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A personalized electronic textile for ultrasensitive pressure sensing enabled by biocompatible MXene/ PEDOT:PSS composite

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Carbon Energy 2024年第3期6卷 224-238页

作者： Yahua Li Wentao Cao Zhi Liu Yue Zhang ziyan chen Xianhong Zheng Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina School of Textile and Garment Anhui Polytechnic UniversityWuhuAnhuiChina Department of Prosthodontics Shanghai Stomatological Hospital and School of StomatologyFudan UniversityShanghaiChina College of Chemistry Chemical Engineering and BiotechnologyDonghua UniversityShanghaiChina

Flexible,breathable,and highly sensitive pressure sensors have increasingly become a focal point of interest due to their pivotal role in healthcare monitoring,advanced electronic skin applications,and disease ***,traditional methods,involving elastomer film-based substrates or encapsulation techniques,often fall short due to mechanical mismatches,discomfort,lack of breathability,and limitations in sensing ***,there is a pressing need,yet it remains a significant challenge to create pressure sensors that are not only highly breathable,flexible,and comfortable but also sensitive,durable,and ***,we present a biocompatible and breathable fabric-based pressure sensor,using nonwoven fabrics as both the sensing electrode(coated with MXene/poly(3,4-ethylenedioxythiophene):polystyrene sulfonate[PEDOT:PSS])and the interdigitated electrode(printed with MXene pattern)via a scalable spray-coating and screen-coating *** resultant device exhibits commendable air permeability,biocompatibility,and pressure sensing performance,including a remarkable sensitivity(754.5 kPa^(−1)),rapid response/recovery time(180/110 ms),and robust cycling ***,the integration of PEDOT:PSS plays a crucial role in protecting the MXene nanosheets from oxidation,significantly enhancing the device's long-term *** outstanding features make this sensor highly suitable for applications in fullrange human activities detection and disease *** study underscores the promising future of flexible pressure sensors in the realm of intelligent wearable electronics,setting a new benchmark for the industry.

关键词： biocompatibility MXene pressure sensor screen printing textile

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A piezoelectric-driven microneedle platform for skin disease therapy

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The Innovation 2024年第3期5卷 110-121页

作者： ziyan chen Xin Liu Zixi Jiang Huayi Wu Tao Yang Lanyuan Peng Lisha Wu Zhongling Luo Mi Zhang Juan Su Yan Tang Jinmao Li Yang Xie Han Shan Qibo Lin Xiuli Wang Xiang chen Hanmin Peng Shuang Zhao Zeyu chen Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Furong Laboratory(Precision Medicine) Changsha 410008China National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Engineering Research Center of Skin Health and Disease Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center of Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China Department of Dermatology Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710000China State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics&AstronauticsNanjing 210016China Institute of Photomedicine Shanghai Skin Disease HospitalSchool of MedicineTongji UniversityShanghai 200443China

With over a million cases detected each year,skin disease is a global public health problem that diminishes the quality of life due to its difficulty to eradicate,propensity for recurrence,and potential for post-treatment *** therapy(PDT)is a treatment with minimal invasiveness or scarring and few side effects,making it well tolerated by ***,this treatment requires further research and development to improve its effective clinical ***,a piezoelectric-driven microneedle(PDMN)platform that achieves high efficiency,safety,and non-invasiveness for enhanced PDT is *** platform induces deep tissue cavitation,increasing the level of protoporphyrin IX and significantly enhancing drug penetration.A clinical trial involving 25 patients with skin disease was conducted to investigate the timeliness and efficacy of PDMN-assisted PDT(PDMN-PDT).Our findings suggested that PDMN-PDT boosted treatment effectiveness and reduced the required incubation time and drug concentration by 25%and 50%,respectively,without any anesthesia compared to traditional *** findings suggest that PDMN-PDT is a safe and minimally invasive approach for skin disease treatment,which may improve the therapeutic efficacy of topical medications and enable translation for future clinical applications.

