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Switchable shape memory polymer bio-inspired adhesive and its application for unmanned aerial vehicle landing

Chinese Journal of Aeronautics 2024年第3期37卷 380-390页

作者： Qingsong HE Zefang zhao Qiyun ZHONG Siyuan LIU Kai DENG Yongqi LIU Ning ZHANG zijie zhao Fengjiang ZHAN Jianfeng zhao Jiangsu Provincial Key Laboratory of Bionic Functional Materials College of Mechanical and Electrical EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China Key Laboratory of Advanced Technology for Small and Medium-Sized UAV Ministry of Industry and Information TechnologyUnmanned Aerial Vehicles Research InstituteNanjing University of Aeronautics and AstronauticsNanjing 210016China State Key Laboratory of Mechanics and Control of Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China Functional Morphology and Biomechanics Institute of ZoologyKiel UniversityKiel 24098Germany

Controlled and switchable adhesion is commonly observed in biological *** recent years,many scholars have focused on making switchable bio-inspired ***,making a bio-inspired adhesive with high adhesion performance and excellent dynamic switching properties is still a challenge.A Shape Memory Polymer Bio-inspired Adhesive(SMPBA)was successfully developed,well realizing high adhesion(about 337 kPa),relatively low preload(about90 kPa),high adhesion-to-preload ratio(about 3.74),high switching ratio(about 6.74),and easy detachment,which are attributed to the controlled modulus and contact area by regulating temperature and the Shape Memory Effect(SME).Furthermore,SMPBA exhibits adhesion strength of80–337 kPa on various surfaces(silicon,iron,and aluminum)with different roughness(Ra=0.021–10.280)because of the conformal contact,reflecting outstanding surface *** finite element analysis verifies the bending ability under different temperatures,while the adhesion model analyzes the influence of preload on contact area and ***,an Unmanned Aerial Vehicle(UAV)landing device with SMPBA was designed and manufactured to achieve UAV landing on and detaching from various *** study provides a novel switchable bio-inspired adhesive and UAV landing method.

关键词： Bio-inspired adhesive Shape memory polymers Switchable adhesive Unmanned aerial vehicle Landing

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一种综合核心处理平台的设计与实现

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信息技术与信息化 2024年第1期 59-62页

作者：赵子杰李成文丰生磊航空工业西安航空计算技术研究所陕西西安710065

综合核心处理平台承担飞机的综合化航空电子系统的系统综合管理、网络综合管理、系统健康监控、系统运行管控、传感器管理、信息存储管理、任务管理、数据处理、图像处理等功能,可使机载设备集成化程度更高,模块数量减少的同时也降低了... 详细信息

综合核心处理平台承担飞机的综合化航空电子系统的系统综合管理、网络综合管理、系统健康监控、系统运行管控、传感器管理、信息存储管理、任务管理、数据处理、图像处理等功能,可使机载设备集成化程度更高,模块数量减少的同时也降低了设备成本、能耗和体积,使得机载计算机具备更高的功能密度,飞机也对机载处理系统提出了性能高、功能强、功耗低、体积小、造价低的迫切要求。设计了一种综合核心处理平台,可使机载设备集成化程度更高,模块数量减少的同时也降低了设备成本、能耗和体积,使得机载计算机具备更高的功能密度。

关键词：综合核心处理平台分布式处理高性能计算设备集成化系统综合管理

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价值认知与实践决策——工业建筑遗产更新中当代建筑师的话语思考

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建筑遗产 2024年第1期 8-16页

作者：赵子杰徐苏斌田甜 [日]青木信夫天津大学建筑学院天津300072 天津大学中国文化遗产保护国际研究中心太原理工大学建筑学院

遗产的价值认知与保护是一个多维度的议题,受到不同认知主体背景差异的影响,可能引发争议,进而影响保护决策的制定。作为工业建筑遗产更新实践的直接策划者与执行者,建筑师的价值认知与实践决策会直接影响实践效果。文章旨在从建筑师的... 详细信息

遗产的价值认知与保护是一个多维度的议题,受到不同认知主体背景差异的影响,可能引发争议,进而影响保护决策的制定。作为工业建筑遗产更新实践的直接策划者与执行者,建筑师的价值认知与实践决策会直接影响实践效果。文章旨在从建筑师的价值认知视角出发,记录这一群体对价值认知与保护决策的思考,以探究建筑师群体对于遗产保护与再利用的当代思考。文章发现,建筑师群体普遍认为工业建筑遗产要走入当代生活,并对工业建筑遗产及其环境的保护利用和干预持正面态度。

