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Timp1 Deletion Induces Anxiety-like Behavior in Mice

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Neuroscience Bulletin 2024年第6期40卷 732-742页

作者： Xiaotong Wang Wei Zheng ziyi Zhu Biyu Xing Weijie Yan Ke Zhu Lingli Xiao Chaojuan Yang Mengping Wei Lei Yang zi-Bing Jin Xueyun Bi chen Zhang State Key Laboratory of Neurology and Oncology Drug Development Nanjing210000China School of Basic Medical Sciences Wenzhou Medical UniversityWenzhou325035China School of Basic Medical Sciences Beijing Key Laboratory of Neural Regeneration and RepairAdvanced Innovation Center for Human Brain ProtectionBeijing Laboratory of Oral HealthCapital Medical UniversityBeijing100069China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing100005China Chinese Institute for Brain Research Beijing102206China Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing100191China

The hippocampus is essential for learning and memory,but it also plays an important role in regulating emotional behavior,as hippocampal excitability and plasticity affect anxiety and *** synaptic plasticity may be regulated by tissue inhibitor of matrix metalloproteinase 1(TIMP1),a known protein inhibitor of extracellular matrix(ECM),and the expression of TIMP1 in the hippocampus can be induced by neuronal excitation and various ***,the involvement of Timp1 in fear learning,anxiety,and hippocampal synaptic function remains to be *** study of Timp1 function in vivo revealed that Timp1 knockout mice exhibit anxiety-like behavior but normal fear *** results suggested that Timp1 knockout mice showed hyperactivity in the ventral CA1 region,but the basic synaptic transmission and plasticity were normal in the Schaffer collateral *** together,our results suggest that deletion of Timp1 in vivo leads to the occurrence of anxiety behaviors,but that Timp1 is not crucial for fear learning.

关键词： Timp1 Anxiety Fear Synaptic transmission Synaptic plasticity

Discovery of CCDC188 gene as a novel genetic target for human acephalic spermatozoa syndrome

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Protein & Cell 2024年第9期15卷 704-709页

作者： Jing Wang Hui-Juan Jin Yi Lu zi-Han Wang Teng-Yan Li Lan Xia Hong-Jun Li Bin-Bin Wang Su-Ren chen Department of Medical Genetics and Developmental Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Key Laboratory of Cell Proliferation and Regulation Biology Ministry of EducationDepartment of BiologyCollege of Life SciencesBeijing Normal UniversityBeijing 100875China Graduate School Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China Department of Urology Peking Union Medical College HospitalBeijing 100005China Center for Genetics National Research Institute of Family PlanningBeijing 100081China NHC Key Laboratory of Reproductive Health Engineering Technology Research(NRIFP) Beijing 100081China

Dear Editor,Male infertility is a widespread health problem and affects approximately 6%–8%of the male population(Jiao et al.,2021).Acephalic spermatozoa syndrome(ASS),a rare but severe type of teratozoospermia,is ch... 详细信息

关键词： al. infertility finally

Series Reports from Professor Wei's Group of Chongqing University:Advancements in Electrochemical Energy Conversions(1/4):Report 1:High-performance Oxygen Reduction Catalysts for Fuel Cells

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电化学（中英文） 2024年第7期30卷 1-27页

作者： Fa-Dong chen Zhuo-Yang Xie Meng-Ting Li Si-Guo chen Wei Ding Li Li Jing Li zi-Dong Wei State Key Laboratory of Advanced Chemical Power Sources(Chongqing University) College of Chemistry and Chemical EngineeringChongqing UniversityChongqing400044China

Two major challenges,high cost and short lifespan,have been hindering the commercialization process of lowtemperature fuel *** Wei's group has been focusing on decreasing cathode Pt loadings without losses of activity and durability,and their research advances in this area over the past three decades are briefly reviewed *** the Pt-based catalysts and the low Pt usage,they have firstly tried to clarify the degradation mechanism of Pt/C catalysts,and then demonstrated that the activity and stability could be improved by three strategies:regulating the nanostructures of the active sites,enhancing the effects of support materials,and optimizing structures of the three-phase *** Pt-free catalysts,especialiy carbon-based ones,several strategies that they proposed to enhance the activity of nitrogen-/heteroatom-doped carbon catalysts are firstly ***,an indepth understanding of the degradation mechanism for carbon-based catalysts is discussed,and followed by the corresponding stability enhancement ***,the carbon-based electrode at the micrometer-scale,faces the challenges such as low active-site density,thick catalytic layer,and the effect of hydrogen peroxide,which require rational structure design for the integral cathodic *** review finally gives a brief conclusion and outlook about the low cost and long lifespan of cathodic oxygen reduction catalysts.

