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Temporal Change in Treatment Patterns of Metastatic Colorectal Cancer and Its Association with Patient Survival:A Retrospective Cohort Study Based on an Intelligent Big-Data Platform

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Engineering 2021年第4期7卷 526-533页

作者： zi-xian wang Yi-Chen Yao Zong-Jiong Mai Wu-Hao Lin You-Sheng Huang Ying Jin Hui-Yan Luo Dong-Sheng Zhang Feng-Hua wang Feng wang Gong Chen Pei-Rong Ding Yun-Fei Yuan Yu-Hong Li Jin-Hua Huang Zhi-Zhong Pan Rui-Hua Xu Department of Medical Oncology State Key Laboratory of Oncology in South China&Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China Artificial Intelligence Laboratory Sun Yat-sen University Cancer CenterGuangzhou 510060China Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical SciencesGuangzhou 510060China Department of Colorectal Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Hepatobiliary Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Minimally Invasive Therapy Sun Yat-sen University Cancer CenterGuangzhou 510060China

There is a lack of high-quality,large-scale,real-world evidence from patients with metastatic colorectal cancer(mCRC),especially in *** remains unclear whether efforts to improve the quality of care for mCRC would improve patient survival outcomes in real-world *** the basis of an intelligent bigdata platform,we established a large-scale retrospective cohort of mCRC *** investigated the temporal changes in the systemic and local treatment(resection,ablation,or radiation to liver,lung,or extrahepatic and/or extrapulmonary metastases)patterns of mCRC,and whether these changes were associated with improved overall survival(OS)over *** July 2012 and December 2018,3403 eligible patients were included in this *** median OS was 42.8 months(95%confidence interval(CI),40.7–46.6)for the entire cohort,25.6 months(95%CI,24.7–26.9)for those treated with systemic therapy only,and not reached(95%CI,78.6 months–not reached)for those receiving local *** utility rate of local therapy increased continuously from 37.9%in 2012–2014 to 46.9%in 2017–2018.A dramatic increase in the utility rate of either cetuximab or bevacizumab was observed since 2017(39.9%,43.2%,and 60.3%in 2012–2014,2015–2016,and 2017–2018,respectively).Compared with 2012–2014,the OS of the entire population significantly improved in 2015–2016(hazard ratio(HR)=0.87(95%CI,0.78–0.99);P=0.034),but not for patients receiving systemic therapy only(HR=0.99(95%CI,0.86–1.14);P=0.889),whereas an improved OS was found in 2015–2018 for both the entire population(HR=0.75(95%CI,0.70–0.81);P<0.001)and for patients receiving systemic therapy only(HR=0.83(95%CI,0.77–0.91);P<0.001).In summary,the quality of care for mCRC,as indicated by the utility rate of targeted and local therapies,has been continuously improving over time in this study cohort,which is associated with continuously improving survival outcomes for these patients.

关键词： Metastatic colorectal cancer Real-world evidence Treatment pattern Survival Big-data platform

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Optical facet coatings for high-performance LWIR quantum cascade lasers atλ∼8.5μm

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红外与毫米波学报 2024年第4期43卷 497-502页

作者： MA Yuan LIN Yu-Zhe WAN Chen-Yang wang zi-xian ZHOU Xu-Yan ZHANG Jin-Chuan LIU Feng-Qi ZHENG Wan-Hua Laboratory of Solid-State Optoelectronics Information Technology Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Weifang Academy of Advanced Opto-Electronic Circuits Weifang 261021China

We report on the performance improvement of long-wave infrared quantum cascade lasers(LWIR QCLs)by studying and optimizing the anti-reflection(AR)optical facet *** to the Al2O3 AR coat⁃ing,the Y_(2)O_(3)AR coating exhibits higher catastrophic optical mirror damage(COMD)level,and the optical facet coatings of both material systems have no beam steering effect.A 3-mm-long,9.5-μm-wide buried-heterostruc⁃ture(BH)LWIR QCL ofλ~8.5μm with Y_(2)O_(3)metallic high-reflection(HR)and AR of~0.2%reflectivity coating demonstrates a maximum pulsed peak power of 2.19 W at 298 K,which is 149%higher than that of the uncoated *** continuous-wave(CW)operation,by optimizing the reflectivity of the Y_(2)O_(3)AR coating,the maximum output power reaches 0.73 W,which is 91%higher than that of the uncoated device.

