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Investigation on the performance of a helico-axial multiphase pump under slug flow

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Petroleum Science 2022年第4期19卷 1812-1824页

作者： Jia-Xiang Zhang Jin-Ya Zhang Ye Zhou zi-yi-yi cheng Guang-Da Cao College of Mechanical and Transportation Engineering China University of PetroleumBejing102249China Beijing Key Laboratory of Process Fluid Filtration and Separation China University of PetroleumBejing102249China China Institute of Water Resources and Hydropower Research Beijing100044China

The helico-axial multiphase pump is often used for gas-liquid mixture transportation in offshore oilfields,and slug flow is the main reason for the unstable operation of the *** for slug flow condition,a self-designed three-stage multiphase pump is set to the object to perform unsteady simulations and fluid-structure interaction calculations,and the inlet gas void fraction(IGVF)is set from 20%to 80%.The results show that affected by the flow from the slug,the gas-liquid two-phase flow pattern in the multiphase pump changes sharply,resulting in severe fluctuations in the differential pressure,spindle torque and deformation of the multiphase *** gas-phase enters the first-impeller along the suction blade surface when affected by Taylor bubbles,while the second and third-stage impellers gas-phases are in the form of small air masses flow into the impeller along the pressure blade *** deformation trend of impeller torque,differential pressure and the main pump spindle is similar to that of trigonometric function,while the fluctuation of torque is more intense,and the shape variable of spindle increases with the inflow of liquid plug,and the maximum deformation amount increases by10.9%at high GVF relative to IGVF.

关键词： Multiphase pump Slug flow Gas void fraction(GVF) Hydraulic performance Fluid-structure interaction

Heterogeneous dual memristive circuit:Multistability,symmetry,and FPGA implementation

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Chinese Physics B 2021年第12期30卷 237-247页

作者： yi-zi cheng Fu-Hong Min Zhi Rui Lei Zhang School of Electrical and Automation Engineering Nanjing Normal UniversityNanjing 210023China

An improved heterogeneous dual memristive circuit(DMC)is proposed based on Chua's circuit,which shows good symmetry and *** the difficulty in controlling the initial conditions,which restricts the engineering applications,the 3 rd-order model(3 OM)in flux-charge domain is derived from the 5 th-order model(5 OM)in volt-ampere domain by using the flux-charge analysis method(FCAM).The consistence of symmetry and multistability before and after dimensionality decreasing is meticulously investigated via bifurcation diagram,Lyapunov exponents,and especially attraction *** comparative analysis validates the effectiveness of reduction model and improves the controllability of the *** avoid the noise in the analog circuit,a field-programmable gate array(FPGA)is utilized to realize the reduction model,which is rarely reported and valuable for relevant research and application.

关键词： memristive circuit chaos multistability FPGA implementation

Design of a large momentum acceptance proton therapy gantry utilizing AG-CCT magnets

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-11页

作者： Liao, yi-cheng Liu, Xu Wang, Wei Yang, zi-yi Chen, Qu-Shan Qin, Bin Huazhong Univ Sci & Technol State Key Lab Adv Electromagnet Technol Wuhan 430074 Peoples R China

The application of superconducting (SC) technology enables magnets to excite strong fields with small footprints, which has great potential for miniaturizing proton therapy gantries. However, the slow ramping rate of SC magnets results in a low treatment efficiency compared with normal-conducting (NC) gantries. To address this problem, this study proposes a compact proton therapy gantry design with a large momentum acceptance utilizing alternating-gradient canted-cosine-theta (AG-CCT) SC magnets. In our design, a high-transmission degrader is mounted in the middle of the gantry, and the upstream beamline employs NC magnets with small apertures. Downstream of the degrader, large-bore AG-CCT magnets with strong alternating focusing gradients are set symmetrically as a local achromat, which realizes a momentum acceptance of 20% (or 40% in the energy domain). Therefore, only three magnetic working points are required to cover a treatment energy of 70-230 MeV. Owing to the large momentum acceptance, the proton beam after the degrader can be directly delivered to the isocenter without truncating its energy spectrum, which can significantly increase the treatment efficiency but causes severe dispersion effects during pencil beam scanning. Therefore, a compensation method was introduced by tuning the normal and skewed quadrupoles during the scanning process. As a result, the new gantry not only presents a remarkable reduction in the size and weight of the facility but also shows good potential for fast treatment.

