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Timp1 Deletion Induces Anxiety-like Behavior in Mice

Neuroscience Bulletin 2024年第6期40卷 732-742页

作者： Xiaotong Wang Wei Zheng ziyi zhu Biyu Xing Weijie Yan Ke zhu Lingli Xiao Chaojuan Yang Mengping Wei Lei Yang zi-Bing Jin Xueyun Bi Chen Zhang State Key Laboratory of Neurology and Oncology Drug Development Nanjing210000China School of Basic Medical Sciences Wenzhou Medical UniversityWenzhou325035China School of Basic Medical Sciences Beijing Key Laboratory of Neural Regeneration and RepairAdvanced Innovation Center for Human Brain ProtectionBeijing Laboratory of Oral HealthCapital Medical UniversityBeijing100069China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing100005China Chinese Institute for Brain Research Beijing102206China Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing100191China

The hippocampus is essential for learning and memory,but it also plays an important role in regulating emotional behavior,as hippocampal excitability and plasticity affect anxiety and *** synaptic plasticity may be regulated by tissue inhibitor of matrix metalloproteinase 1(TIMP1),a known protein inhibitor of extracellular matrix(ECM),and the expression of TIMP1 in the hippocampus can be induced by neuronal excitation and various ***,the involvement of Timp1 in fear learning,anxiety,and hippocampal synaptic function remains to be *** study of Timp1 function in vivo revealed that Timp1 knockout mice exhibit anxiety-like behavior but normal fear *** results suggested that Timp1 knockout mice showed hyperactivity in the ventral CA1 region,but the basic synaptic transmission and plasticity were normal in the Schaffer collateral *** together,our results suggest that deletion of Timp1 in vivo leads to the occurrence of anxiety behaviors,but that Timp1 is not crucial for fear learning.

关键词： Timp1 Anxiety Fear Synaptic transmission Synaptic plasticity

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Airblast evolution initiated by Wangjiayan landslides in the M_(s)8.0 Wenchuan earthquake and its destructive capacity analysis

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China Geology 2024年第2期7卷 237-247页

作者： yu-feng Wang Qian-gong Cheng Qi zhu Department of Geological Engineering Southwest Jiaotong UniversityChengdu 610031China Sichuan Highway Planning SurveyDesign and Research Institute LtdChengdu 610041China

Airblasts,as one common phenomenon accompanied by rapid movements of landslides or rock/snow avalanches,commonly result in catastrophic damages and are attracting more and more scientific *** quantitatively analyze the intensity of airblast initiated by landslides,the Wangjiayan landslide,occurred in the Wenchuan earthquake,is selected here with the landslide propagation and airblast evolution being studied using FLUENT by introducing the Voellmy rheological *** results reveal that:(1)For the Wangjiayan landslide,its whole travelling duration is only 12 s with its maximum velocity reaching 36 m/s at t=10 s;(2)corresponding to the landslide propagation,the maximum velocity,28 m/s,of the airblast initiated by the landslide also appears at t=10 s with its maximum pressure reaching594.8 Pa,which is equivalent to violent storm;(3)under the attack of airblast,the load suffered by buildings in the airblast zone increases to 1300 Pa at t=9.4 s and sharply decreased to-7000 Pa as the rapid decrease of the velocity of the sliding mass at t=10 s,which is seriously unfavorable for buildings and might be the key reason for the destructive collapse of buildings in the airblast zone of the Wangjiayan landslide.

关键词： Landslide Voellmy rheological law 3D FLUENT simulation Airblast Intensity Building destructive collapse Wenchuan earthquake Geological hazards survey engineering

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A novel optical emission spectroscopy method for diagnostics of contribution of different ionization mechanisms and flux of ions in different valences in discharge channel of a Hall thruster

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Chinese Journal of Aeronautics 2024年第4期37卷 294-307页

作者： Yanfei WANG Ximing zhu Renqiu ZOU Shilin YAN Junwei JIA Zhongxi NING Daren yu School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Key Laboratory of Aerospace Plasma Propulsion Ministry of Industry and Information TechnologyHarbin 150001China Beijing Orient Institute of Measurement and Test Beijing 100094China Beijing Aerospace Long March Aircraft Research Institute Beijing 100076China