关键词： needle anesthesia clinical

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掺氢天然气管道氢损伤管外漏磁检测机构设计

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机床与液压 2024年第15期52卷 75-81页

作者：陈子俨赵弘中国石油大学(北京)机械与储运工程学院北京102249

掺氢天然气管道受氢损伤等因素影响,容易产生缺陷进而导致管道失效,因此需要定期对掺氢管道进行检查。通过对掺氢管道的主要缺陷产生机制和缺陷特征进行分析,得到主要的缺陷形式,设计一种针对掺氢管道氢损伤的管外漏磁检测机构对管道进... 详细信息

掺氢天然气管道受氢损伤等因素影响,容易产生缺陷进而导致管道失效,因此需要定期对掺氢管道进行检查。通过对掺氢管道的主要缺陷产生机制和缺陷特征进行分析,得到主要的缺陷形式,设计一种针对掺氢管道氢损伤的管外漏磁检测机构对管道进行缺陷检测,利用Maxwell进行漏磁检测仿真模拟,采用响应面法建立检测探头各参数与轴向漏磁曲线峰谷差值、吸附力和成本之间的函数,得到探头的结构参数最优组合。最后搭建实验台,利用单组探头进行单通道的漏磁检测。结果表明:与未优化结构对比,优化后管外缺陷检测效果提高26.2%,管内缺陷检测效果提升11%,探头与管壁吸附力降低56.7%,探头成本降低14%,检测效果得到提升;优化探头不仅能检测到已成型的比较明显的掺氢管道缺陷,也可以在缺陷形成早期管壁损失达到整体壁厚40%时将其检测出来。缺陷检测实验验证了文中设计方案的可行性。

关键词：漏磁检测掺氢管道外检测探头结构优化响应面法

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图神经网络的类别解耦小样本分类

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计算机工程与应用 2024年第2期60卷 129-136页

作者：邓戈龙黄国恒陈紫嫣广东工业大学计算机学院广州510006

现有的基于度量的小样本图像分类模型展现了一定的小样本学习性能,然而这些模型往往忽略了原始数据被分类关键特征的提取。图像数据中与分类无关的冗余信息被融入小样本模型的网络参数中,容易造成基于度量方法的小样本图像分类性能瓶颈... 详细信息

现有的基于度量的小样本图像分类模型展现了一定的小样本学习性能,然而这些模型往往忽略了原始数据被分类关键特征的提取。图像数据中与分类无关的冗余信息被融入小样本模型的网络参数中,容易造成基于度量方法的小样本图像分类性能瓶颈。针对这个问题,提出一种基于图神经网络的类别解耦小样本图像分类模型(VT-GNN),该模型结合图像自注意力与分类任务监督的变分自编码器作为图像嵌入模块,得到原始图像类别解耦特征信息,成为图结构中的一个图节点。通过一个多层感知机为节点之间构建具有度量信息的边特征,将一组小样本训练数据构造为图结构数据,借助图神经网络的消息传递机制实现小样本学习。在公开数据集Mini-Imagenet上,VT-GNN在分别5-way1-shot与5-way 5-shot设置中相较于基线图神经网络模型分别获得了17.9个百分点和16.25个百分点的性能提升。

关键词：小样本学习图神经网络变分自编码器图像自注意力

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SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance:Implications for Antibody Therapy and Vaccinations against COVID-19

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Research 2024年第3期2023卷 1-15页

作者： Xiaoying Ma Jady Liang Guangheng Zhu Preeti Bhoria Aron A.Shoara Daniel T.MacKeigan Christopher J.Khoury Sladjana Slavkovicl Lisha Lin Danielle Karakas ziyan chen Viktor Prifti Zhenze Liu Chuanbin Shen Yuchong Li cheng Zhang Jiayu Dou Zack Rousseau Jiamin Zhang Tiffany Ni Xi Lei Pingguo chen Xiaoyu Wu Hamed Shaykhalishahi Samira Mubareka Kim AConnelly Haibo Zhang Ori Rotstein Heyu Ni Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Department of Laboratory Medicine Keenan Research Centre for Biomedical Science of St.Michael’s HospitalTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Department of Physiology University of TorontoTorontoONCanada CCOA Therapeutics Inc. TorontoONCanada Canadian Blood Services Centre for Innovation TorontoONCanada The State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Laboratory Medicine The Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina Advanced Pharmaceutics&Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoTorontoONCanada Department of Medical Microbiology and Infectious Disease Sunnybrook Health Science CentreToronto ONCanada Department of Medicine University of TorontoTorontoONCanada Division of Cardiology.St.Michael's Hospital TorontoONCanada Department of Anesthesiology and Pain Medicine and Division of Critical Care Medicine University of TorontoTorontoONCanada interdepartmental Division of Critical Care Medicine University of TorontoTorontoONCanada Department of Surgery University of Toronto TorontoONCanada.