关键词： Alternating-gradient canted-cosine-theta magnets Large momentum acceptance gantry Pencil beam scanning Proton therapy ENERGY DEGRADER BEAM OPTICS OPTIMIZATION

Multi-distortion suppression for neutron radiographic images based on generative adversarial network

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Nuclear Science and Techniques 2024年第4期35卷 176-188页

作者： cheng-Bo Meng Wang-Wei Zhu Zhen Zhang zi-Tong Wang Chen-yi Zhao Shuang Qiao Tian Zhang School of Physics Northeast Normal UniversityChangchun 130024China

Neutron radiography is a crucial nondestructive testing technology widely used in the aerospace,military,and nuclear ***,because of the physical limitations of neutron sources and collimators,the resulting neutron radiographic images inevitably exhibit multiple distortions,including noise,geometric unsharpness,and white ***,these distortions are particularly significant in compact neutron radiography systems with low neutron ***,in this study,we devised a multi-distortion suppression network that employs a modified generative adversarial network to improve the quality of degraded neutron radiographic *** neutron radiographic image datasets with various types and levels of distortion were built for the first time as multi-distortion suppression ***,the coordinate attention mechanism was incorporated into the backbone network to augment the capability of the proposed network to learn the abstract relationship between ideally clear and degraded *** experiments were performed;the results show that the proposed method can effectively suppress multiple distortions in real neutron radiographic images and achieve state-of-theart perceptual visual quality,thus demonstrating its application potential in neutron radiography.

关键词： Neutron radiography Multi-distortion suppression Generative adversarial network Coordinate attention mechanism

Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction

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World Journal of Stem Cells 2024年第4期16卷 444-458页

作者： cheng-Jin Ai Ling-Juan Chen Li-Xuan Guo Ya-Ping Wang zi-yi Zhao Department of Laboratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Department of Ophthalmology Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Central Laboratory Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Traditional Chinese Medicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina

BACKGROUND Leukemia stem cells(LSCs)are found to be one of the main factors contributing to poor therapeutic effects in acute myeloid leukemia(AML),as they are protected by the bone marrow microenvironment(BMM)against conventional *** acetic acid(GAA),which is extracted from the seeds of cotton plants,exerts anti-tumor roles in several types of cancer and has been reported to induce apoptosis of LSCs by inhibiting *** To investigate the exact roles of GAA in regulating LSCs under different microenvironments and the exact *** In this study,LSCs were magnetically sorted from AML cell lines and the CD34+CD38-population was *** expression of leucine-rich pentatricopeptide repeat-containing protein(LRPPRC)and forkhead box M1(FOXM1)was evaluated in LSCs,and the effects of GAA on malignancies and mitochondrial RESULTS LRPPRC was found to be upregulated,and GAA inhibited cell proliferation by degrading *** induced LRPPRC degradation and inhibited the activation of interleukin 6(IL-6)/janus kinase(JAK)1/signal transducer and activator of transcription(STAT)3 signaling,enhancing chemosensitivity in LSCs against conventional chemotherapies,including L-Asparaginase,Dexamethasone,and *** was also found to downregulate FOXM1 indirectly by regulating ***,GAA induced reactive oxygen species accumulation,disturbed mitochondrial homeostasis,and caused mitochondrial *** inhibiting IL-6/JAK1/STAT3 signaling via degrading LRPPRC,GAA resulted in the elimination of ***,GAA induced oxidative stress and subsequent cell damage by causing mitochondrial *** Taken together,the results indicate that GAA might overcome the BMM protective effect and be considered as a novel and effective combination therapy for AML.

