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Rare Metals 2024年第2期43卷 511-521页

作者： Jian-Peng Sun Yu Zheng zi-sheng zhang Xiang-Chao Meng zi-Zhen Li Key Laboratory of Marine Chemistry Theory and Technology(Ministry of Education) College of Chemistry and Chemical EngineeringOcean University of ChinaQingdao266100China Shanxi Institute of Energy Taiyuan030600China Department of Chemical and Biological Engineering Faculty of EngineeringUniversity of OttawaOttawaONK1N6 N5Canada

Herein,a novel single-atomic Pt doping and interface-rich CoS/Co(OH)_(2)(Pt-CoS/Co(OH)_(2)/C)electrocatalyst has been successfully *** from precise regulation of d-orbital electronic structure modulation on Co site,Pt-CoS/Co(OH)_(2)/C exhibited remarkable HER activity and high stability for hydrogen evolution in splitting both water(73 mV@10 mA·cm^(−2)) and seawater(87 mV@10 mA·cm^(−2)).Notably,atomic Pt doping was introduced into CoS/Co(OH)_(2),which could produce local unbalanced Coulombic force and significantly increased the number of S vacancies,and then expose abundant Co ***,Co(OH)_(2) in Pt-CoS/Co(OH)_(2)/C could act as the adsorption sites for H_(2)O in hydrogen evolution reaction *** functional theory results also proved that atomic Pt doping,S vacancies and Co(OH)_(2) coupling could result in the formation of enriched electronic Co sites and optimize d_(z2) orbital electronic structure,and then realize the depth upward shift of d-band center and enhance the adsorption of H*on Co sites.

关键词： Electrocatalysts Hydrogen evolution reaction Pt-CoS/Co(OH)_(2) d-band center Electronic structure Water/seawater electrolysis

Arabidopsis MADS-Box Transcription Factor AGL21 Acts as Environmental Surveillance of Seed Germination by Regulating ABI5 Expression

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Molecular Plant 2017年第6期10卷 834-845页

作者： Lin-Hui Yu Jie Wu zi-sheng zhang zi-Qing Miao Ping-Xia Zhao Zhen Wang Cheng-Bin Xiang School of Life Sciences University of Science and Technology of China Hefei Anhui Province 230027 China Shanghai Center for Plant Stress Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China

Seed germination is a crucial checkpoint for plant survival under unfavorable environmental conditions. Ab- scisic acid （ABA） signaling plays a vital role in integrating environmental information to regulate seed germination. It has been well known that MCMI/AGAMOUS/DEFICIENS/SRF （MADS）-box transcription factors are key regulators of seed and flower development in Arabidopsis. However, little is known about their functions in seed germination. Here we report that MADS-box transcription factor AGL21 is a negative regulator of seed germination and post-germination growth by controlling the expression of ABA-INSENSITIVE 5 （ABIb＇） in Arabidopsis. The AGL21-overexpressing plants were hypersensitive to ABA, salt, and osmotic stresses during seed germination and early post-germination growth, whereas ag121 mutants were less sensitive. We found that AGL21 positively regulated ABI5 expression in seeds. Consistently, genetic analyses showed that AGL21 is epistatic to ABI5 in controlling seed germination. Chromatin immunoprecipitation assays further demonstrated that AGL21 could directly bind to the ABI5 promoter in plant cells. Moreover, we found that AGL21 responded to multiple environmental stresses and plant hormones during seed germination. Taken together, our results suggest that AGL21 acts as a surveillance integrator that incorporates environmental cues and endogenous hormonal signals into ABA signaling to regulate seed germination and early post-germination growth.

关键词： MADS AGL21 seed germination ABA ABI5

Nitrate-responsive OsMADS27 promotes salt tolerance in rice

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Plant Communications 2023年第2期4卷 136-150页

作者： Alamin Alfatih Jing zhang Ying Song Sami Ullah Jan zi-sheng zhang Jin-Qiu Xia Zheng-Yi zhang Tahmina Nazish Jie Wu Ping-Xia Zhao Cheng-Bin Xiang Division of Life Sciences and Medicine Division of Molecular&Cell BiophysicsHefei National Science Center for Physical Sciences at the MicroscaleMOE Key Laboratory for Membraneless Organelles and Cellular DynamicsUniversity of Science and Technology of ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui Province 230027China

