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Neural Regeneration Research 2023年第9期18卷 2075-2081页

作者： zi-qian cheng Jie Fan Fang-Yi Zhao Jing-Yun Su Qi-Han Sun Ran-Ji Cui Bing-Jin Li Jilin Provincial Key Laboratory on Molecular and Chemical Genetic The Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Jilin Engineering Laboratory for Screening of Antidepressant ChangchunJilin ProvinceChina

Recent studies have shown that a 9-hour fast in mice reduces the amount of time spent immobile in the forced swimming *** r,whether 9-hour fasting has therapeutic effects in female mice with depressive symptoms has not been ***,in this study,we simulated perimenopausal depression via an ovariectomy in mice,and subjected them to a single 9-hour fasting 7 days *** found that the ovariectomy increased the time spent immobile in the forced swimming test,inhibited expression of the mammalian target of rapamycin complex 1 signaling pathway in the hippocampus and prefro ntal cortex,and decreased the density of dendritic spines in the *** 9-hour acute fasting alleviated the above-mentioned ***,all of the antidepressant-like effects of 9-hour fasting were reve rsed by an inhibitor of the mammalian to rget of rapamycin complex *** data showed a remarkable increase in long-term potentiation in the hippocampal CA1 of the ovariectomized mice subjected to fasting compared with the findings in the ovariectomized mice not subjected to *** findings show that the antidepressant-like effects of 9-hour fasting may be related to the activation of the mammalian target of the rapamycin complex 1 signaling pathway and synaptic plasticity in the mammalian ***,fasting may be a potential treatment for depression.

关键词： antidepressant brain-derived neurotrophic factor dendritic spine fasting hippocampus LTP mTOR complex 1 neural plasticity ovariectomized mice rapamycin

带拼接板螺栓连接耗能梁段的可恢复功能钢框筒结构抗震性能研究

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工程力学 2025年第1期42卷 83-102页

作者：连鸣戴子琳程倩倩西安建筑科技大学土木工程学院西安710055 西安建筑科技大学结构工程与抗震教育部重点实验室西安710055 中国建筑西北设计研究院有限公司西安710018

为了提升传统钢框筒结构的延性和耗能能力，提出采用拼接板螺栓连接的可恢复功能剪切耗能型钢框筒结构(FTS-SRSL)，该结构结合了可更换剪切型耗能梁段和钢框筒结构具有良好的抗震性能。该文对一个2/3缩尺的单层单跨FTS-SRSL子结构试件... 详细信息

为了提升传统钢框筒结构的延性和耗能能力，提出采用拼接板螺栓连接的可恢复功能剪切耗能型钢框筒结构(FTS-SRSL)，该结构结合了可更换剪切型耗能梁段和钢框筒结构具有良好的抗震性能。该文对一个2/3缩尺的单层单跨FTS-SRSL子结构试件进行了往复加载试验，试验结果表明，FTS-SRSL子结构试件具有良好的抗震性能，结构损伤集中于耗能梁段，且耗能梁段可实现更换。在试验的基础上，以耗能梁段长度比、耗能梁段腹板加劲肋间距、螺栓直径、翼缘拼接板和腹板拼接板厚度为参数，利用ABAQUS建立了15个足尺的单层单跨FTS-SRSL有限元模型，探究各模型的抗震性能，包括承载力、刚度、耗能以及塑性变形能力。有限元分析结果表明：改变拼接板螺栓连接的剪切型耗能梁段长度比会显著影响结构的承载力、刚度及耗能，建议FTS-SRSL中的拼接板螺栓连接剪切型耗能梁段长度比取0.73~1.09;改变耗能梁段腹板加劲肋间距对结构的承载力、刚度和耗能影响较小，基于该文的分析结果，建议FTS-SRSL中的拼接板螺栓连接剪切型耗能梁段腹板加劲肋间距取e/4~e/3(e为耗能梁段长度)，且间距应满足我国抗规的规定;改变翼缘拼接板和腹板拼接板厚度对结构的承载力、刚度及耗能基本无影响;改变螺栓直径对结构承载力、刚度及耗能影响较小。

关键词：可更换耗能梁段拼接板螺栓连接钢框筒结构抗震性能参数分析

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静载试验和低应变法对PHC管桩性能的检测

建材技术与应用 2024年第5期 45-49页

作者：靳涛钱自成张紫光中国建筑第五工程局有限公司湖南长沙410000

采用静载试验和低应变反射波法对PHC管桩的性能进行检测,通过抽检小比例PHC管桩进行静载试验对承载力进行检测,利用低应变反射波法对桩身完整性进行检测。结果表明:利用静载试验得出位移-荷载曲线的最大沉降量为14.78 mm,位移-对数时间... 详细信息

采用静载试验和低应变反射波法对PHC管桩的性能进行检测,通过抽检小比例PHC管桩进行静载试验对承载力进行检测,利用低应变反射波法对桩身完整性进行检测。结果表明:利用静载试验得出位移-荷载曲线的最大沉降量为14.78 mm,位移-对数时间曲线均较为平直发展;利用低应变反射波法检测PHC管桩桩身的完整性,其符合设计要求,可满足工程安全性要求。

