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Harnessing decellularised extracellular matrix microgels into modular bioinks for extrusion-based bioprinting with good printability and high post-printing cell viability

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Biomaterials Translational 2023年第2期4卷 115-127页

作者： Hanyu Chu Kexin Zhang Zilong rao Panpan Song Zudong Lin Jing Zhou Liqun Yang Daping Quan Ying Bai Key laboratory for Polymeric Composite&Functional Materials of Ministry of Education School of ChemistrySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Engineering Technology Research Centre for Functional Biomaterials Key Laboratory for Polymeric Composite&Functional Materials of Ministry of EducationSchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

The printability of bioink and post-printing cell viability is crucial for extrusion-based bioprinting.A proper bioink not only provides mechanical support for structural fidelity,but also serves as suitable three-dimensional(3D)microenvironment for cell encapsulation and *** this study,a hydrogel-based composite bioink was developed consisting of gelatin methacryloyl(GelMA)as the continuous phase and decellularised extracellular matrix microgels(DMs)as the discrete phase.A flow-focusing microfluidic system was employed for the fabrication of cell-laden DMs in a high-throughput *** gentle mixing of the DMs and GelMA,both rheological characterisations and 3D printing tests showed that the resulting DM-GelMA hydrogel preserved the shear-thinning nature,mechanical properties,and good printability from *** integration of DMs not only provided an extracellular matrix-like microenvironment for cell encapsulation,but also considerable shear-resistance for high post-printing cell *** DM sizes and inner diameters of the 3D printer needles were correlated and optimised for nozzle-based ***,a proof-of-concept bioink composedg of RSC96 Schwann cells encapsulated DMs and human umbilical vein endothelial cell-laden GelMA was successfully bioprinted into 3D constructs,resulting in a modular co-culture system with distinct cells/materials ***,the modular DM-GelMA bioink provides a springboard for future precision biofabrication and will serve in numerous biomedical applications such as tissue engineering and drug screening.

关键词： 3D bioprinting bioinks cell viability decellularised extracellular matrix microgels

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Novel insights into cryo-EM structure of African Swine Fever Virus

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science Foundation in china 2020年第2期28卷 79-84页

作者：王男赵东明王佳灵张杨玲步志高饶子和王祥喜 CAS Key laboratory of Infection and Immunity CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China State Key laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150000China Shanghai institute for Advanced Immunochemical Studies and School of Life science and Technology ShanghaiTech UniversityShanghai 201210China university of chinese academy of sciences Beijing 100049China laboratory of structural biology School of MedicineTsinghua UniversityBeijing 100084China State Key laboratory of Medicinal Chemical biology Nankai UniversityTianjin 300353China

African swine fever virus(ASFV)is a giant and complex DNA virus that causes a highly contagious and lethal swine disease for which there is no vaccine *** we describe the cryo—electron microscopy(cryo-EM)structure of ASFV,the first virus(to our knowledge)that has been found to use two lipid membrane layers and two protein shells to encapsidate and protect its *** an optimized image reconstruction strategy,we solved the AFSV capsid structure up to 4.1-angstroms,which is built from 17,280 proteins,including one major(MCP)and four minor capsid proteins(M1249 L,p17,p49 and H240 R),and organized into pentasymmetrons and *** atomic structure of the MCP informs putative conformational epitopes,which determine the specific differences between the virus types,being valuable for epitope-focused immunogen design against ASFV *** minor capsid proteins form a complicated network below the outer capsid shell,stabilizing the capsid by holding adjacent capsomers *** as core organizers,100-nm-length M1249 L proteins,running along each edge of the trisymmetrons and bridging two neighboring pentasymmtrons,form extensive intermolecular networks with other capsid proteins to guide the formation of capsid *** structural details unveil the basis of capsid stability and assembly,opening up new avenues for ASF vaccine development.

