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Stratigraphic framework and sedimentary evolution during the Cryogenian-Ediacaran transition in northeastern Sichuan Basin,South China

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Petroleum Science 2024年第2期21卷 823-835页

作者： Yi Zhang Hong-Wei Kuang Yong-Qing Liu Qiang Shi Dong-Ge Wang Ke-Ning Qi Yu-Chong Wang Da-Wei Qiao Xiao-Shuai chen Li-Zhi Wu Meng Tian Long chen Yi Wei Liao-Yuan Song Jian Li zi-Gang Wu Yun-Qian Liu Xuan-Chun Liu An-Qing chen Zhi-Wei Liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological Team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China Chongqing Institute of Geological Survey Chongqing401122China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent ***,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic *** study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern *** results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied *** Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb *** stratigraphic correlations indicate that the C-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three ***,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast *** proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing *** the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early ***,the early Ediacaran

关键词： Marinoan glaciation Doushantuo formation Cap dolomite Deglacial and coastal deposits Detrital zircon U-Pb dating

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iTRAQ-based proteomics reveals the mechanism of action of Yinlai decoction in treating pneumonia in mice consuming a high-calorie diet

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 21-32页

作者： Qianqian Li Tiegang Liu chen Bai Xueyan Ma Hui Liu zi’an Zheng Yuxiang Wan He Yu Yuling Ma Xiaohong Gu School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Institute of Chinese Medicine Epidemic Disease Beijing University of Chinese MedicineBeijing 102488China School of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550025China Department of Acupuncture and Mini-invasive Oncology Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China OCMRC Center University of OxfordOxford OX13PTUnited Kingdom

Objective:To uncover the underlying mechanisms of action of the Yinlai decoction on high-calorie dietinduced pneumonia through proteomics ***:Based on the Gene Expression Omnibus(GEO)database,lung tissue samples from normal and high-fat diet(HFD)fed mice in the GSE16377 dataset were selected as test cohorts to identify differentially expressed genes and conduct bioinformatics *** the animal experiments,mice were randomly divided into the control(N),high-calorie diet pneumonia(M),and Yinlai decoction treatment(Y)*** in the M group received high-calorie feed and a 0.5 mg/mL lipopolysaccharide solution spray for 30 min for 3 *** mice in the Y group were intragastrically administered 2 mL/10 g Yinlai decoction twice daily for 3 *** evaluation of the lung tissue was *** expressed proteins(DEPs)in the lung tissue were identified using quantitative proteomics and bioinformatics *** drug-target relationships between Yinlai decoction and core DEPs in the lung tissue were verified using AutoDock Vina and Molecular Graphics Laboratory(MGL)*** were verified by western ***:GEO data mining showed that an HFD altered oxidative phosphorylation in mouse lung *** Yinlai decoction alleviated pathological damage to lung tissue and pneumonia in mice that were fed a high-calorie diet.A total of 47 DEPs were identified between the Y and M *** analysis revealed their association with energy metabolism pathways such as the tricarboxylic acid cycle(TCA)and oxidative *** protein-protein interaction network revealed that Atp5a1,Pdha1,and Sdha were the target proteins mediating the therapeutic effects of Yinlai *** docking results suggested that the mechanism of the therapeutic effect of Yinlai decoction involves the binding of brassinolide,praeruptorin B,chrysoeriol,and other components in Yinlai decoction to ***:The Yinlai decoction allevia

关键词： Yinlai decoction High-calorie diet Pneumonia iTRAQ proteomics Energy metabolism

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Short-term effects of cupping and scraping therapy for chronic nonspecific low-back pain:A prospective,multicenter randomized trial

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Journal of Integrative Medicine 2024年第1期22卷 39-45页

作者： Jun-yan He Xiao-yu Tu zi-fei Yin Hui Mu Ming-jun Luo Xing-yu chen Wei-bin Cai Xue Zhao Can Peng Fan-fu Fang Can Lü Bai Li School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Department of Rehabilitation Medicine and Physiotherapy the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Rehabilitation Medicine and Training PLA 458 HospitalGuangzhou 510602Guangdong ProvinceChina No.3 Ward of Acupuncture Rehabilitation Department Guangdong Second Traditional Chinese Medicine HospitalGuangzhou 510095Guangdong ProvinceChina

