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Journal of Geriatric Cardiology 2024年第7期21卷 713-715页

作者： jian-Jun li Cardiometabolic Center National Center for Cardiovascular DiseaseChinese Academy of Medical ScienceFuwai HospitalBeijingChina

It is well-known that elevated low-density lipoprotein cholesterol(LDL-C)is a causal risk factor for atheroscler-otic cardiovascular disease(ASCVD),statins are cornerstone drugs for the cause-based treatment of ASCVD,which has created a new era for ASCVD ***,statin intolerance is not clinically uncommon,which there are several issues with confu-sion and ***,a file named Chinese Expert Consensus on the Diagnosis and Management Strategy of Pa-tients With Statin Intolerance,like a navigator,has recently been published written by a team of experts from the Cardiovascular Metabolic Medicine Professional Committee,Expert Committee of the National Center for Cardiovascular Diseases aiming to en-hance the standardized clinical application of statins and improve the prevention and clinical *** this article,author briefly summarized the key points of above consensus in order to helping to comprehending the content of the consensus sugges-tions.

关键词： Expert Strategy corners

An aptamer-driven DNA nanodevice for improved delivery of synthetic immunostimulants

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Nano Research 2024年第10期17卷 9078-9083页

作者： Dejie Lu Zhenghan Di Lele li jian Zhao li Zheng Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and ApplicationGuangxi Key Laboratory of Regenerative MedicineThe First Affiliated Hospital of Guangxi Medical UniversityGuangxi Medical UniversityNanning 530021China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing 100190China

Efficient delivery of therapeutics to immune cells remains a formidable challenge for cancer *** this work,we demonstrate that an aptamer-driven DNA nanodevice,constructed through linkage of a synthetic immunostimulant(Toll-like receptor 9 agonist:CpG motif)to an aptamer,could significantly enhance the immunostimulatory activity by facilitating the uptake and retention of therapeutics in *** administration of the DNA nanodevice results in efficient tumor growth inhibition in both breast cancer and melanoma mouse *** studies suggest that the DNA nanodevice leads to reeducation of tumor-associated macrophages and ultimately to reversing the tumor immune *** strategy for aptamer-mediated and vehicle-free delivery of immunostimulatory oligonucleotides provides a potential platform for cancer immunotherapy.

关键词： aptamer immunostimulatory oligonucleotides DNA nanodevice tumor-associated macrophages cancer therapy

Design strategies of high-performance lead-free electroceramics for energy storage applications

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Rare Metals 2024年第3期43卷 853-878页

作者： Biao Guo Fei Jin li li zi-Zhao Pan Xin-Wei Xu Hong Wang Department of Materials Science and Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055China School of Microelectronics and State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an710049China

A greater number of compact and reliable electrostatic capacitors are in demand due to the Internet of Things boom and rapidly growing complex and integrated electronic systems,continuously promoting the development of high-energy-density ceramic-based *** significant successes have been achieved in obtaining high energy densities in lead-based ferroelectric ceramics,the utilization of lead-containing ceramies has been restricted due to environmental and health hazards of ***-free ferroelectric ceramics have garnered tremendous attention and are expected to replace lead-based ceramics in the near ***,the energy density of lead-free ceramics is still lagging behind that of lead-containing ***,severely limiting their *** efforts have been made to enhance the energy storage performance of lead-free ceramics using multi-scale design strategies,and exciting progress has been achieved in the past *** review briefly discusses the energy storage mechanism and fundamental characteristics of a dielectric capacitor,summarizes and compares the state-of-the-art design strategies for high-energy-density lead-free ceramics,and highlights several critical issues and requirements for industrial *** prospects and challenges of lead-free ceramics for energy storage applications are also discussed.

关键词： Dielectric materials Lead-free ceramic Environment friendly Energy storage Design strategy

Rockburst prediction and prevention in underground space excavation

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Underground Space 2024年第1期14卷 70-98页

作者： jian Zhou Yulin Zhang Chuanqi li Haini He Xibing li School of Resources and Safety Engineering Central South UniversityChangsha 410083China Laboratory 3SR CNRS UMR 5521Grenoble Alpes UniversityGrenoble 38000France

The technical challenges associated with deep underground space activities have become increasingly *** these challenges,one major concern is the assessment of rockburst risks and the instability of rock *** research has been conducted by numerous scholars to mitigate the risks and prevent occurrences of rockburst through various assessment *** incidents commonly occur during the excavation of hard rock in underground environments,posing severe threats to personnel safety,equipment integrity,and operational ***,it is crucial to systematically document real cases of rockburst,allowing for a comprehensive understanding of the underlying mechanisms and triggering *** understanding will contribute to the advancement of rockburst prediction and prevention *** selection of an appropriate rockburst assessment method is a fundamental aspect in underground ***,there is a limited number of studies that summarize and compare different prediction and prevention methods of *** paper aims to address this gap by analyzing global trends using CiteSpace software since *** discusses rockburst classification and characteristics,comprehensively reviews research findings related to rockburst prediction,including empirical,simulation,mathematical modeling,and microseismic monitoring ***,the paper presents a compilation of current rockburst prevention ***,the paper emphasizes the significance of control strategies,which provide key insights into the effective utilization of stored energy within ***,the paper concludes by suggesting six directions for implementing intelligent management techniques to mitigate hazards during underground operations and reduce the probability of rockburst incidents.

