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Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI（4,5）P2 and extended synaptotagmins

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Science China(Life Sciences) 2019年第9期62卷 1117-1135页

作者： Jian Xiao Jie Luo Ao Hu Ting Xiao Meixin Li Zekai Kong Luyi Jiang zimu zhou Yacheng Liao Chang Xie Beibei Chu Honghua Miao Boliang Li Xiongjie Shi Bao-Liang Song College of Life Sciences the Institute for Advanced StudiesWuhan UniversityWuhan 430072China State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Shenzhen Institute of Wuhan University Shenzhen 518057China

Most mammalian cells take up cholesterol from low-density lipoproteins(LDLs) via receptor-mediated *** reaching lysosomes,LDL-derived cholesterol continues to transport to downstream organelles including the ER for specific structural and functional *** are recently found to receive cholesterol from lysosomes through lysosomeperoxisome membrane ***,whether and how cholesterol is conveyed from peroxisomes to the ER remain ***,by combining high-resolution microscopic analyses and in vitro reconstitution of highly purified organelles or artificial liposomes,we demonstrate that peroxisomes form membrane contacts with the ER through the interaction between peroxisomal PI(4,5)P2 and ER-resident extended synaptotagmin-1,2 and 3(E-Syts).Depletion of peroxisomal PI(4,5)P2 or ESyts markedly decreases peroxisome-ER membrane contacts and induces cholesterol accumulation in ***,we show that cholesterol is delivered from 3H-labeled peroxisomes or PI(4,5)P2-containing liposomes to the ER in vitro,and that the presence of peroxisomes augments cholesterol transfer from lysosomes to the ***,our study reveals a new cholesterol transport pathway along the lysosome-peroxisome-ER membrane contacts in the cell.

关键词： Peroxisome ER membrane contacts E-Syts PI(4,5)P2

我国大学生“慢就业”研究现状与热点趋势--基于CiteSpace的可视化分析

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淮南师范学院学报 2024年第6期26卷 50-56页

作者：任恒陈孝柱周子沐安徽理工大学安全科学与工程学院安徽淮南232001 安徽理工大学土木建筑学院安徽淮南232001 安徽建筑大学经济与管理学院安徽合肥230009

新形势下大学生“慢就业”问题是当前的研究热点。为宏观了解大学生“慢就业”研究现状与热点趋势,文章借助CiteSpace软件对2016-2024年CNKI数据库中的相关文献进行可视化分析。结果表明:大学生“慢就业”研究经历了缓慢增长阶段和快速... 详细信息

新形势下大学生“慢就业”问题是当前的研究热点。为宏观了解大学生“慢就业”研究现状与热点趋势,文章借助CiteSpace软件对2016-2024年CNKI数据库中的相关文献进行可视化分析。结果表明:大学生“慢就业”研究经历了缓慢增长阶段和快速增长阶段;研究机构主要集中在高校,在权威期刊上发表文献数量较少,内部之间的合作较多;部分作者对该领域的持续研究能力不足,尚未形成该领域研究的中坚力量,作者之间合作较少;研究热点主题集中在慢就业、高职院校、大学生、毕业生、对策等关键词;未来的研究趋势集中在就业服务、影响因素、引导策略、就业质量主题方面。

关键词：大学生慢就业 CiteSpace 研究热点

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密闭空间微生物消杀方法研究进展

北京理工大学学报 2025年第1期45卷 87-104页

作者：戴荣继郭子沐张莹北京理工大学生命学院北京100081

空间站是一种在近地轨道长时间运行、可供多名航天员巡访、长期工作和生活的载人航天器,在密闭恒温恒湿的环境下,微生物的数量会快速增加,如果不加以控制,就会危害宇航员的身体健康,腐蚀或损坏航天器材,对航天安全产生不利的影响.通过... 详细信息

空间站是一种在近地轨道长时间运行、可供多名航天员巡访、长期工作和生活的载人航天器,在密闭恒温恒湿的环境下,微生物的数量会快速增加,如果不加以控制,就会危害宇航员的身体健康,腐蚀或损坏航天器材,对航天安全产生不利的影响.通过阐明空间微生物污染的主要来源与空间微生物污染对宇航员健康和设备安全方面造成的危害,综述了各种杀菌消毒方法如高温、辐射、环氧乙烷、臭氧、超临界流体、气体等离子体、光催化氧化、自清洁表面和诱导发光聚集等的作用原理、应用场景以及各方法可否应用于空间环境的优缺点,并且对适用于空间微生物污染防控的方法进行了评价.

