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Efficacy and safety of acupuncture for polycystic ovary syndrome:An overview of systematic reviews

Journal of Integrative Medicine 2023年第2期21卷 136-148页

作者： han Yang Zhi-yong Xiao zi-han yin Zheng Yu Jia-jia Liu Yan-qun Xiao Yao Zhou Juan Li Jie Yang Fan-rong Liang Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina College of Medical Information and Engineering Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Traditional Chinese Medicine Department Chengdu Xinan Gynecological HospitalChengdu 610051Sichuan ProvinceChina Infertility Clinic Chengdu Xinan Gynecological HospitalChengdu 610051Sichuan ProvinceChina Health Preservation and Rehabilitation School Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina

Background:Polycystic ovary syndrome(PCOS)is the primary cause of anovulatory infertility,bringing serious harm to women’s physical and mental *** may be an effective treatment for ***,systematic reviews(SRs)on the efficacy and safety of acupuncture for PCOS have reported inconsistent results,and the quality of these studies has not been adequately ***:To summarize and evaluate the current evidence on the efficacy and safety of acupuncture for PCOS,as well as to assess the quality and risks of bias of the available *** strategy:Nine electronic databases(Cochrane Library,MEDLINE,Embase,PsycINFO,CINAHL,Chinese National Knowledge Infrastructure,Wanfang Data,Chongqing VIP Chinese Science and Technology Periodical Database,and China Biology Medicine disc)were searched from their establishment to July 27,*** on the principle of combining subject words with text words,the search strategy was constructed around search terms for“acupuncture,”“polycystic ovary syndrome,”and“systematic review.”Inclusion criteria:SRs of randomized controlled trials that explored the efficacy and(or)safety of acupuncture for treating patients with PCOS were *** extraction and analysis:Two authors independently extracted study data according to a predesigned *** for evaluating the methodological quality,risk of bias,reporting quality,and confidence in study outcomes,including A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),Risk of Bias in Systematic Reviews(ROBIS),Preferred Reporting Items for Systematic Reviews and Metaanalyses for Acupuncture(PRISMA-A),and the Grading of Recommendations Assessment,Development and Evaluation(GRADE),were used to score the included ***:A total of 885 studies were retrieved,and 11 eligible SRs were finally included in this *** methodological quality of 2 SRs(18.18%)was low,while the other 9 SRs(81.82%)were scored as extremely *** SRs(36.36%)were considered to be of

关键词： Acupuncture Polycystic ovary syndrome Systematic review Meta-analysis

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Global research trends in postoperative ileus from 2011 to 2023:A scientometric study

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 3020-3031页

作者： Yan Zhou zi-han yin Ming-Sheng Sun Yang-Yang Wang Chen Yang Shu-Hao Li Fan-Rong Liang Fang Liu Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Department of Integrated Chinese and Western Medicine Sichuan Clinical Research Center for CancerSichuan Cancer Hospital&InstituteSichuan Cancer CenterAffiliated Cancer Hospital of University of Electronic Science and Technology of ChinaChengdu 610041Sichuan ProvinceChina

BACKGROUND Postoperative ileus(POI)is a common complication after abdominal surgery with high morbidity,which hinders patient recovery,prolongs hospitalization,and increases healthcare ***,POI has become a global public health *** triggering is *** and hormonal mechanisms are generally involved in POI *** studies have shown that beta adrenergic signaling of enteric glia is a POI ***,the status quo,trends,and frontiers of global research on POI remain *** To explore the current status,trends,and frontiers of POI research from 2011 to the present based on bibliometric *** Publications published on POI research from 2011 to 2023 were retrieved on June 1,2023,from the Web of Science Core *** 6.2.R2 and VOSviewer were used to conduct bibliometric *** In total,778 POI records published from 2011 to 2023 were *** the past few decades,the annual cumulative number of related articles has linearly increased,with China and the United States of America contributing *** publications were from 59 countries and *** and the University of Bonn were the top contributing country and institution,***&Motility was the most prolific *** Journal of Gastrointestinal Surgery had the highest number of *** Sven was the most productive *** keywords(e.g.,colon,prolonged ileus,acupuncture,paralytic ileus,pathophysiology,rectal cancer,gastrointestinal function,risk)and a series of reference citation bursts provided evidence for the research frontiers in recent *** This study demonstrates trends in the published literature on POI and provides new insights for *** emphasizes the importance of multidisciplinary cooperation in the development of this field.

