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Differential Occupational Health Risks between Methylated PAHs and PAHs:Monitoring 126 PAHs and 6 Oxidative Stress Markers in Paired Serum−Urine Samples

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Environment & Health 2024年第3期2卷 150-160页

作者： Ke-Xin Zhao Chao Jiang Yue han Wen-Long Li Yu-Wei Li Li-Yan Liu Wan-Li Ma Ying-Hua Hu zi-Feng Zhang International Joint Research Center for Persistent Toxic Substances(IJRC-PTS) State Key Laboratory of Urban Water Resource and Environment/School of EnvironmentHarbin Institute of Technology(HIT)Harbin 150090China Wadsworth Center New York State Department of Healthand Department of Environmental Health SciencesSchool of Public HealthState University of New York at AlbanyAlbanyNew York 12237United States

The hazards of polycyclic aromatic hydrocarbons(PAHs)on occupationally exposed population have been widely ***,the occupational exposure risks associated their derivatives,methylated PAHs,remain poorly *** study conducted a screen of 126 PAHs and 6 oxidative stress biomarkers(OSBs)in paired serum−urine samples from 110 petrochemical workers to assess the risk associated with different PAHs *** results showed that the median concentrations of unmetabolized 16 priority PAHs(p-PAHs),16 regular PAHs(R-PAHs),50 methyl-PAHs(Me-PAHs),and 30 nitro-PAHs(N-PAHs)in serum(urine)were 97.98(66.46),11.02(0.00),77.76(31.77),and 1.93(0.10)ng/mL,*** median concentration of metabolized hydroxy PAHs(OH-PAHs)in urine was 12.00 ng/mL(9.49 ng/mg creatinine).OSBs indicate that the hazards of Me-PAHs on exposed populations manifest as protein damage,while the hazards of p-PAHs mainly result in lipid and DNA *** from common diseases and PAH exposure demonstrate a correlation between liver damage and PAH exposure,and Me-PAHs are more difficult to metabolize through urine due to their stronger *** study suggests that traditional health screenings targeting p-PAHs may be insufficient and likely underestimate the exposure risks for occupational populations.

关键词： Petrochemical workers Methyl-PAHs Nitro-PAHs Oxidative stress biomarkers Health risk

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Evidence for distortion-induced local electric polarization in α-RuCl_(3)

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 165-173页

作者： Xinrun Mi De Hou Xiao Wang Sabreen Hammouda Caixing Liu zijian xiong han Li Yan Liu Guiwen Wang Aifeng Wang Yisheng Chai Yang Qi Wei Li Xiaoyuan Zhou Yixi Su DIKhomskii Mingquan He Zhigao Sheng Young Sun College of Physics Center of Quantum Materials and DevicesChongqing UniversityChongqing 401331China Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryHefei Institutes of Physical ScienceAnhuiChinese Academy of SciencesHefei 230031 China University of Science and Technology of China Hefei 230026China Jülich Centre for Neutron Scienceat Heinz Maier-Leibnitz Zentrum(JCNS-MLZ) Forschungszentrum Jülich GmbHGarching D-85747Germany School of Physics Beihang UniversityBeijing 100191China Analytical and Testing Center Chongqing UniversityChongqing 401331China State Key Laboratory of Surface Physics Department of PhysicsFudan UniversityShanghai 200433China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Ⅱ.Physikalisches Institut Universität zu KölnKöln D-50937Germany

The spin-orbit assisted Mott insulator α-RuCl_(3) is a prime candidate for material realization of the Kitaev quantum spin *** little attention has been paid to charge degrees of freedom,charge effects,such as electric polarization,may arise in this ***,we report distortion-induced local electric polarization in α-RuCl_(3) as evidenced by single-crystal X-ray diffraction,second harmonic generation(SHG)and dielectric *** SHG signal appears at room temperature and develops substantially in the Kitaev paramagnetic state when short-range spin correlations come into *** sizable pyroelectric currents in the Kitaev paramagnetic state,the absence of hysteresis in the polarization-electric field(P-E)points to the shortrange nature of electric *** localized electric polarization is likely the result of distortion-induced charge dimerization,achieved through virtual hopping-induced charge *** addition,the electric polarization is boosted by short-range spin correlations via spin-phonon coupling in the Kitaev paramagnetic *** results emphasize the importance of charge degrees of freedom in α-RuCl_(3),which establish a novel platform to investigate charge effects in Kitaev materials.