关键词：工业建筑遗产更新建筑师价值认知

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Heat stress induced hepatocyte apoptosis in largemouth bass Micropterus salmoides via IRE1α/TRAF2/ASK1/JNK pathway

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Journal of Oceanology and Limnology 2024年第3期42卷 988-1000页

作者： Xuqian zhao Wenjia MAO zijie LIN Qufei LING School of Biology and Basic Medical Sciences Suzhou Medical College of Soochow UniversitySuzhou 215000China

Heat stress(HS)has been shown to adversely affect fish livers and can lead to extensive *** investigate the relationship between endoplasmic reticulum(ER)stress and HS-induced apoptosis in fish livers,we isolated and cultured primary hepatocytes of largemouth bass,Micropterus salmoides by trypsin method,then established an in-vitro model of liver cells under HS(35℃).The contents of lactic dehydrogenase(LDH)and hydrogen peroxide(H2O2)were determined to evaluate the effects of HS on hepatocyte injury and oxidative ***-qPCR was performed to discover the key genes in unfolded protein response(UPR)pathways involved at different HS *** inhibitor 4-PBA and IRE1αinhibitor 4μ8C were used to further investigate the effects of HS on IRE1αapoptosis pathway in *** show that HS led to significant increases in the release of LDH,the content of H2O2,and the expressions of oxidative protein folding genes(ero1αand pdi)under HS,suggesting severe hepatocyte injury and oxidative stress happened in heat-stressed largemouth bass *** continuous activation of IRE1αpathway genes(grp78,grp94,atf6,perk,eif2a,atf4,chop,ire1α,traf2,ask1,jnk1,and jnk2)indicated that HS led significantly to ER *** particular,the mRNA expression levels of ER stress-related genes(grp78,grp94,atf6,perk,ire1α,chop,jnk1,and jnk2)in the high temperature(HT)+4-PBA group and the HT+4μ8C group were significantly down-regulated under *** 4μ8C treatment,the expression levels of apoptosis-related genes(caspase-2,caspase-3,caspase-6,caspase-7,caspase-8,caspase-9,and caspase-10)and LDH content were significantly decreased,whereas the cell survival rate was significantly increased when given 4-PBA or 4μ8C *** findings demonstrate that HS could induce liver apoptosis of largemouth bass through the IRE1αpathway,which may act as a key switch mediating liver apoptosis of largemouth bass under HS.

关键词： heat stress Micropterus salmoides endoplasmic reticulum stress apoptosis oxidative stress

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益肾五苓汤联合血液透析治疗尿毒症52例

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西部中医药 2024年第2期37卷 145-148页

作者：赵紫杰张坤余冠华龚睿琼王雀宋世超太和县中医院安徽太和236608

目的:观察益肾五苓汤联合血液透析治疗尿毒症的临床疗效。方法:选取104例进行血液透析治疗的尿毒症患者,按就诊顺序进行分组,对照组仅进行血液透析治疗,观察组在进行血液透析的同时服用益肾五苓汤。对比两组临床治疗效果、肾功能、疼痛... 详细信息

目的:观察益肾五苓汤联合血液透析治疗尿毒症的临床疗效。方法:选取104例进行血液透析治疗的尿毒症患者,按就诊顺序进行分组,对照组仅进行血液透析治疗,观察组在进行血液透析的同时服用益肾五苓汤。对比两组临床治疗效果、肾功能、疼痛程度视觉模拟评分法(visual analogue score,VAS)评分、症状积分及血红蛋白(hemoglobin,Hb)、血细胞比容(hematocrit,HCT)、总蛋白(total protein,TP)水平。结果:总有效率观察组[92.3%(48/52)]高于对照组[78.8%(41/52)](P0.05),治疗后水平观察组Ccr明显高于对照组,SCr、24 h尿蛋白量、BUN水平低于对照组(P0.05),治疗后观察组均明显降低(P0.05),治疗后观察组均明显升高(P<0.05),且高于对照组(P<0.05)。结论:在尿毒症患者血液透析时,应用益肾五苓汤可提升临床疗效,减轻患者透析过程中的疼痛程度,调节肾功能及Hb、HCT、TP水平。

关键词：尿毒症益肾五苓汤血液透析肌酐 24 h尿蛋白量尿素氮

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Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1159-1174页