The mass application of Hall thrusters poses the need for a diagnostic method of ionization mechanism in the discharge channel to boost the iteration and optimization of thruster *** work presents an Optical Emission Spectroscopy (OES) method for diagnostics of the contribution of different ionization mechanisms and the flux of ions in different valences in the discharge channel of a Hall *** emission spectra in the discharge channel are analyzed by jointly utilizing a collisional-radiative model,an ionization-excitation model,and a flux-conservation *** is found that the intensities of some spectral lines can be converted into the reaction rates of collision processes,e.g.,electron-induced excitation and ionization *** latter can further be used to determine the evolutions of particle fluxes by utilizing the conservation law of *** novel method is demonstrated on a kilo-watt Hall *** evolutions of several parameters are determined using this method along the discharge channel,including the ionization rates of different mechanisms,particle fluxes,particle densities,and particle *** novel method can be further developed by being jointly utilized with spectral imaging and tomography techniques,enabling diagnostics of multi-dimensional distributions of the above-mentioned parameters in the discharge channel and near-field plume.

关键词： Hall thruster Optical emission spectroscopy Ionization mechanism Particle flux Divalent ion

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Asexual Reproduction of Aurelia coerulea Polyps in situ on Settling Plates in Jiaozhou Bay,China

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Journal of Ocean University of China 2024年第5期23卷 1371-1380页

作者： MI Tiezhu zhu Jianbin ZHEN yu WANG Guoshan WANG Jianyan Key Laboratory of Marine Environment and Ecology Ministry of EducationCollege of Environmental Science and EngineeringOcean University of ChinaQingdao 266100China Laboratory for Marine Ecology and Environmental Science Qingdao Marine Science and Technology CenterQingdao 266237China Frontiers Science Center for Deep Ocean Multispheres and Earth System Ocean University of ChinaQingdao 266100China National Marine Hazard Mitigation Service Ministry of Natural ResourcesBeijing 100194China Department of Life Sciences National Natural History Museum of ChinaBeijing 100050China

Jellyfish blooms are increasingly prevalent coastal phenomena,with Aurelia coerulea being a significant *** complex life history of jellyfish,featuring a sessile polyp stage,is a key factor in bloom formation,yet it is challenging to study in the *** study aimed to describe the asexual reproduction of *** polyps in Jiaozhou Bay,China,and to assess their ability to form sedentary colonies and their relationship with environmental *** settling plates,we observed polyps in situ and documented three asexual reproduction modes:budding,strobilation,and podocyst *** parameters including temperature,salinity,dissolved oxygen(DO),chlorophyll a(Chl a),and the biomass of phytoplankton and zooplankton were *** was the predominant reproductive method,featuring stolon budding in autumn and direct budding during the winter and spring *** took place in the colder months,releasing ephyrae between April and *** abundance was positively correlated with seawater temperature and negatively correlated with DO *** at 1.0 m depth showed higher survivorship and proliferation over 8 months,whereas those at 2.0 m depth experienced a steady decline and died within 4 *** study enhances our understanding of the life cycle and asexual reproduction strategies of *** polyps in the field,with implications for predicting and managing jellyfish *** findings underscore the importance of temperature and DO in polyp survival and suggest that initial polyp population proliferation is crucial for long-term survival.

关键词： jellyfish bloom polyps budding strobilation asexual reproduction

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Elemental Compositions of Clinopyroxenes from Southern Okinawa Trough Basalt:Implications for Magmatism and Structural Environment in an Initial Back-Arc Basin

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Journal of Ocean University of China 2024年第3期23卷 643-653页

作者： GUO Kun ZHAI Shikui FAN Di ZHANG Xia ZHANG yu zhu Zhimin Laoshan Laboratory Qingdao 266237China Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of EducationCollege of Marine GeosciencesOcean University of ChinaQingdao 266100China Key Laboratory of Submarine Geosciences&Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China

