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Roadmap for rechargeable batteries:present and beyond

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Science China Chemistry 2024年第1期67卷 13-42页

作者： Sen Xin Xu Zhang Lin wang Haijun Yu Xin Chang Yu-ming Zhao Qinghai Meng Pan Xu Chen-zi Zhao Jiahang Chen Huichao Lu Xirui Kong Jiulin wang Kai Chen Gang Huang Xinbo Zhang Yu Su Yao Xiao Shu-Lei Chou Shilin Zhang Zaiping Guo Aobing Du Guanglei Cui Gaojing Yang Qing Zhao Liubing Dong Dong Zhou Feiyu Kang Hu Hong Chunyi Zhi Zhizhang Yuan Xianfeng Li Yifei Mo Yizhou Zhu Dongfang Yu Xincheng Lei Jianxiong Zhao Jiayi wang Dong Su Yu-Guo Guo Qiang Zhang Jun Chen Li-Jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences.Beijing 100049 China Institute of Advanced Battery Materials and Devices Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Key Laboratory of Advanced Functional Materials Ministry of EducationBeijing University of TechnologyBeijing 100124China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of Chemistry and Utilization of Carbon-Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China Department of Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChangchun 130022China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaide 5000Australia Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Frontiers Science Center for New Organic Matter Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China College of Chemistry and Materials Science Jinan UniversityGuangzhou 511443China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Division of Energy Storage Dalian National Laboratory for Clean Energy(DNL)Dalian Institute of Chem

Rechargeable batteries currently hold the largest share of the electrochemical energy storage market,and they play a major role in the sustainable energy transition and industrial decarbonization to respond to global climate *** to the increased popularity of consumer electronics and electric vehicles,lithium-ion batteries have quickly become the most successful rechargeable batteries in the past three decades,yet growing demands in diversified application scenarios call for new types of rechargeable *** efforts are made to developing the next-generation post-Li-ion rechargeable batteries,which include,but are not limited to solid-state batteries,lithium–sulfur batteries,sodium-/potassium-ion batteries,organic batteries,magnesium-/zinc-ion batteries,aqueous batteries and flow *** the great achievements,challenges persist in precise understandings about the electrochemical reaction and charge transfer process,and optimal design of key materials and interfaces in a *** roadmap tends to provide an overview about the current research progress,key challenges and future prospects of various types of rechargeable *** computational methods for materials development,and characterization techniques will also be discussed as they play an important role in battery research.

关键词： energy storage rechargeable batteries battery materials electrochemistry

Potential efficacy and mechanism of medicinal plants on chronic kidney disease-associated vascular calcification:a review

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Traditional Medicine Research 2024年第9期9卷 21-31页

作者： Han-Qing Zhang Shuang Wu Xin Chen Ya-Xuan Fang Qiu-Mei Lan zi-Jun Zhou Yan-Heng Qiao Jie Li Yan-Ru Zhao ming Pei Bo Yang Department of Nephropathy First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China

Vascular calcification is a crucial risk factor that affects the incidence and mortality of cardiovascular disease in chronic kidney disease *** medicine relies on calcium-phosphorus binding agents,calcium mimetics,active vitamin D,and hemodialysis to prevent and treat vascular calcification,however,their efficacy is unsatisfactory and adverse reactions often *** plant therapy can act as an integrative regulator in patients with chronic kidney disease-associated vascular calcification,which can significantly improve patients’symptoms,but its specific mechanism has not been fully elucidated *** this paper,we reviewed the domestic and international theoretical studies on the pathogenesis mechanism of chronic kidney disease-associated vascular calcification in recent years,summarized eight active ingredients of medicinal plants as well as four compound formulas for improving chronic kidney disease-associated vascular calcification,and explored the mechanism of action of herbal medicine,which will provide a new strategy for promoting the prevention and treatment of vascular calcification.

关键词： chronic kidney disease chronic kidney disease-mineral and bone disorder(CKD-MBD) vascular calcification medicinal plants herbal monomers

Deep learning framework for comprehensive molecular and prognostic stratifications of triple-negative breast cancer

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Fundamental Research 2024年第3期4卷 678-689页

作者： Shen Zhao Chao-Yang Yan Hong Lv Jing-Cheng Yang Chao You zi-Ang Li Ding Ma Yi Xiao Jia Hu Wen-Tao Yang Yi-Zhou Jiang Jun Xu Zhi-ming Shao Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghai 200032China Institute for AI in Medicine School of Artificial IntelligenceNanjing University of Information Science and TechnologyNanjing 210044China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China Greater Bay Area Institute of Precision Medicine Guangzhou 511466China Department of Radiology Fudan University Shanghai Cancer CenterShanghai 200032China

