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Impact of the cold surge event in January 2021 on the power system of China

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Advances in Climate Change Research 2022年第6期13卷 803-810页

作者： Chang-Yi LIU Bo LU Lu JIN Hao CHEN Jie WU Yang XIANG Zhi-Yuan MA zi-jian zhao Fang YANG Qing LIU jiang-Tao LI Global Energy Interconnection Development and Cooperation Organization(GEIDCO) Beijing 100031China National Climate Centre China Meteorological AdministrationBeijing 100081China Renmin University of Chin1 Beijing 100872China State Grid Energy Research Institute Co. Ltd.Beijing 102211China

During 6-10 January 2021,a recorded strong cold surge took place in China,with over 800 observational stations reaching their historical *** previous studies that focused on the response of either the power load or generation separately,this study quantitatively revealed the impacts on the balance between the demand and supply sides of the *** the demand side,the sensitivity of power load was found to increase substantially higher in southern China(0.533 GW°C^(−1))than in the northern region(0.139 GW°C^(−1))due to the limited municipal heating *** the supply side,the hourly wind power generation dropped from the highest of 110 GW on 6 January to the lowest of 54 GW on 9 January due to the reduction in wind *** addition,a reduction in solar power generation was observed during 8-10 ***,the balance of the power system was influenced by this cold *** an effective adaptation measure,results further showed that early warning by three weeks ahead can be obtained by an operational climate *** sensitivity of China's power system to such cold surge events may increase remarkably due to the expected increase in the proportion of wind and solar power generation in future new-type power ***,close cooperation between climate scientists and power engineers is needed to build the resilience of the power system to the cold extremes.

关键词： Cold surge event Power load Renewable power generation Sub-seasonal prediction Adaptation

Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications

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World Journal of Diabetes 2024年第10期15卷 2041-2057页

作者： Ming-Wei Fan Jin-Lan Tian Tan Chen Can Zhang Xin-Ru Liu zi-jian zhao Shu-Hui Zhang Yan Chen Department of Gastroenterology Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina

Diabetes mellitus(DM)is one of the major causes of mortality worldwide,with inflammation being an important factor in its onset and *** review summarizes the specific mechanisms of the cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon genes(STING)pathway in mediating inflammatory ***,it compre-hensively presents related research progress and the subsequent involvement of this pathway in the pathogenesis of early-stage DM,diabetic gastroenteropathy,diabetic cardiomyopathy,non-alcoholic fatty liver disease,and other ***,the role of cGAS-STING in autonomic dysfunction and intes-tinal dysregulation,which can lead to digestive complications,has been ***,this study provides a comprehensive analysis of the research advances regarding the cGAS-STING pathway-targeted therapeutic agents and the prospects for their application in the precision treatment of DM.

关键词： Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes Diabetes mellitus Inflammation Glycolipid metabolism Diabetes gastroenteropathy Nonalcoholic fatty liver disease Diabetes cardiovascular disease Diabetes nephropathy

Design of Power Supply for On-line Monitoring System of Transmission Lines

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Energy and Power Engineering 2013年第4期5卷 570-574页

作者： Kai Chen zi-jian zhao Yu-ning Zhang Yang-chun Cheng Yuan Dai Guangdong Power Test & Research Institution Guangzhou Guangdong Province China State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources Beijing Key Laboratory of High Voltage and EMC North China Electric Power University Beijing China State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources Beijing Key Laboratory of High Voltage and EMC North China Electric Power University Beijing ChinaState Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources Beijing Key Laboratory of High Voltage and EMC North China Electric Power University Beijing China

This paper uses CT to gain the energy directly from the high-voltage transmission line, to address the problem of power supply for monitoring system in high voltage side of transmission line. The draw-out power coil can induce voltage from the transmission line, using single-chip microcomputer to analog and output PMW wave to control the charging module, provides a stable 3.4 V DC voltage to the load, and solve the problem of easy saturating of core. The power supply based on this kind of draw-out power coil has undergone the overall testing, and it is verified-showing that it can properly work in a non-saturated status within the current range of 50 - 1000 A, and provide a stable output. The equipment also design protection circuit to improve the reliability to avid the impacts of the impulse current or short-circuit current. It effectively solves the problem of power supply for On-line Monitoring System of Transmission.

关键词： Monitoring System Power Supply of High-voltage Transmission Line Draw-out Power Coil Single-chip Microcomputer

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肺损伤性毒剂的实验研究进展

国际药学研究杂志 2017年第6期44卷 527-530,543页

作者：李子轲赵建丁日高军事医学科学院毒物药物研究所抗毒药物与毒理学国家重点实验室北京100850 武警黄金指挥部门诊部北京100045

肺损伤性毒剂,也称肺刺激剂和窒息性毒剂,作用靶器官主要是肺,可引起潜在持久的呼吸抑制,并可迅速发展为急性肺损伤(ALI)、肺水肿,严重者将导致死亡。近年来,随着对其作用机制研究的深入,开展了不少针对性的实验研究,并取得了一定的进... 详细信息

肺损伤性毒剂,也称肺刺激剂和窒息性毒剂,作用靶器官主要是肺,可引起潜在持久的呼吸抑制,并可迅速发展为急性肺损伤(ALI)、肺水肿,严重者将导致死亡。近年来,随着对其作用机制研究的深入,开展了不少针对性的实验研究,并取得了一定的进展。本文从肺损伤性毒剂研究概况、致病机制、生物标志物等3个方面综述了近年来肺损伤性毒剂实验研究的相关进展,为推动中毒性ALI的预防、诊断和临床治疗提供参考借鉴。

关键词：肺损伤性毒剂光气急性肺损伤致病机制生物标志物

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

科技进步对经济增长贡献率的测算与分析——基于甘肃省1995年—2015年数据

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河北地质大学学报 2018年第4期41卷 83-88页

作者：曹子坚赵敏兰州大学经济学院甘肃兰州730000

对科技贡献率的准确测算,是明确区域经济增长源泉、制定科技政策的基本前提。文章利用甘肃省1995年—2015年间的相关数据,采用基于柯布-道格拉斯生产函数的索洛余值法以及灰色关联度分析法,对甘肃省科技进步贡献率进行了测算与分析,并... 详细信息

对科技贡献率的准确测算,是明确区域经济增长源泉、制定科技政策的基本前提。文章利用甘肃省1995年—2015年间的相关数据,采用基于柯布-道格拉斯生产函数的索洛余值法以及灰色关联度分析法,对甘肃省科技进步贡献率进行了测算与分析,并探究了影响甘肃省经济增长的相关因素。结合判断结果,资金投入对经济增长的贡献率最大,推动甘肃省经济增长的主要因素仍在于资本因素;其次是科技进步贡献率,呈现波动性变化;劳动投入贡献率最低,长期低位徘徊。依据判断结果,文章提出了促进甘肃省科技进步的相关政策建议。

关键词：科技贡献率索洛余值法灰色关联度分析法

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan zhao Yidan Zhang Xin Liu jian Zhang Ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang jian Wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li jian Xiang Lu Qiu Xiaohan Chen Yinkun zhao Yujue Wang Qu Yue Taotao Gao Wenlong Liu Dan Xiao zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AziBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AziBs.

关键词： Solvation