关键词： quantum cascade lasers long-wave infrared optical facet coatings catastrophic optical mirror damage

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胃肠肿瘤免疫治疗的进展、挑战与对策

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Science Bulletin 2023年第8期68卷 763-766页

作者：王梓贤潘艺芊李薛鑫 Takeshi Tsubata 徐瑞华 Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhou 510060China Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical SciencesGuangzhou 510060China Department of Medical Biochemistry and Biophysics Karolinska InstituteStockholm 17165Sweden Department of Immunology Medical Research InstituteTokyo Medical and Dental UniversityTokyo 113-8510Japan

Cancer immunotherapy,largely based on programmed cell death-1(PD-1)/PD-ligand 1(PD-L1)immune checkpoint blockade,has achieved remarkable advancements over the past decade in the treatment of human cancers[1,2],includi... 详细信息

关键词：肿瘤免疫治疗 Cancer immunotherapy

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求解最小公倍数问题的量子安全多方计算协议

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计算机学报 2024年第6期47卷 1393-1412页

作者：李子贤刘文杰南京信息工程大学软件学院南京210044 江苏省大气环境与装备技术协同创新中心南京210044 江苏省先进计算与智能服务工程研究中心南京210044

最小公倍数是解决很多数学问题的基础工具,在隐私保护的情况下如何对其进行多方协同计算具有一定的研究价值.部分经典安全多方计算协议虽然能够求解该问题,但计算复杂度为指数级.本文通过将最小公倍数问题转化为求多个周期函数的连接函... 详细信息

最小公倍数是解决很多数学问题的基础工具,在隐私保护的情况下如何对其进行多方协同计算具有一定的研究价值.部分经典安全多方计算协议虽然能够求解该问题,但计算复杂度为指数级.本文通过将最小公倍数问题转化为求多个周期函数的连接函数的周期,提出了一个基于量子周期查找算法的最小公倍数协议,将复杂度降为多项式级.在协议中,发起方对每个参与方发送一个粒子.每个参与方对粒子施加一个Oracle操作,其中Oracle函数的周期即各自的私有整数.然后,发起方通过运行量子周期查找算法来计算出连接函数的周期,即各自整数的最小公倍数.为了防御共谋和伪造攻击,采用星-环混合拓扑结构对粒子发送方进行诚实性检验.由于量子周期查找算法存在一定的失败概率,设计了一个量子匿名输出检验协议来检验最小公倍数结果的正确性.安全性分析表明了该协议在恶意模型下具有无条件安全性,且协议的计算复杂度和通信复杂度分别为O(n^(3)m^(2)log(nm))和O(n^(2)mlog(nm)),均为多项式级.此外,该协议具有较好的扩展性,可应用于安全多方最大公约数计算、有理数求和、最值计算等问题.

关键词：量子计算量子信息安全多方计算最小公倍数量子周期查找算法匿名输出检验隐私计算

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产业政策与跨境并购:政策导向还是创新驱动?

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科学学研究 2024年第1期42卷 54-66页

作者：吴先明马子涵武汉大学经济与管理学院湖北武汉430072

本文以2008-2018年进行国内并购和跨境并购的中国A股上市公司为研究对象,实证检验了产业政策对企业跨境并购倾向的影响。研究结果表明,产业政策对跨境并购倾向具有显著的正向影响。产业政策主要通过获得政府补助和提高商业信用进而影响... 详细信息

本文以2008-2018年进行国内并购和跨境并购的中国A股上市公司为研究对象,实证检验了产业政策对企业跨境并购倾向的影响。研究结果表明,产业政策对跨境并购倾向具有显著的正向影响。产业政策主要通过获得政府补助和提高商业信用进而影响企业跨境并购倾向。行业竞争环境、市场化程度、环境不确定性、企业创新能力和高管薪酬粘性会影响产业政策的实施效果。产业政策没有显著影响跨境并购的交易金额,但提高了跨境并购的股权水平和完成率;同时,战略资产寻求动因能够显著增强产业政策对跨境并购交易金额和股权水平的影响。揭示了产业政策对企业跨境并购倾向的独特作用,不仅丰富了产业政策对跨境并购影响机制的研究,同时也为如何更好地运用产业政策提升跨境并购的效果提供了政策参考。

关键词：产业政策跨境并购投资偏好

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青少年道德决策的同伴影响及合理性促进

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教育理论与实践 2024年第14期44卷 37-40页

作者：赵献梓河北师范大学教育学院河北石家庄050024

同伴在青少年心目中有着十分重要的地位,个体会通过同伴来凸显自身的独立性,也会依赖同伴满足某些情感需求。由于同伴在青少年学习生活中的重要地位,会较多地影响青少年的道德认知、决策情绪和决策思维。外因通过内因发挥作用,内因在事... 详细信息