关键词： swine Swine structure

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Homology Modeling,Molecular Docking,and Molecular Dynamic Simulation of the Binding Mode of PA-1 and Botrytis cinerea PDHc-E1

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chinese Journal of structural Chemistry 2022年第3期41卷 227-234,I0013页

作者：饶缔贺军波冯江涛张维农蔡萌贺红武 Key laboratory for Deep Processing of Major Grain and Oil Ministry of EducationCollege of Food Science&EngineeringWuhan Polytechnic UniversityWuhan 430023China Key laboratory of Pesticide&Chemical biology Ministry of EducationDepartment of ChemistryCentral China Normal UniversityWuhan 430079China

To reveal the potential fungicidal mechanism of 5-((4-((4-chlorophenoxy)methyl)-5-iodo-1H-1,2,3-triazole-1-yl)methyl)-2-methylpyrimidin-4-amine(PA-1)against Botrytis cinerea(***),the three-dimensional structure of *** pyruvate dehydrogenase complex E1 component(PDHc-E1)is homology modeled,as the PA-1 shows potent *** PDHc-E1 and *** *** molecular docking indicates the PA-1 can tightly bind to *** *** dynamic simulation and MM-PBSA calculation both demonstrate that two in-termolecular interactions,π-πstacking and hydrophobic forces,provide the most contributions to the binding of PA-1 and *** ***,the halogen bonding interaction between the iodine atom in PA-1 and OH in Ser181 is also *** present study provides a valuable attempt to homology model the structure of *** PDHc-E1 and some key factors for the rational structure optimization of PA-1.

关键词： 5-iodo-1,2,3-triazole Botrytis cinerea PDHc-E1 inhibitor homology modeling molecular dynam-ic simulation

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Ti2CTx MXene-based all-optical modulator

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InfoMat 2020年第3期2卷 601-609页

作者： Jun Yi Jie Li Shuohan Huang Longyu Hu Lili Miao Chujun Zhao Shuangchun Wen Vadym N.Mochalin Apparao M.rao Key laboratory for Micro/Nano Optoelectronic Devices of Ministry of Education and Hunan Provincial Key laboratory of Low-Dimensional structural Physics and Devices School of Physics and ElectronicsHunan UniversityChangshaChina Department of Physics and Astronomy Clemson Nanomaterials InstituteClemson UniversityClemsonSouth Carolina Department of Chemistry Missouri University of Science and TechnologyRollaMissouri Department of Materials science and Engineering Missouri University of Science and TechnologyRollaMissouri

MXenes,a new class of 2D transition metal carbides,nitrides,and carbonitrides,have attracted much attention due to their outstanding ***,we report the broadband spatial self-phase modulation of Ti2CTx MXene nanosheets dispersed in deionized water in the visible to near-infrared regime,highlighting the broadband nonlinear optical(NLO)response of Ti2CTx *** ultrafast pulsed laser excitation,the nonlinear refractive index n2 and the thirdorder nonlinear susceptibility χ^(3)monolayer of Ti2CTx MXene were measured to be^10^−13 m^2/W and ~10^−10 esu,*** the large optical nonlinearity of Ti2CTx MXene,an all-optical modulator in the visible regime was fabricated based on the spatial cross-phase modulation *** work suggests that 2D MXenes are ideal broadband NLO materials with excellent prospects in NLO applications.

关键词： 2D materials all-optical modulator MXene spatial cross-phase modulation spatial self-phase modulation

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淀粉多层级结构的分离、表征及应用研究进展

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食品工业科技 2023年第19期44卷 481-490页

作者：杨璇李钦饶雷赵靓王永涛廖小军中国农业大学食品科学与营养工程学院国家果蔬加工工程技术研究中心农业农村部果蔬加工重点实验室食品非热加工北京市重点实验室北京100083

淀粉是人类饮食的主要组成部分,具有淀粉颗粒、淀粉外壳、淀粉小体、直链淀粉和支链淀粉等丰富的多层级结构,可作为食品加工中多种理想的原料,因此涉及到各个层级结构的分离,而为了能够在合适范围内应用,还需要通过不同表征方法对多层... 详细信息

淀粉是人类饮食的主要组成部分,具有淀粉颗粒、淀粉外壳、淀粉小体、直链淀粉和支链淀粉等丰富的多层级结构,可作为食品加工中多种理想的原料,因此涉及到各个层级结构的分离,而为了能够在合适范围内应用,还需要通过不同表征方法对多层级结构的结构特性进行准确表征。因此,本文对淀粉各层级结构的分离方法和结构表征进行了分析,并介绍了淀粉多层级结构不同的应用范围,以期为淀粉资源的开发和利用提供一定参考。

