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Preface In Honor of the 80th Birthday of Professor Ronald Breslow

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Science China Chemistry 2011年第12期54卷 1667-1669页

作者： XUE zi-ling Nanjing University Nanjing College of Pharmacy China

We are very pleased to have the opportunity to make a ded- ication in this issue to mark the 80th birthday of Dr. Ronald Breslow, S. L. Mitchill Professor of Chemistry and University Professor of Columbia University, USA, and to honor his many contributions to chemistry, education, and China-US scientific exchanges over the years. Three articles by Drs. LIU Lei of Tsinghua University ,

关键词： Aromatic compounds Aromatization Silicon compounds Teaching

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[IrO_4]^+ at the IX(+9) oxidation state observed, report states

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Science China Chemistry 2015年第1期58卷 4-5页

作者： zi-ling Xue the University of Tennessee USA

IrO4^＋ cations have been generated and observed in mass spectra （MS）, a recent letter in Nature reported [1]. IX is now the highest known formal oxidation state, according to the paper. The authors have characterized [IrO4]^＋.Ar by IR photodissociation spectroscopy, and the spectrum is consistent with tetrahedral [IrO4]^＋ containing four terminal Ir=O bonds （Scheme 1）. Quantum-chemical calculations support the identification of [IrO4]^＋ in experiments. The work was conducted by the research groups of Mingfei Zhou at Fudan University, Gary J. Schrobilgen at McMaster University, Jun Li of Tsinghua University, and Sebastian Riedel at the University of Freiburg and Free University of Berlin

关键词：氧化态复旦大学量子化学计算实验鉴定清华大学阳离子四面体光谱

China celebrates the International Year of Chemistry

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Science China Chemistry 2011年第12期54卷 2016-2017页

作者： XUE zi-ling Department of Chemistry University of Tennessee Knoxville Tennessee 37996-1600 USA

China played an active role in the establishment of the International Year of Chemistry （IYC） 2011. Year-around programs in the country have celebrated the wonderful changes in our lives brought about by advances in chemical sciences. Chemists, chemical engineers, students, and the general public have used a range of interactive, entertaining, and educational activities around the country to celebrate the achievements of chemistry and its contributions to society.

关键词：化学科学国际国庆国家方案教育活动化学家工程师娱乐性

From China to the world:Science China Chemistry celebrates the International Year of Chemistry

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Science China Chemistry 2012年第1期55卷 195-200页

作者： ZHU XiaoWen XUE zi-ling Science China Press 16 Donghuangchenggen North StreetBeijing 100717China Department of Chemistry University of TennesseeKnoxvilleTennessee 37996-1600USA

1 Introduction Science China Chemistry is considered the best and most comprehensive chemistry journal in *** primary mission is to communicate the results of basic and innovative chemistry research. The subject areas... 详细信息

关键词：化学研究中国科学国际世界物理化学有机化学无机化学

Microwave-assisted hydrothermal synthesis of cube-like Ag-Ag_2MoO_4 with visible-light photocatalytic activity

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Science China Chemistry 2013年第4期56卷 443-450页

作者： LI ZhaoQian CHEN XueTai XUE zi-ling State Key Laboratory of Coordination Chemistry Nanjing National Laboratory of Microstructures School of Chemistry and Chemical Engineering Nanjing University Department of Chemistry The University of Tennessee Knoxville

Cube-like Ag-Ag2MoO4 composite has been successfully prepared in the presence of PVP （potyvinylpyrrolidone） via a facile microwave-assisted hydrothermal process. Studies of its photocatalytic performance in the decomposition of RhB indicate that the cube-like Ag-Ag2MoO4 composite exhibits good catalytic activities under visible-light irradiation. The face that Ag pro- motes the absorption of visible light may be attributed to the surface plasmon resonance. Further XRD characterization after recycle photocatalytic tests confirms that partial Ag~ ions in Ag2MoO4 have been reduced to metallic Ag. Reaction temperature, reaction time and the amount of PVP have also been studied and found to play crucial roles in the formation of the cube-like microstructures.

关键词： microwave hydrothermal photocatalytic activity surface plasmon resonance

Patient-derived induced pluripotent stem cells with a MERTK mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential

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World Journal of Stem Cells 2024年第5期16卷 512-524页

作者： Hang Zhang ling-zi Wu Zhen-Yu Liu zi-Bing Jin Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