关键词：桩基检测 PHC管桩静载试验 Q-s曲线低应变反射波法

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-qiang Xu Ying-Tong Di Man-cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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倒T型管道的振动特性分析与优化控制

建材技术与应用 2024年第3期 9-13页

作者：靳涛钱自成张紫光朱秋张晓露中国建筑第五工程局有限公司湖南长沙410000 中国建筑第一工程局第二建筑有限公司北京102600

三通管道是管网中最基本的连接单元之一,在管网的布置过程中有不可或缺的作用。通过利用ANSYS Workbench大型软件建立倒T型三通管道模型,从多个影响因素考虑,对倒T型管道的振动特性进行研究,最后对其振动特性提出优化控制。研究结果表明... 详细信息

三通管道是管网中最基本的连接单元之一,在管网的布置过程中有不可或缺的作用。通过利用ANSYS Workbench大型软件建立倒T型三通管道模型,从多个影响因素考虑,对倒T型管道的振动特性进行研究,最后对其振动特性提出优化控制。研究结果表明:在其他条件相同的情况下,双进单出的倒T型三通管道的固有频率比单进双出的固有频率稍大,倒T型圆形三通管道的固有频率略大于方形三通管道的固有频率,不同入水口压强和不同管道壁厚对固有频率有一定的影响;通过增加约束可以对管道的振动有较好的控制。

关键词：倒T型三通管道振动特性固有频率优化控制

FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis

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Science China Life Sciences 2025年

作者： Rongmei Gao Kanchao Chen Yimin Wang Rongxia Guo Xiaoyu Zhang Peng Wu Weili Wang Qingxiang Huang Xuemei Xie Shangda Yang Yanling Lü qian Ren Fei Liu Song Chen Fengxia Ma Tao cheng Hui cheng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College CAMS Center for Stem Cell Medicine PUMC Department of Stem Cell and Regenerative Medicine

Hematopoiesis is a finely tuned process that generates all blood cell types through self-renewal and differentiation, which is crucial for maintaining homeostasis. Acute infections can prompt a hematopoietic response known as emergency myelopoiesis. In this study, using a Candida albicans (C. albicans) infection model, we demonstrated for the first time that disruption of Fhl2 led to increased fungal burden,heightened inflammatory response and reduced survival rates. Impaired myeloid hematopoiesis and immune cell production were evident, as proved by the decreased numbers of hematopoietic stem and progenitor cells (HSPCs) and granulocytes in the bone marrow of Fhl2-deficient mice. In conclusion, FHL2 regulated emergency myelopoiesis in response to C. albicans, affecting the host’s defense against pathogens.

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绿豆胰蛋白酶抑制剂┐猪胰蛋白酶复合物的四方晶体结构

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生物化学与生物物理学报 1998年第4期30卷 45-50页

作者：刘小舟刘博卢光莹卫新成华子千戚正武北京大学生命科学学院蛋白质工程及植物基因工程国家重点实验室中国科学院上海生物化学研究所

本文报道了绿豆胰蛋白酶抑制剂－猪胰蛋白酶（１∶２）复合物的四方晶体的结构测定。晶体属于Ｉ４２２空间群，衍射分辨率为０．２５ｎｍ，共确定了绿豆抑制剂５６个残基的空间位置。与已报道的三方晶体结构相比，其中的抑制剂分子的结... 详细信息

本文报道了绿豆胰蛋白酶抑制剂－猪胰蛋白酶（１∶２）复合物的四方晶体的结构测定。晶体属于Ｉ４２２空间群，衍射分辨率为０．２５ｎｍ，共确定了绿豆抑制剂５６个残基的空间位置。与已报道的三方晶体结构相比，其中的抑制剂分子的结构基本相同，并且抑制剂－酶三元复合物在四方晶体中也处于堆积无序状态，即复合物按两种取向进行堆积：Ｔａ∶ＭａＭｂ∶Ｔｂ和Ｔｂ∶ＭｂＭａ∶Ｔａ（Ｔａ，Ｔｂ为胰蛋白酶，Ｍａ为抑制剂结合环Ⅰ，Ｍｂ为抑制剂结合环Ⅱ）。但四方晶体结构比三方晶体结构多测定了一个抑制剂残基Ｐｒｏ１１的位置，同时，四方晶体中的抑制剂不存在膺β－折叠片层结构，其构象与三方晶体中的抑制剂相比有所变化。分析表明抑制剂的两个刚性的结构域之间的连接肽具有一定的柔性，并因此形成不同的晶型。此外，绿豆抑制剂与其他Ｂｏｗｍａｎ－Ｂｉｒｋ抑制剂相比，分子的两个双股的反平行β－折叠片层和抑制活性位点所在的结合环的结构具有很高的保守性

