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Contrast-enhanced ultrasound manifestations of synchronous combined hepatocellular-cholangiocarcinoma and hepatocellular carcinoma:A case report

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World Journal of Clinical Cases 2022年第11期10卷 3615-3623页

作者： Ling Gao Jia-Yan Huang zi-jian lu Qiang lu Department of Ultrasound West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Ultrasound Chengdu BOE hospitalChengdu 610219Sichuan ProvinceChina Department of Pathology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Synchronous combined hepatocellular-cholangiocarcinoma(CHC)and hepatocellular carcinoma(HCC)is very rare,with few literature reports and poor clinical outcomes associated with the *** resection is the main treatment,which makes the preoperative diagnosis very ***,due to imaging manifestations overlapping with HCC,diagnosis of this type of synchronous cancer is challenging and it tends to be misdiagnosed as multiple ***,we report the contrast-enhanced ultrasound(CEUS)manifestations of a case of synchronous CHC and HCC,aiming at adding to the understanding of this *** displayed exquisite vascularity and tissue perfusion in real time with good spatial and temporal resolution and more accurately reflect tumor washin and washout times than contrast-enhanced computed tomography(CT)in this *** SUMMARY The patient was a 69-year-old female with a 20-year history of chronic hepatitis *** to months of epigastric pain and anorexia,she reffered to our hospital for *** days before hospitalization,abdominal magnetic resonance imaging performed at another hospital detected a space-occupying lesion in the *** her hospitalization,laboratory tests showed elevated alpha-fetoprotein and carbohydrate antigen 19-9 *** suspicious liver lesions located in S4 and S6,respectively,were identified in a cirrhotic background by abdominal contrast-enhanced CT(CECT).Furthermore,the lesion in S4 and S6 were detected by CEUS and assigned to CEUS LI-RADS 5 and M categories,*** patient underwent tumor radical ***-operative pathology confirmed the S4 and S6 lesions to be HCC and CHC,respectively.A newly-found suspicious liver nodule with potential malignancy was detected in liver S1 by both CEUS and CECT 7 mo after *** The CEUS characteristics of CHC and HCC are *** features in combination with clinical information could help in effective diagnosis,clinical decisio

关键词： Contrast-enhanced ultrasound Synchronous dual primary malignancies of liver Combined hepatocellular and cholangiocarcinoma Hepatocellular carcinoma Case report

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基于UHPLC-LTQ/Orbitrap MS法的苦荬菜内酯Z和11,13α-二氢苦荬菜内酯Z的大鼠肝微粒体体外代谢产物鉴定

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质谱学报 2018年第3期39卷 257-267页

作者：张秀平蔡伟姚泓张加余王子健卢建秋刘颖北京中医药大学中药学院北京100102 湖南医药学院侗医药研究湖南省重点实验室湖南怀化418000 北京中医药大学中医药研究院北京100029 北京中医药大学图书馆北京100029

苦荬菜内酯Z和11,13α-二氢苦荬菜内酯Z是苦碟子(Ixeris sonchifolia(Bunge)Hance)中2种重要的倍半萜内酯类成分。为研究它们在大鼠肝微粒体中的代谢产物,采用Waters Acquity UPLC BEH C18色谱柱(2.1mm×50mm×1.7μm)分离,以0.1%甲酸水... 详细信息