Background As one of the most common musculoskeletal ailments,chronic nonspecific low-back pain(CNLBP)causes persistent disability and substantial medical *** evidence shows that the incidence rate of CNLBP in young and middle-aged people who are demanded rapidly recovery and social contribution is *** guidelines indicate a reduced role for medicines in the management of *** The present study investigates the short-term effects of cupping and scraping therapy using a medicated balm,compared to nonsteroidal anti-inflammatory drug(NSAID)with a capsaicin plaster,in the treatment of ***,setting,participants and interventions We designed a prospective multicenter randomized clinical trial enrolling patients from January 1,2022 to December 31,2022.A total of 156 patients with CNLBP were randomized into two parallel *** sodium-sustained release tablets were administered orally to participants in the control group for one week while a capsaicin plaster was applied *** in the test group were treated with cupping and scraping using a medical device and medicated *** outcome measures Primary outcome was pain recorded using the visual analogue scale(VAS).Two secondary outcomes were recorded using the Japanese Orthopedic Association low-back pain scale(JOA)and the traditional Chinese medicine(TCM)syndrome integral scale(TCMS)as assessment *** Between baseline and postintervention,all changes in outcome metric scales were statistically significant(P<0.001).Compared to the control group,patients in the test group had a significantly greater treatment effect in all outcome variables,as indicated by lower VAS and TCMS scores and higher JOA scores,after the one-week intervention period(P<0.001).Further,according to the findings of multivariate linear regression analysis,the participants’pain(VAS score)was related to their marital status,age,smoking habits and body mass *** adverse r

关键词： Chronic nonspecific low-back pain Traditional Chinese medicine Cupping and scraping therapy

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Si含量对Al-Si-Cu-Ni-Mg合金组织和性能的影响

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铸造 2024年第6期73卷 779-787页

作者：韩杨相志磊陈子勇北京工业大学北京100124

采用搅拌铸造工艺制备不同Si含量合金,旨在揭示Si含量对Al-Si-Cu-Ni-Mg合金微观组织、力学性能和耐磨性的影响。结果表明,随着Si含量升高,合金中共晶Si长径比和平均长度先升高后降低,Si含量为16wt.%合金的长径比和平均长度最大,分别为8.... 详细信息

采用搅拌铸造工艺制备不同Si含量合金,旨在揭示Si含量对Al-Si-Cu-Ni-Mg合金微观组织、力学性能和耐磨性的影响。结果表明,随着Si含量升高,合金中共晶Si长径比和平均长度先升高后降低,Si含量为16wt.%合金的长径比和平均长度最大,分别为8.8μm、24.1μm。经过520℃/6 h固溶+180℃/5 h时效处理后,共晶Si形貌由纤维状变为球状,初晶Si棱角钝化。合金中共晶Si长径比和平均长度均有明显降低,保持与铸态合金相同的变化趋势;Si含量为16wt.%合金的长径比和平均长度分别为3.5μm、12.4μm,初晶Si尺寸没有明显变化。随着Si含量的升高,铸态合金拉伸性能逐渐降低,宏观硬度逐渐上升。经过T6热处理后,合金的拉伸性能和宏观硬度有了明显提升,保持与铸态合金相同的变化趋势,随着Si含量的升高,合金磨损失重减少,耐磨性得到改善。Si含量为16wt.%的合金磨损失重最少,耐磨性最好;继续增加Si含量时,合金耐磨性降低。

关键词： Al-Si合金 Si含量微观组织耐磨性力学性能

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Identification of marker genes associated with N6-methyladenosine and autophagy in ulcerative colitis

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World Journal of Clinical Cases 2024年第10期12卷 1750-1765页

作者： Xiao-Yan Liu Dan Qiao Ya-Li Zhang zi-Xuan Liu You-Lan chen Ren-Ye Que Hong-Yan Cao Yan-cheng Dai Department of Gastroenterology Shanghai Traditional Chinese Medicine-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Institute of Digestive Diseases Long Hua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Gastroenterology Shu Guang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Both N6-methyladenosine(m6A)methylation and autophagy are considered relevant to the pathogenesis of ulcerative colitis(UC).However,a systematic exploration of the role of the com-bination of m6A methylation and autophagy in UC remains to be *** To elucidate the autophagy-related genes of m6A with a diagnostic value for *** The correlation between m6A-related genes and autophagy-related genes(ARGs)was ***,gene set enrichment analysis(GSEA)was performed on the characteristic ***,the expression levels of four characteristic genes were verified in dextran sulfate sodium(DSS)-induced colitis in *** GSEA indicated that BAG3,P4HB and TP53INP2 were involved in the inflammatory response and TNF-αsignalling via nuclear factor ***,polymerase chain reaction results showed significantly higher mRNA levels of BAG3 and P4HB and lower mRNA levels of FMR1 and TP53INP2 in the DSS group compared to the control *** This study identified four m6A-ARGs that predict the occurrence of UC,thus providing a scientific reference for further studies on the pathogenesis of UC.

