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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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双色荧光辐射差分超分辨显微系统研究

中国光学 2018年第3期11卷 329-336页

作者：张智敏匡翠方王子昂朱大钊陈友华李传康刘文杰刘旭浙江大学光电科学与工程学院浙江杭州310058

为了拓展荧光辐射差分(Fluorescence Emission Difference,FED)显微术的应用,使得该方法可以同时对生物样品的不同组织结构进行超分辨成像,本文对双色FED显微系统展开了研究。FED的基本原理是将实心光斑扫描得到的共焦显微图像减去空心... 详细信息

为了拓展荧光辐射差分(Fluorescence Emission Difference,FED)显微术的应用,使得该方法可以同时对生物样品的不同组织结构进行超分辨成像,本文对双色FED显微系统展开了研究。FED的基本原理是将实心光斑扫描得到的共焦显微图像减去空心光斑扫描得到的负共焦图像,以此获得超分辨显微图像。在对单色FED显微系统进行研究后,本文提出了一种可行的双色FED显微成像系统方案。实验结果表明,在488 nm和640 nm激发光下,该系统在荧光颗粒上分别实现了135 nm和160 nm的空间分辨率,另外也能对生物样品的不同组织进行多色同时超分辨显微成像,满足了实际应用的要求。

关键词：光学显微衍射极限荧光荧光辐射差分超分辨

Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

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Nano Research 2025年第1期18卷 443-454页

作者： Wei Wang zi-Qing Chen Yong-Qi Li Yu-Long Wang Mei-Chen Liu Yun-Bo Ruan Yang Zhang Shu-Juan Liu Qiang zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe Jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation Medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVLIG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVLIG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVLIG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric

Research on Decision-Making for End Around Taxiway Usage Based on Control Decision Area

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： zi'ang Chen Zheng zhao College of Civil Aviation， Nanjing University of Aeronautics and Astronautics

Many airports with Closely Spaced Parallel Runways (CSPR) have constructed end-around taxiways (EATs) to reduce the risk of runway incursions. However， the prevalent taxi-around operation， preferred for safety， increases taxi-in time. To improve efficiency and increase arrival crossings， we propose a strategy using Shanghai Hongqiao Airport as a case study， incorporating runway status lights (RWSLs). The strategy has two stages: First， we expand the RWSL monitoring area based on the time required for arrivals to cross the runway without impediment. Second， during the tactical stage， the decision to taxi around or cross directly is based on the illumination of Runway Entry Lights (RELs). We developed a model for the arrival crossing and taxi-around process， integrating it with the AirTOP simulation software to determine key node timings. These timings are input into our model to simulate airport operations. The initial stage's monitoring area size is influenced by the uncertainty of taxiing speed. To address this， we introduce a chance-constrained programming (CCP) model， generating scenarios based on taxiing speed distribution. To explore the relationship between conservatism in the area and operational efficiency， we established six scenarios. Simulations using historical data from Shanghai Hongqiao Airport show that our strategy reduces taxi-in time by at least 20 seconds (6.7%)， increases runway crossings by at least 17%， and maintains low additional taxi-in time and taxiing waits compared to a full taxi-around strategy.

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In-situ cation exchange enhances room temperature phosphorescence of a family of metal-organic frameworks

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Science China Chemistry 2022年第1期65卷 128-134页

作者： Rui Feng zi-Ying Li zhao-Quan Yao zi-ang Guo Yi-Nan Zhang Hao-Xiang Sun Wei Li Xian-He Bu College of Chemistry State Key Laboratory of Elemento-Organic ChemistryNankai UniversityTianjin 300071China School of Materials Science and Engineering Tianjin Key Laboratory of Metal and Molecule-Based Material ChemistryNankai UniversityTianjin 300350China

The rational designability and chemical tunability of metal-organic frameworks(MOFs)are enabling tributes to efficaciously enhance their room temperature phosphorescence(RTP)performance.A family of stable anionic MOFs,[Zn_(2)(4,5-ImDC)_(2)]M_(2)(NKU-132,M=(CH_(3))_(2)NH_(2)or(CH_(2)CH_(3))_(2)NH_(2)),featuring significant RTP have been *** rational cation selection and in-situ replacement from dimethylammonium to diethylammonium,the phosphorescence lifetime is increased from 30.88 to126.3 ms,along with less sensitivity to *** work provides an anti-quenching and lifetime tuning example for RTP-MOFmaterials via facile host-guest chemistry.

关键词： metal-organic framework room temperature phosphorescence crystal engineering in situ regulation

Entropic destruction of heavy quarkonium with hyperscaling violation

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Chinese Physics C 2021年第10期45卷 47-52页

作者： ang Li zi-Qiang Zhang School of Mathematics and Physics China University of GeosciencesWuhan 430074China Key Laboratory of Quark and Lepton Physics(MOE) Central China Normal UniversityWuhan 430079China

We study the entropic destruction of heavy quarkonium in strongly coupled theories with an anisotropic scaling symmetry in time and a spatial *** consider Lifshitz and hyperscaling violation theories,which are covariant under a generalized Lifshitz scaling symmetry with the dynamical exponent z and hyperscaling violation exponentθ.It is shown that the entropic force depends on the parameters of these *** particular,increasing z decreases the entropic force,thus reducing the quarkonium dissociation,while increasingθhas the opposite effect.

