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Journal of Magnesium and Alloys 2024年第6期12卷 2345-2359页

作者： Ke Liu Dalong Hu Feng Lou zijian yu Shubo Li Xian Du Wenbo Du Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China

In this investigation,a high-strength Mg-12Gd-1.0Er-0.5Zr(wt.%)alloy sheet was produced by hot extrusion(HE)and subsequent hard-plate rolling(HPR)at different *** results indicate that the microstructures of these final-rolled sheets are inhomogeneous,mainly including coarse deformed grains and dynamic recrystallized(DRXed)grains,and the volume fraction of these coarse deformed grains increases as the rolling temperature ***,more DRXed grains can be found in R-385℃sheet,resulting in a smaller average grain size and weaker basal texture,while the biggest grains and the highest strong basal texture are present in R-450℃*** of dynamic precipitation ofβphases which are mainly determined by the rolling temperature are present in these sheets,and its precipitation can consume the content of Gd solutes in the *** a result,the lowest number density ofβphase in R-450℃sheet is beneficial to modify the age hardening ***,the R-450℃sheet displays the best age hardening response because of a severe traditional precipitation ofβ’(more)andβH/βM(less)precipitates,resulting in a sharp improvement in strength,*** tensile strength(UTS)of∼518±17 MPa and yield strength(YS)of∼438±18 ***,the elongation(EL)of this sheet reduces greatly,and its value is∼2.7±0.3%.By contrasting,the EL of the peak-aging R-385℃sheet keeps better,changing from∼4.9±1.2%to∼4.8±1.4%due to a novel dislocation-induced chain-like precipitate which is helpful to keep good balance between strength and ductility.

关键词： Mg-Gd-Er-Zr sheets Age hardening response Precipitates Mechanical properties

Allotetraploidization event of Coptis chinensis shared by all Ranunculales

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Horticultural Plant Journal 2024年第1期10卷 288-303页

作者： Yan Zhang Weina Ge Jia Teng Yanmei Yang Jianyu Wang zijian yu Jiaqi Wang Qimeng Xiao Junxin Zhao Shaoqi Shen Yishan Feng Shoutong Bao yu Li yuxian Li Tianyu Lei yuxin Pan Lan Zhang Jinpeng Wang Department of Bioinformatics School of Life SciencesNorth China University of Science and TechnologyTangshanHebei 063000China School of Life Sciences North China University of Science and TechnologyTangshanHebei 063000China State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of ScienceBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China

Coptis chinensis Franch.,also named Chinese goldthread is a member of Ranunculaceae in the order Ranunculales and represents an important lineage of early eudicots with traditional medicinal *** our study,by using syntenic analysis combined with phylogenomic analysis of *** and four other representative genomes from basal and core eudicots,we confirmed that the WGD event in *** was shared by Aquilegia coerulea and Papaver somniferum *** quickly occurred after Ranunculales diverged from other eudicots,likely a Ranunculales common tetraploidization(RCT).The synonymous nucleotide substitutions at synonymous sites distribution of syntenic blocks across these genomes showed that the evolutionary rate of the *** genome is faster than that of the *** genome by approximately 13.7%,possibly due to Papaveraceaes having an additional special tetraploidization event(PST).After Ks correction,the RCT dated to 115—130 million years ago(MYA),which was close to the divergence of Ranunculaceaes and Papaveraceaes approximately115.45—130.51 ***,we identified homologous genes related to polyploidization and speciation and constructed multiple sequence alignments with different reference ***,the event-related subgenomes in the basal genomes all showed genomic fractionation bias,suggesting a likely allopolyploid nature of the RCT,PST and T-Alpha and T-Beta events in Tetracentron *** addition,we detected that the sixteen P450 subfamilies were markedly expanded in the genomes of Ranunculales,and most of them were related to the RCT and PST *** constructed a new platform for Early Eudicot Comparative Genomic Research(http://***/***)to store more *** summary,our findings support the WGD of *** shared by Ranunculales,which is likely an allotetraploidization *** present effort offered new insights into the evolution of key polyploidization events and the genes related to second

关键词： Coptis chinensis Ranunculales Polyploidization Genomic fractionation P450 genes

A likely paleo-autotetraploidization event shaped the high conservation of Nyssaceae genome

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Horticultural Plant Journal 2024年第3期10卷 911-930页

作者： Yishan Feng Zhenyi Wang Qimeng Xiao Jia Teng Jianyu Wang zijian yu Jiaqi Wang Qiang Xu Yan Zhang Shaoqi Shen Shoutong Bao yu Li Zimo Yan yue Ding Zihan Liu yuxian Li Tianyu Lei Min yuan Xiu-Qing Li Jinpeng Wang Department of Bioinformatics School of Life SciencesNorth China University of Science and TechnologyTangshanHebei 063000China Fredericton Research and Development Centre Agriculture and Agri-Food CanadaFrederictonNew Brunswick E3B 4Z7Canada State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of ScienceBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China