关键词： Ulcerative colitis m6A Autophagy Characteristic genes Immune infiltration

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类H型结构的太赫兹带阻滤波器

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中国光学（中英文） 2024年第4期17卷 757-763页

作者：陈祥雪付子亲王凤超陈进杨晶上海应用技术大学理学院上海201418

本文基于对称的类H型结构设计了一种超材料太赫兹带阻滤波器,这种H型结构的连续金属臂可以流通电流。利用电磁仿真软件CST Microwave Studio 2021研究了该滤波器的滤波特性。通过改变H型双臂间距臂长、周期长度、双H间距离等,确定了滤... 详细信息

本文基于对称的类H型结构设计了一种超材料太赫兹带阻滤波器,这种H型结构的连续金属臂可以流通电流。利用电磁仿真软件CST Microwave Studio 2021研究了该滤波器的滤波特性。通过改变H型双臂间距臂长、周期长度、双H间距离等,确定了滤波器的几何参数。结果表明,该结构可实现偏振选择的功能,在y偏振条件下,滤波器在0.2~2.3 THz范围内没有明显的谐振峰,但透过率范围在-15到-3 dB之间。而在x偏振条件下,在中心频率1.34 THz处可获得FWHM带宽为0.15 THz的一个阻带,传输参数约为-30 dB。最后,采用微加工工艺制备了超材料滤波器样品以验证仿真结果,使用透射式太赫兹时域光谱系统对样品进行测试,测试结果与仿真结果吻合较好。

关键词：太赫兹超材料类H型结构带阻滤波器

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Predicting the Risk of Arterial Stiffness in Coal Miners Based on Different Machine Learning Models

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Biomedical and Environmental Sciences 2024年第1期37卷 108-111页

作者： chen Qian Wei HUANG Xue Zan DING Yu ZHU Feng Ren WANG Jia ZOU Yuan Jie DU Yuan Zhen ZHANG Ya Jun HUI zi Wen ZHU Feng Lin MU Min The Project was supported by Open Research Grant of Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHefei 232001AnhuiChina School of Public Health Anhui University of Science and TechnologyHefei 232001AnhuiChina Key Laboratory of Industrial Dust Prevention and Control Occupational Safety and HealthMinistry of EducationAnhui University of Science and TechnologyHefei 232001AnhuiChina Anhui Institute of Occupational Safety and Health Anhui University of Science and TechnologyHefei 232001AnhuiChina Joint Research Center of Occupational Medicine and Health Institute of Grand HealthHefei Comprehensive National Science CenterAnhui University of Science and TechnologyHefei 232001AnhuiChina Department of Occupational&Environmental Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina

Coal is one of the world’s main energy resources,accounting for approximately 68%of China’s current total power ***,several studies have demonstrated that dust,exhaust fumes,and other harmful factors in coal mines increase the risk of cardiovascular disease(CVD)among miners^([1]).Arterial stiffness(AS)is an independent risk factor of CVD,and epidemiological studies have shown that AS plays a vital role in assessing the risk of CVD^([2]).

关键词： Arterial cardiovascular assessing

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Late Cambrian Magmatic Events in SW Yunnan and Implications for the Tectonic Reconstruction of Northern Gondwana

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Journal of Earth Science 2024年第5期35卷 1407-1425页

作者： Guichun Liu Jianwei zi Xiaomei Nie M.Santosh Cai Zhu Wei Wang Tianyu Zhao Guangyan chen Qinglai Feng Yunnan Institute of Geological Sciences Kunming 650216China School of Earth Sciences China University of GeosciencesWuhan 430074China State Key Lab of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China John de Laeter Centre State Key Curtin UniversityBentley 6102Australia School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Department of Earth Science University of AdelaideAdelaide SA5005Australia Yunnan Geotechnical Engineering Survey and Design Institute Kunming 650214China Yunnan Exploration Institute of Geology and Mineral Resources Kunming 650051China

In this study,we investigated Early Paleozoic magmatic rocks of the Manlai Formation exposed along the eastern margin of the Lancang terrane to better understand the tectonic history of the *** present petrological,geochemical and whole-rock Sr-Nd and zircon Hf isotopic data for basalts and gabbros sampled from the Qianmai mé*** grains from six basaltic and gabbroic samples yielded U-Pb ages of 495-482 *** rocks are characterized by tholeiitic and Nbenriched compositions,with Nb/La ratios in the range of 0.38-1.38,similar to the typical Nb-enriched *** the mafic rocks show slightly negative to positiveε_(Nd)(t)(-1.67 to+4.32)and zirconε_(Hf)(t)values(-7.3 to+3.8).Elemental and isotopic data suggest that the Qianmai Nb-enriched mafic rocks were mainly derived from the mixing of an OIB-like source with a subduction-modified mantle wedge *** with magmatic and sedimentary records of similar ages in the Lancang terrane and the Baoshan Block,our results reveal Early Paleozoic magmatic and sedimentary sequences along an active margin of the *** into account the recently identified Early Paleozoic ophiolitic mélange in the Yunxian-Menghai belt,we consider the Qianmai magmatic rocks to represent the products of early-stage subduction-related magmatism within a primitive island arc or fore-arc setting associated with the southward subduction of the *** infer that prolonged south-dipping subduction on the northern margin of Gondwana persisted from the Cambrian to the Late Ordovician.

