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A Knowledge-enhanced Two-stage Generative Framework for Medical Dialogue Information Extraction

Machine Intelligence Research 2024年第1期21卷 153-168页

作者： Zefa Hu ziyi ni Jing Shi Shuang Xu Bo Xu School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Institute of Automation Chinese Academy of SciencesBeijing 100190China

This paper focuses on term-status pair extraction from medical dialogues(MD-TSPE),which is essential in diagnosis dia-logue systems and the automatic scribe of electronic medical records(EMRs).In the past few years,works on MD-TSPE have attracted increasing research attention,especially after the remarkable progress made by generative ***,these generative methods output a whole sequence consisting of term-status pairs in one stage and ignore integrating prior knowledge,which demands a deeper un-derstanding to model the relationship between terms and infer the status of each *** paper presents a knowledge-enhanced two-stage generative framework(KTGF)to address the above *** task-specific prompts,we employ a single model to com-plete the MD-TSPE through two phases in a unified generative form:We generate all terms the first and then generate the status of each generated *** this way,the relationship between terms can be learned more effectively from the sequence containing only terms in the first phase,and our designed knowledge-enhanced prompt in the second phase can leverage the category and status candidates of the generated term for status ***,our proposed special status"not mentioned"makes more terms available and en-riches the training data in the second phase,which is critical in the low-resource *** experiments on the Chunyu and CMDD datasets show that the proposed method achieves superior results compared to the state-of-the-art models in the full training and low-re-sourcesettings.

关键词： Medical dialogue understanding information extraction text generation knowledge-enhanced prompt low-resource setting dataaugmentation

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东南丘陵山区深水水库两种浮床植物脱氮效率对比研究

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湖泊科学 2024年第1期36卷 123-136页

作者：倪子怡许海詹旭程新良王裕成朱广伟朱梦圆邹伟孙起亮中国科学院南京地理与湖泊研究所湖泊与环境国家重点实验室南京210008 江南大学环境与土木工程学院无锡214122 浙江省杭州市生态环境局淳安分局杭州311700 浙江省杭州市桐庐县环境保护监测站桐庐311500

为探究东南丘陵山区深水水库中生态浮床技术深度脱氮的效率及管理措施,以大型山谷型深水水库千岛湖为例,选取湿生植物空心菜(Ipomoea aquatica)和水生植物粉绿狐尾藻(Myriophyllum aquaticum),采用生态浮床技术,开展了原位模拟实验对比... 详细信息

为探究东南丘陵山区深水水库中生态浮床技术深度脱氮的效率及管理措施,以大型山谷型深水水库千岛湖为例,选取湿生植物空心菜(Ipomoea aquatica)和水生植物粉绿狐尾藻(Myriophyllum aquaticum),采用生态浮床技术,开展了原位模拟实验对比研究,探究不同营养盐浓度和光强下两种植物的生长状况与氮素去除效率。结果发现:(1)空心菜长势受营养盐和光照条件影响明显,添加氮磷后(TN=2.37 mg/L,TP=0.046 mg/L)的空心菜生物量是原位水体(TN=0.66mg/L,TP=0.028 mg/L)的1.6倍,适当遮光有助于浮床植物生长,40%遮光条件下空心菜的生物量是不遮光条件下的1.5倍;而粉绿狐尾藻生长受营养盐和光照条件影响均较小。(2)空心菜对于水体氮素净化能力显著高于粉绿狐尾藻,在最佳条件下空心菜和粉绿狐尾藻对氮素的去除效率分别达到213.30和44.23 mg/(m^(2)·d)。(3)空心菜去除氮主要以植物同化作用为主,占70%以上TN去除量,40%遮光环境通过明显提升空心菜同化吸收氮量和根系反硝化速率增强了氮的去除能力;粉绿狐尾藻同化吸收和反硝化脱氮作用各占50%左右,以遮光75%下脱氮效果最好。本研究表明,采用生态浮床技术能够强化深水水库的脱氮能力,空心菜更适合在氮浓度较高的水体生长,夏季为空心菜和粉绿狐尾藻浮床分别进行40%和75%的遮光处理将有更好的水质净化效果。因此,在滨岸湿地匮乏的深水水库实施多种植物搭配的生态浮床技术强化水体脱氮作用是一种行之有效的水质改善方法。