The major and trace elemental compositions of clinopyroxene from basalt were used to characterize the nature of the primitive magma and structural environment beneath the southern Okinawa Trough(SOT),which is an initial back-arc basin at a continental *** clinopyroxenes in the basalt were augite with variable Mg^(#)contents(73.37-78.22).The regular variations in major oxide contents(i.e.,CaO,FeO,TiO_(2),and Cr)with decreasing Mg#implied that the clinopyroxenes evolved from being enriched in Mg,Ca,and Cr to being enriched in Fe and *** clinopyroxenes had relatively low rare earth element concentrations(7.51×10^(-6) to 12.68×10^(-6))and negative Eu anomalies(δEu=0.67-0.95).The Kd_(cpx) values of clinopyroxenes(0.2-0.26),which were used to examine whether the clinopyroxene was equilibrated with its host basalt,demonstrate that these clinopyroxene phenocrysts were not captured crystals but were instead produced by crystallization differentiation of the *** calculated clinopyroxene crystallization temperatures showed a narrow range of 990-1061℃,and their crystallization pressures ranged from 2.0 to 3.2 *** geochemistry features of these clinopyroxenes indicated that the parent magma belonged to the subalkaline tholeiitic magma series and suggested that the magma experienced crystallization differentiation of olivine,plagioclase,and clinopyroxene,where the crystallization of plagioclase occurred earlier than that of *** with geophysical data,this research on primitive magma and its crystallization differentiation from clinopyroxene indicates that the SOT is in the stage of‘seafloor spreading’and that basaltic rocks produced from tholeiitic magma represent the generation of oceanic crust.

关键词： trace elements clinopyroxenes southern Okinawa Trough seafloor spreading back-arc basin

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Experimental Study on the Sinking and Leveling of A Large-Capacity Offshore Wind Turbine Five-Bucket Foundation in Sand

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China Ocean Engineering 2024年第4期38卷 586-601页

作者： LIAN Ji-jian zhu Hang GUO Yao-hua WANG Hai-jun yu Tong-shun State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300072China School of Civil Engineering Tianjin UniversityTianjin 300072China Tianjin University of Technology Tianjin 300384China College of Engineering Ocean University of ChinaQingdao 266100China

As offshore wind farms expand into deeper and farther ocean regions and the unit capacity of offshore wind turbines(OWTs)increases,there is a pressing need for a new foundation structure that can accommodate deep-sea conditions and support large capacities while maintaining economical and *** meet this goal of integrated transportation and one-step installation,a novel five-bucket jacket foundation(FBJF),with its suction installation and leveling methods in sand,has been proposed,analyzed and experimentally ***,seepage failure experiments of the FBJF at various depths were conducted,and a formula for calculating the critical suction of seepage failure suitable for the FBJF in sand was chosen and recommended for use with a range of values for the permeability coefficient ***,through leveling experiments of the FBJF at different depths,the maximum adjustable leveling angle during the sinking process was defined using seepage failure and the adjustable leveling angle of the foundation as control *** leveling control strategies were proposed and ***,an automatic sinking and leveling control system for the FBJF was developed and experimentally verified for feasibility.

关键词： offshore wind turbine(OWT) bucket foundation seepage failure suction installation

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Yolk-shell FeSe_(2)@CoSe_(2)/FeSe_(2) heterojunction as anode materials for sodium-ion batteries with high rate capability and stability

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Journal of Materials Science & Technology 2024年第5期172卷 185-195页

作者： Liuyang Zhang Bicheng zhu Difa Xu zibao Qian Ping Xie Tao Liu Jiaguo yu Laboratory of Solar Fuel Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430078China Hunan Key Laboratory of Applied Environmental Photocatalysis Changsha UniversityChangsha 410022China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Sodium-ion batteries are promising candidates for large-scale grid storage systems and other *** foremost advantage derives from superior environmental credentials,enhanced safety as well as lower raw material costs than lithium-ion *** is still challenging to explore desirable anode *** this study,FeSe_(2)@CoSe_(2)/FeSe_(2),with a yolk-shell structure was prepared by ion exchange and *** FeSe_(2)@CoSe_(2)/FeSe_(2)prepared as anode material for sodiumion batteries exhibits excellent rate capability due to the synergistic effect of bimetallic selenides and the interfacial effect of the ***,it delivers high performance(510 mAh g^(-1)at 0.2 A g^(-1)),superior rate capa-bility(90%retention at 5 A g^(-1)),and good long-time cycling stability(78%capacity retention after 1800 cycles at a high current density of 2 A g^(-1)).The optimized sodiumion full cell with FeSe_(2)@CoSe_(2)/FeSe_(2)as the anode and Na 3 V 2(PO 4)3 as the cathode still demonstrates excellent ***,a ca-pacity of 272 mAh g^(-1)(at 1 A g^(-1))within the operating voltage from 1 to 3.8 V can be *** work illustrates the potential of bimetallic selenides with heterostructures for performance enhancement of sodium-ion batteries.