Scientific knowledge about the ancestral genome of core eudicot plant kingdom can potentially have profound impacts on both basic and applied research,including evolution,genetics,genomics,ecology,agriculture,forestry,and global *** investigate which plant conserves best the core eudicots common ancestor genome,we compared Arcto-Tertiary relict Nyssaceae and 30 other eudicot plant *** genomes of Davidia involucrata(a known living fossil),Camptotheca acuminata and Nyssa sinensis,one per existent genus of Nyssaceae,were performed comparative genomic *** found that Nyssaceae originated from a single Nyssaceae common tetraploidization event(NCT)-autotetraploidization 28-31 Mya after the core eudicot common hexaploidization(ECH).We identified Nyssaceae orthologous and paralogous genes,determined its chromosomal evolutionary trajectory,and reconstructed the Nyssaceae most recent ancestor *** genome contained the entire seven paleochromosomes and 17 ECH-generated eudicot common ancestor chromosomes and was the slowest in mutation among the analyzed 42 species of 31 plant *** both its high retention of paleochromosomes and its low mutation rate,*** provides the best case in conservation of the core eudicot paleogenome.

关键词： Nyssaceae Polyploidization Multigenome alignment Evolutionary rate Autotetraploidization Karyotype evolution

Microstructure,Texture Evolution,and Strain Hardening Behaviour of As-extruded Mg-Zn and Mg-Y Alloys under Compression

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Journal of Wuhan University of Technology(Materials Science) 2023年第2期38卷 430-439页

作者： HAN Xiuzhu XIAO Tao yu zijian Beijing Institute of Spacecraft System Engineering Beijing100094China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing100124China

Microstructure,texture evolution and strain hardening behaviour of the Mg-1Y and Mg-1Zn(wt%)alloys were investigated under room temperature *** characterization was performed by optical microscopy,scanning electron microscopy,electron back scattered diffraction and transmission electron *** experimental results show that Mg-1Zn alloy exhibits conventional three-stage strain hardening curves,while Mg-1Y alloy exhibits novel six-stage strain hardening *** Mg-1Y alloy,rare earth texture leads to weak tensile twinning activity in compression and consequently results in a moderate evolution to***,inefficient tensile twinning activity and weak slip-twinning interaction give rise to excellent ductility and high hardening capacity but low strain hardening *** Mg-1Zn alloy,basal texture leads to pronounced tensile twinning activity in compression and consequently results in rapid evolution to*** intense tensile twinning activity and strong slip-twinning interaction lead to high strain hardening rate but poor ductility and low hardening capacity.

关键词： magnesium alloy texture rare earth twinning strain hardening behavior

Improving the Mechanical Properties of Mg–Gd–Y–Ag–Zr Alloy via Pre‑Strain and Two‑Stage Ageing

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Acta Metallurgica Sinica(English Letters) 2023年第3期36卷 456-468页

作者： Baotian Du zijian yu Kang Shi Ke Liu Shubo Li Wenbo Du Faculty of Materials and Manufacturing Beijing University of Technology100 PingleyuanChaoyang DistrictBeijing 100124People’s Republic of China

In this study,we investigated the effects of single-stage ageing(SSA),two-stage ageing(TSA),2%pre-strain+single-stage ageing(P2%SSA)and 2%pre-strain-I-two-stage ageing(P2%TSA)on the mechanical properties of as-extruded Mg-8Gd-3Y-0.5Ag-0.5Zr alloy(E alloy).Compared with the SSA treatment,the TSA treatment increased the number density of/β'*** P2%SSA and P2%TSA treatments generated theγ'phase and chain-like precipitates in addition to the/β'*** contributions of these ageing treatments to the alloy strengthening can be ranked as P2%TSA>P2%SSA>TSA>SSA,because the increments in the tensile yield strength were estimated to be 199 MPa>148 MPa>144 MPa>110 ***ferent from the traditional strengthening of/β'phase in the E+SSA and E+TSA alloys,the composite precipitates comprising the/β'phase,γ'phase and chain-like precipitates in the E+P2%SSA and E+P2%TSA alloys provided better combined strengthening ***/β'phase was still dominated in the strengthening effect of the composite *** to the higher number density of/β'phase in the composite precipitates,the E+P2%TSA alloy exhibited the better mechanical performance as compared with the E+P2%SSA ***,the E+P2%TSA alloy had the ultimate tensile strength of 452 MPa,the tensile yield strength of 401 MPa and elongation to failure of 3.3%.