关键词： Mott insulator Kitaev quantum spin liquid electric polarization

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巷道蝶形破坏强度准则低敏感性研究及工程应用

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岩土力学 2024年第1期45卷 117-130页

作者：刘洪涛韩子俊刘勤裕陈子晗韩洲张红凯杨永松中国矿业大学(北京)能源与矿业学院北京100083 巷道支护与灾害防治煤炭行业工程研究中心北京100083

巷道围岩的塑性区形态对巷道的破坏形式及破坏程度有重要影响。为探究三向应力场下塑性区形态演化过程,基于弹性力学推导了轴向应力表达式,并依据蝶形塑性区边界方程求解思路,确定了三维强度准则下三向塑性区近似解的求解方法。通过等... 详细信息

巷道围岩的塑性区形态对巷道的破坏形式及破坏程度有重要影响。为探究三向应力场下塑性区形态演化过程,基于弹性力学推导了轴向应力表达式,并依据蝶形塑性区边界方程求解思路,确定了三维强度准则下三向塑性区近似解的求解方法。通过等球应力p、等偏应力q以及不同Lode角θσ来确定围岩应力加载方案,对不同三维强度准则下的围岩塑性区形态演化规律进行深入研究,论证了蝶形破坏的准则低敏感性。基于蝶形破坏理论对羊场湾160206回风巷道的非对称变形破坏机制及控制技术进行深入分析。研究结果表明:(1)在相同p、q及不同θσ的应力加载条件下,5种强度准则下的塑性区形态均呈现圆形、类椭圆及蝶形的演化规律,且每种强度准则在相同θσ的情况下围岩的塑性区形态基本一致。(2)相同应力大小、不同应力方向的加载方案下,围岩的塑性区形态大不相同。圆巷围岩的塑性区形态很大程度上由水平侧压比决定,轴向侧压对围岩的塑性区尺寸影响较大,对塑性区形态影响较小。(3)羊场湾160206回风巷道在叠加采动影响下顶板呈现非对称大变形破坏,基于蝶形塑性区支护思路,应用非对称锚杆索+超前单元支架+钻孔卸压的协同支护技术,取得了良好的支护效果。

关键词：塑性区边界蝶形塑性区强度准则采动影响巷道围岩控制

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Tuna dark muscle peptides modulate host iron metabolism in the intestine through the gut microbiota and ameliorate iron deficiency anemia

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Food Science and Human Wellness 2024年

作者： Jiaojiao han Jiayi xiong Zhixiang Bai Yang Qin Chenyang Lu Jun Zhou Ye Li Tinghong Ming Zhen Zhang Xiurong Su State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products， Ningbo University School of Marine Science， Ningbo University

Iron deficiency anemia (IDA) is a nutritional deficiency disease with a high incidence rate worldwide. Bioactive peptides are safe and effective， have multiple functions and can serve as potential candidates for alleviating IDA. In this study， the anti-anemia effects of tuna dark muscle peptides were explored in a diet-induced IDA mouse model. The results showed that tuna dark muscle peptides alleviated the IDA phenotype， oxidative stress and iron metabolism. In addition， tuna dark muscle peptides reversed gut microbiota dysbiosis in IDA mice. Furthermore， the transplanted fecal microbiota from tuna dark muscle peptide-treated mice also alleviated IDA symptoms and regulated iron metabolism and the gut microbiota， indicating that the anti-anemic effects were at least partially mediated by the gut microbiota. Thus， we identified a new and safe prebiotic material to alleviate IDA and provided ideas for the development of peptides. At the same time， these data also provided a theoretical basis for fecal microbiota transplantation (FMT) to alleviate IDA.