关键词： Cobalt-iron selenide Heterojunctions Sodium storage Anode material Full battery

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A Symmetric-Actuating Linear Piezoceramic Ultrasonic Motor Capable of Producing a Scissoring Effect

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Research 2024年第1期2023卷 571-581页

作者： Zhanmiao Li Xingyu Yi Rongqi zhu Zhonghui yu Xiaoting yuan MohammadJavad PourhosseiniAsl Shuxiang Dong School of Materials Science and Engineering Peking UniversityBeijing 100871China College of Mechatronics and Control Engineering and Institute for Advanced StudyShenzhen UniversityShenzhen 518051China

Conventionally,to produce a linear motion,one motor’s stator is employed to drive one runner moving forward or *** far,there is almost no report of one electromechanical motor or piezoelectric ultrasonic motor that can directly generate two symmetrical linear motions,while this function is desired for precise scissoring and grasping in the minimally invasive surgery ***,we report a brandnew symmetric-actuating linear piezoceramic ultrasonic motor capable of generating symmetrical linear motions of two outputs directly without additional mechanical transmission *** key component of the motor is an(2×3)arrayed piezoceramic bar stator operating in the coupled resonant mode of the first longitudinal(L_(1))and third bending(B_(3))modes,leading to symmetric elliptical vibration trajectories at its two ends.A pair of microsurgical scissors is used as the end-effector,demonstrating a very promising future for high-precision microsurgical operations.

关键词： field symmetric backward

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Endogenous retrovirus activation: potential for immunology and clinical applications

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National Science Review 2024年第4期11卷 21-23页

作者： Jundan yu Peishan Qiu Jingwen Ai Bo Liu Guan-zhu Han Fan zhu Wenhong Zhang Jie Cui Department of Infectious Diseases Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response National Medical Center for Infectious Diseases Huashan Hospital Shanghai Medical College Fudan University CAS Key Laboratory of Molecular Virology &Immunology Shanghai Institute of Immunity and Infection Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai Huashen Institute of Microbes and Infections College of Life Sciences Nanjing Normal University State Key Laboratory of Virology and Department of Medical Microbiology School of Basic Medical SciencesWuhan University The Institute of Infection and Health Research Fudan University Key Laboratory of Medical Molecular Virology(MOE/MOH) Shanghai Medical CollegeFudan University Laboratory for Marine Biology and Biotechnology Qingdao Marine Science and Technology Center

Endogenous retroviruses (ERVs), the remnants of ancient retrovirus infections, constitute approximately 8% of the human genome and play important roles in human evolution, development,and diseases. Multiple drugs, such as DNA methyltransferase inhibitors and lysine-specific histone demethylase 1inhibitors, reactivate ERVs, induce viral mimicry and trigger innate immune responses to enhance tumor immunogenicity.

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Single-atom alloys prepared by two-step thermal evaporation

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Nano Research 2024年第4期17卷 2808-2813页

作者： Honglin Wang Jing Li Meirong Huang Jizhe Cui Zhiying Cheng Rong yu Hongwei zhu State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China State Key Lab of Solid Waste Reuse for Building Materials Beijing Building Materials Academy of Science ResearchBeijing 100041China

Single-atom alloys(SAAs)have gained significant attention due to their remarkable atomic utilization efficiency,interactions between single atoms(SAs)and metal supports,and free-atom-like electronic structure of dopant *** this work,we observed the formation of SAs in pre-deposited metal particles by a two-step thermal evaporation technique,thereby establishing the first instance of discovering SAAs by thermal *** discovery of SAAs by thermal evaporation extends the range of SAAs preparation methods to include this traditional synthetic technique,which offers convenience,cost-efficiency,and *** formation mechanism of SAAs prepared using this technique was elucidated by density functional theory *** was demonstrated that thermal evaporation can be utilized to prepare SAAs with multiple SAs,further highlighting its universal applicability.

关键词： single-atom alloys thermal evaporation density functional theory

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