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Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy

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Chinese Chemical Letters 2024年第4期35卷 420-425页

作者： Hao Cai Xiaoyan Wu Lei Jiang Feng Yu Yuxiang Yang Yan li Xian Zhang Jian liu zijian li Hong Bi School of Materials Science and Engineering Anhui UniversityHefei 230601China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China

The reactive oxygen species(ROS) generation efficiency is always limited by the extreme tumor microenvironment(TME), leading to unsatisfactory antitumor effects in photodynamic therapy(PDT). As a promising gas therapy molecule, nitric oxide(NO) is independent of oxygen and could even synergize ROS to enhance the therapeutic effect. However, the short half-life, instability, and uncontrollable release of exogenous NO limited the application of tumor synergistic therapy. Herein, we reported a novel kind of red-emissive carbon dots(CDs) that was capable of lysosome-targeted and light-controlled NO delivery. The CDs were synthesized by using metformin and methylene blue(MB) via a hydrothermal *** obtained metformin-MB CDs(MMCDs) exhibited a higher1O2quantum yield and NO generation efficiency under light emitting diode(LED) light irradiation. Noteworthily, the1O2could further in situ oxidize NO into peroxynitrite anions(ONOO-), which own the higher cytotoxicity against cancer *** experiments indicate that MMCDs could destruct lysosome membrane integrity and kill almost 80%of Hep G2 cells under light irradiation while very low cytotoxicity in the dark. Moreover, MMCDs significantly decreased tumor volume and weight after phototherapy in hepatoma Hep G2-bearing mice. Our study provides a new strategy for light-controlled NO generation as well as precise lysosome-targeting for enhancement of PDT efficiency.

关键词： Carbon dots Nitric oxide Lysosome-targeting Photodynamic therapy Cancer

Tuning electronic structure of RuO_(2)by single atom Zn and oxygen vacancies to boost oxygen evolution reaction in acidic medium

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Journal of Energy Chemistry 2024年第1期88卷 94-102,I0003页

作者： Qing Qin Tiantian Wang zijian li Guolin Zhang Haeseong Jang liqiang Hou Yu Wang Min Gyu Kim Shangguo liu Xien liu College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042ShandongChina Department of Chemistry City University of Hong KongHong Kong 999077China Department of Advanced Materials Engineering Chung-Ang UniversityAnseong-siGyeonggi-do 17546SeoulRepublic of Korea Beamline Research Division Pohang Accelerator Laboratory(PAL)Pohang 37673Gyeongsangbuk-doRepublic of Korea

The poor stability of RuO_(2)electrocatalysts has been the primary obstacles for their practical application in polymer electrolyte membrane *** dramatically enhance the durability of RuO_(2)to construct activity-stability trade-off model is full of significance but ***,a single atom Zn stabilized RuO_(2)with enriched oxygen vacancies(SA Zn-RuO_(2))is developed as a promising alternative to iridium oxide for acidic oxygen evolution reaction(OER).Compared with commercial RuO_(2),the enhanced Ru–O bond strength of SA Zn-RuO_(2)by forming Zn-O-Ru local structure motif is favorable to stabilize surface Ru,while the electrons transferred from Zn single atoms to adjacent Ru atoms protects the Ru active sites from ***,the optimized surrounding electronic structure of Ru sites in SA ZnRuO_(2)decreases the adsorption energies of OER intermediates to reduce the reaction *** a result,the representative SA Zn-RuO_(2)exhibits a low overpotential of 210 mV to achieve 10 mA cm^(-2)and a greatly enhanced durability than commercial RuO_(2).This work provides a promising dual-engineering strategy by coupling single atom doping and vacancy for the tradeoff of high activity and catalytic stability toward acidic OER.

关键词： Electrocatalyst Acidic oxygen evolution reaction Electronic structure engineering Durability Reaction barrier

WirelessLLM:Empowering Large Language Models Towards Wireless Intelligence

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Journal of Communications and Information Networks 2024年第2期9卷 99-112页

作者： Jiawei Shao Jingwen Tong Qiong Wu Wei Guo zijian li Zehong lin Jun Zhang Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China

The rapid evolution of wireless technologies and the growing complexity of network infrastructures necessitate a paradigm shift in how communication networks are designed,configured,and managed. Recent advancements in large language models (LLMs) have sparked interest in their potential to revolutionize wireless communication systems. However, existing studies on LLMs for wireless systems are limited to a direct application for telecom language understanding. To empower LLMs with knowledge and expertise in the wireless domain, this paper proposes WirelessLLM, a comprehensive framework for adapting and enhancing LLMs to address the unique challenges and requirements of wireless communication networks. We first identify three foundational principles that underpin WirelessLLM:knowledge alignment, knowledge fusion, and knowledge evolution. Then,we investigate the enabling technologies to build WirelessLLM, including prompt engineering, retrieval augmented generation, tool usage, multi-modal pre-training, and domain-specific fine-tuning. Moreover, we present three case studies to demonstrate the practical applicability and benefits of WirelessLLM for solving typical problems in wireless networks. Finally, we conclude this paper by highlighting key challenges and outlining potential avenues for future research.

