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Normobaric oxygen for cerebral ischemic injury

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Neural Regeneration Research 2013年第31期8卷 2885-2894页

作者： Chunhua chen Haimeng Cui zihe Li Ruifeng Wang Changman Zhou Department of Anatomy and Histoembryology Peking University Health Science Center

Oxygen inhalation has been shown to increase oxygen supply to tissues after cerebral ischemia/ reperfusion injury, protecting injured neural cells. However, hyperbaric oxygen may aggravate oxi- dative stress. By contrast, normobaric oxygen has the rapid and non-invasive characteristics and may have therapeutic effects on ischemic/hypoxic disease. Rats inhaled normobaric oxygen （95% 02） for 6 consecutive days, and then a rat model of focal cerebral ischemia was established. Nisst and 2,3,5-triphenyltetrazolium chloride （TTC） staining revealed that normobaric oxygen pretreat- ment improved neurological deficits and reduced infarct volume. Immunohistochemical staining and western blot assay revealed that the expression of hypoxia-inducible factor-la, Notch-l, vascular endothelial growth factor and erythropoietin were increased. Behavioral studies also verified that neurological deficit scores increased. The hypoxia-inducible factor inhibitor 2-methoxyestradiol treatment at 1 hour before administration of normobaric oxygen could suppress the protective effect of normobaric oxygen. Given these observations, normobaric oxygen pretreatment may alleviate cerebral ischemic injury via the hypoxia-inducible factor signal pathway.

关键词： neural regeneration brain injury normobaric oxygen cerebral ischemia focal cerebral ischemia blood-brain barrier hypoxia-inducible factor-la grants-supported paper neuroregeneration

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武汉城市生活垃圾分类收运系统综合评价

交通节能与环保 2021年第6期17卷 46-49,54页

作者：张矢宇辜子瑱张宇陈梓禾杨雯博武汉理工大学交通学院湖北武汉430063

为评估武汉城市生活垃圾分类收运系统现状,促进武汉市生态化、环境友好型城市建设,以武汉市杨园街道为研究对象,综合考虑运行状况、环境影响、经济投入等因素,构建城市生活垃圾分类收运系统评估指标体系。通过实地考察走访辅以网络调查... 详细信息

为评估武汉城市生活垃圾分类收运系统现状,促进武汉市生态化、环境友好型城市建设,以武汉市杨园街道为研究对象,综合考虑运行状况、环境影响、经济投入等因素,构建城市生活垃圾分类收运系统评估指标体系。通过实地考察走访辅以网络调查的方式获取收运系统的现状数据,并利用层次分析法与模糊综合评价法进行综合评估。评估结果表明,城市生活垃圾分类收运系统得分为56.33,评价为中等,目前存在垃圾分类覆盖率低、垃圾收运车分类回收效率低等问题。并提出对垃圾收运系统的线路及节点进行优化、加大对居民垃圾分类相关知识的宣传教育、在武汉市范围内进一步开展不同尺度的城市区域生活垃圾分类收运系统的调查与评价等建议。

关键词：武汉市生活垃圾分类收运系统 AHP 模糊综合评价

针灸改善帕金森病非运动症状的机制临床研究进展

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中医药导报 2023年第11期29卷 113-117页

作者：陈梓訸蔡娲高垣杨子越沈卫东上海中医药大学附属曙光医院上海201203

针灸治疗帕金森病(PD)非运动症状与调节5-羟色胺、α-突触核蛋白、神经免疫炎症、氧化应激、肠道菌群、微小核糖核酸、脑源性神经营养因子、铁代谢相关蛋白等机制相关,且针灸治疗可以改善PD伴便秘、睡眠障碍、嗅觉减退、抑郁情绪、疲劳... 详细信息

针灸治疗帕金森病(PD)非运动症状与调节5-羟色胺、α-突触核蛋白、神经免疫炎症、氧化应激、肠道菌群、微小核糖核酸、脑源性神经营养因子、铁代谢相关蛋白等机制相关,且针灸治疗可以改善PD伴便秘、睡眠障碍、嗅觉减退、抑郁情绪、疲劳、认知功能障碍和疼痛等非运动症状。