苦荬菜内酯Z和11,13α-二氢苦荬菜内酯Z是苦碟子(Ixeris sonchifolia(Bunge)Hance)中2种重要的倍半萜内酯类成分。为研究它们在大鼠肝微粒体中的代谢产物,采用Waters Acquity UPLC BEH C18色谱柱(2.1mm×50mm×1.7μm)分离,以0.1%甲酸水(A)-乙腈(B)为流动相进行梯度洗脱,采用高效液相色谱-线性离子阱静电轨道场质谱(UHPLC-LTQ/Orbitrap MS)技术,在ESI负离子模式下分析样品。筛选出18个化合物(包括苦荬菜内酯Z和11,13α-二氢苦荬菜内酯Z,及其16个代谢产物),并对其中15个代谢产物进行结构鉴定。结果表明,苦荬菜内酯Z和11,13α-二氢苦荬菜内酯Z经大鼠肝微粒体主要发生了羟基化、加氢和脱氢的Ⅰ相代谢反应。该结果初步阐明了苦荬菜内酯Z和11,13α-二氢苦荬菜内酯Z在大鼠肝微粒体中的代谢规律,可为新药、毒理学研究提供支持。

关键词：苦荬菜内酯Z 11,13-二氢苦荬菜内酯Z 大鼠肝微粒体高效液相色谱-线性离子阱静电轨道场质谱(UHPLC-LTQ/OrbitapMS) 代谢产物

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甜菜碱对蛋鸡蛋品质影响及机理研究

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畜牧兽医学报 2001年第5期32卷 397-402页

作者：许梓荣卢建军邹晓庭浙江大学饲料科学研究所杭州310029

选 2 0周龄伊莎蛋鸡 80 0羽 ,随机分成 2组 (每组设 4个重复 ,每个重复 10 0羽 ) ,一组为对照组 ;另一组为 60 0mg/kg甜菜碱组。分别在 5 0、70周龄时测定蛋品质、血清有关生化指标、蛋壳腺磷脂组分含量。结果表明 :添加甜菜碱使蛋鸡日... 详细信息

选 2 0周龄伊莎蛋鸡 80 0羽 ,随机分成 2组 (每组设 4个重复 ,每个重复 10 0羽 ) ,一组为对照组 ;另一组为 60 0mg/kg甜菜碱组。分别在 5 0、70周龄时测定蛋品质、血清有关生化指标、蛋壳腺磷脂组分含量。结果表明 :添加甜菜碱使蛋鸡日平均产蛋率提高 12 33% (P <0 0 1)。料蛋比降低 9 92 % (P <0 0 5 )。使 5 0周龄和 70周龄蛋壳厚度分别增加了 2 5 % (P <0 0 8)和 10 81%(P <0 0 5 ) ,蛋壳相对重提高 6 69% (P <0 0 5 )和 6 94 % (P <0 0 5 ) ;蛋黄指数、哈夫单位有提高趋势。使 70周龄蛋鸡蛋壳腺中卵磷脂 (PC)含量提高了 16 2 8% (P <0 0 1) ,PC/PE比值提高了2 2 60 % (P <0 0 3) ,对脑磷脂 (PE)含量无明显影响。 5 0周龄和 70周龄蛋鸡血清中卵磷脂浓度分别提高 33 4 6% (P <0 0 1)和 2 2 4 2 % (P <0 0 1) ;而对血清中Ca、P含量无明显影响。 5 0周龄和70周龄蛋鸡血清及肝中甜菜碱含量与对照组相比均无明显差异。

关键词：蛋鸡甜菜碱蛋品质饲料添加剂生产性能

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Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li jian Xiang lu Qiu Xiaohan Chen Yinkun Zhao Yujue Wang Qu Yue Taotao Gao Wenlong Liu Dan Xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AziBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AziBs.

关键词： Solvation

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Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao Hao zi-jian Wang Xiu-Liang Xu jiang-Hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： jian Yang jiang Wu Xueshun Xie Pengfei Xia Jinxin lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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Fluidization characteristics of different sizes of quartz particles in the fluidized bed

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Petroleum Science 2016年第3期13卷 584-591页

作者： zi-jian Wang Jun Tang Chun-Xi lu State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)

Fluidization characteristics of quartz particles with different sizes are experimentally investigated in a fluidized bed with an inner diameter of 300 mm and height of 8250 *** show that the average solid holdup increases with the increase in superficial gas velocity and the decrease in initial solid holdup in the dense zone of the fluidized *** average cross-sectional solid holdup decreases with increasing bed height and superficial gas *** bed expansion coefficient increases with the increase in superficial gas velocity and the decrease in solid *** of average solid holdup,average cross-sectional solid holdup and bed expansion coefficient are also established and *** correlations can provide guidelines for better understanding of the fluidization characteristics.