Salt stress is a major constraint on plant growth and ***(N)fertilizers are known to alleviate salt ***,the underlying molecular mechanisms remain ***,we show that nitratedependent salt tolerance is mediated by OsMADS27 in *** expression of OsMADS27 is specifically induced by *** salt-inducible expression of OsMADS27 is also nitrate ***27 knockout mutants are more sensitive to salt stress than the wild type,whereas OsMADS27 overexpression lines are more *** analyses revealed that OsMADS27 upregulates the expression of a number of known stress-responsive genes as well as those involved in ion homeostasis and *** demonstrate that OsMADS27 directly binds to the promoters of OsHKT1.1 and OsSPL7 to regulate their ***,OsMADS27-mediated salt tolerance is nitrate dependent and positively correlated with nitrate *** results reveal the role of nitrate-responsive OsMADS27 and its downstream target genes in salt tolerance,providing a molecular mechanism for the enhancement of salt tolerance by nitrogen fertilizers in ***27 overexpression increased grain yield under salt stress in the presence of sufficient nitrate,suggestingthatOsMADS27 is a promising candidate for the improvementof salt tolerance inrice.

关键词： OsMADS27 nitrate-dependent salt tolerance salt stress grain yield

Knockout of OsSPL10 confers enhanced glufosinate resistance in rice

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Plant Communications 2024年第2期5卷 7-10页

作者： Jin-Qiu Xia Qin-Yu Liang Da-Yu He Zheng-Yi zhang Jie Wu Jing zhang Ping-Xia Zhao zi-sheng zhang Cheng-Bin Xiang Division of Life Sciences and Medicine Division of Molecular&Cell BiophysicsHefei National Science Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui Province 230027China

Dear Editor,Rice(Oryza sativa L.)is one of the world’s major food crops,feeding more than half of the global *** reduce labor and production costs,direct seeding is becoming popular for rice cultivation,but weeds have become a serious problem(Jin et al.,2022).Chemical herbicides are one of the most effective ways to control ***,the development of herbicide-resistant rice has great significance for modern rice production.

关键词： crops population. weed

Loss of OsARF18 function confers glufosinate resistance in rice

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Molecular Plant 2023年第9期16卷 1355-1358页

作者： Jin-Qiu Xia Da-Yu He Qin-Yu Liang Zheng-Yi zhang Jie Wu zi-sheng zhang Jing zhang Lin Wang Cong-He zhang Ping-Xia Zhao Cheng-Bin Xiang Division of Life Sciences and Medicine Division of Molecular&Cell BiophysicsHefei National Science Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui ProvinceChina Win-All Hi-Tech Seed Co.HefeiAnhui ProvinceChina

Dear Editor,Weeds are one of the most common biotic stresses causing severe crop yield decline(Jin et al.,2022).Chemical herbicides are an economical and effective method for weed control and are widely used in modern agriculture(Amna et al.,2019).However,the improper use of herbicides can impede crop growth,ultimately leading to reduced crop ***,it is of great significance to develop herbicide-resistant crops to alleviate weed infestations and maintain sustainable crop production.

关键词： crops weed maintain

A gain-of-function mutation of the MATE family transporter DTX6 confers paraquat resistance in Arabidopsis

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Molecular Plant 2021年第12期14卷 2126-2133页

作者： Jin-Qiu Xia Tahmina Nazish Ayesha Javaid Mohsin Ali Qian-Qian Liu Liang Wang Zheng-Yi zhang zi-sheng zhang Yi-Jie Huang Jie Wu Zhi-Sen Yang Lin-Feng Sun Yu-Xing Chen Cheng-Bin Xiang School of Life Sciences Division of Molecular&Cell BiophysicsHefei National Science Center for Physical Sciences at the MicroscaleMOE Key Laboratory for Membraneless Organelles and Cellular DynamicsUniversity of Science and Technology of ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui Province 230027China

Paraquat is one of the most widely used nonselective herbicides and has elicited the emergence of para-quat-resistant ***,the molecular mechanisms of paraquat resistance are not completely *** we report the Arabidopsis gain-of-function mutant pqt15-D with significantly enhanced resistance to paraquat and the corresponding gene PQT15,which encodes the Multidrug and Toxic Extru-sion(MATE)transporter DTX6.A point mutation at+932 bp in DTX6 causes a G311E amino acid substitution,enhancing the paraquat resistance ofpqt15-D,and overexpression of DTX6/PQT15 in the wild-type plants also results in strong paraquat ***,heterologous expression of DTX6 and DTX6-D in Es-cherichia coil significantly enhances bacterial resistance to ***,overexpression of DTX6-D enables Arabidopsis plants to tolerate 4 mM paraquat,a near-commercial application ***6/PQT15 is localized in the plasma membrane and endomembrane,and functions as a paraquat efflux transporter as demonstrated by paraquat efflux assays with isolated protoplasts and bacterial *** together,our results demonstrate that DTX6/PQT15 is an efflux transporter that confers paraquat resis-tance by exporting paraquat out of the *** findings reveal a molecular mechanism of paraquat resistance in higher plants and provide a promising candidate gene for engineering paraquat-resistant crops.