关键词：帕金森病针灸非运动症状机制研究临床研究综述

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填料对聚合物水泥防水涂料性能的影响研究

河南科技 2022年第1期41卷 94-97页

作者：李雪玲付弯弯卢雨婷陈梓禾王欢武汉轻工大学土木工程与建筑学院湖北武汉430023

填料填充于聚合物乳胶粒和水泥之间的空隙,使涂膜结构更加密实,增强聚合物水泥防水涂料的拉伸性能并提高其硬度。研究了填料种类及其用量对聚合物水泥防水涂料性能的影响,得出如下结论:随着填料用量的增加,涂膜的抗拉强度先提高后降低,... 详细信息

填料填充于聚合物乳胶粒和水泥之间的空隙,使涂膜结构更加密实,增强聚合物水泥防水涂料的拉伸性能并提高其硬度。研究了填料种类及其用量对聚合物水泥防水涂料性能的影响,得出如下结论:随着填料用量的增加,涂膜的抗拉强度先提高后降低,断裂伸长率降低;在液粉比为1.0的情况下,以粉煤灰为填料的聚合物水泥防水涂料的抗拉强度高达2.58 MPa,断裂伸长率为271%,且硬度达到5H,得到的涂膜性能最佳。

关键词：聚合物水泥防水涂料填料抗拉强度断裂伸长率硬度

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An effective method to screen sodium-based layered materials for sodium ion batteries

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npj Computational Materials 2018年第1期4卷 560-565页

作者： Xu Zhang zihe Zhang Sai Yao An chen Xudong Zhao Zhen Zhou School of Materials Science and Engineering National Institute for Advanced MaterialsComputational Centre for Molecular ScienceInstitute of New Energy Material ChemistryCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300350China

Due to the high cost and insufficient resource of lithium,sodium-ion batteries are widely investigated for large-scale ***,insertion-type materials possess better cyclic stability than alloy-type and conversion-type ***,in this work,we proposed a facile and effective method to screen sodium-based layered materials based on Materials Project database as potential candidate insertion-type materials for sodium ion *** obtained Na-based layered materials contains 38 kinds of space group,which reveals that the credibility of our screening approach would not be affected by the space ***,some important indexes of the representative materials,including the average voltage,volume change and sodium ion mobility,were further studied by means of density functional theory *** materials with extremely low volume changes and Na diffusion barriers are promising candidates for sodium ion *** believe that our classification algorithm could also be used to search for other alkali and multivalent ion-based layered materials,to accelerate the development of battery materials.

关键词： layered insertion sodium

振动冲击下PDC切削齿在层理岩层的破岩仿真分析

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中国锰业 2020年第1期38卷 16-21页

作者：陈子贺张玉广于涛李玮秦国伟王旭东东北石油大学石油工程学院黑龙江大庆163318 大庆油田有限责任公司采油工程研究院黑龙江大庆163453 大庆钻探工程公司钻井生产技术服务一公司黑龙江大庆163358 西安石油大学陕西西安710065 中海油研究总院有限责任公司北京100027

层理岩层是钻井工程中经常遇到的一类岩层,存在地质条件复杂、非均质性强、软硬交错、地层倾角大等特点,PDC钻头在该类岩层破岩效率低,经常发生先期损失。为了提高PDC钻头在层理岩层的破岩效率,以Drucker-Prager准则作为岩石的本构关系... 详细信息

层理岩层是钻井工程中经常遇到的一类岩层,存在地质条件复杂、非均质性强、软硬交错、地层倾角大等特点,PDC钻头在该类岩层破岩效率低,经常发生先期损失。为了提高PDC钻头在层理岩层的破岩效率,以Drucker-Prager准则作为岩石的本构关系,用有限元软件建立PDC切削齿在振动冲击下破岩的仿真模型,研究了层理岩层在PDC切削齿切削过程中的破碎情况及PDC切削齿在不同振动频率和冲击幅度下对层理岩层破岩效率的影响。研究表明:振动频率越高,破岩比功越小,冲击幅值大小与破岩比功无明显相关性,振动冲击载荷有利于提高层理岩层的破岩效率。