同伴在青少年心目中有着十分重要的地位,个体会通过同伴来凸显自身的独立性,也会依赖同伴满足某些情感需求。由于同伴在青少年学习生活中的重要地位,会较多地影响青少年的道德认知、决策情绪和决策思维。外因通过内因发挥作用,内因在事物发展中起决定性作用。青少年道德决策合理化的关键在于夯实青少年道德认知,增加个道德决策的理性成分;传授青少年道德决策方法,夯实个体道德决策的智慧基础;加强青少年独立人格建设,增强同伴导向下个体决策自主性;利用同伴与青少年的情感联结,促使个体基于积极情感体验做出决策。

关键词：青少年道德决策同伴影响道德认知道德情感道德思维

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Preparation of kakkatin derivatives and their anti-tumor activity

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World Journal of Clinical Oncology 2024年第8期15卷 1078-1091页

作者： Yu-Ying Jiang Hui-Hua Dong Wen-Ting Zhou Jia-zi Luo xian Wei Yan-Qiang Huang Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Collaborative Innovation Center for Guangxi Ethnic Medicine The School of Chemistry and Pharmaceutical SciencesYoujiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Research Center for the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Modern pharmacological studies have confirmed that plant-derived compounds from Puerariae flos(PF)has significant biological activities against liver damage,tumors and *** is an isoflavone polyphenolic compound isolated from PF ***,the effect of kakkatin and its derivatives on anti-tumor has not been well *** To design and synthesize a kakkatin derivative[6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one(HK)]to explore its anti-tumor biological *** Hept-6-yn-1-yl ethanesulfonate was introduced to replace hydrogen at the hydroxyl position of kakkatin phenol,and the derivative of kakkatin was prepared;the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide was used to detect cell viability,a clone formation assay was adopted to detect cell proliferation,apoptosis,necrosis,and cell cycles were analyzed by Annexin V/propidium iodide staining and flow *** migration and invasion ability were evaluated by cell scratch assay and transwell *** potential mechanism of HK on hepatocellular carcinoma(HCC)SMMC-7721 cells was explored through network pharmacology and molecular docking,and finally real-time PCR assays was used to verify the potential targets and evaluate the biological activity of *** Compared with kakkatin,the modified HK did not significantly increase the inhibitory activity of gastric cancer MGC803 cells,but the inhibitory activity of HCC SMMC-7721 cells was increased by about 30 times,with an IC50 value of 2.5μM,and the tumor inhibition effect was better than cisplatin,which could significantly inhibit the cloning,invasion and metastasis of HCC SMMC-7721 cells,and induce apoptosis and G2/M cycle *** mechanism of action is mainly related to the upregulation of PDE3B and NFKB1 target proteins in the cAMP *** HK have a significant inhibitory effect on HCC SMMC-7721 cells,and the targets of their action may be PDE3B and NFKB1 prote

关键词： Kakkatin Derivative Hepatocellular carcinoma Anti-tumor Biological activity

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燃气分析法测量小尺寸全环燃烧室出口温度场

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航空动力学报 2024年第7期39卷 169-176页

作者：资海林马瑛张阳李维张险中国航发湖南动力机械研究所湖南株洲412002

为探索燃气分析法测量小尺寸全环燃烧室出口温度场的应用,介绍了适应小尺寸全环燃烧室出口通道高度的多点非混合式水冷燃气取样探针设计,燃烧室出口分别布置2支5点非混合式水冷燃气取样探针和双铂铑热电偶,随位移机构旋转180°,实现正... 详细信息

为探索燃气分析法测量小尺寸全环燃烧室出口温度场的应用,介绍了适应小尺寸全环燃烧室出口通道高度的多点非混合式水冷燃气取样探针设计,燃烧室出口分别布置2支5点非混合式水冷燃气取样探针和双铂铑热电偶,随位移机构旋转180°,实现正、反双向数据采集,测量二氧化碳(CO_(2))、一氧化碳(CO)和未燃碳氢化合物(UHC)3种组分的体积分数进而计算燃气温度.试验结果表明:燃气分析法与热电偶法测量的燃烧室出口温度分布基本一致,两者测量的相对偏差在2%以内;同时表明燃气分析法在测量航空发动机燃烧室温度场具有测温上限高、测量准确的优点.

