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Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

Genomics, Proteomics & Bioinformatics 2024年第2期22卷 81-92页

作者： zitian huo Yaqi Duan Dongdong Zhan Xizhen Xu Nairen Zheng Jing Cai Ruifang Sun Jianping Wang Fang Cheng Zhan Gao Caixia Xu Wanlin Liu Yuting Dong Sailong Ma Qian Zhang Yiyun Zheng Liping Lou Dong Kuang Qian Chu Jun Qin Guoping Wang Yi Wang Institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Health Commission Key Laboratory of Respiratory Diseases Tongji HosptialTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Beijing Pineal Diagnostics Co. Ltd.Beijing 102206China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China Institution of Pathology The First Affiliated Hospital of Henan UniversityKaifeng 475001China Department of Tumor Biobank Shanxi Cancer HospitalTaiyuan 030013China Chongqing Key Laboratory of Big Data for Bio Intelligence School of BioinformationChongqing University of Posts and TelecommunicationsChongqing 400065China

Small cell lung cancer(SCLC)is a highly malignant and heterogeneous cancer with limited therapeutic options and prognosis prediction ***,we analyzed formalin-fixed,paraffin-embedded(FFPE)samples of surgical resections by proteomic profiling,and stratified SCLC into three proteomic subtypes(S-I,S-II,and S-III)with distinct clinical outcomes and chemotherapy *** proteomic subtyping was an independent prognostic factor and performed better than current tumor–node–metastasis or Veterans Administration Lung Study Group staging *** subtyping results could be further validated using FFPE biopsy samples from an independent cohort,extending the analysis to both surgical and biopsy *** signatures of the S-II subtype in particular suggested potential benefits from *** overexpressed proteins in S-III,the worst prognostic subtype,allowed us to nominate potential therapeutic targets,indicating that patient selection may bring new hope for previously failed clinical ***,analysis of an independent cohort of SCLC patients who had received immunotherapy validated the prediction that the S-II patients had better progression-free survival and overall survival after first-line ***,our study provides the rationale for future clinical investigations to validate the current findings for more accurate prognosis prediction and precise treatments.

关键词： Small cell lung cancer Proteomics Prognosis Chemotherapy response Immunotherapy

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Intratumoral CD103^(+)CD8^(+)T cells predict response to neoadjuvant chemoimmunotherapy in advanced head and neck squamous cell carcinoma

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Cancer Communications 2023年第10期43卷 1143-1163页

作者： Siqi Ren Tianjun Lan Fan Wu Suling Chen Xue Jiang Chuying huo zitian Li Shule Xie Donghui Wu Ruixin Wang Yanyan Li Lin Qiu Guoxin Huang Shurui Li Xiaojuan Wang Meifeng Cen Tingting Cai Zhaoyu Lin Jinsong Li Bowen Li Department of Oral and Maxillofacial Surgery Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityGuangdongP.R.China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangdongP.R.China Department of Gynecological Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangdongP.R.China School of Stomatology Jilin UniversityJilinP.R.China Stomatology Hospital of Haizhu district GuangdongP.R.China

Background Immune cell heterogenicity is known to determine the therapeutic response to cancer *** chemoimmunotherapy(NACI)has shown clinical benefits in some patients with advanced head and neck squamous cell carcinoma(HNSCC),but the underlying mechanism behind this clinical response is *** efficacy of NACI needs to be potentiated by identifying accurate biomarkers to predict clinical ***,we attempted to identify molecules predicting NACI response in advanced *** We performed combined single-cell RNA sequencing(scRNA-seq)and multiplex immunofluorescence(mIHC)staining with tumor samples derived from NACI-treated HNSCC patients to identify a new tumor-infiltrating cell(TIL)subtype,CD103^(+)CD8^(+)TILs,associated with clinical response,while both in vitro and in vivo assays were carried out to determine its antitumor *** regulatory mechanism of the CD103^(+)CD8^(+)TILs population was examined by performing cell-cell interaction analysis of the scRNA-seq data and spatial analysis of the mIHC *** We established intratumoral CD103^(+)CD8^(+)TILs density as a determinant of NACI efficacy in *** scRNA-seq results indicated that the population of CD103^(+)CD8^(+)TILs was dramatically increased in the responders of NACI-treated HNSCC patients,while mIHC analysis confirmed the correlation between intratumoral CD103^(+)CD8^(+)TILs density and NACI efficacy in HNSCC *** receiver operating characteristic curve analysis defined this TIL subset as a potent marker to predict patient response to *** assays showed that CD103^(+)CD8^(+)TILs were tumor-reactive T cells,while programmed cell death protein-1(PD-1)blockade enhanced CD103^(+)CD8^(+)TILs cytotoxicity against tumor growth in ***,targeting the triggering receptor expressed on myeloid cells 2-positive(TREM2^(+))macrophages might enhance the population of CD103^(+)CD8^(+)TILs and facilitate antitumor immunity

关键词： CD103 CD8 head and neck squamous cell carcinoma neoadjuvant chemoimmunotherapy predictive marker tumor-infiltrating lymphocyte

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考虑动能回收的电动客车长下坡制动盘温升状态

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汽车安全与节能学报 2023年第3期14卷 274-281页

作者：李子添李彬霍珅扬张晶吕小侠长安大学汽车学院西安710064 宝鸡吉利汽车部件有限公司宝鸡721300 北京小米移动软件有限公司北京100085

为了提高纯电动客车的安全性,研究了对中央驱动式纯电动客车,在长下坡工况制动盘温升过高的问题。采用模拟仿真和实际道路试验,对某电动客车的制动器和制动卡钳温升进行相关性研究,基于Ansys Workbench软件建立制动盘的热力耦合模型,利... 详细信息

为了提高纯电动客车的安全性,研究了对中央驱动式纯电动客车,在长下坡工况制动盘温升过高的问题。采用模拟仿真和实际道路试验,对某电动客车的制动器和制动卡钳温升进行相关性研究,基于Ansys Workbench软件建立制动盘的热力耦合模型,利用Matlab根据实验数据拟合出制动钳与制动盘温升的相关函数。结果表明:该中央驱动式纯电动客车利用电机反拖持续制动坡度约为3.99%,坡度更大时需要行车制动参与。制动卡钳和制动盘温升相关系数高达0.9,从而,制动卡钳温度可用于监测制动盘热衰退和安全预警。这些结果,可为纯电动客车长下坡制动安全提供数据支撑。

关键词：纯电动客车制动动能回收长下坡温升有限元分析

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