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Trinity immune enhancing nanoparticles for boosting antitumor immune responses of immunogenic chemotherapy

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Nano Research 2022年第2期15卷 1183-1192页

作者： Yudi Xu Sheng Ma Jiayu Zhao Xinghui Si zichao huang Yu Zhang Wantong Song Zhaohui Tang Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Chinese Academy of Sciences Beijing 100039China University of Science and Technology of China Hefei 230026China Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China

Certain chemo drugs have been reported to potentially induce tumor-specific immune recognition by triggering immunogenic cell death(ICD),which provides a promising alternative way for cancer ***,the immunogenic effects of such treatments are still weak and robust systemic antitumor immune responses are rarely seen when these agents were used ***,we proposed a trinity immune enhancing nanoparticles(TIENs)for boosting antitumor immune responses of chemo *** TIENs was constructed with Food and Drug Administration(FDA)approved polylactic acid(PLA),canonical proton-sponging cationic polymer polyethyleneimine(PEI),and Toll-like receptor 9(TLR9)agonist cytosine phosphate guanine oligodeoxynucleotide(CpG-ODN).In in vitro studies,the TIENs was proved to(1)promote antigen capturing,(2)antigen-presenting cells(APCs)activation,and(3)antigen *** in vivo studies,intratumorally injected TIENs greatly enhanced antitumor effect and robust immune responses of oxaliplatin and doxorubicin in murine CT26 and 4T1 tumor models,***,after decoration with a detachable shielding,the TIENs was proved to be effective in promoting the antitumor effects of chemo agents after intravenous *** combination of TIENs with clinically widely used chemo agents should be meaningful in boosting effective antitumor immune responses and cancer therapy.

关键词： nanoparticles immunotherapy antigen capturing cross-presentation immune activation

Modularized viromimetic polymer nanoparticle vaccines(VPNVaxs) to elicit durable and effective humoral immune responses

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National Science Review 2024年第3期11卷 200-214页

作者： zichao huang Xinyu Zhuang Liping Liu Jiayu Zhao Sheng Ma Xinghui Si Zhenyi Zhu Fan Wu Ningyi Jin Mingyao Tian Wantong Song Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences School of Applied Chemistry and Engineering University of Science and Technology of China Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences Jilin Biomedical Polymers Engineering Laboratory State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

Virus-like particle(VLP) vaccines had shown great potential during the COVID-19 pandemic, and was thought to be the next generation of antiviral vaccine technology due to viromimetic structures. However,the time-consuming and complicated processes in establishing a current recombinant-protein–based VLP vaccine has limited its quick launch to the out-bursting pandemic. To simplify and optimize VLP vaccine design, we herein report a kind of viromimetic polymer nanoparticle vaccine(VPNVax), with subunit receptor-binding domain(RBD) proteins conjugated to the surface of polyethylene glycol-b-polylactic acid(PEG-b-PLA) nanoparticles for vaccination against SARS-CoV-2. The preparation of VPNVax based on synthetic polymer particle and chemical post-conjugation makes it possible to rapidly replace the antigens and construct matched vaccines at the emergence of different viruses. Using this modular preparation system, we identified that VPNVax with surface protein coverage of 20%–25% had the best immunostimulatory activity, which could keep high levels of specific antibody titers over 5 months and induce virus neutralizing activity when combined with an aluminum adjuvant. Moreover, the polymer nano-vectors could be armed with more immune-adjuvant functions by loading immunostimulant agents or chemical chirality design. This VPNVax platform provides a novel kind of rapidly producing and efficient vaccine against different variants of SARS-CoV-2 as well as other viral pandemics.

关键词： vaccine polymer nanomaterials SARS-CoV-2

Heterocyclic Molecules Tethered Branched Polymers with Innate Immune Stimulating Activity

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CCS Chemistry 2024年第5期6卷 1278-1288页

作者： Jiayu Zhao Liping Liu Yibo Wang zichao huang Yu Zhang Ruirui Qiao Thomas P.Davis Zhaohui Tang Wantong Song Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026 Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 Jilin Biomedical Polymers Engineering Laboratory Changchun 130022 Australian Institute of Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueensland 4072

We report herein an interesting finding that heterocyclic molecules tethered branched polymers exhibit innate immune stimulating *** we conjugated a series of five-,six-,or seven-membered heterocyclic molecules to branched polyethylenimine(bPEI),over 70%of them could induce the secretion of interferon-β(IFN-β)from murine dendritic and human leukemia monocytic(DC2.4 and THP-1)cells through activating the stimulator of interferon genes(STING)*** further proved that this kind of innate stimulating activity was dependent on the macromolecular architecture as heterocyclic molecules tethered linear PEI(lPEI)or dendritic polyamidoamine(PAMAM)induced no or much less IFN-β***,we prepared a series of poly-L-lysine(PLL)-derivatives with different branches to tether with heterocyclic molecules and proved that this kind of bPEI-like structure was important in en hancing the binding affinity with STING proteins and for exhibiting innate stimulating activity.