The COVID-19 pandemic caused by SARS-CoV-2 virus is an ongoing global health *** cases of COVID-19 and the rare cases of COVID-19 vaccine-induced-thrombotic-thrombocytopenia(VITT)are both associated with thrombosis and thrombocytopenia;however,the underlying mechanisms remain inadequately *** infection and vaccination utilize the spike protein receptor-binding domain(RBD)of *** found that intravenous injection of recombinant RBD caused significant platelet clearance in *** investigation revealed the RBD could bind platelets,cause platelet activation,and potentiate platelet aggregation,which was exacerbated in the Delta and Kappa *** RBD–platelet interaction was partially dependent on theβ3 integrin as binding was significantly reduced inβ3−/−***,RBD binding to human and mouse platelets was significantly reduced with relatedαIIbβ3 antagonists and mutation of the RGD(arginine-glycine-aspartate)integrin binding motif to RGE(arginine-glycine-glutamate).We developed anti-RBD polyclonal and several monoclonal antibodies(mAbs)and identified 4F2 and 4H12 for their potent dual inhibition of RBD-induced platelet activation,aggregation,and clearance in vivo,and SARS-CoV-2 infection and replication in Vero E6 *** data show that the RBD can bind platelets partially thoughαIIbβ3 and induce platelet activation and clearance,which may contribute to thrombosis and thrombocytopenia observed in COVID-19 and *** newly developed mAbs 4F2 and 4H12 have potential not only for diagnosis of SARS-CoV-2 virus antigen but also importantly for therapy against COVID-19.

关键词： Antibody diagnosis vaccine

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浅析中国釉上彩瓷发展及17~18世纪中日彩瓷对比

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陶瓷 2024年第5期 40-42页

作者：陈梓岩景德镇陶瓷大学江西景德镇333000

中日两国一衣带水,已有两千多年的交流历史,中国文化作为主流的输出,日本积极地吸取中国的先进文化,在中国文化的基础上,衍生出大和民族的本国文化。笔者以17~18世纪中日彩瓷为切入点,探寻了中日彩瓷交流史上的重要意义。

关键词：釉上彩瓷 17~18世纪中日彩瓷对比

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在线社交网络竞争信息传播研究与稳定性分析

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情报理论与实践 2024年第8期47卷 150-159页

作者：陈梓彦袁得嵛程佳琳中国人民公安大学北京100038

[目的/意义]当前,在线社交网络已成为人们获取和传播信息的重要途径,在线社交网络上的谣言发酵很快就会引发群体效应,为了应对谣言传播,政府机构等也会发布辟谣信息,所以正确把握两种意思相反的竞争信息传播的特点,有利于对谣言的管控。... 详细信息

[目的/意义]当前,在线社交网络已成为人们获取和传播信息的重要途径,在线社交网络上的谣言发酵很快就会引发群体效应,为了应对谣言传播,政府机构等也会发布辟谣信息,所以正确把握两种意思相反的竞争信息传播的特点,有利于对谣言的管控。[方法/过程]基于竞争信息在在线社交网络中的传播关系,提出一种竞争信息扩散模型SC2I2R来描述两类信息在社会网络中的扩散过程,分析无病平衡点的局部稳定性和全局稳定性,并通过数值模拟研究扩散过程。[结果/结论]被接收和转发概率大的信息并不一定传播更广泛,信息传播还会受社交网络结构、初始传播节点数量等的影响。[局限]为了简化模型,没有考虑在线社交平台的推荐机制、热搜机制等可以跨越拓扑结构传播的机制以及各个平台之间的影响,也没有考虑其他影响传播的因素。

关键词：在线社交网络信息传播模型局部稳定性全局稳定性

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牙周辅助加速成骨正畸增加牙槽骨量前后正畸牙移动的生物力学特征

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中国组织工程研究 2024年第14期28卷 2133-2139页

作者：赵鹤翔陈子嫣王婧葛振林兰州大学口腔医学院正畸科甘肃省兰州市730000

背景:人们对正畸治疗的需求日益增加,牙周辅助加速成骨正畸技术可以使以往受限于菲薄牙槽骨三维形态的正畸牙移动有了更多的可能。目的:利用三维有限元分析法对牙周辅助加速成骨正畸手术增加牙槽骨量前、后正畸牙移动的生物力学进行探... 详细信息