关键词： Leukemia stem cells Gossypol acetic acid Reactive oxygen species Mitochondrial dysfunction Interleukin 6/janus kinase 1/signal transducer and activator of transcription 3 signaling

Azacitidine maintenance therapy for blastic plasmacytoid dendritic cell neoplasm allograft: A case report

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World Journal of Clinical Cases 2024年第1期12卷 136-141页

作者： Li-Li Tao Hui-Ting Wen zi-yi Wang Juan cheng Li Zhao Department of Hematology The First Clinical Medical CollegeLanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Hematology The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare,highly invasive malignant *** is no universally accepted standard of care because of its rarity and the dearth of prospective *** is still challenging for some patients to achieve persistent clinical remission or cure,despite the success of allogeneic hematopoietic stem cell transplantation(allo-HSCT),indicating that there is still a significant recurrence *** report a case of prevention of BPDCN allograft recurrence by azacitidine maintenance therapy and review the relevant *** SUMMARY We report a 41-year-old man with BPDCN who was admitted to hospital due to skin sclerosis for>5 mo’*** was diagnosed by combined clinical assessment and laboratory *** diagnosis,the patients underwent induction consolidation chemotherapy to achieve the first complete remission,followed by bridging ***-transplantation,azacitidine(75 mg/m2 for 7 d)was administered as maintenance therapy,with repeat administration every 4–6 wk and appropriate extension of the chemotherapy *** 10 cycles,the patient has been disease free for 26 mo after *** assessments of bone marrow morphology,minimal residual disease,full donor chimerism,Epstein–Barr virus,and cytomegalovirus all yielded normal results with no abnormalities *** Azacitidine may be a safe and effective maintenance treatment for BPDCN following transplantation because there were no overt adverse events during the course of treatment.

关键词： Blastic plasmacytoid dendritic cell neoplasm Azacitidine Allogeneic hematopoietic stem cell transplantation Maintenance therapy Case report

Reliable calculations of nuclear binding energies by the Gaussian process of machine learning

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Nuclear Science and Techniques 2024年第6期35卷 130-144页

作者： zi-yi Yuan Dong Bai Zhen Wang Zhong-Zhou Ren School of Physics Science and Engineering Tongji UniversityShanghai 200092China College of Science Hohai UniversityNanjing 211100China Key Laboratory of Advanced Micro-Structure Materials Ministry of EducationShanghai 200092China

Reliable calculations of nuclear binding energies are crucial for advancing the research of nuclear physics. Machine learning provides an innovative approach to exploring complex physical problems. In this study, the nuclear binding energies are modeled directly using a machine-learning method called the Gaussian process. First, the binding energies for 2238 nuclei with Z > 20 and N > 20 are calculated using the Gaussian process in a physically motivated feature space, yielding an average deviation of 0.046 MeV and a standard deviation of 0.066 MeV. The results show the good learning ability of the Gaussian process in the studies of binding energies. Then, the predictive power of the Gaussian process is studied by calculating the binding energies for 108 nuclei newly included in AME2020. The theoretical results are in good agreement with the experimental data, reflecting the good predictive power of the Gaussian process. Moreover, the α-decay energies for 1169 nuclei with 50 ≤ Z ≤ 110 are derived from the theoretical binding energies calculated using the Gaussian process. The average deviation and the standard deviation are, respectively, 0.047 MeV and 0.070 MeV. Noticeably, the calculated α-decay energies for the two new isotopes ^ (204 )Ac(Huang et al. Phys Lett B 834, 137484(2022)) and ^ (207) Th(Yang et al. Phys Rev C 105, L051302(2022)) agree well with the latest experimental data. These results demonstrate that the Gaussian process is reliable for the calculations of nuclear binding energies. Finally, the α-decay properties of some unknown actinide nuclei are predicted using the Gaussian process. The predicted results can be useful guides for future research on binding energies and α-decay properties.