关键词： bioactive materials polymers heterocycles branched structure immunity

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环境温度对预混瓦斯气体爆炸特性的影响

煤矿安全 2021年第2期52卷 1-6页

作者：黄子超中煤科工集团重庆研究院有限公司重庆400037

为了研究不同环境温度条件下预混瓦斯气体爆炸特性参数的变化和危险性,利用20 L爆炸特性实验装置,采用夹层和内腔双加热、高压放电点火的方法,对不同环境温度(20~200℃)瓦斯爆炸压力特性、爆炸燃烧特性参数、爆炸极限等参数进行了测试... 详细信息

为了研究不同环境温度条件下预混瓦斯气体爆炸特性参数的变化和危险性,利用20 L爆炸特性实验装置,采用夹层和内腔双加热、高压放电点火的方法,对不同环境温度(20~200℃)瓦斯爆炸压力特性、爆炸燃烧特性参数、爆炸极限等参数进行了测试。研究表明:在实验条件下,爆炸最大压力、爆炸反应时间、爆炸点火延迟时间均随环境温度的升高而逐渐降低或减少;当环境温度升高至200℃时,爆炸最大压力降低了43.8%,而爆炸反应时间、点火延迟时间分别减少了54、14.4 ms;压力上升速率受温度影响较小;随环境温度升高,分子内能增加,原来稳定的不燃系统越容易变成可燃、可爆系统,爆炸极限范围变宽。

关键词：环境温度瓦斯爆炸爆炸压力压力上升速率爆炸极限点火延迟时间

抛光铝粉爆炸及ABC粉体抑爆特性的实验研究

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中国安全生产科学技术 2020年第7期16卷 119-124页

作者：黄子超中煤科工集团重庆研究院有限公司火灾爆炸防治研究分院重庆400037 瓦斯灾害监控与应急技术国家重点实验室重庆400037

为研究抛光铝粉的爆炸危险和ABC粉体的抑爆特性,在对实验粉体粒径分布进行分析的基础上,采用20 L粉尘爆炸特性实验装置,分别对不同铝粉尘浓度、不同抑爆剂浓度条件下的爆炸特性参数进行测试。研究结果表明:在实验条件下,铝粉的爆炸下限... 详细信息

为研究抛光铝粉的爆炸危险和ABC粉体的抑爆特性,在对实验粉体粒径分布进行分析的基础上,采用20 L粉尘爆炸特性实验装置,分别对不同铝粉尘浓度、不同抑爆剂浓度条件下的爆炸特性参数进行测试。研究结果表明:在实验条件下,铝粉的爆炸下限为45 g/m^3

关键词：抛光铝粉抑爆爆炸特性浓度爆炸压力爆炸反应时间

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粉体云幕对瓦斯煤尘爆炸隔爆效果的试验研究

中国安全科学学报 2020年第3期30卷 74-81页

作者：黄子超司荣军中煤科工集团重庆研究院有限公司火灾爆炸防治研究分院重庆400037 瓦斯灾害监控与应急技术国家重点实验室重庆400037

为了探索瓦斯煤尘爆炸的防治技术措施,在大尺度断面巷道开展粉体云幕的隔爆性能测试。运用直径2 m大尺度管道及其附属敞开空间,研究粉体云幕的形成过程及其动态分布特征;在此基础上,以爆炸压力、火焰速度为特征参数,在断面7. 2 m^2大型... 详细信息

为了探索瓦斯煤尘爆炸的防治技术措施,在大尺度断面巷道开展粉体云幕的隔爆性能测试。运用直径2 m大尺度管道及其附属敞开空间,研究粉体云幕的形成过程及其动态分布特征;在此基础上,以爆炸压力、火焰速度为特征参数,在断面7. 2 m^2大型地下巷道内进行瓦斯煤尘爆炸及隔爆试验。研究结果表明:隔爆粉体在60 ms时可覆盖7. 4 m^2断面,在1 200 ms绝大部分粉体喷出,形成有效隔爆屏障;在试验条件下,粉体云幕面密度8. 1 kg/m^2时,爆炸火焰在13 m范围内被完全熄灭,最大爆炸压力由云幕前的0. 293 MPa降低至0. 126 MPa,下降了57. 0%,140 m位置的爆炸压力上升时间延迟了137 ms;随粉体云浓度的增加,隔爆效果增强,粉体云幕能在短距离范围内扑灭爆炸火焰,并大幅衰减爆炸冲击波压力。