Triple-negative breast cancer(TNBC)is the most challenging breast cancer *** stratification and target therapy bring clinical benefit for TNBC patients,but it is difficult to implement comprehensive molecular testing in clinical ***,using our multi-omics TNBC cohort(N=425),a deep learning-based framework was devised and validated for comprehensive predictions of molecular features,subtypes and prognosis from pathological whole slide *** framework first incorporated a neural network to decompose the tissue on WSIs,followed by a second one which was trained based on certain tissue types for predicting different ***-omics molecular features were analyzed including somatic mutations,copy number alterations,germline mutations,biological pathway activities,metabolomics features and immunotherapy *** was shown that the molecular features with therapeutic implications can be predicted including the somatic PIK3CA mutation,germline BRCA2 mutation and PD-L1 protein expression(area under the curve[AUC]:0.78,0.79 and 0.74 respectively).The molecular subtypes of TNBC can be identified(AUC:0.84,0.85,0.93 and 0.73 for the basal-like immune-suppressed,immunomodulatory,luminal androgen receptor,and mesenchymal-like subtypes respectively)and their distinctive morphological patterns were revealed,which provided novel insights into the heterogeneity of TNBC.A neural network integrating image features and clinical covariates stratified patients into groups with different survival outcomes(log-rank P<0.001).Our prediction framework and neural network models were externally validated on the TNBC cases from TCGA(N=143)and appeared robust to the changes in patient *** potential clinical translation,we built a novel online platform,where we modularized and deployed our framework along with the validated *** can realize real-time one-stop prediction for new *** summary,using only pathological WSIs,our proposed framework

关键词： Triple-negative breast cancer Deep learning Digital pathology Patient stratification Online platform

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甲基苯丙胺成瘾的表观遗传学机制

生物化学与生物物理进展 2024年第4期51卷 873-880页

作者：刘明鑫司紫珍刘昱宁波大学医学部宁波315211

苯丙胺类兴奋剂是全世界第二大滥用程度的药物,甲基苯丙胺作为苯胺类兴奋剂中的主要药物,是中国滥用的“头号毒品”。而现有的研究对甲基苯丙胺成瘾机制尚不清晰,且临床上对药物成瘾的治疗依然存在无药可医的局面。因此,发现新的成瘾机... 详细信息

苯丙胺类兴奋剂是全世界第二大滥用程度的药物,甲基苯丙胺作为苯胺类兴奋剂中的主要药物,是中国滥用的“头号毒品”。而现有的研究对甲基苯丙胺成瘾机制尚不清晰,且临床上对药物成瘾的治疗依然存在无药可医的局面。因此,发现新的成瘾机制和治疗策略尤为迫切。甲基苯丙胺成瘾与额前叶皮质(mPFC)、中脑腹侧被盖区(VTA)和伏隔核(NAc)中的多巴胺(DA)、谷氨酸(Glu)、去甲肾上腺素(NE)和血清素(SNRIS)等神经递质的异常释放有关。研究表明,这些神经递质受到表观遗传机制中组蛋白乙酰化、甲基化、泛素化和非编码RNA等调节,某些基因的表达在甲基苯丙胺的诱导过程中增强或被抑制,导致甲基苯丙胺依赖性产生。本文将针对表观遗传学对甲基苯丙胺成瘾机制的影响进行着重论述,以期推进临床开发甲基苯丙胺戒断药物的研究。

关键词：甲基苯丙胺表观遗传学组蛋白修饰非编码RNA

苦参碱抑制人肾癌细胞系GRC-1细胞株增殖和促凋亡的实验研究

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中西医结合学报 2006年第4期4卷 388-391页

作者：种铁牛建强王子明佘军军黄晨西安交通大学第二医院泌尿外科陕西西安710004 西安交通大学环境与疾病相关基因教育部重点实验室陕西西安710061

目的观察苦参碱对体外人肾癌细胞系GRC-1细胞株增殖及细胞凋亡的影响,探讨苦参碱诱导GRC-1细胞株凋亡的作用机制。方法应用不同浓度的苦参碱分别作用于人肾癌细胞系GRC-1细胞株24、48、72、96h。采用MTT法观察苦参碱对GRC-1细胞株的细... 详细信息