关键词：生态浮床反硝化千岛湖光照营养盐浓度

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Temperature effect on nanotwinned ni under nanoindentation using molecular dynamic simulation

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Chinese Physics B 2024年第1期33卷 603-612页

作者：何茜徐子翼倪玉山 Department of Aeronautics and Astronautics Fudan UniversityShanghai 200433China

Temperature effect on atomic deformation of nanotwinned ni (nt-ni) under localized nanoindentation is investigated in comparison with nanocrystalline ni (nc-ni) through molecular *** nt-ni exhibits enhanced critical load and hardness compared to nc-ni,where perfect,stair-rod and Shockley dislocations are activated at (111),(111) and (111) slip planes in nt-ni compared to only SSockley dislocation nucleation at (111) and (111) slip planes of *** nt-ni exhibits a less significant indentation size effect in comparison with nc-ni due to the dislocation slips hindrance of the twin *** atomic deformation associated with the indentation size effect is investigated during dislocation *** from the decreasing partial slips parallel to the indenter surface in nc-ni with increasing temperature,the temperaturedependent atomic deformation of nt-ni is closely related to the twin boundary:from the partial slips parallel to the twin boundary (~10 K),to increased confined layer slips and decreased twin migration(300 K–600 K),to decreased confined layer slips and increased dislocation interaction of dislocation pinning and dissociation (900 K–1200 K).Dislocation density and atomic structure types through quantitative analysis are implemented to further reveal the above-mentioned dislocation motion and atomic structure *** study is helpful for understanding the temperature-dependent plasticity of twin boundary in nanotwinned materials.

关键词： nanoindentation twin boundary plastic deformation molecular dynamics simulation

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niO@ni nanoparticles embedded in N-doped carbon for efficient photothermal CO_(2) methanation coupled with H_(2)O splitting

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Nano Research 2024年第4期17卷 2283-2290页

作者： Yun Zhou Peng Zheng Fang Wang Fangna Gu Wenqing Xu Qinyang Lu Tingyu Zhu ziyi Zhong Guangwen Xu Fabing Su Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China Key Laboratory on Resources Chemicals and Materials of Ministry of Education Shenyang University of Chemical TechnologyShenyang 110142China Institute of Industrial Chemistry and Energy Technology Shenyang University of Chemical TechnologyShenyang 110142China School of Ecology and Environment Beijing Technology and Business UniversityBeijing 100048China Beijing Key Laboratory of Enze Biomass Fine Chemicals College of New Materials and Chemical EngineeringBeijing Institute of Petrochemical TechnologyBeijing 102617China International School of Beijing 10 An Hua Street Shunyi DistrictBeijing 100048China Department of Chemical Engineering Guangdong Technion Israel Institute of Technology(GTIIT)Shantou 515063China Technion Israel Institute of Technology(IIT) Haifa32000Israel

Photothermal carbon dioxide(CO_(2))methanation has attracted increasing interest in solar fuel synthesis,which employs the advantages of photocatalytic H_(2)O splitting as a hydrogen source and photothermal catalytic CO_(2) *** work prepared three-dimensional(3D)honeycomb N-doped carbon(NC)loaded with core–shell niO@ni nanoparticles generated in situ at 500℃(niO@ni/NC-500).Under the photothermal catalysis(200℃,1.5 W/cm^(2)),the CH_(4) evolution rate of niO@ni/NC-500 reached 5.5 mmol/(g·h),which is much higher than that of the photocatalysis(0.8 mmol/(g·h))and the thermal catalysis(3.7 mmol/(g·h)).It is found that the generated localized surface plasmon resonance enhances the injection of hot electrons from ni to niO,while thermal heating accelerates the thermal motion of radicals,thus generating a strong photo-thermal synergistic effect on the *** CO_(2) reduction to CH_(4) follows the*OCH *** work demonstrates the synergistic effect of niO@ni and NC can enhance the catalytic performance of photothermal CO_(2) reduction reaction coupled with water splitting reaction.