作者： Heng Xu Hongfang zhao Chunyong Ding Defang Jiang zijie zhao Yang Li Xiaoyu Ding Jing Gao Hu Zhou Cheng Luo Guoqiang Chen Ao Zhang Ying Xu Hao Zhang School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Chemical Biology Research Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Department of Pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of EducationShanghai Jiao Tong University School of MedicineShanghai 200025China Pharm-X center College of Pharmaceutical SciencesShanghai Jiao Tong UniversityShanghai 200240China School of Chinese Materia Medica Nanjing University of Chinese Medicine138 Xianlin RoadQixiaNanjing 210023 JiangsuChina University of Chinese Academy of Sciences No.19A Yuquan RoadBeijing 100049China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRen-Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China

As a terpenoids natural product isolated from the plant Thunder God Vine,Celastrol is widely studied for its pharmacological activities,including anti-tumor *** clinical application of Celastrol is strictly limited due to its severe side effects,whereas previously revealed targets and mechanism of Celastrol seldom reduce its in vivo toxicity via structural *** identification has a far-reaching influence on the development of innovative drugs,and omics data has been widely used for unbiased target ***,it is difficult to enrich target of specific phenotype from thousands of genes or proteins,especially for natural products with broad promising ***,we developed a text-mining-based web-server tool to enrich targets from omics data of inquired *** peroxiredoxin 1(PRDX1)was identified as the ROS-manipulating target protein of Celastrol in colorectal *** solved high-resolution crystal structure revealed the unique covalent binding mode of Celastrol with *** derivative compound 19-048 with improved potency against PRDX1 and selectivity towards PRDX2~PRDX6 were synthesized based on crystal structure *** Celastrol and 19-048 effectively suppressed the proliferation of colorectal cancer *** anti-tumor efficacy of Celastrol and 19-048 was significantly diminished on xenograft nude mice bearing PRDX1 knock-down colorectal cancer *** downstream genes of p53 signaling pathway were dramatically up-regulated with Celastrol or 19-048 *** findings reveal that the side effects of Celastrol could be reduced via structural modification,and PRDX1 inhibition is promising for the treatment of colorectal cancer.

关键词： colorectal cancer nude

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Differential expression of miRNAs and mRNAs in the livers of largemouth bass Micropterus salmoides under heat stress

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Journal of Oceanology and Limnology 2024年第2期42卷 594-608页

作者： Xuqian zhao zijie LIN Caijuan LI Hao ZHU Lingling LI Wenjia MAO Qufei LING School of Biology and Basic Medical Sciences Suzhou Medical College of Soochow UniversitySuzhou 215000China

Global warming threatens freshwater ecosystems and compromises fish *** elucidate the role of miRNAs in the livers of heat stressed largemouth bass,juvenile fish was subject to heat stress under 37°*** mRNA-seq and miRNA-seq were conducted on the liver tissues under control and heat stress *** gene expression analysis and enrichment analysis were performed on mRNA and miRNA expression profiles.A total of 406 differentially expressed genes(DEGs)were discovered,of which 212 were up-regulated and 194 were *** of the DEGs were significantly implicated in the regulation of“protein processing in endoplasmic reticulum”,“proteasome”,“steroid biosynthesis”,and“ornithine decarboxylase inhibitor activity”*** addition,47 differentially expressed miRNAs(DEMs)were identified in largemouth bass livers under heat stress,including 21 up-regulated and 25 down-regulated miRNAs.A negatively regulated miRNA-mRNA network including 12 miRNAs and 19 mRNAs was constructed with DEMs involved in“protein degradation”,“calcium ion regulation”,“cell apoptosis”,and“lipid metabolism”.Moreover,this study indicated novel-miR-144 activated the IRE1 signaling pathway by targeting txndc5 to induce liver apoptosis in largemouth bass under heat *** study revealed the involvement of miRNA regulation in largemouth bass in response to heat stress.

关键词： heat stress largemouth bass miRNA-mRNA interaction

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Nanoimprint-induced strain engineering of two-dimensional materials

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Microsystems & Nanoengineering 2024年第2期10卷 323-332页

作者： Chuying Sun Jianwen Zhong Zhuofei Gan Liyang Chen Chuwei Liang Hongtao Feng zhao Sun zijie Jiang Wen-Di Li The University of Hong Kong Hong KongChina

The high stretchability of two-dimensional(2D)materials has facilitated the possibility of using external strain to manipulate their ***,strain engineering has emerged as a promising technique for tailoring the performance of 2D materials by controlling the applied elastic strain *** various types of strain engineering methods have been proposed,deterministic and controllable generation of the strain in 2D materials remains a challenging ***,we report a nanoimprint-induced strain engineering(NISE)strategy for introducing controllable periodic strain profiles on 2D materials.A three-dimensional(3D)tunable strain is generated in a molybdenum disulfide(MoS_(2))sheet by pressing and conforming to the topography of an imprint *** strain profiles generated in MoS_(2)are demonstrated and verified by Raman and photoluminescence(PL)*** strain modulation capability of NISE is investigated by changing the imprint pressure and the patterns of the imprint molds,which enables precise control of the strain magnitudes and distributions in MoS_(2).Furthermore,a finite element model is developed to simulate the NISE process and reveal the straining behavior of MoS_(2).This deterministic and effective strain engineering technique can be easily extended to other materials and is also compatible with common semiconductor fabrication processes;therefore,it provides prospects for advances in broad nanoelectronic and optoelectronic devices.

