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Efficacy,safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart:A pilot study

World Journal of Diabetes 2025年第1期16卷 65-73页

作者： Na Yang lu Lv Shu-Meng Han Li-Yun He zi-Yi Li Yu-Cheng Yang Fan Ping Ling-Ling Xu Wei Li Hua-Bing Zhang Yu-xiu Li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient data from the Chinese *** To demonstrate the efficacy,safety,and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus(T2DM).METHODS In this 12-week open-label,non-randomized,single-center,pilot study,patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin *** doses,hemoglobin A1c(HbA1c)levels,fasting blood glucose(FBG),hypoglycemic events,a Diabetes Treatment Satisfaction Questionnaire,and other parameters were assessed at baseline and *** This study included 21 participants.A marked enhancement was observed in the FBG level(P=0.02),daily total insulin dose(P=0.03),and overall diabetes treatment satisfaction(P<0.01)in the participants who switched to *** was a decrease in HbA1c levels(7.6±1.1 vs 7.4±0.9,P=0.31)and the frequency of hypoglycemic events of those who switched to IDegAsp decreased,however,there was no statistically significant *** The present findings suggest that treatment with IDegAsp enhances clinical outcomes,particularly FBG levels,daily cumulative insulin dose,and overall satisfaction with diabetes treatment.

关键词： Insulin degludec/aspart Type 2 diabetes management Basal-bolus insulin therapy Pre-mixed insulin Diabetes treatment satisfaction questionnaire

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Genomic insights into ecological adaptation of oaks revealed byphylogenomic analysis of multiple species

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Plant Diversity 2025年第1期47卷 53-67页

作者： Tian-Rui Wang Xin Ning Si-Si Zheng Yu Li zi-Jia lu Hong-Hu Meng Bin-Jie Ge Gregor Kozlowski Meng-Xiao Yan Yi-Gang Song Eastern China Conservation Centre for Wild Endangered Plant Resources Shanghai Chenshan Botanical GardenShanghai 201602China College of Forestry and Biotechnology Zhejiang A&F UniversityHangzhou 311300China College of Life Sciences Shanghai Normal UniversityShanghai 200234China Plant Phylogenetics and Conservation Group Centre for Integrative ConservationXishuangbanna Tropical Botanical GardenChinese Academy of SciencesKunming 650223China Department of Biology and Botanic Garden University of FribourgFribourgSwitzerland Natural History Museum Fribourg FribourgSwitzerland

Understanding the ecological adaptation of tree species can not only reveal the evolutionary potential but also benefit biodiversity conservation under global climate *** is a keystone genus in Northern Hemisphere forests,and its wide distribution in diverse ecosystems and long evolutionary history make it an ideal model for studying the genomic basis of ecological *** we used a newly sequenced genome of Quercus gilva,an evergreen oak species from East Asia,with 18 published Fagales genomes to determine how Fagaceae genomes have evolved,identify genomic footprints of ecological adaptability in oaks in general,as well as between evergreen and deciduous *** found that oak species exhibited a higher degree of genomic conservation and stability,as indicated by the absence of large-scale chromosomal structural variations or additional whole-genome duplication *** addition,we identified expansion and tandem repetitions within gene families that contribute to plant physical and chemical defense(e.g.,cuticle biosynthesis and oxidosqualene cyclase genes),which may represent the foundation for the ecological adaptation of oak *** rhythm and hormone-related genes may regulate the habits of evergreen and deciduous *** study provides a comprehensive perspective on the ecological adaptations of tree species based on phylogenetic,genome evolutionary,and functional genomic analyses.