关键词： Postoperative ileus Scientometric analysis VOSviewer CiteSpace Visualization Trends

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Acupuncture therapies in combination with conservative treatments for postoperative ileus:a systematic review and network meta-analysis

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TMR Integrative Medicine 2023年第8期7卷 1-12页

作者： zi-Wen Chen zi-han yin Tao Xu Jian Xiong Fan-Rong Liang School of Acu-Mox and Tuina Chengdu University of Traditional Chinese MedicineChengdu 610075China

Background:Although acupuncture therapies have been widely used in combination with conservative treatments(CT)for postoperative ileus(POI),evidence of their safety and efficacy remains *** evaluate and rank the efficacy of different acupuncture therapies combined with CT for ***:A comprehensive search was carried out in several databases(Embase,PubMed,Cochrane Library,Chinese National Knowledge Infrastructure,Wanfang Data,VIP Chinese Science and Technology Periodical Database and China Biology Medicine disc)for relevant randomized controlled trials(RCTs)investigating different acupuncture therapies for POI from inception to February 17,*** Cochrane risk of bias tool was used to determine the risks of bias of the included *** primary outcomes included the time to first defecation,time to first flatus,and time to first bowel movement;and the secondary outcome was the response *** meta-analysis was performed by Review Manager 5.3 software,and network meta-analysis was carried out by Stata v.15.0 *** cumulative ranking curve was obtained with Stata v.15.0 and was utilized to rank the included ***:29 studies with 2,600 participants were included in this systematic *** meta-analysis demonstrated that all acupuncture therapies combined with CT were superior to conservative treatments alone in time to first defecation,time to first flatus,time to first bowel movement,and response *** 10 evaluated methods,auricular needle with CT was the most effective treatment to reduce the time to first ***,moxibustion with CT was the most effective in reducing the time to first flatus,and warm needling with CT most markedly reduced the time to first bowel movement among 9 ***,manual acupuncture with CT showed the largest improvement in response ***:This meta-analysis revealed that all acupuncture therapies are effective and safe for POI,with warm needling+CT being t

关键词： acupuncture therapies conservative treatments postoperative ileus network meta-analysis randomized controlled trials

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Acupuncture and/or moxibustion for the treatment of lumbar disc herniation:quality assessment of systematic reviews

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Traditional Medicine Research 2020年第4期5卷 282-294页

作者： zi-han yin Chao-Xi Zhu Gui-Xing Xu Cheng ying Ai-Ling Huang Ya-Nan Fu Jiao Chen Ling Zhao Fan-Rong Liang Chengdu University of Traditional Chinese Medicine Chengdu 610075China

Objective:In the current systematic review on acupuncture and/or moxibustion for lumbar disc herniation(LDH),we evaluated the methodology and quality of evidence and reports to provide necessary information for accurate clinical decision-making regarding acupuncture and/or moxibustion for ***:From databases such as CBM(Chinese biomedical literature database),VIP(China science and technology journal database),CNKI(China national knowledge infrastructure),WF(Wanfang database),Web of Science,Embase,Medline,and Cochrane Library,systematic reviews on acupuncture and/or moxibustion for LDH were retrieved,and the methodological quality of the literature was evaluated according to the assessment of multiple systematic reviews(AMSTAR)***,the grading of recommendations assessment,development and evaluation(GRADE)system was used to grade the quality of evidence and the preferred reporting items for systematic reviews and meta-analyses(PRISMA)statement to evaluate the quality of the ***:A total of 18 systematic reviews were included,and the conclusion is that acupuncture and/or moxibustion have some advantages in terms of efficacy and safety with regard to LDH *** to the AMSTAR score,there were 4 high-quality studies,13 moderate-quality studies,and 1 low-quality *** showed that quality of evidence such as total effective rate of LDH and VAS was low and that of other forms of evidence was *** PRISMA statement showed that 8 articles were in line with 20 or more of the 27 items,and 10 articles were in line with 10-19 of the 27 ***:At present,acupuncture and/or moxibustion for LDH has a good curative *** importantly,its methodological quality was of moderate level and the report quality was generally good and relatively ***,the poor quality of the original research results was reflected in the quality of *** studies are needed to make sure whether acupuncture is more effective

关键词： Lumbar disc herniation Acupuncture therapy Overview of systematic reviews AMSTAR GRADE PRISMA.