关键词：空间生物学空间站消毒杀菌方法超临界流体气体等离子体光催化氧化自清洁表面聚集诱导发光

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A Two-Stage State Recognition Method for Asynchronous SSVEP-Based Brain-Computer Interface System

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机器人 2013年第1期35卷 45-51页

作者： ZHANG zimu DENG Zhidong State Key Laboratory of Intelligent Technology and Systems Tsinghua National Laboratory for Information Science and TechnologyDepartment of Computer Science and TechnologyTsinghua University

A two-stage state recognition method is proposed for asynchronous SSVEP(steady-state visual evoked potential) based brain-computer interface(SBCI) *** two-stage method is composed of the idle state(IS) detection and control state(CS) discrimination *** on blind source separation and continuous wavelet transform techniques,the proposed method integrates functions of multi-electrode spatial filtering and feature *** IS detection module,a method using the ensemble IS feature is *** CS discrimination module,the ensemble CS feature is designed as feature vector for control intent ***,performance comparisons are investigated among our IS detection module and other existing *** the experimental results validate the satisfactory performance of our CS discrimination module.

关键词：检测模块机器人连续小波变换技术视觉诱发

Survey on path and view planning for UAVs

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Virtual Reality & Intelligent Hardware 2020年第1期2卷 56-69页

作者： Xiaohui zhou zimu YI Yilin LIU Kai HUANG Hui HUANG Visual Computing Research Center Shenzhen UniversityShenzhen 518060China

Background In recent decades,unmanned aerial vehicles(UAVs)have developed rapidly and been widely applied in many domains,including photography,reconstruction,monitoring,and search and *** such applications,one key issue is path and view planning,which tells UAVs exactly where to fly and how to *** With specific consideration for three popular UAV applications(scene reconstruction,environment exploration,and aerial cinematography),we present a survey that should assist researchers in positioning and evaluating their works in the context of existing ***/Conclusions It should also help newcomers and practitioners in related fields quickly gain an overview of the vast *** addition to the current research status,we analyze and elaborate on advantages,disadvantages,and potential explorative trends for each application domain.

关键词： Unmanned aerial vehicle Path planning View panning Multi-view reconstruction Autonomous exploration Scene navigation Obstacle avoidance Drone cinematography Camera control

Capturing the crack process of the Antarctic A74 iceberg with Sentinel-1 based offset tracking and radar interferometry techniques

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International Journal of Digital Earth 2022年第1期15卷 397-415页

作者： zimu Li Qingliang Wu College of Engineering and Technology Southwest UniversityChongqingPeople's Republic of China College of Computer and Information Science College of Software Southwest UniversityChongqingPeople's Republic of China

In this paper,the crack process of the A74 iceberg is carefully monitored in different aspects by using synthetic aperture radar(SAR)***,a offset tracking strategy is designed to retrieve the temporal evolution of the glacier velocity ***,a signal coherence factor(SCF)is proposed to analyze the interferometric *** resulting SCF maps can present a more distinct rupture pattern than the SAR magnitude images,which enables the development of rift to be tracked more ***,a new approach is proposed to explore the temporal change of the ice *** this approach is based on interferometric phase signals,it is more sensitive than the offset tracking ***,the abnormal variation signals associated with the rupture process can be discovered from the experimental results in an earlier *** results also show that the area with abnormal signals is almost identical to the region of the calved ice,which demonstrates that the scale of the iceberg might be predicted at least two months before the rupture ***,such a consistent pattern may indicate a total alteration of ice characteristics,implying that the complete separation between A74 and BIS is inevitable.

关键词： Offset tracking InSAR change detection glacier velocity field iceberg rupture

A Relative Error Estimation Approach for Multiplicative Single Index Model

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Journal of Systems Science & Complexity 2017年第5期30卷 1160-1172页

作者： WANG Zhanfeng CHEN zimu WU Yaohua Department of Statistics and Finance School of ManagementUniversity of Science and Technology of ChinaHefei 230026China

As an alternative to absolute error methods, such as the least square and least absolute deviation estimations, a product relative error estimation is proposed for a multiplicative single index regression model. Regression coefficients in the model are estimated via a two-stage procedure and their statistical properties such as consistency and normality are studied. Numerical studies including simulation and a body fat example show that the proposed method performs well.