关键词： Qianmai melange Nb-enriched basalts island arc Proto-Tethys northern margin of Gondwana SW Yunnan tectonics geochemistry

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Notopterygium Incisum Extract Promotes Apoptosis by Preventing the Degradation of BIM in Colorectal Cancer

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Current Medical Science 2024年第4期44卷 833-840页

作者： Jun-he chen cheng-ming WEI Qian-yu LIN zi WANG Fu-ming ZHANG Mei-na SHI Wen-jian LAN Chang-gang SUN Wan-jun LIN Wen-zhe MA State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao999078China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou510006China College of Traditional Chinese Medicine Weifang Medical UniversityWeifang261053China

Objective Colorectal cancer(CRC),a prevalent malignancy worldwide,has prompted extensive research into anticancer *** Chinese medicinal materials offer promising avenues for cancer management due to their diverse pharmacological *** study investigated the effects of Notopterygium incisum,a traditional Chinese medicine named Qianghuo(QH),on CRC cells and the underlying *** The sulforhodamine B assay and colony formation assay were employed to assess the effect of QH extract on the proliferation of CRC cell lines HCT116 and *** iodide(PI)staining was utilized to detect cell cycle progression,and PE Annexin V staining to detect *** blotting was conducted to examine the levels of apoptotic proteins,including B-cell lymphoma 2-interacting mediator of cell death(BIM),B-cell lymphoma 2(Bcl-2),Bcl-2-associated X protein(BAX)and cleaved caspase-3,as well as BIM stability after treatment with the protein synthesis inhibitor *** expression of BAX was suppressed using lentivirus-mediated shRNA to validate the involvement of the BIM/BAX axis in QH-induced *** in vivo effects of QH extract on tumor growth were observed using a xenograft ***,APC^(Min+)mice were used to study the effects of QH extract on primary intestinal *** QH extract exhibited significant in vitro anti-CRC activities evidenced by the inhibition of cell proliferation,perturbation of cell cycle progression,and induction of ***,QH extract significantly increased the stability of BIM proteins,which undergo rapid degradation under unstressed *** of BAX,the downstream effector of BIM,significantly rescued QH-induced ***,the in vitro effect of QH extract was recapitulated in *** extract significantly inhibited the tumor growth of HCT116 xenografts in nude mice and decreased the number of intestinal polyps in the APC^(Min+)*** QH extract

关键词： Notopterygium incisum colorectal cancer apoptosis B-cell lymphoma 2-interacting mediator of cell death

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Observation of accurately designed bound states in the continuum in momentum space

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Photonics Research 2024年第4期12卷 638-647页

作者： JIAJU WU JINGGUANG chen XIN QI ZHIWEI GUO JIAJUN WANG FENG WU YONG SUN YUNHUI LI HAITAO JIANG LEI SHI JIAN zi HONG chen MOE Key Laboratory of Advanced Micro-Structured Materials School of Physics Science and EngineeringTongji UniversityShanghai 200092China State Key Laboratory of Surface Physics Key Laboratory of Micro-and Nano-Photonic Structures(Ministry of Education)and Department of PhysicsFudan UniversityShanghai 200433China School of Optoelectronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510665China

Bound states in the continuum(BICs)in artificial photonic structures have received considerable attention since they offer unique methods for the extreme field localization and enhancement of light-matter ***,the symmetry-protected BICs are located at high symmetric points,while the positions of accidental BICs achieved by tuning the parameters will appear at some points in momentum *** to now,to accurately design the position of the accidental BIC in momentum space is still a ***,we theoretically and experimentally demonstrate an accurately designed accidental BIC in a two-coupled-oscillator system consisting of bilayer gratings,where the optical response of each grating can be described by a single resonator *** changing the interlayer distance between the gratings to tune the propagation phase shift related to wave vectors,the position of the accidental BIC can be arbitrarily controlled in momentum ***,we present a general method and rigorous numerical analyses for extracting the polarization vector fields to observe the topological properties of BICs from the polarization-resolved transmission ***,an application of the highly efficient second harmonic generation assisted by quasi-BIC is *** work provides a straightforward strategy for manipulating BICs and studying their topological properties in momentum space.

关键词： polarization tuning resonator

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