目的观察苦参碱对体外人肾癌细胞系GRC-1细胞株增殖及细胞凋亡的影响,探讨苦参碱诱导GRC-1细胞株凋亡的作用机制。方法应用不同浓度的苦参碱分别作用于人肾癌细胞系GRC-1细胞株24、48、72、96h。采用MTT法观察苦参碱对GRC-1细胞株的细胞毒作用;透射电镜和流式细胞术观察、检测苦参碱诱导的细胞凋亡;免疫细胞化学技术检测苦参碱对GRC-1细胞株Bcl-2、Bax蛋白表达的影响。结果不同浓度的苦参碱对GRC-1细胞株均有一定的增殖抑制作用,且呈量效和时效关系。苦参碱能明显诱导GRC-1细胞株凋亡。经苦参碱作用后,GRC-1细胞株Bcl-2蛋白表达明显减弱而Bax蛋白表达明显增强。结论苦参碱对体外人肾癌细胞系GRC-1细胞株有一定的增殖抑制作用,其机制可能与调节Bcl-2/Bax蛋白表达比值以诱导细胞凋亡相关。

关键词：苦参碱肾肿瘤细胞凋亡

不同改良剂对酸性紫色土团聚体和有机碳的影响

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环境科学 2024年第2期45卷 974-982页

作者：李越徐曼谢永红王颖黄容谢军王子芳高明西南大学资源环境学院重庆400715 重庆农科院果树所重庆401329 重庆市规划与自然资源局重庆401147 四川农业大学资源学院成都611130

研究不同改良剂对酸性紫色土团聚体和有机碳变化特征的影响,为酸性紫色土修复提供科学依据.以紫色土为研究对象,设置不施肥(CK)、单施化肥(F)、化肥配施石灰(SF)、化肥配施有机肥(OM)、化肥配施生物炭(BF)和化肥配施酒糟灰渣(JZ)共6个处... 详细信息

研究不同改良剂对酸性紫色土团聚体和有机碳变化特征的影响,为酸性紫色土修复提供科学依据.以紫色土为研究对象,设置不施肥(CK)、单施化肥(F)、化肥配施石灰(SF)、化肥配施有机肥(OM)、化肥配施生物炭(BF)和化肥配施酒糟灰渣(JZ)共6个处理.比较不同改良剂施用下酸性紫色土的团聚体组成情况,以及各粒级团聚体有机碳分布规律,结合团聚体稳定性指标,明确不同改良剂对酸化紫色土团聚体结构的影响.结果表明,施肥处理均显著提高土壤pH,以JZ处理效果最显著,施肥均显著提高土壤有机质含量,以OM处理效果最好,BF和OM处理显著降低土壤容重,同时SF和BF处理显著提高土壤含水率(P0.25 mm的团聚状结构单位)的含量,同时施肥处理均显著提高了土壤几何平均直径(GMD)、平均重量直径(MWD)和R_(0.25)值(>0.25 mm团聚体含量),降低分形维数(D)和团聚体破坏率(PAD)值(P<0.05),促进了土壤团聚体的团聚化和稳定性,以OM处理效果最好;与CK处理相比,施肥能显著提高土壤有机碳含量31.71%~209.67%,其中以OM处理最显著;不同处理土壤有机碳主要分布在大团聚体中,与CK处理相比,各处理显著提高大团聚体中有机碳贡献率为19.34%~47.76%,其中OM处理效果最为显著(P<0.05).综合来看,化肥配施有机肥能促进酸性紫色土大团聚体的形成,提高土壤团聚体稳定性,增加土壤有机碳含量,是改善酸性紫色土土壤结构和提升土壤质量的有效措施.

关键词：改良剂紫色土土壤酸化土壤团聚体土壤有机碳

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增质提量:城镇化推进与迁移人口人力资本

山西财经大学学报 2024年第2期46卷 1-15页

作者：吕洋高子茗南开大学经济学院天津300071

针对现阶段中国人口流动过程中出现的由迁移规模快速增长向素质结构调整转变这一现象,从城镇化推进角度作出解释。首先构建理论模型,阐述城市扩张通过影响迁移摩擦和就业市场技能溢价从而影响迁移人口人力资本投资的作用机制,之后从城... 详细信息

针对现阶段中国人口流动过程中出现的由迁移规模快速增长向素质结构调整转变这一现象,从城镇化推进角度作出解释。首先构建理论模型,阐述城市扩张通过影响迁移摩擦和就业市场技能溢价从而影响迁移人口人力资本投资的作用机制,之后从城乡接合部土地出让视角刻画区县层面的城镇化水平,并匹配CHIP数据展开实证分析。结果显示,随着各地城乡接合部土地出让总量的提高,迁移人口的人力资本水平呈现“U型”变化,迁移摩擦消减和技能溢价先减后增为其主要驱动。研究结论可为进一步理解中国城市迁移人口的现有演变特征以及研判未来变化趋势提供一定帮助。