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郑州市PM_(2.5)中有机酸的污染特征、来源解析及二次生成

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环境科学 2024年第2期45卷 700-708页

作者：李子涵董喆尚璐琪孔梓涵李晓张瑞芹郑州大学生态与环境学院郑州450001 郑州大学化学学院郑州450001

大气颗粒物中的有机酸广泛参与大气中的各种物理化学反应,对二次有机气溶胶和霾的形成贡献极大,因此分析颗粒物中有机酸的浓度分布特征、评估其污染来源、探究其二次生成,对深入研究有机气溶胶及其二次转化具有重要意义.在郑州市不同季... 详细信息

大气颗粒物中的有机酸广泛参与大气中的各种物理化学反应,对二次有机气溶胶和霾的形成贡献极大,因此分析颗粒物中有机酸的浓度分布特征、评估其污染来源、探究其二次生成,对深入研究有机气溶胶及其二次转化具有重要意义.在郑州市不同季节采集大气细颗粒物(PM_(2.5))样品,识别并定量二元酸类、脂肪酸类和树脂酸类有机酸共30种,探究其浓度分布特征、季节变化、来源贡献及二次生成.定量的二元酸类以丙二酸(di-C_(3))和琥珀酸(di-C_(4))含量最为丰富,并且表现出明显的季节变化特征:夏季>秋季>冬季>春季;脂肪酸类表现出明显的双峰优势,以棕榈酸和硬脂酸(C_(18))最为丰富,季节变化特征为冬季最高,春季最低.利用主成分分析结合多元线性回归(MLR)方法对郑州市PM_(2.5)中的有机酸进行来源解析,结果表明,35%的有机酸来自于燃烧源和交通源,24%来自于烹饪源、23%来自于二次生成以及17%来自于天然源.利用标记物种的比值(如di-C_(3)/di-C_(4)、F/M和C_(18):1/C_(18))探究有机气溶胶二次形成及其老化过程.结果表明,夏季光化学反应剧烈,有机气溶胶老化或二次生产比例较高,冬季光化学反应较弱,有机气溶胶老化程度较低.采用相关性分析与MLR相结合的方法,量化了气相氧化和液相氧化对二元酸形成的相对贡献,气相氧化在采样过程中起主导作用,占比为58%,特别是夏季,占总二次转化的61%.

关键词：二元酸脂肪酸二次有机气溶胶二次生成气相氧化

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Scintillation Arc from FRB 20220912A

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 134-142页

作者： zi-Wei Wu Robert AMain Wei-Wei Zhu Bing Zhang Peng Jiang Jia-Rui Niu Jin-Lin han Di Li Ke-Jia Lee Dong-zi Li Yuan-Pei Yang Fa-Yin Wang Rui Luo Pei Wang Chen-Hui Niu Heng Xu Bo-Jun Wang Wei-Yang Wang Yong-Kun Zhang Yi Feng De-Jiang Zhou Yong-Hua Xu Can-Min Deng Yu-Hao Zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Max-Planck-Institut für Radioastronomie Bonn 53121Germany Institute for Frontier in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Nevada Center for Astrophysics and Department of Physics and Astronomy University of NevadaLas VegasNV 89154USA CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy University of Chinese Academy of SciencesBeijing 100049China NAOC-UKZN Computational Astrophysics Centre University of KwaZulu-NatalDurban 4000South Africa Department of Astronomy Peking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Cahill Center for Astronomy and Astrophysics California Institute of TechnologyPasadena 91125USA South-Western Institute For Astronomy Research Yunnan UniversityKunming 650504China School of Astronomy and Space Science Nanjing UniversityNanjing 210093China Key Laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210023China CSIRO Space and Astronomy Epping 1710Australia Department of Astronomy School of Physics and Materials ScienceGuangzhou UniversityGuangzhou 510006China Research Center for Intelligent Computing Platforms Zhejiang LaboratoryHangzhou 311100China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Guangxi Key Laboratory for Relativistic Astrophysics Department of PhysicsGuangxi UniversityNanning 530004China