关键词： large language models multi-modal models wireless communications power allocation spectrum sensing protocol understanding

Electron-deficient ZnO induced by heterointerface engineering as the dominant active component to boost CO_(2)-to-formate conversion

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Carbon Energy 2024年第5期6卷 127-136页

作者： Qing Qin zijian li Yingzheng Zhang Haeseong Jang li Zhai liqiang Hou Xiaoqian Wei Zhe Wang Min Gyu Kim Shangguo liu Xien liu College of Chemical Engineering Qingdao University of Science and TechnologyQingdaoChina Department of Chemistry City University of Hong KongHong Kong SARChina Department of Advanced Materials Engineering Chung-Ang UniversityAnseong-siGyeonggi-doRepublic of Korea Beamline Research Division Pohang Accelerator Laboratory(PAL)PohangRepublic of Korea

Electrocatalytic CO_(2)-to-formate conversion is considered an economically viable *** general,Zn-based nanomaterials are well-known to be highly efficient electrocatalysts for the conversion of CO_(2) to CO,but seldom do they exhibit excellent selectivity toward *** this article,we demonstrate that a heterointerface catalyst ZnO/ZnSnO3 with nanosheet morphology shows enhanced selectivity with a maximum Faradaic efficiency(FE)of 86%at−0.9 V versus reversible hydrogen electrode and larger current density for the conversion of CO_(2) to formate than pristine ZnO and *** particular,the FEs of the C1 products(CO+HCOO−)exceed 98%over the potential *** experimental measurements combined with theoretical calculations revealed that the ZnO in ZnO/ZnSnO3 heterojunction delivers the valence electron depletion and accordingly optimizes Zn d-band center,which results in moderate Zn-O hybridization of HCOO*and weakened Zn-C hybridization of competing COOH*,thus greatly boosting the HCOOH *** study highlights the importance of charge redistribution in catalysts on the selectivity of electrochemical CO_(2) reduction.

关键词： charge redistribution CO_(2)reduction reaction electrocatalyst heterointerfaces selectivity

COVID-19患者使用G-CSF的安全性

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中国临床药理学与治疗学 2024年第3期29卷 334-338页

作者：刘恒李子坚兰州大学第一临床医学院甘肃兰州730000 兰州大学第一医院血液科甘肃兰州730000

2019新冠病毒病(COVID-19)被定义为由SARS-CoV-2感染引起的疾病,短时间内就造成了全球大流行,其关键免疫病理特征包括淋巴细胞减少、中性粒细胞增多以及细胞因子风暴和肺等实质器官的免疫损伤等。COVID-19的临床表现因人而异,但最常见... 详细信息

2019新冠病毒病(COVID-19)被定义为由SARS-CoV-2感染引起的疾病,短时间内就造成了全球大流行,其关键免疫病理特征包括淋巴细胞减少、中性粒细胞增多以及细胞因子风暴和肺等实质器官的免疫损伤等。COVID-19的临床表现因人而异,但最常见、最严重的症状一般是呼吸系统疾病相关的表现,肺是病毒的主要靶器官。COVID-19的一个显著特征是促炎细胞因子(包括GCSF)升高,而G-CSF可能会引发过度炎症反应,也许会使部分患者病情加重,故COVID-19是否要应用G-CSF治疗,目前颇有争议,还需要临床医生根据每个病人的具体情况评估使用G-CSF的有效性和安全性。

关键词： 2019新冠病毒病急性呼吸综合征冠状病毒2 粒细胞集落刺激因子获益风险

数字时代GPT技术对中国舞蹈教育的影响探析

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艺术科技 2024年第9期37卷 229-231,246页

作者：李紫键莫斯科国立文化学院俄罗斯莫斯科141406

目的:文章旨在探讨人工智能技术的重要突破——GPT系统(Generative Pre-trained Transformer)对中国舞蹈教育领域产生的影响,分析GPT系统在中国舞蹈教育中的潜在作用,探讨其如何改进教学方法,优化学生的学习体验,并促进中国舞蹈传统的... 详细信息