关键词： paraquat paraquat resistance DTX/MATE transporter subfamily AtDTX6/PQT15

Balanced nitrogen–iron sufficiency boosts grain yield and nitrogen use efficiency by promoting tillering

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Molecular Plant 2023年第12期16卷 1661-1677页

作者： Ying Song Guang-Yu Wan Jing-Xian Wang zi-sheng zhang Jin-Qiu Xia Liang-Qi Sun Jie Lu Chuan-Xi Ma Lin-Hui Yu Cheng-Bin Xiang Jie Wu Division of Life Sciences and Medicine Division of Molecular&Cell BiophysicsHefei National Science Center for Interdisciplinary Sciences at the MicroscaleMOE Key Laboratory for Membraneless Organelles and Cellular DynamicsUniversity of Science and Technology of ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui Province 230027China School of Agronomy Anhui Agricultural UniversityHefeiAnhui Province 230036China State Key Laboratory of Crop Stress Biology for Arid Areas and Institute of Future Agriculture Northwest A&F UniversityYanglingShaanxi 712100China

Crop yield plays a critical role in global food *** optimal plant growth and maximal crop yields,nutrients must be ***,the potential significance of balanced nitrogen-iron(N-Fe)for improving crop yield and nitrogen use efficiency(NUE)has not previously been ***,we show that balanced N-Fe sufficiency significantly increases tiller number and boosts yield and NUE in rice and ***-like protein 4(OsNLP4)plays a pivotal role in maintaining the N-Fe balance by coordinately regulating the expression of multiple genes involved in N and Fe metabolism and ***4 also suppresses OsD3 expression and strigolactone(SL)signaling,thereby promoting *** N-Fe sufficiency promotes the nuclear localization of OsNLP4 by reducing H_(2)O_(2) levels,reinforcing the functions of ***,we found that OsNLP4 upregulates the expression of a set of H2O2-scavenging genes to promote its own accumulation in the ***,we demonstrated that foliar spraying of balanced N-Fe fertilizer at the tillering stage can effectively increase tiller number,yield,and NUE of both rice and wheat in the ***,these findings reveal the previously unrecognized effects of N-Fe balance on grain yield and NUE as well as the molecular mechanism by which the OsNLP4-OsD3 module integrates N-Fe nutrient signals to downregulate SL signaling and thereby promote rice *** study sheds light on how N-Fe nutrient signals modulate rice tillering and provide potential innovative approaches that improve crop yield with reduced N fertilizer input for benefitting sustainable agriculture worldwide.

关键词： nitrogen-iron balance tller NUE grain yield OsNLP4 rice

OsNLP3 enhances grain weight and reduces grain chalkiness in rice

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Plant Communications 2024年第10期5卷 82-99页

作者： Liang-Qi Sun Yu Bai Jie Wu Shi-Jun Fan Si-Yan Chen Zheng-Yi zhang Jin-Qiu Xia Shi-Mei Wang Yu-Ping Wang Peng Qin Shi-Gui Li Ping Xu Zhong Zhao Cheng-Bin Xiang zi-sheng zhang Division of Life Sciences and Medicine Division of Molecular&Cell BiophysicsHefei National Science Center for Interdisciplinary Sciences at the MicroscaleUniversity of Science and Technology of ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui Province 230027China Experimental Center of Engineering and Materials Science University of Science and Technology of ChinaHefei 230027China Rice Research Institute Anhui Academy of Agricultural ScienceHefeiChina State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Rice Research InstituteSichuan Agricultural UniversityChengduSichuanChina Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChinese Academy of SciencesShanghaiChina

Grain weight,a key determinant of yield in rice(Oryza sativa L.),is governed primarily by genetic factors,whereas grain chalkiness,a detriment to grain quality,is intertwined with environmental factors such as mineral ***(N)is recognized for its effect on grain chalkiness,but the underlying molecular mechanisms remain to be *** study revealed the pivotal role of rice NODULE INCEPTION-LIKE PROTEIN 3(OsNLP3)in simultaneously regulating grain weight and grain *** investigation showed that loss of OsNLP3 leads to a reduction in both grain weight and dimension,in contrast to the enhancement observed with OsNLP3 ***3 directly suppresses the expression of OsCEP6.1 and OsNF-YA8,which were identified as negative regulators associated with grain ***,two novel regulatory modules,OsNLP3-OsCEP6.1 and OsNLP3-OsNF-YA8,were identified as key players in grain weight ***,the OsNLP3-OsNF-YA8 module not only increases grain weight but also mitigates grain chalkiness in response to *** research clarifies the molecular mechanisms that orchestrate grain weight through the OsNLP3-OsCEP6.1 and OsNLP3-OsNF-YA8 modules,highlighting the pivotal role of the OsNLP3-OsNF-YA8 module in alleviating grain *** findings reveal potential targets for simultaneous enhancement of rice yield and quality.