We present the interstellar scintillation analysis of fast radio burst(FRB)20220912A during its extremely active episode in 2022using data from the Five-hundred-meter Aperture Spherical Radio Telescope(FAST).We detect a scintillation arc in the FRB’s secondary spectrum,which describes the power in terms of the scattered FRB signals’time delay and Doppler *** arc indicates that the scintillation is caused by a highly localized *** analysis favors a Milky Way origin of the ionized interstellar medium(IISM)for the localized scattering medium but cannot rule out a host galaxy *** present our method for detecting the scintillation arc,which can be applied generally to sources with irregularly spaced bursts or *** methods could help shed light on the complex interstellar environment surrounding the FRBs and in our Galaxy.

关键词： fast radio burst scintillation FRB 20220912A

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基于决策变量关系的动态多目标优化算法

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控制与决策 2024年第1期39卷 78-86页

作者：呼子宇李紫晗孙浩魏立新王聪燕山大学电气工程学院河北秦皇岛066004 燕山大学智能控制系统与智能装备教育部工程研究中心河北秦皇岛066004

动态多目标优化问题(DMOPs)需要进化算法跟踪不断变化的Pareto最优前沿,从而在检测到环境变化时能够及时有效地做出响应.为了解决上述问题,提出一种基于决策变量关系的动态多目标优化算法.首先,通过决策变量对收敛性和多样性贡献大小的... 详细信息

动态多目标优化问题(DMOPs)需要进化算法跟踪不断变化的Pareto最优前沿,从而在检测到环境变化时能够及时有效地做出响应.为了解决上述问题,提出一种基于决策变量关系的动态多目标优化算法.首先,通过决策变量对收敛性和多样性贡献大小的检测机制将决策变量分为收敛性相关决策变量(CV)和多样性相关决策变量(DV),对不同类型决策变量采用不同的优化策略;其次,提出一种局部搜索多样性维护机制,使个体在Pareto前沿分布更加均匀;最后,对两部分产生的组合个体进行非支配排序构成新环境下的种群.为了验证DVR的性能,将DVR与3种动态多目标优化算法在15个基准测试问题上进行比较,实验结果表明, DVR算法相较于其他3种算法表现出更优的收敛性和多样性.

关键词：动态多目标优化进化算法预测决策变量关系引导个体多样性保持

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原子层沉积金属氧化物缓冲层制备高性能大面积钙钛矿太阳电池

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物理学报 2024年第9期73卷 317-325页

作者：瞿子涵赵洋马飞游经碧中国科学院半导体研究所半导体物理实验室北京100083 中国科学院大学材料科学与光电工程中心北京100049

研制具有较大活性面积的钙钛矿太阳电池对领域面向产业化的发展具有重要意义.当前,大面积钙钛矿太阳电池的性能与小面积钙钛矿太阳电池之间仍存在较大差距.本文提出一种在透明导电薄膜衬底上预先原子层沉积TiO_(2)薄层的策略,有效避免... 详细信息

研制具有较大活性面积的钙钛矿太阳电池对领域面向产业化的发展具有重要意义.当前,大面积钙钛矿太阳电池的性能与小面积钙钛矿太阳电池之间仍存在较大差距.本文提出一种在透明导电薄膜衬底上预先原子层沉积TiO_(2)薄层的策略,有效避免了衬底局部突起与钙钛矿吸光层直接接触导致的漏电现象,提升了小面积器件制备工艺的重复一致性.改善的电子输运和光管理过程也提高了小面积器件的效率.更重要的是,本文基于原子层沉积的TiO_(2)开展了0.5 cm^(2)大面积钙钛矿太阳电池的研究,通过优化TiO_(2)层的厚度,研制出光电转换效率高达24.8%的冠军器件(第三方认证效率24.65%),器件的制备工艺也表现出较好的重复性.此外,原子层沉积了TiO_(2)缓冲层的电池器件在氮气氛围下存储1500 h后仍然能够保留初始性能的95%以上.总之,在粗糙衬底上预先原子层沉积TiO_(2)薄层可以有效抑制局部漏电通道的产生,有利于制备高性能的大面积钙钛矿太阳电池.