目的:文章旨在探讨人工智能技术的重要突破——GPT系统(Generative Pre-trained Transformer)对中国舞蹈教育领域产生的影响,分析GPT系统在中国舞蹈教育中的潜在作用,探讨其如何改进教学方法,优化学生的学习体验,并促进中国舞蹈传统的传承。同时揭示GPT技术应用于舞蹈教育中面临的挑战和问题。方法:文章采用文献综述、案例分析等方法。首先对GPT系统的基本原理和应用领域进行详细的文献综述,以理解其功能和潜力。然后通过案例分析,深入探讨GPT系统在中国舞蹈教育中的实际应用,重点关注个性化教学、创意激发和舞蹈传承等方面。结果:研究表明,GPT系统在中国舞蹈教育中具有巨大的应用潜力。采取个性化教学手段,GPT可以根据学生的需求和水平提供个性化的学习材料,从而提高学习效率。此外,GPT的创意生成功能可以激发学生的创造力和想象力,促进他们在舞蹈领域的创新。同时,GPT还可以用于记录和传承中国传统舞蹈,以促进这一珍贵文化遗产的传承和弘扬。结论:GPT系统对中国舞蹈教育领域具有重要的影响。然而,也必须谨慎应对技术应用中的挑战,如平衡人机关系和隐私保护。最终,在中国舞蹈教育中高效应用GPT技术需要技术与教育者的紧密合作,以确保学生能够充分受益于这一创新,同时保护他们的权益和隐私。通过深入挖掘GPT系统的潜力,中国舞蹈教育将迎来更繁荣的未来,同时促进中国传统舞蹈的保护与传承。

关键词： GPT系统中国舞蹈教育个性化教学数字时代技术应用挑战

酿酒酵母对浓香型白酒酒醅微生物群落结构及功能的影响

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中国食品学报 2024年第2期24卷 71-82页

作者：马世源李子健罗惠波孙跃鹏李津黄丹四川轻化工大学生物工程学院四川自贡643000 酿酒生物技术及应用四川省重点实验室四川自贡643000 宜宾今良造制酒有限公司四川宜宾644000

通过分析酿酒酵母对浓香型白酒酒醅微生物组成及挥发性代谢物的影响,探究其对酒醅微生物生态网络、挥发性代谢物以及微生物群落代谢功能的作用。将1株分离自浓香型白酒酒醅的酿酒酵母(Y1)扰动酒醅固态发酵过程,采用高通量测序技术和顶... 详细信息

通过分析酿酒酵母对浓香型白酒酒醅微生物组成及挥发性代谢物的影响,探究其对酒醅微生物生态网络、挥发性代谢物以及微生物群落代谢功能的作用。将1株分离自浓香型白酒酒醅的酿酒酵母(Y1)扰动酒醅固态发酵过程,采用高通量测序技术和顶空固相微萃取质谱联用技术分析微生物群落构成和挥发性代谢物组成,利用随机森林学习算法计算能够表征试验组与空白组间差异的生物标志物,基于共现性网络模型分析试验组与空白组的微生物生态网络差异,采用PLS-DA和斯皮尔曼相关性分别分析其挥发性风味物质差异、差异代谢物与生物标志物的相关性,最后通过PICRUST2功能预测以及通路富集分析微生物群落潜在功能的改变。结果表明,5种细菌和15种真菌可以作为表征酿酒酵母扰动酒醅中微生物组成的生物标志物,并且提高了微生物生态网络的复杂性;挥发性代谢物的组成发生了改变,共有18种差异代谢物,部分挥发性代谢物的含量得到提高,绝大多数生物标志物与差异代谢呈显著相关。此外,酿酒酵母的扰动效应导致微生物群落出现180个上调基因,46个下调基因,这些基因大多数与物质的代谢有关。这些结果为酿酒酵母在白酒发酵中的应用及优化酒醅发酵过程提供了试验依据。

关键词：酒醅酿酒酵母共现性网络生物扰动挥发性代谢物功能预测

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弹−塑性基础边界两侧采空(留煤柱)基本顶板结构初次破断特征

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煤炭学报 2024年第5期49卷 2195-2211页

作者：陈冬冬李子健谢生荣何富连罗昱蒋再胜马翔李辉中国矿业大学(北京)能源与矿业学院北京100083

为了研究两侧采空留煤柱工程条件下基本顶板结构的断裂位态及工程指导意义,构建考虑实体煤弹塑性变形与两侧煤柱宽度及支撑能力弱化的基本顶板结构双塑化基础边界力学模型,基于有限差分算法与主弯矩破断准则系统计算了在非对称煤柱区和... 详细信息