关键词： Fluidization characteristic Solid holdup Axial average section solid holdup Bed expansion coefficient

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Intelligent geochemical interpretation of mass chromatograms:Based on convolution neural network

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Petroleum Science 2024年第2期21卷 752-764页

作者： Kai-Ming Su Jun-Gang lu jian Yu zi-Xing lu Shi-Jia Chen Hubei Key Laboratory of Petroleum Geochemistry and Environment Wuhan430100HubeiChina College of Resources and Environment Yangtze UniversityWuhan430100HubeiChina School of Geoscience and Technology Southwest Petroleum UniversityChengdu610500SichuanChina Changqing Oilfield Company PetroChinaXi'an710021ShaanxiChina

Gas chromatography-mass spectrometry(GC-MS)is an extremely important analytical technique that is widely used in organic *** is the only approach to capture biomarker features of organic matter and provides the key evidence for oil-source correlation and thermal maturity ***,the conventional way of processing and interpreting the mass chromatogram is both timeconsuming and labor-intensive,which increases the research cost and restrains extensive applications of this *** overcome this limitation,a correlation model is developed based on the convolution neural network(CNN)to link the mass chromatogram and biomarker features of samples from the Triassic Yanchang Formation,Ordos Basin,*** this way,the mass chromatogram can be automatically *** research first performs dimensionality reduction for 15 biomarker parameters via the factor analysis and then quantifies the biomarker features using two indexes(*** and PMI)that represent the organic matter thermal maturity and parent material type,***,training,interpretation,and validation are performed multiple times using different CNN models to optimize the model structure and hyper-parameter setting,with the mass chromatogram used as the input and the obtained MI and PMI values for supervision(label).The optimized model presents high accuracy in automatically interpreting the mass chromatogram,with R2values typically above 0.85 and0.80 for the thermal maturity and parent material interpretation results,*** significance of this research is twofold:(i)developing an efficient technique for geochemical research;(ii)more importantly,demonstrating the potential of artificial intelligence in organic geochemistry and providing vital references for future related studies.

关键词： Organic geochemistry Biomarker Mass chromatographic analysis Automated interpretation Convolution neural network Machine learning

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Effect of in-situ nanoparticles on the mechanical properties and hydrogen embrittlement of high-strength steel

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International Journal of Minerals,Metallurgy and Materials 2021年第4期28卷 644-656页

作者： Rong-jian Shi zi-dong Wang Li-jie Qiao Xiao-lu Pang Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Corrosion and Protection Center University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

We investigated the critical influence of in-situ nanoparticles on the mechanical properties and hydrogen embrittlement(HE)of high-strength *** results reveal that the mechanical strength and elongation of quenched and tempered steel(919 MPa yield strength,17.11%elongation)are greater than those of hot-rolled steel(690 MPa yield strength,16.81%elongation)due to the strengthening effect of insitu Ti_(3)O_(5)–Nb(C,N)*** addition,the HE susceptibility is substantially mitigated to 55.52%,approximately 30%lower than that of steels without in-situ nanoparticles(84.04%),which we attribute to the heterogeneous nucleation of the Ti_(3)O_5 nanoparticles increasing the density of the *** with hard TiN inclusions,the spherical and soft Al_(2)O_(3)–MnS core–shell inclusions that nucleate on in-situ Al_(2)O_(3) particles could also suppress ***-situ nanoparticles generated by the regional trace-element supply have strong potential for the development of high-strength and hydrogen-resistant steels.

关键词： in-situ nanoparticles hydrogen embrittlement high-strength steel mechanical properties microstructure

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