关键词： Asymptotic properties least product relative error relative errors single index model

Insight into the relationship between microorganism communities and flavor quality of Chinese dry-cured boneless ham with different quality grades

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Food Bioscience 2022年第6期50卷 1890-1901页

作者： zimu Li Ying Wang Daodong Pan Fang Geng Changyu zhou Jinxuan Cao Key Laboratory of Animal Protein Food Processing Technology of Zhejiang Province College of Food&Pharmaceutical SciencesNingbo UniversityNingbo315211China School of Food and Health Beijing Technology and Business University (BTBU)BeijingBeijing100048PR China Meat Processing Key Laboratory of Sichuan Province School of Food and Biological EngineeringChengdu UniversityNo.2025 Chengluo AvenueChengdu610106China

Microorganisms played a key role in developing the flavor quality,while few studies focused on the relationship between microbial diversity and flavor quality of dry-cured boneless *** explore the relationship,sensory evaluation,lipases,microorganism communities,free fatty acids and volatile compounds were investigated in dry-cured boneless ham with different quality grades(NS,WS and GS groups);the correlation between cored microbes and crucial volatiles was further evaluated by metabolic network *** group showed the highest scores in aroma and overall acceptance among three *** highest values of phospholipase activities(7.88 U*g−1 protein)were shown in GS group,while the lowest values of TBARS(0.93 mg/kg)were observed in GS among three ***-throughput sequencing revealed that fungi showed the most various among three groups;Xerochrysium,Aspergillus,Penicillium and Debaryomyces were the most genera in ***-GC-MS revealed that GS showed higher contents and numbers in volatiles than other groups;aldehydes and furans were intensely response to the variations of volatiles among these *** pathway further revealed that several key species derived from Penicillium and Aspergillus accelerated the formation of volatiles byβ-lipoxidation and Strecker *** results indicated that molds could be the major contributors in developing and differentiating the flavor quality of Chinese dry-cured boneless ham.

关键词： Dry-cured boneless ham Microbial communities Volatile compounds Lipid oxidation Metabolic network

生态环境多源卫星遥感数据传输系统设计与实现

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环境与可持续发展 2021年第6期46卷 138-142页

作者：孙建欣李成芳雷云龙曹飞徐丹周子牧吴跃孙中平生态环境部卫星环境应用中心北京100094 国家对地观测科学数据中心生态环境卫星数据资源分中心北京100094

基于覆盖范围广、信息量大、可连续观测的特点,卫星遥感技术在生态环境保护工作中发挥了不可或缺的作用,有力地支撑了生态环境监测、督察监管等重要工作。根据卫星遥感数据在生态环境监测、监管方面的应用,将多源遥感数据集合,设计并实... 详细信息

基于覆盖范围广、信息量大、可连续观测的特点,卫星遥感技术在生态环境保护工作中发挥了不可或缺的作用,有力地支撑了生态环境监测、督察监管等重要工作。根据卫星遥感数据在生态环境监测、监管方面的应用,将多源遥感数据集合,设计并实现了生态环境多源卫星遥感数据的主动快速传输系统。该系统整合不同数据源卫星数据到同一个平台中,根据用户需求,实现对数据的及时、高效、按需推送,为生态环境监测提供基础数据支撑。研究表明,生态环境多源卫星遥感数据传输系统实现了多源卫星遥感数据的主动快速推送,为生态环境监管提供了及时高效的基础数据支撑。目前已完成江苏南京、江苏泰州、陕西西安等节点的部署和上线运行,为秸秆焚烧、黑臭水体、自然保护区、饮用水源地、生态保护红线等重点业务提供了数据保障,在生态环境监测与监管过程中发挥了积极作用。下一步将开发区域定制化数据服务,不断优化系统功能,提供更高时效的生态环境卫星遥感数据,大幅度提高生态环境监测能力,为生态环境质量考核评价、污染解析、预警应急、监督执法、风险管理等重点工作提供数据服务。

关键词：推送系统生态环境卫星多源数据遥感