关键词：淀粉多层级结构分离表征应用

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Accelerating water dissociation kinetics of Ni3N by tuning interfacial orbital coupling

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Nano Research 2021年第10期14卷 3458-3465页

作者： Yishang Wu Yufang Xie Shuwen Niu Yipeng Zang Jinyan Cai Zenan Bian Xuanwei Yin Yanyan Fang Da Sun Di Niu Zheng Lu Amirabbas Mosallanezhad Huijuan Wang Dewei rao Hongge Pan Gongming Wang Hefei national laboratory for Physical science at the Microscale Department of ChemistryUniversity of Science and Technology of ChinaHefei 230026China Experimental Center of Engineering and Material science University of Science and Technology of ChinaHefei 230026China School of Materials science and Engineering Jiangsu UniversityZhenjiang 212013China institute of science and Technology for New Energy Xi’an Technological UniversityXi’an 710021China School of Materials science and Engineering State Key Laboratory of Silicon MaterialsZhejiang UniversityHangzhou 310027China

The high unoccupied d band energy of Ni_(3)N basically results in weak orbital coupling with water molecule,consequently leading to slow water dissociation ***,we demonstrate Cr doping can downshift the unoccupied d orbitals and strengthen the interfacial orbital coupling to boost the water dissociation *** prepared Cr-Ni_(3)N/Ni displays an impressive overpotential of 37 mV at 10 mA·cmgeo-2,close to the benchmark Pt/C in 1.0 M KOH *** structural analysis reveals the Cr dopant exists as the Cr-N_(6)states and the average d band energy of Ni_(3)N is also *** functional theory calculation further confirms the downshifted d band energy can strengthen the orbital coupling between the unpaired electrons in O 2p and the unoccupied state of Ni 3d,which thus facilitates the water adsorption and *** work provides a new concept to achieve on-demand functions for hydrogen evolution catalysis and beyond,by regulating the interfacial orbital coupling.

关键词： unoccupied d orbitals Ni_(3)N Cr-N_(6)doping interfacial orbital coupling hydrogen evolution reaction

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Correction: PROTAC mediated FKBP12 degradation enhances Hepcidin expression via BMP signaling without immunosuppression activity

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2623-2623页

作者： Tianbai Zhong Xiuyun Sun Li Yu Yongbo Liu Xin Lin Yu rao Wei Wu MOE Key laboratory of Protein sciences Beijing Advanced Innovation Center for Structural Biology School of Life Sciences Tsinghua University 100084 Beijing China MOE Key laboratory of Protein sciences School of Pharmaceutical Sciences MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology Tsinghua University 100084 Beijing China institute for Immunology and School of Medicine Tsinghua University 100084 Beijing China

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Al-Cu-Li合金在盐溶液中的腐蚀行为以及腐蚀机理研究进展

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稀有金属材料与工程 2023年第12期52卷 4099-4116页

作者：张鹏包磊饶思贤吴进军李永兵熊成悦孙朝阳安徽工业大学机械工程学院安徽马鞍山243032 中国机械科学研究总院集团有限公司北京100044 北京机科国创轻量化科学研究院有限公司先进成形技术与装备国家重点实验室北京100083 北京科技大学机械工程学院北京100083

Al-Cu-Li合金是航天航空工业中重要的轻质结构材料,已成为国产大飞机结构件的关键材料之一。飞行器在海洋等潮湿环境服役时,易受到具有腐蚀性的卤化物阴离子的侵蚀,尤其是在Cl离子侵蚀作用下,Al-Cu-Li合金构件表面易出现点蚀、晶间腐蚀... 详细信息