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Double-network hydrogel enhanced by SS31-loaded mesoporous polydopamine nanoparticles:Symphonic collaboration of near-infrared photothermal antibacterial effect and mitochondrial maintenance for full-thickness wound healing in diabetes mellitus

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Bioactive Materials 2023年第9期27卷 409-428页

作者： Qing-Song Deng Yuan Gao Bi-Yu Rui Xu-Ran Li Po-Lin Liu zi-yin han Zhan-ying Wei Chang-Ru Zhang Fei Wang Helen Dawes Tong-He Zhu Shi-Cong Tao Shang-Chun Guo Department of Orthopedic Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine600 Yishan RoadShanghai200233China School of Medicine Shanghai Jiao Tong University227 South Chongqing RoadShanghai200025China Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine600 Yishan RoadShanghai200233China Department of Rheumatology The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityNo.29XinglongxiangTianning DistrictChangzhou213000China Shanghai Clinical Research Centre of Bone Diseases Department of Osteoporosis and Bone DiseasesShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200233China Shanghai Key Laboratory of Orthopedic Implants Department of Orthopedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineNo.639 Zhizaoju RoadShanghai200011China Clinical and Translational Research Center for 3D Printing Technology Medical 3D Printing Innovation Research CenterShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200125China Department of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin Second RoadShanghai200025China Faculty of Health and Life Science Oxford Brookes UniversityHeadington RoadOxfordOX30BPUK NIHR Oxford Health Biomedical Research Centre OxfordOX37JXUK College of Medicine and Health St Lukes CampusUniversity of ExeterHeavitree RoadExeterEX12LUUK School of Chemistry and Chemical Engineering Shanghai Engineering Research Center of Pharmaceutical Intelligent EquipmentShanghai Frontiers Science Research Center for Druggability of Cardiovascular Non-Coding RNAInstitute for Frontier Medical TechnologyShanghai University of

Diabetic wound healing has become a serious healthcare *** high-glucose environment leads to persistent bacterial infection and mitochondrial dysfunction,resulting in chronic inflammation,abnormal vascular function,and tissue *** solve these issues,we developed a double-network hydrogel,constructed with pluronic F127 diacrylate(F127DA)and hyaluronic acid methacrylate(HAMA),and enhanced by SS31-loaded mesoporous polydopamine nanoparticles(MPDA NPs).As components,SS31,a mitochondria-targeted peptide,maintains mitochondrial function,reduces mitochondrial reactive oxygen species(ROS)and thus regulates macrophage polarization,as well as promoting cell proliferation and migration,while MPDA NPs not only scavenge ROS and exert an anti-bacterial effect by photothermal treatment under near-infrared light irradiation,but also control release of SS31 in response to *** F127DA/HAMA-MPDA@SS31(FH-M@S)hydrogel has characteristics of adhesion,superior biocompatibility and mechanical properties which can adapt to irregular wounds at different body sites and provide sustained release of MPDA@SS31(M@S)*** addition,in a diabetic rat full thickness skin defect model,the FH-M@S hydrogel promoted macrophage M2 polarization,collagen deposition,neovascularization and wound ***,the FH-M@S hydrogel exhibits promising therapeutic potential for skin regeneration.

关键词： Mesoporous polydopamine nanoparticles(MPDA NPs) SS31 Photothermal antibacterial Mitochondrial function maintenance Diabetic wound healing

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A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang Song Xie zi-Meng han Hao-Cheng Liu Chong-han yin Wen-Bin Sun Zhang-Chi Ling Huai-Bin Yang De-han Li Qing-Fang Guan Shu-Hong Yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

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椎体后凸成形后相邻椎体生物力学的有限元分析

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中国组织工程研究与临床康复 2010年第4期14卷 598-602页

作者：韩紫音路青林张敬涛张文强山东大学附属千佛山医院骨科山东省济南市250014 山东大学生物医学工程研究所山东省济南市250061

背景:椎体后凸成形后相邻椎体新发骨折的发生率为2.4%～23%,并且6个月内2/3骨折发生于邻近椎体,其原因是骨质疏松的发展,还是骨水泥强化的结果,目前存有争论。目的:应用脊柱有限元分析方法分析生理载荷作用下,椎体后凸成形后相邻椎体终... 详细信息