关键词：绿豆胰蛋白酶抑制剂猪胰蛋白酶复合物晶体结构

A monolithic 3D IGZO-RRAM-SRAM-integrated architecture for robust and efficient compute-in-memory enabling equivalent-ideal device metrics

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Science China(Information Sciences) 2025年

作者： Shengzhe YAN Zhaori CONG zi WANG Zhuoyu DAI Zeyu GUO Zhihang qian Xufan LI Xu ZHENG Chuanke CHEN Nianduan LU Chunmeng DOU Guanhua YANG Xiaoxin XU Di GENG Jinshan YUE Lingfei WANG Ling LI Ming LIU Institute of Microelectronics of the Chinese Academy of Sciences University of Chinese Academy of Sciences

Abstract Compute-in-memory (CIM) based on various devices such as static random access memory (SRAM) and resistive random access memory (RRAM) and other emerging devices such as indium-gallium-zinc-oxide (IGZO) transistor, magnetoresistive RAM (MRAM), and ferroelectric RAM (FeRAM) has been explored for better performance and energy efficiency on neural networks applications. However, CIM based on a single-type device suffers a variety of non-ideal metrics to reach the simultaneous optimal accuracy, density, and energy efficiency. This work presents equivalent-ideal CIM (Eq-CIM), a monolithic 3D(M3D) IGZO-RRAM-SRAM integrated architecture for robust and efficient compute-in-memory enabling equivalent-ideal device metrics. To overcome the non-ideality (variation, endurance, temperature, etc.) of the single-type devices, system-technology co-optimization (STCO) is performed. This work highlights the non-ideality-aware functionality breakdown for robust high accuracy and simultaneous high density/efficiency, by utilizing 2T0C IGZO for temporal activation storage, RRAM for high-density weight storage, and SRAM for accurate CIM. Device-to-algorithm variation transfer is applied to analyze the system-level accuracy. We benchmark Eq-CIM architecture on CIFAR-10/ImageNet, with 5.06×storage density and 5.05×/2.45×area/energy efficiency compared with single-type-device-based CIM, and high robustness (<0.27%accuracy loss) from-40℃ to 120℃.

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Prediction of Maximum Section Flattening of Thin-walled Circular Steel Tube in Continuous Rotary Straightening Process

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Journal of Iron and Steel Research International 2016年第8期23卷 745-755页

作者： zi-qian ZHANG School of Mechanical Engineering and Automation Northeastern University

Cross-sectional ovalization of thin-walled circular steel tube because of large plastic bending,also known as the Brazier effect,usually occurs during the initial stage of tube′s continuous rotary straightening *** amount of ovalization,defined as maximal cross section flattening,is an important technical parameter in tube′s straightening process to control tube′s bending deformation and prevent ***,for the lack of special analytical model,the maximal section flattening was determined in accordance with the specified charts developed by experienced operators on the basis of experimental data;thus,it was inevitable that the localized buckling might occur during some actual straightening *** normal strain component formulas were derived based on the thin shell ***,strain energy of thin-walled tube（per unit length）was obtained using the elastic-plastic theory.A rational model for predicting the maximal section flattening of the thin-walled circular steel tube under its straightening process was presented by the principle of minimum potential *** new model was validated by experiments and numerical *** results show that the new model agrees well with the experiments and the numerical simulations with error of less than 10%.This new model was expected to find its potential application in thin-walled steel tube straightening machine design.

关键词： walled Rotary bending buckling length maximal radius localized Prediction rotary

Supervised Vessels Classification Based on Feature Selection

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Journal of Computer Science & Technology 2017年第6期32卷 1222-1230页

作者： Bei-Ji Zou Yao Chen cheng-Zhang Zhu Zai-Liang Chen zi-qian Zhang School of Information Science and Engineering Central South University Changsha 410083 China ‘Mobile Health' Ministry of Education-China Mobile Joint Laboratory Central South University Changsha 410083 China College of Literature and Journalism Central South University Changsha 410083 China

Arterial-venous classification of retinal blood vessels is important for the automatic detection of cardiovascular diseases such as hypertensive retinopathy and stroke. In this paper, we propose an arterial-venous classification （AVC） method, which focuses on feature extraction and selection from vessel centerline pixels. The vessel centerline is extracted after the preprocessing of vessel segmentation and optic disc （OD） localization. Then, a region of interest （ROI） is extracted around OD, and the most efficient features of each centerline pixel in ROI are selected from the local features, grey-level co-occurrence matrix （GLCM） features, and an adaptive local binary patten （A-LBP） feature by using a max-relevance and min-redundancy （mRMR） scheme. Finally, a feature-weighted K-nearest neighbor （FW-KNN） algorithm is used to classify the arterial-venous vessels. The experimental results on the DRIVE database and INSPIRE-AVR database achieve the high accuracy of 88.65% and 88.51% in ROI, respectively.

关键词： fundus image arterial-venous classification adaptive local binary patten(A-LBP) feature selection feature-weighted K-nearest neighbor(FW-KNN)