关键词： OsNLP3 OsCEP6.1 OsNF-YA8 grain weight grain chalkiness rice Oryza sativa L.

Pharmacokinetic study of single and multiple oral dose administration of antofloxacin hydrochloride in healthy male volunteers

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Chinese Medical Journal 2011年第2期124卷 242-245页

作者： LU Yuan KANG zi-sheng ZHU Yan zhang Ming LIU Yan zhang Man LI Tian-yun XIAO Yong-hong Institute of Clinical Pharmacology First Hospital Peking University Beijing 100191 China

Background A new fluroquinolone antibacterial agent,antofloxacin hydrochloride,developed in China,is an 8-NH2 derivant of *** purpose of the study was to evaluate the pharmacokinetic characteristics of single and multiple oral doses of antofloxacin hydrochloride in Chinese healthy male *** An open-label,non-randomized,single and multiple dose clinical trial was *** single dose study,12 subjects took 200 mg antofloxacin *** multiple dose study,12 subjects took antofloxacin hydrochloride 400 mg once on day 1 and 200 mg once daily from day 2 to day *** was used to assay the serum and urinary concentrations of *** In single dose study,the maximum concentration of drug in serum （Cmax）,the time to reach Cmax （Tmax）,and the area under the serum concentration-time curve （AUC （O-∞）） of antofloxacin were （1.89±0.65） mg/L,（1.29±0.26） hours,39.1%.In multiple dose study,blood concentration of antofloxiacin achieved stable state on day 2 after *** minimum concentration drug in serum （Cmin）,AUCss,mean concentration of drug in serum （Cav）,and degree offluctuation （DF） were （0.73±0.18） mg/L, （47.59±7.85） mg·h^-1·L^-1, （1.98±0.33） mg/L, and 1.74±0.60, respectively. On day 7 after dosing, Tmax ,Cmax and AUC （0-∞） was （1.14±0.50） hours, （2.52±0.38） mg/L, and （48.77±8.44） mg·h^-1·L^-1, respectively. Accumulating elimination rate of antofloxaxin from urine within 120 hours after the last dosing was 60.06%.Conclusions The regimen of 400 mg loading dose given on the first treatment day and then 200 mg dose once daily results in satisfactory serum drug concentration.

关键词： antofloxaxcin hydrochloride single dose multiple dose pharmacokinetics healthy volunteer

含磷酸结合口袋的BRCT结构域功能位点预测

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Zoological Research 2011年第5期32卷 509-514页

作者：盛自章黄京飞中国科学院昆明动物研究所遗传资源与进化国家重点实验室云南昆明650223 中国科学院研究生院北京100049 中国科学院昆明动物研究所和香港中文大学生物多样性和人类疾病模型联合研究中心云南昆明650223

BRCT(BRCA1C-terminus)是真核生物DNA损伤修复系统重要的信号传导和蛋白靶向结构域。为了探讨含磷酸结合口袋的BRCT与磷酸化配体结合的机制,对XRCC1BRCT1、PTIP BRCT4、ECT2BRCT1和TopBP1BRCT1进行了结构保守性和表面静电势分析。结果显... 详细信息

BRCT(BRCA1C-terminus)是真核生物DNA损伤修复系统重要的信号传导和蛋白靶向结构域。为了探讨含磷酸结合口袋的BRCT与磷酸化配体结合的机制,对XRCC1BRCT1、PTIP BRCT4、ECT2BRCT1和TopBP1BRCT1进行了结构保守性和表面静电势分析。结果显示,4个BRCT的磷酸结合口袋周围所存在的结构保守并带正电势的沟槽很可能是其功能位点,并且类似的沟槽在含磷酸结合口袋的BRCT中普遍存在。沟槽两侧及底部均带有极性氨基酸残基,两侧带正电荷,而底部疏水。这说明沟槽与配体的结合以静电和疏水相互作用为主。沟槽主要位于单个BRCT中,而且4个BRCT的沟槽在形状和电荷分布上都不同,说确明BRCT配体特异性主要由单个BRCT决定。磷酸结合口袋位于沟槽中心,说明沟槽可能同时结合磷酸化残基的N端和C端附近残基。

关键词： BRCT结构域磷酸结合口袋 DNA损伤修复表面静电势