关键词： Quercus Ecological adaptation Phylogenomics Transcriptomes Fagaceae

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中国传统数学文化中的经学观反思

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科学技术哲学研究 2025年第1期42卷 105-110页

作者：杨子路西南大学国家治理学院哲学系重庆400715

经学作为中国前现代时期的主流思想,是古代社会文化结构的反映,中国传统数学的成型、发展亦难免受制于儒家经学思潮的影响。数学本身的起源、性质、功能亦一般被学人从经学角度加以规定,其地位居于六艺之末而实为经学附庸。然而,诸如北... 详细信息

经学作为中国前现代时期的主流思想,是古代社会文化结构的反映,中国传统数学的成型、发展亦难免受制于儒家经学思潮的影响。数学本身的起源、性质、功能亦一般被学人从经学角度加以规定,其地位居于六艺之末而实为经学附庸。然而,诸如北宋末算学先师之祀等数学文化中的黄帝崇拜表明中算家未尝没有对主流观念的象征反抗。明清之际在本土启蒙思潮与西学东渐的双重影响下,数学性质、功能及墨家思想之数学史意义被重新加以审视,数学文化中的某些经学观念亦被逐渐矫正。

关键词：中国传统数学经学数学文化

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A monolithic 3D IGZO-RRAM-SRAM-integrated architecture for robust and efficient compute-in-memory enabling equivalent-ideal device metrics

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Science China(Information Sciences) 2025年第2期68卷 322-337页

作者： Shengzhe YAN Zhaori CONG zi WANG Zhuoyu DAI Zeyu GUO Zhihang QIAN Xufan LI Xu ZHENG Chuanke CHEN Nianduan lu Chunmeng DOU Guanhua YANG Xiaoxin XU Di GENG Jinshan YUE Lingfei WANG Ling LI Ming LIU Institute of Microelectronics of the Chinese Academy of Sciences University of Chinese Academy of Sciences

Compute-in-memory(CIM) based on various devices such as static random access memory(SRAM) and resistive random access memory(RRAM) and other emerging devices such as indium-gallium-zinc-oxide(IGZO) transistor, magnetoresistive RAM(MRAM), and ferroelectric RAM(FeRAM) has been explored for better performance and energy efficiency on neural networks applications. However, CIM based on a single-type device suffers a variety of non-ideal metrics to reach the simultaneous optimal accuracy, density, and energy efficiency. This work presents equivalent-ideal CIM(Eq-CIM), a monolithic 3D(M3D) IGZO-RRAM-SRAM integrated architecture for robust and efficient compute-in-memory enabling equivalent-ideal device metrics. To overcome the non-ideality(variation, endurance, temperature, etc.) of the single-type devices, system-technology co-optimization(STCO) is performed. This work highlights the non-ideality-aware functionality breakdown for robust high accuracy and simultaneous high density/efficiency, by utilizing 2T0C IGZO for temporal activation storage, RRAM for high-density weight storage, and SRAM for accurate CIM. Device-to-algorithm variation transfer is applied to analyze the system-level accuracy. We benchmark Eq-CIM architecture on CIFAR-10/ImageNet, with 5.06× storage density and 5.05×/2.45× area/energy efficiency compared with single-type-device-based CIM, and high robustness(<0.27% accuracy loss) from-40℃ to 120℃.

关键词： compute-in-memory (CIM) monolithic 3D RRAM IGZO 3D-stack simulation

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Laser assisted phase transformation of carbon-based transition metal oxide electrode for high-performance supercapacitor application

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Science China Chemistry 2025年

作者： Mingzhen xiu Jianghong Zhang Yu lu Xun Cao Kang Huang Siyu Zhu Bowei Zhang Yu Liang Chunwang Zhao Junsheng Wu Yizhong Huang School of Materials Science and Engineering Nanyang Technological University Energy Research Institute Interdisciplinary Graduate Programme Nanyang Technological University Institute of Sustainability for Chemicals Energy and Environment Agency for Science Technology and ResearchSingapore Institute of Advanced Materials and Technology University of Science and Technology Beijing School of Materials Science and Technology Shenyang University of Chemical Technology School of Materials Science and Hydrogen Energy Foshan University