背景:人们对正畸治疗的需求日益增加,牙周辅助加速成骨正畸技术可以使以往受限于菲薄牙槽骨三维形态的正畸牙移动有了更多的可能。目的:利用三维有限元分析法对牙周辅助加速成骨正畸手术增加牙槽骨量前、后正畸牙移动的生物力学进行探究。方法:选择1例需正畸前进行牙周辅助加速成骨正畸手术以增加下颌前牙区唇侧骨量的患者,根据其术前及术后6个月的锥形束CT数据构建术前及术后三维有限元分析模型,结合患者临床隐形矫治中正畸牙的移动过程,2个模型均分别模拟33牙远中移动0.25 mm、舌向移动0.25 mm、压低移动0.10 mm,利用ANSYS workbench 2020软件分析在无托槽隐形矫治器的作用下33牙牙体、牙周膜、周围牙槽骨的应力分布及初始位移趋势。结果与结论:①牙体应力:在相同的正畸牙移动方式下,术前33牙牙体的最大Von-Mises应力与整体应力均大于术后,手术前后的最大等效应力分布区域相近、Von-Mises应力整体分布趋势接近;②牙周膜应力:在相同的正畸牙移动方式下,术前33牙牙周膜的最大Von-Mises应力与整体应力均大于术后,手术前后的最大等效应力分布区域相近、Von-Mises应力整体分布趋势接近;③牙槽骨应力:在相同的正畸牙移动方式下,术前33牙周围牙槽骨的最大Von-Mises应力值大于术后,手术前后的等效应力分布表现为由牙槽嵴顶处向根方逐步减小;④初始位移:在相同的正畸牙移动方式下,术前33牙6个观测点在主要位移方向上的初始位移量均小于术后,并且呈现出位移量由牙尖向根尖点逐步减小的趋势;⑤结果显示:牙周辅助加速成骨正畸手术增加牙槽骨量前后,正畸牙移动的生物力学特征存在差异,在隐形矫治器的作用下,术后牙体、牙周膜、周围牙槽骨的等效应力较术前小,术后正畸牙的初始位移较术前大,这提示牙周辅助加速成骨正畸手术可以通过增加牙槽骨厚度解除菲薄牙槽骨对正畸牙移动的限制,有效改善牙根、牙周膜、牙槽骨的受力,避免了菲薄牙槽骨区正畸牙受力移动时产生应力集中从而引起并发症的状况,同时提高了牙齿的移动效率。

关键词：正畸治疗牙周辅助加速成骨正畸无托槽隐形矫治器三维有限元法生物力学

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The key piece of the airway remodeling puzzle revealed-LIGHT signaling in the lung

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Genes & Diseases 2023年第4期10卷 1131-1132页

作者： ziyan Rachel chen Jim Hu Programmes in Translational Medicine Research InstituteHospital for Sick ChildrenTorontoOntario M5G 0A4Canada Department of Laboratory Medicine and Pathobiology University of TorontoTorontoOntario M5S 1A8Canada Department of Paediatrics University of TorontoTorontoOntario M5S 1A8Canada

Asthma is a chronic lung disease that primarily affects the lower respiratory tract in more than 300 million people *** is often triggered by exposure to certain substances or conditions,such as allergens or cold *** overreaction to the allergens causes inflammation and narrowing of the airway,which leads to episodic or persistent symptoms including shortness of breath,nocturnal cough,chest tightness,and wheezing.

关键词： airway lung inflammation

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Three-dimensional cooperative guidance strategy and guidance law for intercepting highly maneuvering target

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Chinese Journal of Aeronautics 2021年第5期34卷 485-495页

作者： ziyan chen Jianglong YU Xiwang DONG Zhang REN School of Automation Science and Electrical Engineering Science and Technology on Aircraft Control LaboratoryBeihang UniversityBeijing 100191China Beijing Advanced Innovation Center for Big Data cmd Brain Computing Beihang UniversityBeijing 100191China

Cooperative interception of the target with strong maneuverability by multiple missiles with weak maneuverability in the three-dimensional nonlinear model is ***,the three-dimensional nonlinear model of cooperative guidance is *** three-dimensional reachable region is represented composed of lateral acceleration and longitudinal acceleration in the two-dimensional coordinate ***,the problem of the multiple missile’s reachable coverage area is transformed into the problem of cooperative coverage.A cooperative coverage strategy is proposed and an algorithm for quickly calculating the number of required missiles is ***,the guidance law based on the cooperative coverage strategy is proposed,and it is proved that cooperative interception of the target can be achieved under the acceleration ***,the relations among the number of missiles,the initial array position of terminal guidance and the coverage area of the target’s large maneuver are *** dynamic adjustment strategy of guidance parameters is proposed to reduce the guidance ***,simulation results show that multiple missiles with low maneuverability can achieve effective interception of target with strong maneuverability through the proposed cooperative strategy and cooperative guidance method.

关键词： Acceleration constraint Cooperative interception Coverage strategy Guidance law Highly maneuvering target

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