背景:椎体后凸成形后相邻椎体新发骨折的发生率为2.4%～23%,并且6个月内2/3骨折发生于邻近椎体,其原因是骨质疏松的发展,还是骨水泥强化的结果,目前存有争论。目的:应用脊柱有限元分析方法分析生理载荷作用下,椎体后凸成形后相邻椎体终板的应力变化与相邻椎体新发骨折的相关性。方法:收集老年骨质疏松女性胸腰椎CT扫描资料,利用一系列计算机辅助设计软件构造相对应的T12-L1-L2骨质疏松性椎体的三维有限元模型。模拟L1椎体为楔形压缩骨折椎体(前缘高度较正常降低60%),模拟经皮椎体后凸成形模型,复位骨折椎体(L1椎体高度较正常降低10%,代表骨折椎体复位),在L1椎体内置入2个对称的圆柱体PMMA骨水泥块共约4mL。分析轴向压缩、前屈和后伸3种加载状态下正常椎体、手术前后相邻椎体的应力变化情况。结果与结论:与正常椎体比较,L1压缩性骨折模型和椎体后凸成形后模型相邻椎体终板最大应力值分别增高76%和27%;椎体后凸成形模型后部结构的应力水平较正常椎体平均增加13.2%,其中椎弓根增加4.5%,峡部增加6.15%和关节点增加25.6%。与L1椎体压缩性骨折模型相比,L1椎体后凸成形后椎弓根、峡部和关节突应力均有所降低。结果说明椎体后凸成形后,T12椎体下位终板和L2椎体上位终板的应力值在各种状态下均较正常椎体增加,应力增加可能导致终板骨折可能性增加,进而导致相邻椎体骨折的风险性增加,这一观点尚需进一步研究的支持。

关键词：经皮穿刺椎体后凸成形有限元分析骨质疏松性椎体压缩性骨折应力生物力学

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Plasmon-induced local electric field improved hydrogen evolution reaction on Ag/Mo_(2)C nanosheets

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Nano Research 2025年第1期18卷 270-277页

作者： HuangJingWei Li Xin zi Jun Wu Xinli Wang Li Zhu Qiyou Wang Jianfu han Junwei Fu Hongmei Li Kai Huang Yu Chen Min Liu School of Physics State Key Laboratory of Powder MetallurgyHunan Joint International Research Center for Carbon Dioxide Resource UtilizationCentral South UniversityChangsha 410083China School of Metallurgy and Environment Central South UniversityChangsha 410083China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Nano-Institute Munich Faculty of PhysicsLudwig-Maxilimians-Universität MünchenMünchen 80539Germany Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China

Electrocatalytic water splitting offers a promising way for hydrogen production with near-zero ***,such as molybdenum carbides(Mo_(2)C),are promising materials for hydrogen evolution reaction(HER)but still suffer from poor intrinsic water activation ***,we developed a plasmon-induced local electric field(PILEF)strategy to solve this ***(Ag)nanoparticles decorated Mo_(2)C nanosheets(Ag/Mo_(2)C)were successfully prepared by electrostatic *** visible light excited the PILEF on Ag/Mo_(2)C remarkably reducing the activation energy by 92.7 kJ·mol^(-1)from 147.3 kJ·mol^(-1)of Mo_(2)C to 54.6 kJ·mol^(-1).As a result,the plasmonic Ag/Mo_(2)C significantly enhances~2.3-fold of the current density from 2.8 mA·cm^(-2)of Mo_(2)C to 6.5 mA·cm^(-2)at-3 V *** and reduces the overpotential by 104 mV from 403 mV of dark state to 299 mV of light state at the current density of 10 mA·cm^(-2),achieving better performance than reported *** research demonstrates that PILEF enhances HER activities,offering a potential strategy for boosting the intrinsic activities of catalysts.