关键词： Nuclear binding energies decay Machine learning Gaussian process

Reinforcing oxygen electrocatalytic activity via selective dualphase heterointerface engineering for rechargeable Zn-air batteries

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Rare Metals 2024年第4期43卷 1524-1536页

作者： Chao cheng Chuang Zhi Zhong-Ti Sun Yong-Qiang Ming Ting-Ting Xiang Qing-Chao Zhu zi-Rui Wu Bing Li yi Li cheng Jin Yong Cao Juan Yang School of Materials Science and Engineering Jiangsu UniversityZhenjiang212013China Faculty of Material Science and Engineering Kunming University of Science and TechnologyKunming650093China

Dual-phase heterointerface electrocatalysts(DPHE)constructed by oxygen reduction reaction(ORR)-and oxygen evolution reaction(OER)-active elements exhibit excellent bifunctional activity and long-term durability due to the abundant interface exposure and synergistic catalytic ***,low-dimensional N-doped graphene nanoribbons(N-GNRs)coupling with ultrathin CoO nanocomposites(N-GNRs/CoO)were controllably fabricated through a facile two-step approach using synthesized Co(OH)_2 nanosheet as CoO *** functional theory(DFT)calculations and experimental characterizations prove that the formation of interface between N-GNRs and CoO can induce local charge redistribution,contributing to the improvement of catalytic activity and *** optimal N-GNRs/CoO DPHE possesses hierarchically porous architectures and presents outstanding bifunctional activities with a small potential gap of 0.729 V between the potential at 10 mA·cm^(-2)for OER and the halfwave potential for ORR,which outperforms Pt/C+IrO_(2)and the majority of noble-metal-free bifunctional ***-and solid-state rechargeable Zn-air batteries assembled with N-GNRs/CoO as the cathode also display high peak power density and fantastic cycle stability,superior to that of benchmark Pt/C+IrO_(2)*** is anticipated to offer significant benefits toward high activity,stability and mechanical flexibility bifunctional oxygen electrocatalysts for rechargeable Zn-air batteries.

关键词： Interface engineering Graphene nanoribbons CoO Bifunctional electrocatalyst Zn-air batteries

Early prediction and prevention of infected pancreatic necrosis

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World Journal of Gastroenterology 2024年第9期30卷 1005-1010页

作者： cheng Lv zi-Xiong Zhang Lu Ke Department of Critical Care Medicine Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210000Jiangsu ProvinceChina Research Institute of Critical Care Medicine and Emergency Rescue Nanjing UniversityNanjing 210000Jiangsu ProvinceChina

Approximately 20%-30%of patients with acute necrotizing pancreatitis develop infected pancreatic necrosis(IPN),a highly morbid and potentially lethal *** identification of patients at high risk of IPN may facilitate appropriate preventive measures to improve clinical *** the past two decades,several markers and predictive tools have been proposed and evaluated for this *** biomarkers like C-reactive protein,procalcitonin,lymphocyte count,interleukin-6,and interleukin-8,and newly developed biomarkers like angiopoietin-2 all showed significant association with *** the other hand,scoring systems like the Acute Physiology and Chronic Health Evaluation II and Pancreatitis Activity Scoring System have also been tested,and the results showed that they may provide better *** early prevention of IPN,several new therapies were tested,including early enteral nutrition,anti-biotics,probiotics,immune enhancement,etc.,but the results *** together,several evidence-supported predictive markers and scoring systems are readily available for predicting ***,effective treatments to reduce the incidence of IPN are still lacking apart from early enteral *** this editorial,we summarize evidence concerning early prediction and prevention of IPN,providing insights into future practice and study design.A more homo-geneous patient population with reliable risk-stratification tools may help find effective treatments to reduce the risk of IPN,thereby achieving individualized treatment.

关键词： Acute pancreatitis Infected pancreatic necrosis Biomarker Scoring system Nutrition therapy Selective digestive decontamination Probiotics Antibiotics Immune enhancement therapy