关键词： ni localized surface plasmon resonance photothermal methanation

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UMBRELLA: user demand privacy preserving framework based on association rules and differential privacy in social networks

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Science China(Information Sciences) 2019年第3期62卷 205-207页

作者： Chunliu YAN ziyi ni Bin CAO Rongxing LU Shaohua WU Qinyu ZHANG Harbin Institute of Technology (Shenzhen) Faculty of Computer Science University of New Brunswick

Dear editor,The past several years have witnessed that people deeply rely on online services, such as shopping,transportation, and medical services. At the same time, privacy leakage has been a hot topic in social net... 详细信息

关键词： user demand privacy preserving framework based on association rules and differential privacy in social networks Figure

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Recent progress in MnBi2nTe3n+1 intrinsic magnetic topological insulators: crystal growth, magnetism and chemical disorder

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National Science Review 2024年第2期11卷 65-80页

作者： Chaowei Hu Tiema Qian ni ni Department of Physics and Astronomy and California Nano Systems Institute University of California-Los Angeles

The search for magnetic topological materials has been at the forefront of condensed matter research for their potential to host exotic states such as axion insulators, magnetic Weyl semimetals, Chern insulators,etc. To date, the MnBi2nTe3n+1family is the only group of materials showcasing van der Waals-layered structures, intrinsic magnetism and non-trivial band topology without trivial bands at the Fermi level. The interplay between magnetism and band topology in this family has led to the proposal of various topological phenomena, including the quantum anomalous Hall effect, quantum spin Hall effect and quantum magnetoelectric effect. Among these, the quantum anomalous Hall effect has been experimentally observed at record-high temperatures, highlighting the unprecedented potential of this family of materials in fundamental science and technological innovation. In this paper, we provide a comprehensive review of the research progress in this intrinsic magnetic topological insulator family, with a focus on single-crystal growth, characterization of chemical disorder, manipulation of magnetism through chemical substitution and external pressure, and important questions that remain to be conclusively answered.

关键词： MnBi2Te4 magnetic topological insulator magnetism tuning antiferromagnetism ferromagnetism pressure chemical doping

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Regional features of pollen R-values in China

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Science China Earth Sciences 2024年第1期67卷 295-308页

作者： Jie XIA Jian ni College of Life Sciences Zhejiang Normal UniversityJinhua 321004China Jinhua Mountain Observation and Research Station for Subtropical Forest Ecosystems Jinhua 321004China

Establishing a quantitative relationship between modern pollen and vegetation remains a pivotal but intricate pursuit within the field of Quaternary *** R-value,a well-established and traditional metric characterized by its simplicity and direct applicability,serves to calibrate the nonlinear disparities between surface pollen and modern *** study entails the construction of a comprehensive pollen R-value dataset for China derived from R-values published between 1987 and *** dataset,compiled after rigorous screening,calibration,and standardization processes,encompasses 898 modern pollen sampling sites and 2115 pollen R-value data entries,encapsulating 152 pollen taxa spanning 65 families and 113 *** the extracted R-values yielded the following insights:(1)A macrospatial analysis validates previously established knowledge at a site-specific ***,pollen R-value variations across China are statistically *** two-thirds of pollen taxa exhibit underrepresentation(e.g.,Taxodiaceae,Corylus,nitraria,Tamarix,Cyperaceae,Poaceae,and Fabaceae),while the remaining one-third display overrepresentation(e.g.,Pinus,Picea,Betula,Ephedra,Chenopodiaceae,and Artemisia).The degree of underrepresentation surpasses that of overrepresentation,and the representation patterns of Castanea,Quercus,Polygonaceae,and Asteraceae are contingent upon vegetation types.(2)Pollen R-values follow distinct spatial distribution patterns within *** the woody vegetation region of eastern China,R-values progressively decline from north to south,correlating with rising temperatures and ***,in herbaceous vegetation regions of northern and western China,R-values decrease from east to west and from northeast to southwest,corresponding to increased ***,pollen R-values manifest variation contingent on pollen taxa,vegetation types,and climatic regions,even differing for the same taxa across varying

关键词： Pollen R-value Modern pollen-vegetation relationship Regional pattern Variability Paleovegetation reconstruction

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Theoretical optimization of micropillar arrays for structurally stable bioinspired dry adhesives

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 124-129页

作者： Ke ni Zhengzhi Wang Department of Engineering Mechanics School of Civil EngineeringWuhan UniversityWuhan 430072China Wuhan University Shenzhen Research Institute Shenzhen 518108China