Al-Cu-Li合金是航天航空工业中重要的轻质结构材料,已成为国产大飞机结构件的关键材料之一。飞行器在海洋等潮湿环境服役时,易受到具有腐蚀性的卤化物阴离子的侵蚀,尤其是在Cl离子侵蚀作用下,Al-Cu-Li合金构件表面易出现点蚀、晶间腐蚀和剥落腐蚀现象。Al-Cu-Li合金的局部腐蚀主要归因于合金相与合金基体间存在电势差,进而导致在腐蚀介质中形成微型腐蚀原电池。综述了Al-Cu-Li合金在NaCl溶液中的腐蚀行为以及热处理工艺对合金耐腐蚀性能的影响,重点分析了粗大第二相颗粒和时效析出相对Al-CuLi合金腐蚀性能的影响,研究了典型第3代Al-Cu-Li(2A97-T3、2A97-T6、2060-T8和2099-T83)合金以及航空用常规高强铝合金2024-T4在3种不同浓度NaCl溶液中的侵蚀行为以及在质量分数3.5%NaCl溶液中的电化学行为。综合分析各试样的微观腐蚀形貌、腐蚀电化学参数以及腐蚀程度,最终得出各试样的耐腐蚀性能由强至弱为:2A97-T3>2A97-T6>2024-T4>2060-T8>2099-T83。最后揭示了Al-Cu-Li合金在腐蚀介质中的腐蚀机理,总结了在海洋环境下铝合金的防腐措施。本文为后续Al-Cu-Li合金防腐性能的发展和飞机耐腐蚀性能的提升提供了参考。

关键词： Al-Cu-Li合金合金相局部腐蚀腐蚀机理腐蚀防护

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Orbital-regulated interfacial electronic coupling endows Ni3N with superior catalytic surface for hydrogen evolution reaction

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science china Chemistry 2020年第11期63卷 1563-1569页

作者： Yanyan Fang Da Sun Shuwen Niu Jinyan Cai Yipeng Zang Yishang Wu Linqin Zhu Yufang Xie Yun Liu Zixuan Zhu Amirabbas Mosallanezhad Di Niu Zheng Lu Junjie Shi Xiaojing Liu Dewei rao Gongming Wang Yitai Qian Hefei national laboratory for Physical science at the Microscale Department of ChemistryUniversity of Science&Technology of ChinaHefei 230026China School of Materials science and Engineering Jiangsu UniversityZhenjiang 212013China

The interstitial structure and weak Ni-N interaction of Ni3N lead to high unoccupied d orbital energy and unsuitable orbital orientation,which consequently results in weak orbital coupling with H2O and slow water dissociation kinetics for alkaline hydrogen evolution ***,we successfully lower the unoccupied d orbital energy of Ni3N to strengthen the interfacial electronic coupling by employing the strong electron pulling capability of oxygen *** prepared O-Ni3N catalyst delivers an overpotential of 55 mV at 10 mA cm−2,very close to the commercial Pt/*** structural characterization indicates the oxygen incorporation can decrease the electron densities around the Ni ***,density functional theory calculation further proves the oxygen incorporation can create more unoccupied orbitals with lower energy and superior orientation for water adsorption and *** concept of orbital-regulated interfacial electronic coupling could offer a unique approach for the rational design of hydrogen evolution catalysts and beyond.

关键词： hydrogen evolution reaction orbital regulation interfacial electronic coupling Ni3N electrocatalysts

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Density Functional Theory Study on the Complete Substitutions of Nd and Fe by Other Rare-earth and Transition-metal Elements in Nd_(2)Fe_(14)B Compound

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chinese Journal of structural Chemistry 2021年第1期40卷 136-144,5页

作者：饶霜林晨升何长振柴国良 College of Chemistry Fuzhou UniversityFuzhou 350108China State Key laboratory of structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences(CAS)Fuzhou 350002China

To search for proper alternatives to improve the magnetic properties of Nd_(2)Fe_(14)B,using first-principles density functional theory calculations we have systematically studied the R_(2)M_(14)B(R=lanthanides from La to Lu;M=Mn,Fe,Co,and Ni)compounds with the isomorphic structure of Nd_(2)Fe_(14)*** results show that for rare-earth elements,Pr is the most suitable choice for considering as an alternative of *** for the substitution of Fe in Nd_(2)Fe_(14) B by other transition-metal elements,Co is much more suitable than Mn and Ni because the latter two result in too significant reduction of the magnetic moment.

关键词： permanent magnet materials Nd_(2)Fe_(14)B density functional theory calculations

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