为了研究两侧采空留煤柱工程条件下基本顶板结构的断裂位态及工程指导意义,构建考虑实体煤弹塑性变形与两侧煤柱宽度及支撑能力弱化的基本顶板结构双塑化基础边界力学模型,基于有限差分算法与主弯矩破断准则系统计算了在非对称煤柱区和长边实体煤区的断裂线形态、区位属性及整体位态特征,并从7个层面、横纵向4对区域与传统模型对比,阐明新模型所得新结论及工程意义。结论如下:(1)两侧非对称煤柱参数对长边实体煤区域的基本顶主弯矩及破断位置影响小,但分别显著影响煤柱区的主弯矩大小、位置及断裂形态。两侧煤柱区(较强/宽煤柱区+较弱/窄煤柱区)基本顶断裂线形态有3类演化模式,随基本顶厚度及弹模增大而煤柱宽度、支撑能力及悬顶跨度减小,其变化规律为:非对称的“连续单弧形+连续单弧形”→“连续单弧形+开口间断双短弧形”→非对称的“开口间断双短弧形+开口间断双短弧形”。(2)长边实体煤区基本顶的断裂线主要有3类区位属性,随基本顶厚度及弹模增大而实体煤的塑性区宽度、塑化程度及悬顶跨度减小,其演变规律为:断裂线在塑性煤体区(C-S式)→弹塑性煤体分界区(C-TS式)→弹性煤体区(C-T式);(3)考虑断裂线区位属性,随基本顶厚度和弹模增大而煤柱宽度、支撑能力及悬顶跨度减小的基本顶全区域破断模式及演变规律为:C-S式的■→C-TS式的■→C-T式的■→C-T式的■→C-T式的■。针对研究两侧采空(煤柱)基本顶板结构破断的3类力学模型,从7个层面对比了3类模型的重要区别,从横向4个区域(开采区域的前方与后方、两侧煤柱区)与纵向4个区域(非对称遗留煤柱下伏、下伏开采空间出/进煤柱/体)阐明了其重要工程作用。

关键词：遗留煤柱基本顶两侧采空弹−塑性基础板结构

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基于液电效应的高强电爆震致裂页岩试验研究

中国矿业大学学报 2024年第4期53卷 623-633页

作者：聂百胜马正韬柳先锋包松李雄飞何溪融张喆浩李孜健重庆大学煤矿灾害动力学与控制全国重点实验室重庆400044 北京理工大学爆炸科学与安全防护全国重点实验室北京100081 中国矿业大学(北京)应急管理与安全工程学院北京100083 北京航空航天大学可靠性与系统工程学院北京100191

为研究基于液电效应的高强电爆震致裂页岩规律及页岩气储层改造可行性,选取中国四川盆地长宁地区的黑色页岩为试验样品,利用团队自主研制的多地形可移动高强电爆震致裂岩体试验系统,预设放电参数为电压10~14 kV,电容500μF,辅以示波系... 详细信息

为研究基于液电效应的高强电爆震致裂页岩规律及页岩气储层改造可行性,选取中国四川盆地长宁地区的黑色页岩为试验样品,利用团队自主研制的多地形可移动高强电爆震致裂岩体试验系统,预设放电参数为电压10~14 kV,电容500μF,辅以示波系统、应变测试系统和基恩士VHX-6000数码显微系统,分析了高强电爆震致裂页岩试样的电压电流及应变变化特征,阐明了不同放电参量下电爆震作用前后表面裂隙形貌及断面特征,初步揭示了电爆震致裂页岩机制.结果表明:高强电爆震可明显致裂页岩,峰值电流、压-拉应变最大峰峰值、应变第一高峰值、应变第二高峰值均与放电电压呈正相关;高强电爆震致裂后的试件表面裂隙主要包括贯穿裂隙、放射状裂隙和正交裂隙,在14 kV时出现不同裂隙之间沟通的现象,表面裂隙均呈现良好分形特征;高强电爆震作用试件后,作用面、断面的不平整度较大,表面有较多岩石碎屑;高强电爆震作用下页岩破坏主要形式为鳞片状、波浪状、台阶状等张拉破坏.该试验研究可为基于液电效应的高强电爆震技术应用于页岩气储层改造可行性论证提供支撑.

关键词：页岩致裂液电效应高强电爆震表面裂隙电压电流表面应变