关键词： Rockburst Underground space Scientometric analysis Characteristic analysis Rockburst prediction Rockburst prevention

Photocaged activity-based probes for improved monitoring of protein S-sulfenylation in living cells

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Chinese Chemical Letters 2024年第2期35卷 451-454页

作者： Jiahao Zhang Haiyue Peng zi'an Chen Guorui li Jing Huang State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan Provincial Key Laboratory of Animal Models and Molecular MedicineSchool of Biomedical SciencesHunan UniversityChangsha 410082China

Protein S-sulfenylation(protein sulfenic acid),as one of the most significant oxidative post-translational modifications(OxiPTMs),plays a vital role in regulating protein function.A variety of activity-based probes have been developed to profile sulfenic acid in living ***,due to the transient presence and low content of sulfenic acid in living cell,high doses of probes are needed to achieve efficient *** importantly,current probes have no temporal control over sulfenic acid *** overcome these limitations,two caged cysteine sulfenic acid probes DYn-2-ONB and DYn-2-Cou with either an o-nitrobenzyl or coumarin protecting group were developed in this *** probes can be efficiently uncaged via irradiation to produce the active C-nucleophile probe *** assay in living cells demonstrated DYn-2-ONB exhibited better labeling capacity compared with DYn-2,providing it as a powerful tool for improved monitoring of protein S-sulfenylation in living cells.

关键词： Cysteine Sulfenic acid Activity-based probe Photocage light activation Protein S-sulfenylation

WRKY11 up-regulated dirigent expression to enhance lignin/lignans accumulation in lilium regale Wilson during response to Fusarium wilt

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Journal of Integrative Agriculture 2024年第8期23卷 2703-2722页

作者： Jie Deng zi’e Wang Wenyun li Xiaohua Chen Diqiu liu Faculty of life Science and Technology Kunming University of Science and TechnologyKunming 650500China

lilium are highly economically valuable ornamental plants that are susceptible to Fusarium wilt caused by Fusarium *** regale Wilson,a wild lily native to China,is highly resistant to *** this study,a WRKY transcription factor,WRKY11,was isolated from ***,and its function during the interaction between *** and *** was *** ectopic expression of LrWRKY11 in tobacco increased the resistance to F oxysporum,moreover,the transcriptome sequencing and UHPLC-MS/MS analysis indicated that the methyl salicylate and methyl jasmonate levels rose in LrWRKY11 transgenic tobacco,meanwhile,the expression of lignin/lignans biosynthesis-related genes including a dirigent(DiR)was *** lignin/lignans contents in LrWRKY11-transgenic tobacco also significantly increased compared with the wild-type *** addition,the resistance of *** scales in which LrWRKY11 expression was silenced by RNAi evidently decreased,and additionally,the expression of lignin/lignans biosynthesis-related genes including LrDIR1 was significantly ***,LrDIR1 and its promoter(PLrDIR1)sequence containing the W-box element were isolated from *** interaction assay indicated that LrWRKY11 specifically bound to the W-box element in PLrDIR1 and activated LrDIR1 ***,β-glucuronidase activity in the transgenic tobacco co-expressing LrWRKY11/PLrDIR1-β-glucuronidase was higher than that in transgenic tobacco expressing PLrDIR1-β-glucuronidase ***,the ectopic expression of LrDIR1 in tobacco enhanced the resistance to *** and increased the lignin/lignans *** brief,this study revealed that LrWRKY11 positively regulated *** resistance to *** through interaction with salicylic acid/jasmonic acid signaling pathways and modulating LrDIR1 expression to accumulate lignin/lignans.

关键词： lilium regale Fusarium oxysporum WRKY transcription factor dirigent

Enhanced properties of stone coal-based composite phase change materials for thermal energy storage

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 206-215页

作者： Baoshan Xie Huan Ma Chuanchang li jian Chen Key Laboratory of Renewable Energy Electric-Technology of Hunan Province School of Energy and Power EngineeringChangsha University of Science and TechnologyChangsha 410114China State Key Laboratory of Disaster Prevention and Reduction for Power Grid Changsha University of Science and TechnologyChangsha 410114China

Phase change materials (PCMs) can be incorporated with low-cost minerals to synthesize composites for thermal energy storage in building *** coal (SC) after vanadium extraction treatment shows potential for secondary utilization in composite *** prepared SC-based composite PCMs with SC as a matrix,stearic acid (SA) as a PCM,and expanded graphite (EG) as an *** combined roasting and acid leaching treatment of raw SC was conducted to understand the effect of vanadium extraction on promoting loading *** showed that the combined treatment of roasting at 900℃ and leaching increased the SC loading of the composite by 6.2%by improving the specific surface *** loading capacity and thermal conductivity of the composite obviously increased by 127%and 48.19%,respectively,due to the contribution of 3wt% *** data were supported by the high load of 66.69%and thermal conductivity of 0.59 W·m^(-1)·K-1of the designed *** obtained composite exhibited a phase change temperature of 52.17℃,melting latent heat of 121.5 J·g^(-1),and good chemical *** SC-based composite has prospects in building applications exploiting the secondary utilization of minerals.