关键词：出口温度场小尺寸全环燃烧室燃气分析水冷燃气取样探针位移机构双向数据采集

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1990-2019年中国睾丸癌疾病负担分析

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解放军医学杂志 2024年第3期49卷 272-279页

作者：唐诗迪訾豪朱聪王永博曾宪涛武汉大学中南医院泌尿外科湖北武汉430071 武汉大学中南医院循证与转化医学中心湖北武汉430071

目的分析1990-2019年中国睾丸癌疾病负担及变化趋势。方法基于2019年全球疾病负担数据库(GBD 2019),分析1990-2019年中国人群睾丸癌的发病、死亡、伤残调整寿命年(DALYs)、过早死亡损失寿命年(YLLs)、伤残损失寿命年(YLDs)及其变化趋势... 详细信息

目的分析1990-2019年中国睾丸癌疾病负担及变化趋势。方法基于2019年全球疾病负担数据库(GBD 2019),分析1990-2019年中国人群睾丸癌的发病、死亡、伤残调整寿命年(DALYs)、过早死亡损失寿命年(YLLs)、伤残损失寿命年(YLDs)及其变化趋势。通过计算年估计变化百分比(EAPC)评估年龄标准化率(ASR)的变化。按照年龄分组,分析睾丸癌疾病负担的年龄分布特点。结果2019年中国睾丸癌发病例数为17.17×103例,死亡例数为1.21×103例,年龄标准化发病率为2.39/10万,年龄标准化死亡率为0.16/10万。与1990年相比,发病例数、死亡例数、年龄标准化发病率均明显增加或增高,与全球变化趋势一致,而增幅均高于全球水平,但中国和全球年龄标准化死亡率均呈现下降趋势。1990-2019年,中国睾丸癌的DALYs、YLLs、YLDs均明显上升,分别增加了29.66%、9.83%、720.91%。0~15岁和30~35岁是睾丸癌高发的两个年龄段,30~35岁是我国睾丸癌疾病负担最重的年龄段。结论1990-2019年中国睾丸癌的疾病负担整体呈上升趋势。儿童和青壮年发病率较高、疾病负担较重,应作为睾丸癌的重点筛查及防治人群。

关键词：睾丸癌疾病负担发病率死亡率伤残调整寿命年

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Effectiveness and safety of early lens extraction during par plana vitrectomy for proliferative diabetes retinopathy with mild cataract:a randomized clinical trial

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 528-536页

作者： Wei-Bo Feng Lei Zheng Ying-Qi Li Yong-Hao Li Guo-Ming Zhang xian wang Bing-Qian Liu Ling Jin Yi-Nuo Huang Yang-Fan Yang zi-Dong Chen Da-Hui Ma Qing-Shan Chen Chao-Jun Qin Bing-Min Feng Zhu-Min Yang Xing Huang Cheng-Jie Yang Sheng-Hui Liu Ming-Xing Wu State Key Laboratory of Ophthalmology Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesZhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510275Guangdong ProvinceChina Shenzhen Eye Hospital Affiliated to Jinan University Shenzhen 518040Guangdong ProvinceChina The Affiliated Hospital of Guizhou Medical University Guiyang 550004Guizhou ProvinceChina Guangzhou Aier Eye Hospital Guangzhou 510000Guangdong ProvinceChina

●AIM:To evaluate the effectiveness and safety of early lens extraction during pars plana vitrectomy(PPV)for proliferative diabetic retinopathy(PDR)compared to those of PPV with subsequent cataract surgery.●METHODS:This multicenter randomized controlled trial was conducted in three Chinese hospitals on patients with PDR,aged>45y,with mild *** participants were randomly assigned to the combined(PPV combined with simultaneously cataract surgery,i.e.,phacovitrectomy)or subsequent(PPV with subsequent cataract surgery 6mo later)group and followed up for *** primary outcome was the change in best-corrected visual acuity(BCVA)from baseline to 6mo,and the secondary outcomes included complication rates and medical expenses.●RESULTS:In total,129 patients with PDR were recruited and equally randomized(66 and 63 in the combined and subsequent groups respectively).The change in BCVA in the combined group[mean,36.90 letters;95%confidence interval(CI),30.35–43.45]was significantly better(adjusted difference,16.43;95%CI,8.77–24.08;P<0.001)than in the subsequent group(mean,22.40 letters;95%CI,15.55–29.24)6mo after the PPV,with no significant difference between the two groups at *** overall surgical risk of two sequential surgeries was significantly higher than that of the combined surgery for neovascular glaucoma(17.65%vs 3.77%,P=0.005).No significant differences were found in the photocoagulation spots,surgical time,and economic expenses between two *** the subsequent group,the duration of work incapacity(22.54±9.11d)was significantly longer(P<0.001)than that of the combined group(12.44±6.48d).●CONCLUSION:PDR patients aged over 45y with mild cataract can also benefit from early lens extraction during PPV with gratifying effectiveness,safety and convenience,compared to sequential surgeries.

关键词： lens extraction pars plana vitrectomy proliferative diabetic retinopathy cataract simultaneously operations

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