关键词： Fuel cell Oxygen reduction reaction Pt-based catalyst Carbon-based catalyst

Clinical efficacy of magnetic vibration magnetoelectric therapy in the treatment of chronic prostatitischronic pelvic pain syndrome

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World Journal of Clinical Cases 2024年第19期12卷 3837-3844页

作者： zi-Heng Zhang Feng-Juan Chang Yun chen Department of Men Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Provincial Hospital of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

BACKGROUND The prominent symptoms of chronic pelvic pain syndrome(CPPS)are urogenital pain,lower urinary tract symptoms,psychological problems,and sexual *** pharmacological treatments have poor efficacy and more untoward reaction and *** vibration magnetoelectric therapy is a non-invasive form of ***,its effectiveness in improving urinary discomfort and relieving pain in patients requires further *** To investigate the clinical efficacy of the magnetic vibration magnetoelectric therapy instrument in the treatment of chronic prostatitis(CP)/*** Seventy patients with CP/CPPS were collected from the outpatient clinic and ward of the Department of Male Medicine,Jiangsu Province Hospital of Traditional Chinese Medicine,and were treated with magnetic vibration magnetoelectric therapy once a day for a period of 14 *** Institutes of healthchronic prostatitis symptom index(NIH-CPSI),international index of erectile function 5(IIEF-5),premature ejaculation diagnostic tool(PEDT),generalized anxiety disorder(GAD),patient health questionnaire,the pain catastrophizing scale(PCS)and traditional Chinese medicine syndrome(TCMS)scores were performed before and after *** The total effective rate of treatment was 58.5%,and the total NIH-CPSI score,pain symptoms,voiding symptoms,quality of life,IIEF-5,PEDT,GAD,PCS and TCMS scores all decreased significantly(P<0.05).CONCLUSION Magnetic vibration magnetotherapy is effective in improving urinary discomfort,relieving pain,improving quality of life,improving sexual dysfunction and relieving negative emotions such as anxiety in patients with CP/CPPS.

关键词： Magnetic vibration magnetoelectric therapy Chronic pelvic Chronic pelvic pain syndrome CP/CPPS Electrical stimulation

Millisecond dynamics of colloidal suspension studied by X-ray photon correlation spectroscopy at the Shanghai Synchrotron Radiation Facility

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Nuclear Science and Techniques 2024年第1期35卷 1-9页

作者： chen-Hui Cui zi-Mu Zhou Lin-Feng Wei Song-Lin Li Feng Tian Xiu-Hong Li Zhi Guo Yi-Hui Xu Huai-Dong Jiang Ren-Zhong Tai Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China

X-ray photon correlation spectroscopy(XPCS)has emerged as a powerful tool for probing the nanoscale dynamics of soft condensed matter and strongly correlated materials owing to its high spatial resolution and penetration *** technique requires high brilliance and beam coherence,which are not directly available at modern synchrotron beamlines in *** facilitate future XPCS experiments,we modified the optical setup of the newly commissioned BL10U1 USAXS beamline at the Shanghai Synchrotron Radiation Facility(SSRF).Subsequently,we performed XPCS measurements on silica suspensions in glycerol,which were opaque owing to their high *** were collected using a high frame rate area detector.A comprehensive analysis was performed,yielding correlation functions and several key dynamic *** the results were consistent with the theory of Brownian motion and demonstrated the feasibility of XPCS at ***,by carefully optimizing the setup and analyzing the algorithms,we achieved a time resolution of 2 ms,which enabled the characterization of millisecond dynamics in opaque systems.

关键词： XPCS SSRF Silica suspension Glycerol Brownian motion Millisecond dynamics

骨碎补UPLC指纹图谱与人骨肉瘤细胞MG63中碱性磷酸酶活性的谱效关系研究

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天然产物研究与开发 2024年第2期36卷 293-302页

作者：陈香丽张慧敏张紫佳上海中医药大学中药研究所、中药标准化教育部重点实验室上海201203

建立骨碎补生品和砂烫品提取物的UPLC指纹图谱,并研究骨碎补提取物与人骨肉瘤细胞MG63中碱性磷酸酶(ALP)活性之间的谱效关系。采用UPLC法建立骨碎补生品和烫品的指纹图谱并通过UPLC-Q-TOF MS法对其化学成分进行鉴别;通过测定MG63细胞中... 详细信息

建立骨碎补生品和砂烫品提取物的UPLC指纹图谱,并研究骨碎补提取物与人骨肉瘤细胞MG63中碱性磷酸酶(ALP)活性之间的谱效关系。采用UPLC法建立骨碎补生品和烫品的指纹图谱并通过UPLC-Q-TOF MS法对其化学成分进行鉴别;通过测定MG63细胞中ALP活性检测骨碎补提取物对MG63细胞成骨分化的影响;采用灰色关联度分析、双变量相关性分析以及偏最小二乘回归分析法分析骨碎补生品和烫品的UPLC特征指纹峰与其促ALP活性之间的谱效关系。在标定的12个共有峰中,确定了4、5、12号峰与ALP活性呈正相关,其对应的物质依次是咖啡酸-4-O-β-D-吡喃葡萄糖苷、儿茶素7-葡糖苷、柚皮苷,为深入研究骨碎补的促成骨分化活性物质基础提供依据。