关键词： sliver particles plasmon effect field effect hydrogen evolution reaction(HER) electrocatalysis

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季节性自回归移动平均模型在秦皇岛市手足口病发病预测分析中的应用研究

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医学动物防制 2022年第3期38卷 230-234,238页

作者：陶旭史明坤董俊善郑立新杨健韩子寅秦皇岛市疾病预防控制中心河北066000

目的建立季节性自回归移动平均模型(Autoregressive Integrated Moving Average Model,ARIMA),并对秦皇岛市手足口病的发病率进行预测及效果评估,为今后手足口病防控措施的制定提供科学依据。方法通过"中国疾病预防控制信息系统"导出200... 详细信息

目的建立季节性自回归移动平均模型(Autoregressive Integrated Moving Average Model,ARIMA),并对秦皇岛市手足口病的发病率进行预测及效果评估,为今后手足口病防控措施的制定提供科学依据。方法通过"中国疾病预防控制信息系统"导出2009—2018年秦皇岛市手足口病确诊病例和临床诊断病例。利用SPSS 23.0软件对2009—2018年秦皇岛市手足口病发病率进行逐月统计,采用季节性ARIMA模型进行建模拟合及预测分析。结果秦皇岛市2009—2018年各月均有手足口病病例报告,且发病呈明显的季节性分布特征,病例主要集中在6—8月,7月为发病高峰,个别年份在10月或11月病例数略有上升,且具有每隔1~2年发病强度增强的周期性。选用季节性ARIMA模型对手足口病发病进行预测,以ARIMA(2,0,0)(0,1,1);模型最优,2019年各月手足口病发病率实际值均在预测值的95%CI范围内。结论季节性ARIMA模型能较好地拟合手足口病发病率变化趋势,可用于手足口病发病的预测预警,为手足口病防控工作提供依据。

关键词：手足口病发病率自回归移动平均模型预测

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SLC27A6抑制表达对奶牛乳腺上皮细胞脂质代谢的影响

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农业生物技术学报 2021年第9期29卷 1733-1740页

作者：沈子亮姜惠陈代杰韩紫音毛永江李明勋杨章平张慧敏扬州大学动物科学与技术学院

牛奶中的长链脂肪酸(long chain fatty acids, LCFA)尤其是长链多不饱和脂肪酸(polyunsaturated fatty acids, PUFA)有助于降低人类(Homo sapiens)患心血管疾病、癌症、二型糖尿病的风险。但目前对乳腺组织中LCFA合成、代谢的分子机制... 详细信息

牛奶中的长链脂肪酸(long chain fatty acids, LCFA)尤其是长链多不饱和脂肪酸(polyunsaturated fatty acids, PUFA)有助于降低人类(Homo sapiens)患心血管疾病、癌症、二型糖尿病的风险。但目前对乳腺组织中LCFA合成、代谢的分子机制知之甚少。脂肪酸转运蛋白6 (solute carrier family 27 member 6,SLC27A6)的主要功能是促进细胞从外界摄取LCFA,进而参与细胞内的各类脂质代谢。但是目前SLC27A6与乳腺脂质代谢基因之间的调控关系尚不明确。本研究利用siRNA干扰技术干预奶牛(Bos taurus)乳腺上皮细胞(bovine mammary epithelial cells, BMECs)中SLC27A6的表达,采用荧光定量PCR分析乳腺细胞中SLC27A6和脂质代谢相关基因的表达,利用Western blot技术分析了蛋白的表达变化,并对细胞内甘油三酯含量和脂肪酸组成的变化进行分析。结果显示,与对照组相比,转染siRNA SLC27A6-Bos-915后,SLC27A6基因和蛋白质的表达量明显下降,细胞内参与脂肪酸激活和转运的关键基因长链脂肪酸乙酰辅酶A合成酶4基因(long-chain acyl-CoA synthetase 4, ACSL4)和脂肪酸转运蛋白基因CD36、脂肪氧化相关基因肉毒碱棕榈酰转移酶基因(carnitine palmitoyl transferase 1A, CPT1A)的表达量下降,过氧化物酶体增生激活受体γ(peroxisome proliferative activated receptor gamma, PPARG)、脂肪酸结合蛋白(fatty acid binding protein 3, FABP3)基因及脂肪酸去饱和酶(fatty acid desaturase 2, FADS2)基因的表达量上升。与此同时,细胞内的甘油三酯含量上升,棕榈酸(C16∶0)和硬脂酸(C18∶0)的含量降低,油酸(C18∶1cis9)和花生四烯酸(C20∶4cis5,8,11,14)的含量上升。本研究可为解析SLC27A6在调节奶牛乳腺脂质代谢中的机制提供参考,为实现乳成分的定向遗传调控,生产优质原料奶提供理论依据。

关键词：脂肪酸转运蛋白6 (SLC27A6) 奶牛乳腺上皮细胞脂质代谢

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