关键词：迁移人口城镇化推进人力资本迁移摩擦技能溢价

A retrospective study of occlusal reconstruction in patients with old jaw fractures and dentition defects

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Chinese Journal of Traumatology 2024年第5期27卷 272-278页

作者： ming-Chao Ding Bo-Ya Jing Jin Shi Liu Yang Xiang-Dong Liu Jing-Fu wang Shuang Qu Jia-Wu Liang zi-Hao Tang Jin-Long Zhao Lei Tian State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Clinical Research Center for OralDiseasesDepartment of Oral and MaxillofacialSchool of StomatologyThe Fourth Military Medical UniversityXi'an710032China Department of Maxillofacial Trauma and Orthognathic Surgery The Third Affiliated HospitalThe Air Force Military Medical UniversityXi'an710038China Department of Stomatology 941th Hospital of People's Liberation Army Joint Logistic Support ForceXining810000China

Purpose:This study evaluated the methods and clinical effects of multidisciplinary collaborative treatment for occlusal reconstruction in patients with old jaw fractures and dentition ***:Patients with old jaw fractures and dentition defects who underwent occlusal reconstruction at the Third Affiliated Hospital of Air Force Military Medical University from January 2018 to December 2022 were *** treatment was classified into 3 *** phase I,techniques such as orthognathic surgery,microsurgery,and distraction osteogenesis were employed to reconstruct the correct 3-dimensional(3D)jaw position *** phase II,bone augmentation and soft tissue management techniques were utilized to address insufficient alveolar bone mass and poor gingival soft tissue *** phase III,implant-supported overdentures or fixed dentures were used for occlusal reconstruction.A summary of treatment methods,clinical efficacy evaluation,comparative analysis of imageological examinations,and satisfaction questionnaire survey were utilized to evaluate the therapeutic efficacy in patients with traumatic old jaw fractures and dentition *** data are summarized using the arithmetic mean±standard deviation and compared using independent ***:In 15 patients with old jaw fractures and dentition defects(an average age of 32 years,ranging from 18 to 53 years),there were 7 cases of malocclusion of single maxillary fracture,6 of malocclusion of single mandible fracture,and 2 of malocclusion of both maxillary and mandible *** were 5 patients with single maxillary dentition defects,2 with single mandibular dentition defects,and 8 with both maxillary and mandibular dentition *** reconstruct the correct 3D jaw positional relationship,5 patients underwent Le Fort I osteotomy of the maxilla,3 underwent bilateral sagittal split ramus osteotomy of the mandible,4 underwent open reduction and internal fixation for old jaw fracture

关键词： Old jaw fractures Malocclusion Occlusal reconstruction Dental implant prosthesis

Study on the regulatory effect of liver X receptor in HEK293 cells by six main diterpene esters in Semen Euphorbiae

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TMR Modern Herbal Medicine 2024年第2期7卷 35-40页

作者： Si-Yuan Ma Fan-Miao Kong Xiao-Tong Wei Jun-Li Zhang Hai-Ting Zhu Xin-Ning Zhang Yu-Feng Hu ming-Rui Jiang Hui-Nan wang Yi-Cen Xu Ying-zi wang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China

Background:To study the effects of the main diterpene esters in Euphorbia factor L_(1),L_(2),L_(3),L_(7a),L_(7b)and L_(8)on the transcriptional activity and protein expression of liver X receptor(LXR).Methods:The effect of the main diterpene ester components in Semen Euphorbiae on the viability of HEK293 cells were studied by MTT *** LXR-Luc plasmid vector was transfected into HEK293 cells and treated with Euphorbia factor L_(1),L_(2),L_(3),L_(7a),L_(7b)and L_(8)for 24 *** effect of the main diterpene ester components of Semen Euphorbiae on LXR-Luc luciferase activity was investigated by dual luciferase reporter gene system,and the expression of LXRαprotein was detected by Western ***:Euphorbia factor L_(1),L_(2),L_(3),L_(7a),L_(7b)and L_(8)could significantly reduce the relative luciferase activity(RLU)of LXRα,and the expression level of LXRαprotein was significantly ***:Euphorbia factor L_(1),L_(2),L_(3),L_(7a),L_(7b)and L_(8)can inhibit the expression of LXR protein level,which may be achieved by inhibiting the transcriptional activity of LXR.

关键词： Semen Euphorbiae diterpene esters HEK293 LXR dual luciferase reporter gene system