关键词：有限元层理岩层切削齿振动冲击

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减水剂对聚合物水泥防水涂料的性能影响

河南科技 2022年第24期41卷 83-87页

作者：陈梓禾周成宇付弯弯卢雨婷李雪玲武汉轻工大学土木工程与建筑学院湖北武汉430023

减水剂是一种在维持混凝土坍落度不变的条件下,能减少拌合用水量的混凝土外加剂。通过试验研究了不同类型减水剂的掺量对聚合物水泥防水涂料拉伸性能、光泽度以及硬度的影响。结果表明,分别在有机硅减水剂、聚羧酸减水剂以及萘系减水剂... 详细信息

减水剂是一种在维持混凝土坍落度不变的条件下,能减少拌合用水量的混凝土外加剂。通过试验研究了不同类型减水剂的掺量对聚合物水泥防水涂料拉伸性能、光泽度以及硬度的影响。结果表明,分别在有机硅减水剂、聚羧酸减水剂以及萘系减水剂的作用下,聚合物水泥防水涂料的拉伸性能有明显提升,其光泽度在加入一定减水剂比例下有明显提升,但随着加入减水剂比例的增大,光泽度呈现下降趋势,而加入不同类型减水剂掺量对于涂层铅笔硬度的影响不大。

关键词：聚合物水泥防水涂料减水剂拉伸性能光泽度硬度

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Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy

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Protein & Cell 2019年第3期10卷 178-195页

作者： Lin Cao Jizheng chen Yaxin Wang Yuting Yang Jie Qing zihe Rao Xinwen chen Zhiyong Lou College of Pharmacy&State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071China National Laboratory of Macromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China School of Medicine and Collaborative Innovation Center of Biotherapy Tsinghua UniversityBeijing 100084China Beijing No.166 High School Beijing 100006China

Hepatitis C virus(HCV)is a leading cause of liver disease *** several HCV protease/polymerase inhibitors were recently approved by ***,the combination of antivirals targeting multiple processes of HCV lifecycle would optimize anti-HCV therapy and against potential *** entry is an essential target step for antiviral development,but FDA-approved HCV entry inhibitor remains *** we identify serotonin 2A receptor(5-HT2aR)is a HCV entry factor amendable to therapeutic intervention by a chemical biology *** silencing of 5-HT2aR and clinically available 5-HT2aR antagonist suppress cell culture-derived HCV(HCVcc)in different liver cells and primary human hepatocytes at late endocytosis *** mechanism is related to regulate the correct plasma membrane localization of claudin 1(CLDN1).Moreover,phenoxybenzamine(PBZ),an FDAapproved 5-HT2aR antagonist,inhibits all major HCV genotypes in vitro and displays synergy in combination with clinical used anti-HCV *** impact of PBZ on HCV genotype 2a is documented in immune-competent humanized transgenic *** results not only expand the understanding of HCV entry,but also present a promising target for the invention of HCV entry inhibitor.

关键词： HCV serotonin 2A receptor entry antiviral drug

Engineering the inter-island plasmonic coupling in homometallic Au-Au_(n)core-satellite structures

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Nano Research 2023年第7期16卷 10690-10697页

作者： Xiaoying Wu Xiaoli Tian zihe Jiang Yun Wang Tingting Jiang Yuhua Feng Zhenglong Zhang Hongyu chen Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringNanjing Tech UniversityNanjing 211816China School of Science Westlake UniversityHangzhou 310024China School of Physics and Information Technology Shaanxi Normal UniversityXi’an 710062China

We show that through strong ligand mediated interfacial energy control between Au seeds and the deposited Au,the non-wetting growth of Au on Au seeds led to the formation homometallic core-satellite *** modulate the intraparticle plasmonic coupling between the core and the satellites,the number and size of the Au satellites,and their inter-island distances were continuously tuned by varying the growth *** a result of the precise structural control,the plasmonic absorptions of the core-satellite nanostructures were tuned from visible to near-infrared(NIR)spectral range,and the extent of spectral modulation(500-1300 nm)is among the best of the literature *** synthetic advance enriches the toolbox for nanosynthesis and points to a new direction in the exploration of sophisticated functional designs.

关键词： Au heterostructure core-satellite localized surface plasmon resonance(LSPRs) intraparticle coupling strong ligand near-infrared(NIR)absorptions