Transitional metal oxides have a wide range of applications due to their superior *** enhanced performance of metal oxide relies on their desirable oxidation states,which is challenging to achieve and requires complex *** study demonstrates a facile strategy enabling rapid phase transformation of transition metal *** approach involves synthesis of a tetragonal Mn3O4/carbon cloth composite using the liquid plasma discharge deposition （LPDD） technique,followed by laser irradiation with the presence of ethylene glycol under an N2gas *** resulting face-centered cubic MnO/carbon cloth electrode exhibits an excellent capacitance of 1,125 F g-1at 2 A g-1,with remarkable capacitance retention of 95%after10,000 *** approach can be extended to other transition metals including Co,Cu,Cr,Fe,Ni,and *** simulations reveal the significance of ethylene glycol and the underlying mechanism associated with the phase transformation of transition metal *** present study offers a powerful technique for the phase transformation of transition metal oxide which can guide the development of new electrode materials with enhanced electrochemical properties for high-performance energy storage applications.

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Atmospheric CO_(2) Removal Efficiency through Enhanced Silicate Weathering in Croplands:A Review with Emphasis on the Contribution of Fungi

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Journal of Earth Science 2025年第1期36卷 197-211页

作者： zi-Bo Li Gaojun Li Jonathan M.Adams Dong-Xing Guan Liang Zhao Rongjun Bian Qing Hu Xiancai lu Junfeng Ji Jun Chen State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Key Laboratory of Surficial Geochemistry Ministry of EducationSchool of Earth Sciences and Engineering and Frontiers Science Center for Critical Earth Material CyclingNanjing UniversityNanjing 210023China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Institute of Soil and Water Resources and Environmental Science College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China Institute of Resource Ecosystem and Environment of AgricultureNanjing Agricultural UniversityNanjing 210095China Xiong'an Institute of Innovation Chinese Academy of SciencesXiong'an 071700China

Enhanced silicate weathering(ESW)is a geoengineering method aimed at accelerating carbon dioxide(CO_(2))removal(CDR)from atmosphere by increasing the weathering flux of silicate rocks and *** has emerged as a promising strategy for *** studies underscore ESW’s substantial potential for CDR and its diverse benefits for crops when applied to ***,the well-known significant discrepancies in silicate weathering rates between laboratory and field conditions introduce uncertainty in CDR through *** compiling data from recent literature,we calculated and compared CDR efficiency(t CO_(2)t^(-1)_(silicate)ha^(-1)y^(-1))observed in mesocosm experiments and field *** findings indicate that CDR efficiencies in field trials are comparable to or exceeding that observed in mesocosm experiments by 1-3 orders of magnitude,particularly evident with wollastonite *** hierarchy of CDR efficiency among silicates suitable for ESW is ranked as follows:olivine≥wollastonite>basalt>albite≥*** suggest the potential role of biota,especially fungi,in contributing to higher CDR efficiencies observed in field trials compared to mesocosm *** further emphasize introducing fungi known for their effectiveness in silicate weathering could potentially enhance CDR efficiency through ESW in *** before implementing fungal-facilitated ESW,three key questions need addressing:(i)How does the community of introduced fungi evolve over time?(ii)What is the long-term trajectory of CDR efficiency following fungal introduction?and(iii)Could fungal introduction lead to organic matter oxidation,resulting in elevated CO_(2)emissions?These investigations are crucial for optimizing the efficiency and sustainability of fungal-facilitated ESW strategy.

关键词： enhanced weathering carbon dioxide removal efficiency fungi weathering rate altered surface layers

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An assessment model for efficacy of autologous CD19 chimeric antigen receptor T-cell therapy and relapse or refractory diffuse large B-cell lymphoma risk

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中华医学杂志(英文版) 2025年第1期138卷 108-110页

作者： Xue Bin Liu Yifan Zhang Min Xiao Gangfeng luo xiu Zhou Lili Ye Shiguang lu Yan Qian Wenbin Wang Li Li Ping Liang Aibin Department of Hematology Shanghai Tongji Hospital Tongji University School of Medicine Shanghai China Department of Hematology Ningbo No.Hospital Ningbo Zhejiang China Department of Hematology The Second Affiliated Hospital College of Medicine Zhejiang University Hangzhou Zhejiang China Department of Hematology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China