关键词：骨碎补 UPLC指纹图谱碱性磷酸酶活性谱效关系人骨肉瘤细胞MG63

Lithium-induced graphene layer containing Li_(3)P alloy phase to achieve ultra-stable electrode interface for lithium metal anode

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Rare Metals 2024年第2期43卷 562-574页

作者： Jia-Xin chen Guo-Qiang Zhang Xian-Ying Qin Kui Lin zi-Jin Yang Ge-Meng Liang Yue Xia Guo-Bin Zhang Hai-Kun Wu Qiu-Chan Cai Hai Lin Bao-Hua Li Shenzhen Key Laboratory on Power Battery Safety Research and Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolShenzhen518055China Shenzhen Graphene Innovation Center Co. Ltd.Shenzhen518107China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA5005Australia Department of Chemistry City University of Hong KongHong Kong990077China

Uncontrolled growth of lithium dendrite will lead to low Coulombic efficiency and poor cycle stability,which hinders the commercialization of lithium metal ***,a novel modified lithium anode with reduced graphene oxide conductive network containing trace lithiophilic phosphorus(P-rGO/Cu)is prepared by electrospraying technique combined with heat treatment *** rGO layer has a concave and undulating conductive structure,which can significantly improve the effective electrical contact between lithium metal and the current collector,speed up the kinetics of interfacial electron transport and reaction,and improve the resistance of the negative electrode to the internal stress caused by volume change of the lithium,which is advantageous for the stability of the SEI *** extremely small and uniformly distributed red phosphorus element avoids the volume change caused by lithiation to the maximum *** two-phase compound Li_(3)P obtained by alloying P with Li can directionally induce the homogeneous nucleation and dense deposition of lithium metal,address the issue of lithium dendrites and extend the cycle life of the *** obtained P-rGO/Cu exhibits excellent electrochemical performance with an average Coulombic efficiency(CE)of 98%at a current density of 1 mA·cm^(−2) for 400 cycles,and the capacity retention rate of the full cell matched with lithium iron phosphate(LFP)is 83%after 400 cycles at 1C.

关键词： Lithium anode Dendrite-free Lithiophilicity Induced nucleation deposition

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非互易拓扑光子学

物理学报 2024年第6期73卷 1-15页

作者：王子尧陈福家郗翔高振杨怡豪南方科技大学电子与电气工程系深圳518055 浙江大学量子信息交叉中心浙江大学杭州国际科创中心浙江大学极端光学技术与仪器全国重点实验室杭州310027 南方科技大学光纤光缆先进制造与应用技术全国重点实验室深圳518055

拓扑光子学的提出与发展为从根本物理原理上解决传统光学器件易受干扰的问题提供了新思路,基于拓扑保护的新型鲁棒光场调控极大地提高了光学器件的传输效率和稳健性.其中,基于时间反演对称性破缺的非互易拓扑光子学及其手性拓扑态是拓... 详细信息

拓扑光子学的提出与发展为从根本物理原理上解决传统光学器件易受干扰的问题提供了新思路,基于拓扑保护的新型鲁棒光场调控极大地提高了光学器件的传输效率和稳健性.其中,基于时间反演对称性破缺的非互易拓扑光子学及其手性拓扑态是拓扑光子学的重要分支,其拓扑特性由非零陈数或陈矢量表征,表现出超越互易拓扑光子学的严格拓扑保护鲁棒性.本综述将重点介绍非互易拓扑光子学在探索新奇物理现象(手性/反手性边界态、反常非互易拓扑边界态、三维光学陈绝缘体、磁性外尔光子晶体等)和构建非互易鲁棒拓扑光学器件(单向光波导、宽带慢光延迟线、任意形状拓扑激光器、大轨道角动量相干光源等)等方面取得的显著成果.最后对非互易拓扑光子学的发展现状、潜在挑战以及可能取得的突破进行了展望.

关键词：拓扑光子学非互易拓扑光子学光学陈绝缘体非互易拓扑器件

Stratigraphic framework and sedimentary evolution during the Cryogenian-Ediacaran transition in northeastern Sichuan Basin,South China

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Petroleum Science 2024年第2期21卷 823-835页

作者： Yi Zhang Hong-Wei Kuang Yong-Qing Liu Qiang Shi Dong-Ge Wang Ke-Ning Qi Yu-Chong Wang Da-Wei Qiao Xiao-Shuai chen Li-Zhi Wu Meng Tian Long chen Yi Wei Liao-Yuan Song Jian Li zi-Gang Wu Yun-Qian Liu Xuan-Chun Liu An-Qing chen Zhi-Wei Liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological Team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China Chongqing Institute of Geological Survey Chongqing401122China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent ***,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic *** study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern *** results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied *** Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb *** stratigraphic correlations indicate that the C-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three ***,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast *** proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing *** the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early ***,the early Ediacaran

关键词： Marinoan glaciation Doushantuo formation Cap dolomite Deglacial and coastal deposits Detrital zircon U-Pb dating