Inspired by the excellent adhesion performances of setae structure from organisms,micro/nano-pillar array has become one of the paradigms for adhesive *** micropillar arrays are composed of the resin pillars for adhesion and the substrate with different elastic modulus for *** stress singularity at the bi-material corner between the pillars and the substrate can induce the failure of the micropillar-substrate corner and further hinder the fabrication and application of micropillar arrays,yet the design for the stability of the micropillar array lacks systematical and quantitative *** this work,we develop a semi-analytical method to provide the full expressions for the stress distribution within the bi-material corner combining analytical derivations and numerical *** predictions for the stress within the singularity field can be obtained based on the full expressions of the *** good agreement between the predictions and the FEM results demonstrates the high reliability of our *** adopting the strain energy density factor approach,the stability of the pillar-substrate corner is assessed by predicting the failure at the *** the elastic mismatch between the pillar and substrate given in this paper,the stability can be improved by increasing the ratio of the shear modulus of the substrate to that of the *** study provides accurate predictions for the stress distribution at the bi-material corner and can guide the optimization of material combinations of the pillars and the substrate for more stable bioinspired dry adhesives.

关键词： Micropillar array Stability Bi-material corner Dry adhesive

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Oligomerization of drug transporters:Forms,functions,and mechanisms

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1924-1938页

作者： Chunxu ni Mei Hong College of Life Sciences South China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms South China Agricultural UniversityGuangzhou 510642China

Drug transporters are essential players in the transmembrane transport of a wide variety of clinical *** broad substrate spectra and versatile distribution pattern of these membrane proteins infer their pharmacological and clinical *** our accumulating knowledge on the three-dimensional structure of drug transporters,their oligomerization status has become a topic of intense study due to the possible functional roles carried out by such kind of post-translational modification(PTM).In-depth studies of oligomeric complexes formed among drug transporters as well as their interactions with other regulatory proteins can help us better understand the regulatory mechanisms of these membrane proteins,provide clues for the development of novel drugs,and improve the therapeutic *** this review,we describe different oligomerization forms as well as their structural basis of major drug transporters in the ATP-binding cassette and solute carrier superfamilies,summarize our current knowledge on the influence of oligomerization for protein expression level and transport function of these membrane proteins,and discuss the regulatory mechanisms of ***,we highlight the challenges associated with the current oligomerization studies and propose some thoughts on the pharmaceutical application of this important drug transporter PTM.

关键词： Drug development Drug transporters Oligomerization Protein expression Protein–protein interaction Regulatory mechanism Structural basis Transport function

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Rethinking the Encoder-decoder Structure in Medical Image Segmentation from Releasing Decoder Structure

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Journal of Bionic Engineering 2024年第3期21卷 1511-1521页

作者： Jiajia ni Wei Mu An Pan Zhengming Chen School of Artificial Intelligence Anhui Polytechnic UniversityWuhu241000China School of Information Science and Engineering HoHai UniversityChangzhou213000China

Medical image segmentation has witnessed rapid advancements with the emergence of encoder-decoder based *** the encoder-decoder structure,the primary goal of the decoding phase is not only to restore feature map resolution,but also to mitigate the loss of feature information incurred during the encoding ***,this approach gives rise to a challenge:multiple up-sampling operations in the decoder segment result in the loss of feature *** address this challenge,we propose a novel network that removes the decoding structure to reduce feature information loss(CBL-Net).In particular,we introduce a Parallel Pooling Module(PPM)to counteract the feature information loss stemming from conventional and pooling operations during the encoding ***,we incorporate a Multiplexed Dilation Convolution(MDC)module to expand the network's receptive ***,although we have removed the decoding stage,we still need to recover the feature map ***,we introduced the Global Feature Recovery(GFR)*** uses attention mechanism for the image feature map resolution recovery,which can effectively reduce the loss of feature *** conduct extensive experimental evaluations on three publicly available medical image segmentation datasets:DRIVE,CHASEDB and MoNuSeg *** results show that our proposed network outperforms state-of-the-art methods in medical image *** addition,it achieves higher efficiency than the current network of coding and decoding structures by eliminating the decoding component.

关键词： Medical image segmentation Encoder-decoder architecture Attention mechanisms Releasing decoder architecture Neural network

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