关键词： strain dimensional molybdenum

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Highly uniform Co-Cu bimetallic sulfides for rechargeable alkaline aqueous zinc batteries

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Chinese Chemical Letters 2024年第2期35卷 521-526页

作者： Xiaofang Bai Yuwei zhao Mangwei Cui Tianshuo Guo zijie Tang Chuan Li Heng Gao Shuo Yang Lingzhi zhao Chunyi Zhi Hongfei Li Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Songshan Lake Materials Laboratory Dongguan 523808China Department of Materials Science and Engineering City University of Hong KongHong KongChina International Centre for Quantum and Molecular Structures Department of PhysicsShanghai UniversityShanghai 200444China Guangdong Provincial Engineering Technology Research Center for Low Carbon and Advanced Energy Materials Institute of Semiconductor Science and TechnologySouth China Normal UniversityGuangzhou 510631China

Rechargeable alkaline aqueous zinc batteries(RAZBs)have attracted increasing ***,most RAZBs are hindered by the limited availability of cathode *** practical electrochemical performance of most cathode materials is lower than the theoretical value due to their poor electrical conductivity and low utilization *** this work,we develop a facile hydrothermal procedure to prepare highly uniform bimetallic sulfides as novel cathode materials for ***-cobalt binary metallic oxides materials possess higher conductivity and larger capacity compared with their mono-metal oxides compounds due to bimetallic synergistic effects and multiple oxidation ***,bimetallic sulfide compounds have smaller bond energy and longer bond length than their oxides,leading to less structural damage,faster kinetics of electrochemical reactions,and better *** as-prepared Co-Cu bimetallic sulfides show enhanced electrochemical performance due to various valences of Co and Cu as well as the existence of *** a result,aqueous Zn/CuCo_(2)S_(4) battery shows a high specific capacity of 117.4 mAh/g at 4 A/g and a good cycle life of over 8000 *** on PANa hydrogel electrolytes,a flexible Zn/CuCo_(2)S_(4) battery demonstrates excellent cycling *** battery can also meet the requirements of electronic devices with different shapes and performs well in extreme environments,such as freezing,drilling,and *** work opens new avenues to obtain high-rate and long-life cathode materials for RAZBs by utilizing the synergistic effects of bimetallic sulfides and provides a new platform for flexible energy storage devices.

关键词： Aqueous zinc batteries Bimetallic sulfides Cathode materials Rate performance Cycling stability

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Numerical study of the turbulent channel flow under space-dependent electromagnetic force control at different Reynolds numbers

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Applied Mathematics and Mechanics(English Edition) 2019年第4期40卷 435-448页

作者： Daiwen JIANG Hui ZHANG Baochun FAN zijie zhao Jian LI Mingyue GUI Science and Technology on Transient Physics Laboratory Nanjing University of Science and Technology Department of Mathematics Imperial College London

In this paper, the control of turbulent channel flow by space-dependent electromagnetic force and the mechanism of drag reduction are investigated with the direct numerical simulation(DNS) methods for different Reynolds numbers. A formulation is derived to express the relation between the drag and the Reynolds shear stress. With the application of optimal electromagnetic force, the in-depth relations among characteristic structures in the flow field, mean Reynolds shear stress, and the effect of drag reduction for different Reynolds numbers are discussed. The results indicate that the maximum drag reductions can be obtained with an optimal combination of parameters for each case of different Reynolds numbers. The regular quasi-streamwise vortex structures, which appear in the flow field, have the same period with that of the electromagnetic *** structures suppress the random velocity fluctuations, which leads to the absolute value of mean Reynolds shear stress decreasing and the distribution of that moving away from the wall. Moreover, the wave number of optimal electromagnetic force increases,and the scale of the regular quasi-streamwise vortex structures decreases as the Reynolds number increases. Therefore, the rate of drag reduction decreases with the increase in the Reynolds number since the scale of the regular quasi-streamwise vortex structures decreases.

关键词： flow control drag reduction electromagnetic force turbulent channel flow

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