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Correlations of the expression of Cx43,SCF^(FBXW7),p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： Rong-Gang luan Ming-Da Liu zi-Feng Deng Cong-Lan lu Mei-Ling Yu Ming-Yu Zhang Rong Liu Ran An You-Liang Yao Dong-Bei Guo Yong-Xing Zhang Lei Zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCF^(FBXW7),p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCF^(FBXW7),p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCF^(FBXW7)(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCF^(FBXW7) and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(Pluencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCF^(FBXW7) Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

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十堰城区地表水-地下水水化学特征及硝酸盐来源

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环境科学 2025年第1期46卷 253-262页

作者：党秀宁刘亚磊张子燕王宁涛中国地质调查局武汉地质调查中心(中南地质科技创新中心) 武汉430205 中国地质大学环境学院武汉430074 中国地质大学地质调查研究院武汉430074

水体硝酸盐污染是世界性的环境问题,识别硝酸盐来源对保障水资源可持续利用具有重要意义.利用多种水化学指标与硝酸盐氮氧同位素(δ^(15)N-NO_(3)^(-)和δ^(18)O-NO_(3)^(-))对十堰水体水化学特征进行分析,识别水体中硝酸盐来源,并利用S... 详细信息

水体硝酸盐污染是世界性的环境问题,识别硝酸盐来源对保障水资源可持续利用具有重要意义.利用多种水化学指标与硝酸盐氮氧同位素(δ^(15)N-NO_(3)^(-)和δ^(18)O-NO_(3)^(-))对十堰水体水化学特征进行分析,识别水体中硝酸盐来源,并利用SIMMR模型计算水体硝酸盐不同污染来源的贡献率.结果表明,研究区地表水及地下水的水化学类型以HCO_(3)-Ca·Mg型为主,水体中硝酸盐的形成主要受硝化作用影响,反硝化作用不明显.水体中硝酸盐的主要来源为大气沉降、化肥、土壤氮、粪便和污水. SIMMR模型输出结果显示,粪便和污水、大气沉降、化肥和土壤氮对研究区地表水硝酸盐的贡献率分别为43.1%、2.2%、43.3%和11.4%,对地下水硝酸盐的贡献率分别为37.2%、9.4%、28.3%和25.1%,地表水硝酸盐的主要污染源是化肥、粪便和污水,地下水硝酸盐的主要污染源是粪便和污水.

关键词：水化学特征硝酸盐氮氧同位素贝叶斯稳定同位素混合模型(SIMMR) 源解析

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Pyrrolic nitrogen coordinated Ni2+ dual-atom catalyst for boosting CO2 electroreduction

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Science China Chemistry 2025年第2期 570-579页

作者： Zhi-Wei Chen Hong-Juan Wang Chang Liu xiu-Li lu Tong-Bu lu MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of Technology

Nitrogen-doped carbon materials have been widely used for the constructions of single-atom catalysts,while the effect of different species of doped nitrogen on the catalytic activity of CO2electroreduction has rarely been *** we found that pyrrolic-N coordinated Ni2+catalysts display much higher electrocatalytic CO2-to-CO activity and selectivity than the corresponding pyridinic-N coordinated low valent Ni（0–+2）catalysts,and pyrrolic-N coordinated Ni2dual-atoms catalyst of Ni2/N-CNTs exhibits the best electrocatalytic performance,with over 90%Faradaic efficiencies in a broad potentials from -0.6 to-1.2 V *** hydrogen electrode,as well as an outstanding CO specific current of 56.2 A/mgNiand high turnover frequency of 6.2×10～4h-1,over 7-times higher than those of pyridinic-N coordinated Ni *** results indicate the weak electron-donor nature of pyrrolic-N facilitates the generation of a reduced active site at low overpotential for boosting *** functional theory calculations reveal that the reaction free energy for the*COOH formation on pyrrolic-N coordinated Ni catalysts are lower than those on pyridinic-N coordinated Ni catalysts,and a H2O-adsorbed Ni2/N-CNTs displays the optimized reaction free energy for both*COOH formation and CO desorption,which derive the best catalytic performance.

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