关键词： thermal energy storage phase change material stone coal vanadium extraction secondary utilization

The Structure Entropy of Social Networks

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Journal of Systems Science & Complexity 2024年第3期37卷 1147-1162页

作者： li Zhenpeng YAN Zhihua YANG jian TANG Xijin School of Electronics and Information Engineering Taizhou UniversityLinhai 317000China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China Yunnan Key Laboratory of Smart City in Cyberspace Security Yuxi Normal UniversityYuci 653100China University of Chinese Academy of Sciences Beijing 100039China

Micro triadic structure is an important motif and serves the building block of complex *** this paper,the authors define structure entropy for a social network and explain this concept by using the coded triads proposed by Davis and Leinhardt in *** proposed structure entropy serves as a new macro-evolution index to measure the network’s stability at a given *** analysis of real-world network structure entropy discloses rich information on the mechanism that yields given triadic motifs frequency *** paper illustrates the intrinsic link between the micro dyadic/triadic motifs and network structure ***,the authors find that the high proportion of reciprocity and transitivity results in the emergence of hierarchy,order,and cooperation of online social networks.

关键词： Dyadic and triadic motifs network structure entropy reciprocity and transitivity

Recent advances in promising drugs for primary prevention of gastroesophageal variceal bleeding with cirrhotic portal hypertension

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 4-13页

作者： Ji-Yao Sheng zi-Fan Meng Qiao li Yong-Sheng Yang Department of Hepatobiliary and Pancreatic Surgery the Second Hospital of Jilin UniversityChangchun 130041China Jilin Engineering Laboratory for Translational Medicine of Hepatobiliary and Pancreatic Diseases the Second Hospital of Jilin UniversityChangchun 130041China

Background:Gastroesophageal variceal bleeding is one of the most severe complications of patients with *** primary prevention drugs,including non-selectiveβ-blockers,have effectively reduced the incidence of bleeding,their efficacy is limited due to side effects and related *** recent advances in precision medicine,precise drug treatment provides better treatment *** sources:literature search was conducted in PubMed,MEDliNE and Web of Science for relevant articles published up to May *** on clinical trials was obtained from https://***/and http://***/.Results:The in-depth understanding of the pathogenesis and advances of portal hypertension has enabled the discovery of multiple molecular targets for promising *** to the site of action,these drugs could be classified into four classes:intrahepatic,extrahepatic,both intrahepatic and extrahepatic targets and *** these classes of drugs offer advantages over traditional treatments in prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal ***:This review classified and summarized the promising drugs,which prevent gastroesophageal variceal bleeding by targeting specific markers of pathogenesis of portal hypertension,demonstrating the significance of using the precision medicine strategy to discover and develop promising drugs for the primary prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal hypertension.

关键词： Cirrhotic portal hypertension Target drug Primary prevention Bleeding

Human influence on the duration of extreme temperature events in Asia's hotspot regions

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Advances in Climate Change Research 2024年第2期15卷 312-326页

作者： zi-Meng WANG Hong-Yun MA Wei li Hai-Shan CHEN Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)/Key Laboratory of Meteorological Disaster Ministry of Education(KLME)Nanjing University of Information Science and TechnologyNanjing 210044China

Observations and models indicate that human activities exert a considerable impact on the frequency and intensity of extreme temperature events,which are associated with global ***,changes in the duration of extreme temperature events and their association with human influence have not been considered in most ***,the possible relationship between the observed changes in the warm and cold spell duration(WSDI and CSDI)in hotspot regions during 1960-2014 and human influence was investigated based on the NCEP/NCAR reanalysis version 1 and Coupled Model Inter-comparison Project Phase 6(CMIP6)*** projection based on these attribution results was also *** optimal fingerprinting technique was used to compare observed changes in WSDI and CSDI to simulated changes averaged across eight CMIP6 *** show that anthropogenic(ANT)forcing contributed to the observed increase in WSDI in the three hotspot regions(West Asia,South Asia and Southeast Asia),with the majority of the changes being attributed to greenhouse gas ***,a generally weak ANT signal can be observed in the decreasing trend of CSDI and can be detected in South and Southeast *** influence of aerosol forcing remains undetected in either WSDI or CSDI,which differs from the results for frequency and intensity of extreme *** attribution results revealed that the constrained projection of WSDI is lower than the raw projection for 2015-2100 in West Asia and Southeast ***,no differences in future CSDI changes are found in Southeast Asia between the constrained and raw projections.

关键词： Extreme temperature events Duration Detection attribution Constraint projection Hotspot regions