关键词： QGP quarkonium dissociation AdS/CFT correspondence entropic force

Thermoresponsive Lignin-Reinforced Poly(Ionic Liquid)Hydrogel Wireless Strain Sensor

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Research 2021年第1期2021卷 1284-1295页

作者： Xinyu Qu Ye zhao zi’ang Chen Siying Wang Yanfang Ren Qian Wang Jinjun Shao Wenjun Wang Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) School of Physical and Mathematical SciencesNanjing Tech University(NanjingTech)Nanjing 211816China School of Physical Science and Information Technology Liaocheng UniversityLiaocheng 252059China

To meet critical requirements on flexible electronic devices,multifunctionalized flexible sensors with excellent electromechanical performance and temperature perception are ***,lignin-reinforced thermoresponsive poly(ionic liquid)hydrogel is prepared through an ultrasound-assisted synthesized *** from the electrostatic interaction between lignin and ionic liquid,the hydrogel displays high stretchability(over 1425%),excellent toughness(over 132 kPa),and impressive stress loading-unloading cyclic *** hydrogel strain sensor presents excellent electromechanical performance with a high gauge factor(1.37)and rapid response rate(198 ms),which lays the foundation for human body movement detection and smart ***,owing to the thermal-sensitive feature of poly(ionic liquid),the as-prepared hydrogel displays remarkable thermal response sensitivity(0.217℃^(-1))in body temperature range and low limit of detection,which can be applied as a body shell temperature ***,the hydrogel can detect dual stimuli of strain and temperature and identify each signal individually,showing the specific application in human-machine interaction and artificial *** integrating the hydrogel strain sensor into a wireless sensation system,remote motion capture and gesture identification is realized in real-time.

关键词： stability. method. gauge

Study on the prediction and inverse prediction of detonation properties based on deep learning

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Defence Technology（防务技术） 2023年第6期24卷 18-30页

作者： zi-hang Yang Ji-li Rong zi-tong zhao Department of Mechanics School of Aerospace EngineeringBeijing Institute of TechnologyBeijing100081China

The accurate and efficient prediction of explosive detonation properties has important engineering significance for weapon *** methods for predicting detonation performance include empirical formulas,equations of state,and quantum chemical calculation *** recent years,with the development of computer performance and deep learning methods,researchers have begun to apply deep learning methods to the prediction of explosive detonation *** deep learning method has the advantage of simple and rapid prediction of explosive detonation ***,some problems remain in the study of detonation properties based on deep *** example,there are few studies on the prediction of mixed explosives,on the prediction of the parameters of the equation of state of explosives,and on the application of explosive properties to predict the formulation of *** on an artificial neural network model and a one-dimensional convolutional neural network model,three improved deep learning models were established in this work with the aim of solving these *** training data for these models,called the detonation parameters prediction model,JWL equation of state(EOS)prediction model,and inverse prediction model,was obtained through the KHT thermochemical *** training,the model was tested for overfitting using the validation-set *** the model-accuracy test,the prediction accuracy of the model for real explosive formulations was tested by comparing the predicted value with the reference *** results show that the model errors were within 10%and 3%for the prediction of detonation pressure and detonation velocity,*** accuracy refers to the prediction of tested explosive formulations which consist of TNT,RDX and *** the prediction of the equation of state for explosives,the correlation coefficient between the prediction and the reference curves was above *** the prediction of the inverse predi

关键词： Deep learning Detonation properties KHT thermochemical Code JWL equation of states Artificial neural network One-dimensional convolutional neural network

Algebraic Method‑Based Point‑to‑Point Trajectory Planning of an Under‑Constrained Cable‑Suspended Parallel Robot with Variable angle and Height Cable Mast

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Chinese Journal of Mechanical Engineering 2020年第4期33卷 45-62页

作者： Tao zhao Bin zi Sen Qian Jiahao zhao School of Mechanical Engineering Hefei University of TechnologyHefei 230009China Chemical Science and Engineering College North Minzu UniversityYinchuan 750021China

To avoid impacts and vibrations during the processes of acceleration and deceleration while possessing flexible working ways for cable-suspended parallel robots(CSPRs),point-to-point trajectory planning demands an under-constrained cable-suspended parallel robot(UCPR)with variable angle and height cable mast as described in this *** end-effector of the UCPR with three cables can achieve three translational degrees of freedom(DOFs).The inverse kinematic and dynamic modeling of the UCPR considering the angle and height of cable mast are *** motion trajectory of the end-effector comprising six segments is *** connection points of the trajectory segments(except for point P3 in the X direction)are devised to have zero instantaneous velocities,which ensure that the acceleration has continuity and the planned acceleration curve achieves smooth *** trajectory is respectively planned using three algebraic methods,including fifth degree polynomial,cycloid trajectory,and double-S velocity *** results indicate that the trajectory planned by fifth degree polynomial method is much closer to the given trajectory of the *** simulation and experiments are accomplished for the given trajectory based on fifth degree polynomial *** the points where the velocity suddenly changes,the length and tension variation curves of the planned and unplanned three cables are compared and *** OptiTrack motion capture system is adopted to track the end-effector of the UCPR during the *** effectiveness and feasibility of fifth degree polynomial planning are validated.

关键词： Under-constrained cable-suspended parallel robot Variable angle and height cable mast Inverse kinematic and dynamic modeling Algebraic method Point-to-point trajectory planning