)promoted the accumulation of triglycerides in the gastrocnemius muscle of *** calcium supplementation(1.5%)had no effect on pig weight,but significantly improved the flesh color of the longissimus dorsi muscle,reduced the backfat thickness and increased intramuscular fat content in ***,calcium addition had no effect on longissimus dorsi pH,electrical conducti

关键词： C2C12 Calcium Intramuscular fat Meat quality Pig

Menstrual irregularity,pregnancy outcomes,and birth outcomes in patients with systemic lupus erythematosus of childbearing age in China:a multicenter cross-sectional study

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Chinese Medical Journal 2023年第23期136卷 2886-2888页

作者： Yuke Hou Jiayang Jin Liang Luo Yuchao Zhong Zhe Peng ziyi song Chun Li Xuewu Zhang Department of Rheumatology and Immunology Peking University People’s HospitalBeijing 100044China Department of Chinese Medicine Chongqing Yubei People’s HospitalChongqing 401120China Department of Rheumatology and Immunology Peking University Shenzhen HospitalShenzhenGuangdong 518036China Center of Reproductive Medicine Peking University People’s HospitalBeijing 100044China

To the Editor:Systemic lupus erythematosus(SLE)is an autoimmune disease that tends to affect females of childbearing *** are nearly 4 million people in China currently suffering from SLE,which can cause multiple organ damage in its early stages and seriously affect patients’quality of life.[1-3]Menstrual disorders are common in SLE patients and vary from heavy menstrual bleeding to *** etiology of menstrual irregularities includes the disease activity itself,glucocorticoids(GCs)treatment,and the use of some immunosuppressants.[4]This multicenter,cross-sectional,web-based observational study investigated menstrual irregularity,pregnancy outcomes,and birth outcomes on SLE patients across *** research was approved by the Ethics Committee of Peking University People’s Hospital,China(No.2019PHB253-01).The patients were informed that consent was implied with completion of the questionnaire,and the process was anonymous and voluntary.

关键词： patients sectional birth

CBL联合PBL教学法在西学中班中医急诊学教学中的应用

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中医教育 2024年第4期43卷 143-147页

作者：郑宏宋梓铱赵爽赵玉洁李爽聂郁茜魏瑶北京中医药大学东直门医院北京100700 北京市东城区永外社区卫生服务中心北京100075 北京市中西医结合医院北京100083 北京中医药大学北京100029

目的探讨CBL联合PBL教学法在西学中班中医急诊学教学中的应用,提高学生运用中医急诊思维的能力。方法以CBL联合PBL教学法为教学主线,从神昏、脱证、中风等急症和专病入手,通过精选急诊具有代表性的病例与情景模拟教学,以学生为主体,... 详细信息

目的探讨CBL联合PBL教学法在西学中班中医急诊学教学中的应用,提高学生运用中医急诊思维的能力。方法以CBL联合PBL教学法为教学主线,从神昏、脱证、中风等急症和专病入手,通过精选急诊具有代表性的病例与情景模拟教学,以学生为主体,教师与学生共同讨论并分析病案诊治过程中的重点难点,进行中西医急诊思维的对比,最后帮助学生建立中医急诊思维。结果教学结束后,学生对中医治疗急症有效性的认可度得到提高,对中医急症的辨证能力和掌握急救中成药的能力得到提高,经χ^(2)检验,差异有统计学意义(P<0.05)。结论在西学中班中医急诊学教学中应用CBL联合PBL教学法可以帮助学生提高中医急诊辨证思维能力,提高常用急救中成药的使用能力和使用中医技术处理急症的能力。

关键词： CBL教学法 PBL教学法中医急诊学西学中班

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Exploring the impact of Nafion modifier on electrocatalytic CO_(2) reduction over Cu catalyst

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Journal of Energy Chemistry 2024年第1期88卷 543-551,I0012页

作者： Yingshi Su Yonghui Cheng Zhen Li Yanjia Cui Caili Yang ziyi Zhong Yibing song Gongwei Wang Lin Zhuang College of Chemistry&Chemical Engineering and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantou 515063GuangdongChina College of Chemistry and Molecular Sciences Hubei Key Lab of Electrochemical Power SourcesWuhan UniversityWuhan 430072HubeiChina The Institute for Advanced Studies Wuhan UniversityWuhan 430072HubeiChina Department of Chemistry Engineering Guangdong Technion-Israel Institute of Technology(GTIIT)Shantou 515063GuangdongChina Technion-Israel Institute of Technology(IIT) Haifa 32000Israel

Nafion as a universal polymer ionomer was widely applied for nanocatalysts electrode ***,the effect of Nafion on electrocatalytic performance was often overlooked,especially for CO_(2)***,the key roles of Nafion for CO_(2)RR were systematically studied on Cu nanoparticles(NPs)*** found that Nafion modifier not only inhibit hydrogen evolution reaction(HER)by decreasing the accessibility of H_(2)O from electrolyte to Cu NPs,and increase the CO_(2)concentration at electrocatalyst interface for enhancing the CO_(2)mass transfer process,but also activate CO_(2)molecule by Lewis acid-base interaction between Nafion and CO_(2)to accelerate the formation of^(*)CO,which favor of C–C coupling for boosting C_(2)product *** to these features,the HER selectivity was suppressed from 40.6%to 16.8%on optimal Cu@Nafion electrode at-1.2 V versus reversible hydrogen electrode(RHE),and as high as 73.5%faradaic efficiencies(FEs)of C_(2)products were achieved at the same applied potential,which was 2.6 times higher than that on bare Cu electrode(~28.3%).In addition,Nafion also contributed to the long-term stability by hinder Cu NPs morphology ***,this work provides insights into the impact of Nafion on electrocatalytic CO_(2)RR performance.

关键词： Nafion modifier CO_(2)reduction Cu nanoparticles In situ ATR-SEIRAS C_(2)product