关键词：原子层沉积金属氧化物大面积钙钛矿太阳电池

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Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney,and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways

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World Journal of Diabetes 2024年第3期15卷 502-518页

作者： zi-Ang Ma Li-Xin Wang Hui Zhang han-Zhou Li Li Dong Qing-Hai Wang Yuan-Song Wang Bao-ChaoPan Shu-Fang Zhang Huan-Tian Cui Shu-Quan Lv Graduate School Hebei University of Chinese MedicineShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese MedicineCangzhou 061000Hebei ProvinceChina School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 300000China The First School of Clinical Medicine Yunnan University of Traditional Chinese MedicineKunming 065000Yunnan ProvinceChina Department of Endocrinology Hebei Cangzhou Hospital of Integrative MedicineCangzhou 061000Hebei ProvinceChina

BACKGROUND Jianpi Gushen Huayu Decoction(JPGS)has been used to clinically treat diabetic nephropathy(DN)for many ***,the protective mechanism of JPGS in treating DN remains *** To evaluate the therapeutic effects and the possible mechanism of JPGS on *** We first evaluated the therapeutic potential of JPGS on a DN mouse *** then investigated the effect of JPGS on the renal metabolite levels of DN mice using non-targeted ***,we examined the effects of JPGS on c-Jun N-terminal kinase(JNK)/P38-mediated apoptosis and the inflammatory responses mediated by toll-like receptor 4(TLR4)/nuclear factor-kappa B(NF-κB)/NOD-like receptor family pyrin domain containing 3(NLRP3).RESULTS The ameliorative effects of JPGS on DN mice included the alleviation of renal injury and the control of inflammation and oxidative *** metabolomic analysis revealed that JPGS altered the metabolites of the kidneys in DN mice.A total of 51 differential metabolites were *** analysis results indicated that nine pathways significantly changed between the control and model groups,while six pathways significantly altered between the model and JPGS *** related to cysteine and methionine metabolism;alanine,tryptophan metabolism;aspartate and glutamate metabolism;and riboflavin metabolism were identified as the key pathways through which JPGS affects *** experimental validation showed that JPGS treatment reduced the expression of TLR4/NF-κB/NLRP3 pathways and JNK/P38 pathway-mediated apoptosis related *** JPGS could markedly treat mice with streptozotocin(STZ)-induced DN,which is possibly related to the regulation of several metabolic pathways found in ***,JPGS could improve kidney inflammatory responses and ameliorate kidney injuries in DN mice via the TLR4/NF-κB/NLRP3 pathway and inhibit JNK/P38 pathwaymediated apoptosis in DN mice.

关键词： Diabetic nephropathy Jianpi Gushen Huayu Decoction Oxidative stress Inflammation Untargeted metabolomics Toll-like receptor 4/nuclear factor-kappa B/NOD-like receptor family pyrin domain containing 3 pathway c-Jun N-terminal kinase/P38-mediated apoptosis

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SEM视角下人民币汇率风险影响因素研究

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亚太经济 2024年第1期 65-72,119页

作者：蔡梓涵叶琪新加坡南洋理工大学公共管理研究生院新加坡639798 福建师范大学经济学院福州350001

基于SEM视角,结合我国宏观经济特征与制度背景,运用Granger检验方法选取影响人民币汇率风险的备选指标,使用探索性因子对影响因素进行KMO和Bartlett检验,采用方差极大法对因子载荷矩阵实行正交旋转,构建汇率风险测度因子分析模型,并用SE... 详细信息

基于SEM视角,结合我国宏观经济特征与制度背景,运用Granger检验方法选取影响人民币汇率风险的备选指标,使用探索性因子对影响因素进行KMO和Bartlett检验,采用方差极大法对因子载荷矩阵实行正交旋转,构建汇率风险测度因子分析模型,并用SEM模型绘制出人民币汇率风险影响路径系数图,分析影响人民币汇率风险的主要因素,为人民币汇率风险测度提供科学依据。

关键词：汇率风险测度影响因素结构方程模型

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