关键词： Magnesium alloys Rare earth Age hardening Pre-strain Mechanical properties

Precipitate Characteristics and Mechanical Performance of Cast Mg–6RE–1Zn–xCa–0.3Zr(x=0 and 0.4 wt%) Alloys

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Acta Metallurgica Sinica(English Letters) 2022年第4期35卷 596-608页

作者： zijian yu Xi Xu Baotian Du Kang Shi Ke Liu Shubo Li Xiuzhu Han Tao Xiao Wenbo Du College of Materials Science and Engineering Beijing University of TechnologyBeijing 100124China Beijing Institute of Spacecraft System Engineering Beijing 100094China

In this study,the Mg–4Y–1Gd–1Nd–xCa–1Zn–0.3Zr(x=0 and 0.4 wt%)cast alloys with low rare earth concentration were prepared in different routes of heat treatments,and their microstructures and mechanical properties were *** Mg–4Y–1Gd–1Nd–1Zn–0.4Ca–0.3Zr cast alloy with ultimate tensile strength(UTS)of 264±7.8 MPa,tensile yield strength(TYS)of 153±1.2 MPa and elongation to failure(EL)of 17.2±1.2% was successfully developed by appropriate heat *** improved mechanical performance was attributed to the combined strengthening effects of fine grains,Mg24RE5,β′,β_(1),γ′and LPSO *** the heat treatment process,cooling method of T4 treatment affected the microstructure,which consequently determined the mechanical properties air cooling,rather than water cooling,gave rise to the formation of γ′phase in the alloy without Ca ***,Ca addition facilitated the formation of γ′phase,and the γ′phase precipitated in the alloy after T4 treatment either by water cooling or by air cooling,but the air cooling increased the number density of γ′phase in comparison to the water *** the γ′phase strengthened the studied alloys,the formation of γ′phase inhibited the precipitatition of β′and β_(1) phases in the following T6 treatment,and consequently reduced the strengthening effect ofβ′andβ_(1) *** results showed that the mechanical performance of the studied alloys was largely determined by the precipitation of γ′phase,which was regulated by the Ca addition and the cooling method of T4 treatment.

关键词： Magnesium alloy Microstructure Mechanical properties Rare earth Heat treatment

Development and characteristics of a low rare-earth containing magnesium alloy with high strength-ductility synergy

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Journal of Magnesium and Alloys 2023年第5期11卷 1629-1642页

作者： zijian yu Xi Xu Kang Shi Baotian Du Xiuzhu Han Tao Xiao Shubo Li Ke Liu Wenbo Du Faculty of Materials and Manufacturing Beijing University of Technology100 PenLe YuanChaoyang DistrictBeijing 100124China Beijing Institute of Spacecraft System Engineering Beijing 100094China

In this study,we successfully developed a low RE containing Mg-3Y-2Gd-1Nd-0.5Zr(wt%)alloy with high strength-ductility synergy by combined processes of hot extrusion,hot rolling and *** alloy exhibits an excellent strength-ductility balance(UTS of 345±2.0 MPa,TYS of 301±5.0 MPa and EL of 9.2±1.9%),which is better than that of many Mg-RE wrought alloys with higher RE concentration and even comparable to that of 6061 Al wrought alloy.A long-range chain-like structure consisting ofβphase,βH phase,βM phase and zig-zag atomic columns is observed for the first time in the studied *** combined process of hot extrusion and hot rolling boosts the formation of deformed grains and low angle grain boundaries,and makes the deformed grains dominate in the alloy *** this circumstance,the following ageing generates a novel heterogeneous structure comprising the long-range chain-like structure with broad interparticle spacing and the spacious precipitate-free zones in the deformed grains,which plays a key role in the concurrent strengthening and toughening of the *** present study demonstrates that the deformed grains with long-range chain-like structures and precipitate-free zones is desirable microstructure for the low RE containing Mg alloys to achieve high strength-ductility synergy.

