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Fatty acids of erythrocyte membrane in acute pancreatitis patients

World Journal of Gastroenterology 2013年第34期19卷 5678-5684页

作者： Irma Kuliaviene Antanas Gulbinas Johannes Cremers Juozas Pundzius Limas Kupcinskas zilvinas Dambrauskas Eugene Jansen Department of Gastroenterology Medical AcademyLithuanian University of Health Sciences Department of Surgery Medical AcademyLithuanian University of Health Sciences Institute for Digestive Research Medical AcademyLithuanian University of Health Sciences Centre for Health Protection National Institute for Public Health and the Environment 3720 BA Bilthoven The Netherlands

AIM:To evaluate changes in the fatty acid composition of erythrocyte membrane phospholipids during severe and mild acute pancreatitis(AP)of alcoholic and nonalcoholic ***:All consecutive patients with a diagnosis of AP and onset of the disease within the last 72 h admitted to the Hospital of Lithuanian University of Health Sciences between June and December 2007 were *** to the Acute Physiology and ChronicHealth Evaluation(APACHEⅡ)scale,the patients were subdivided into the mild(APACHEⅡscore<7,n=22)and severe(APACHEⅡscore≥7,n=17)AP *** individuals(n=26)were enrolled as *** samples were collected from patients on admission to the *** acids(FAs)were extracted from erythrocyte phospholipids and expressed as percentages of the total FAs present in the *** concentrations of superoxide dismutase and glutathione peroxidase were measured in ***:We found an increase in the percentages of saturated and monounsaturated FAs,a decrease in the percentages of total polyunsaturated FAs(PUFAs)and n-3 PUFAs in erythrocyte membrane phospholipids of AP patients compared with healthy ***(C16:0),palmitoleic(C16:1n7cis),arachidonic(C20:4n6),docosahexaenoic(DHA,C22:6n3),and docosapentaenoic(DPA,C22:5n3)acids were the major contributing factors.A decrease in the peroxidation and unsaturation indexes in AP patients as well as the severe and mild AP groups as compared with controls was *** concentrations of antioxidant enzymes in the mild AP group were lower than in the control *** severe AP of nonalcoholic etiology,the percentages of arachidic(C20:0)and arachidonic(C20:4n6)acids were decreased as compared with the control *** patients with mild AP of nonalcoholic etiology had the increased percentages of total saturated FAs and gama linoleic acid(C18:3n6)and the decreased percentages of elaidic(C18:1n9t),eicosapentaenoic acid(EPA,C20:5n3),DPA(C22:5n3),DHA(C22:6n3)as we

关键词： Acute pancreatitis Alcohol Fatty acids Oxidative stress Systemic inflammatory response syndrome

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