关键词：粉体云幕瓦斯煤尘爆炸隔爆爆炸压力火焰速度

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细水雾特性及煤粉制备系统抑尘抑爆技术研究

矿业安全与环保 2022年第6期49卷 73-78页

作者：黄子超薛少谦瓦斯灾害监控与应急技术国家重点实验室重庆400037 中煤科工集团重庆研究院有限公司重庆400037

为了预防控制煤粉制备系统中细煤粉的泄漏危险和爆炸事故的发生,搭建了细水雾发生测试系统,测试了不同工作压力下,1种实心锥形喷嘴喷出的水雾的喷射雾化角、流量、粒径等特征参数。结果表明:随着喷雾压力的增加,水雾流量呈线性增加,粒... 详细信息

为了预防控制煤粉制备系统中细煤粉的泄漏危险和爆炸事故的发生,搭建了细水雾发生测试系统,测试了不同工作压力下,1种实心锥形喷嘴喷出的水雾的喷射雾化角、流量、粒径等特征参数。结果表明:随着喷雾压力的增加,水雾流量呈线性增加,粒径逐渐减小;当压力为2.0 MPa时,水流分散成粒径足够小的细水雾,流量为19.62 L/min,细水雾中值粒径为146.3μm。基于细水雾降尘、灭火抑爆机理,设计了抑尘抑爆系统,对煤粉制备系统不同区域的水雾供给流量、喷头数量进行了计算,研究了喷头的安装布置方式,为煤粉制备系统的安全运行提供了可靠保障。

关键词：细水雾流量粒径分布煤粉制备系统抑爆水雾喷头

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Enhancing selectivity in acidic CO_(2) electrolysis:Cation effects and catalyst innovation

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Chinese Journal of Catalysis 2024年第8期63卷 61-80页

作者： zichao huang Tinghui Yang Yingbing Zhang Chaoqun Guan Wenke Gui Min Kuang Jianping Yang State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China

The electrochemical reduction of CO_(2)(eCO_(2)R)under ambient conditions is crucial for reducing carbon emissions and achieving carbon *** progress with alkaline and neutral electrolytes,their efficiency is limited by(bi)carbonates *** media have emerged as a solution,addressing the(bi)carbonates challenge but introducing the issue of the hydrogen evolu-tion reaction(HER),which reduces CO_(2) conversion efficiency in acidic *** review focuses on enhancing the selectivity of acidic CO_(2) *** commences with an overview of the latest advancements in acidic CO_(2) electrolysis,focusing on product selectivity and electrocatalytic activity *** then delves into the critical factors shaping selectivity in acidic CO_(2) electrolysis,with a special emphasis on the influence of cations and catalyst ***,the research challenges and personal perspectives of acidic CO_(2) electrolysis are suggested.

关键词： Acidic CO_(2) electrolysis High selectivity Cation effects Catalyst design Competitive HER

显著中心先验和显著-深度概率矫正的RGB-D显著目标检测

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电子与信息学报 2017年第12期39卷 2945-2952页

作者：刘政怡黄子超张志华安徽大学计算智能与信号处理教育部重点实验室合肥230601 安徽大学信息保障技术协同创新中心合肥230601

随着深度特征在图像显著检测领域中发挥越来越重要的作用,传统的RGB图像显著检测模型由于未能充分利用深度信息已经不能适用于RGB-D图像的显著检测。该文提出显著中心先验和显著-深度(S-D)概率矫正的RGB-D显著检测模型,使得深度特征和RG... 详细信息

随着深度特征在图像显著检测领域中发挥越来越重要的作用,传统的RGB图像显著检测模型由于未能充分利用深度信息已经不能适用于RGB-D图像的显著检测。该文提出显著中心先验和显著-深度(S-D)概率矫正的RGB-D显著检测模型,使得深度特征和RGB特征间相互指导,相互补充。首先,依据3维空间权重和深度先验获取深度图像初步显著图;其次,采用特征融合的流形排序算法获取RGB图像的初步显著图。接着,计算基于深度的显著中心先验,并以该先验作为显著权重进一步提升RGB图像的显著检测结果,获取RGB图像最终显著图;再次,计算显著-深度矫正概率,并对深度图的初步显著检测结果使用此概率进行矫正。接着,计算基于RGB的显著中心先验,并以该先验作为显著权重进一步提升深度图像矫正后的显著检测结果,获取深度图像的最终显著图;最后,采用优化框架对深度图像最终显著图进行优化得到RGB-D图像最终的显著图。所有的对比实验都是在公开的数据集NLPR RGBD-1000数据集上进行,实验结果显示该文算法较当前流行的算法有更好的性能。

关键词： 3维空间权重特征融合的流形排序算法显著中心先验显著-深度概率矫正