关键词： Magnesium alloy Microstructure Mechanical properties Rare earth

Epicatechin attenuates lead(Pb)-induced cognitive impairment in mice:regulation on Nrf2 signaling pathway,and interference on the interaction between Pb with albumin

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Food Science and Human Wellness 2024年第2期13卷 1065-1078页

作者： Dai Cheng Qianqian yu Kexin Zhu Dingdong Bu zijian Wu State Key Laboratory of Food Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China School of Biotechnology and Food Science Tianjin University of CommerceTianjin 300134China

Epicatechin(EC)was used in this study to antagonize the cognitive dysfunction caused by lead(Pb)exposure in ***-week-old male Kunming mice were treated with PbCl_(2)(20 mg/kg)and/or EC(50 mg/kg)by gavage administration for 4 *** water maze test showed that EC could improve memory dysfunction induced by *** antagonized Ca^(2+)overload,activated Nrf2 signaling pathway and reduced the accumulation of Pb in the brain and serum,which suggested that EC might alter Pb distribution in *** vitro,spectroscopic analysis,potentiometric titration and docking studies were applied to inquiry into the interaction between bovine serum albumin(BSA)and Pb^(2+)in presence or absence of *** was proved to chelate Pb^(2+)and reduced the interaction between BSA and Pb^(2+).In summary,EC might protect Pb-induced cognitive impairment by activating Nrf2 signaling pathway,and suppressing Pb accumulation via interference on the binding of Pb to albumin.

关键词： Lead Epicatechin Bovine serum albumin Interaction Oxidative stress

Corrosion mechanism of Mg alloys involving elongated long-period stacking ordered phase and intragranular lamellar structure

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Journal of Materials Science & Technology 2023年第20期151卷 190-203页

作者： Jinshu Xie Jinghuai Zhang Zhi Zhang zijian yu Zhihao Xu Ru Wang Daqing Fang Xiaobo Zhang Xiaoru Zhang Ruizhi Wu Key Laboratory of Superlight Material and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing Institute of TechnologyNanjing 211167China

It is a long-term challenge to further improve the corrosion resistance while ensuring the strength of magnesium(Mg)*** the effect of potential fluctuation on the micro-galvanic corrosion and the subsequent film formation is important for understanding the corrosion mechanism of Mg alloys with multiple strengthening phases/***,we prepared the high-strength Mg-14.4Er-1.44Zn-0.3Zr(wt.%)alloys containing hybrid structures,i.e.,elongated long-period stacking ordered(LPSO)blocks+intragranular stacking faults(SFs)/LPSO *** Mg alloy with elongated LPSO blocks and intragranular LPSO lamellae(EZ-500 alloy)obtains good corrosion resistance(2.2 mm y^(–1)),while the Mg alloy containing elongated LPSO blocks and intragranular SFs(EZ-400 alloy)shows a significantly higher corrosion rate(6.9 mm y^(–1)).The results of scanning Kelvin probe force microscopy(SKPFM)show the elongated LPSO blocks act as cathode phase(87 mV in EZ-400 alloy),and the SFs serve as the weak anode(30 mV in EZ-400 alloy),resulting in high potential fluctuation in EZ-400 *** the contrary,both elongated blocks and intragranular lamellae are cathodic LPSO phase(67–69 mV)in EZ-500 alloy,leading to a lower potential *** in-situ atomic force microscope(AFM)observation indicates that high potential fluctuation would cause strong micro-galvanic corrosion,and subsequently leads to the failure in rapid formation of corrosion film,finally forming a loose and porous film,while relatively low potential fluctuation could result in more uniform corrosion mode and facilitate the rapid formation of protective ***,we propose that it is an effective way to develop high-strength corrosionresistant Mg alloys by controlling the potential fluctuation to form a“uniform potential”strengthening microstructure。

关键词： Mg alloys Stacking faults LPSO phase SKPFM Quasi in-situ AFM Corrosion behavior Potential fluctuation

Nanoscale Precise Editing of Multiple Immune Stimulating Ligands on DNA Origami for T Cell Activation and Cell-Based Cancer Immunotherapy

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CCS Chemistry 2024年第3期6卷 719-732页

作者： Lele Sun Fengyun Shen zijian Xiong yu Chao Chunhai Fan Zhuang Liu Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Lab Carbon Based Functional Materials and DevicesSoochow UniversitySuzhou 215123Jiangsu School of Life Sciences Shanghai UniversityShanghai 200444 School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 201240

The spatial arrangement of activating ligands is known to have great influence on T cell ***,independently studying each ligand’s spatial organization parameter that affects T cell activation remains a great ***,with DNA origami,we precisely organized the CD3ɛantibodies simulating T cell receptor(TCR)ligands and CD28 antibodies simulating co-stimulatory ligands to interrogate the independent role of TCR-ligand spacing and local copy numbers as well as the spacing between TCR ligands and co-stimulatory ligands on T cell *** found that T cell activation benefited fromlocally concentrated TCR ligands with a shorter spacing and was maximized by an∼38 nm spacing between TCR ligands and co-stimulatory *** T cell expander constructed based on our findings could efficiently expand CD8+T cells for tumor ***,the DNA nanostructurebased ligands’precise arrangement can be a unique tool in studying immune cell activations and cellbased immunotherapies.

关键词： DNA origami T cell activation T cell receptor immune cancer immunotherapy