BACKGROUND Human induced pluripotent stem cell(hiPSC)technology is a valuable tool for generating patient-specific stem cells,facilitating disease modeling,and invest-igating disease ***,iPSCs carrying specific mutations may limit their clinical applications due to certain inherent *** To investigate the impact of MERTK mutations on hiPSCs and determine whether hiPSC-derived extracellular vesicles(EVs)influence anomalous cell junction and differentiation *** We employed a non-integrating reprogramming technique to generate peripheral blood-derived hiPSCs with and hiPSCs without a MERTK ***-somal karyotype analysis,flow cytometry,and immunofluorescent staining were utilized for hiPSC *** and proteomics were employed to elucidate the expression patterns associated with cell junction abnormalities and cellular differentiation ***,EVs were isolated from the supernatant,and their RNA and protein cargos were examined to investigate the involvement of hiPSC-derived EVs in stem cell junction and *** The generated hiPSCs,both with and without a MERTK mutation,exhibited normal karyotype and expressed pluripotency markers;however,hiPSCs with a MERTK mutation demonstrated anomalous adhesion capability and differentiation potential,as confirmed by transcriptomic and proteomic ***,hiPSC-derived EVs were involved in various biological processes,including cell junction and *** HiPSCs with a MERTK mutation displayed altered junction characteristics and aberrant differentiation ***,hiPSC-derived EVs played a regulatory role in various biological processes,including cell junction and differentiation.

关键词： Cell junction Cellular differentiation Extracellular vesicle Human induced pluripotent stem cells Transcriptomics Proteomics

Regulatory factors of Nrf2 in age-related macular degeneration pathogenesis

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1344-1362页

作者： zi-ling Hu Yu-Xuan Wang zi-Yue Lin Wen-Shuo Ren Bo Liu Hui Zhao Qiong Qin Five Year Program of Ophthalmology and Optometry 2019 Beijing Tong Ren HospitalCapital Medical UniversityBeijing 100054China Four Year Program of Traditional Chinese Pharmacy 2020 School of Traditional Chinese MedicineCapital Medical UniversityBeijing 100069China School of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Beijing Key Laboratory of TCM Collateral Disease Theory Research Beijing 100069China Five Year Program of Ophthalmology and Optometry 2021 School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Biochemistry&Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

Age-related macular degeneration(AMD)is a complicated disease that causes irreversible visual *** evidences pointed retinal pigment epithelia(RPE)cells as the decisive cell involved in the progress of AMD,and the function of anti-oxidant capacity of PRE plays a fundamental physiological *** factor erythroid 2 related factor 2(Nrf2)is a significant transcription factor in the cellular anti-oxidant system as it regulates the expression of multiple anti-oxidative *** functions of protecting RPE cells against oxidative stress(OS)and ensuing physiological changes,including inflammation,mitochondrial damage and autophagy dysregulation,have already been *** the roles of upstream regulators of Nrf2 could provide further insight to the OS-mediated AMD *** the first time,this review summarized the reported upstream regulators of Nrf2 in AMD pathogenesis,including proteins and miRNAs,and their underlying molecular mechanisms,which may help to find potential targets via regulating the Nrf2 pathway in the future research and further discuss the existing Nrf2 regulators proved to be beneficial in preventing AMD.

关键词： Nrf2 upstream regulators retinal pigment epithelia age-related macular degeneration oxidative stress

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World Journal of Clinical Cases 2021年第22期9卷 6329-6342页

作者： Ya-Jing Sun ling-zi Xu Zeng-Hui Ma Yu-Lu Yang Ting-Ni Yin Xiao-Yun Gong zi-Lin Gao Yan-ling Liu Jing Liu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Beijing 100191China Quanzhou Children’s and Women’s Hospital Quanzhou 362000Fujian ProvinceChina Department of Mathematics Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina

BACKGROUND Health-related risky behaviors generally refer to behaviors that have a negative impact on health and quality of ***-related risky behaviors in adolescents with high-functioning autism(HFA)have not been well understood so *** with HFA may have more health-related risky behaviors than neurotypical *** To investigate health-related risky behaviors and their risk factors with *** This is an observational *** study enrolled 110 adolescents aged 12-19-years-old meeting Diagnostic and Statistical Manual of Mental Disorders 4th edition criteria for *** were recruited from Peking University Sixth *** were also 110 age,sex and nationality matched controls enrolled who came from a public school in Beijing,*** groups completed the Adolescents Health-related Risky Behavior *** tests were carried out for comparison of the Adolescents Health-related Risky Behavior Inventory scores between the two *** recognition,the Inventory of Subjective Life Quality for Child and Adolescent,Chinese Wechsler Intelligence Scale for Children,Wechsler Intelligence Scale for Adult-Chinese Revised,Theory of Mind test and Autism Spectrum Screening Questionnaire were assessed in the autism group to explore factors associated with health-related risky *** regression analysis was conducted to explore the risk factors of health-related risky behaviors in the HFA *** The results showed that the total score of the Adolescents Health-related Risky Behavior Inventory and scores of“aggression and violence,”“suicide and selfinjury,”“health compromising behavior”and“unprotected sex”subscales in the HFA group were significantly higher than those in the control group(Z range-4.197 to-2.213,P<0.05).Among the associated factors,poor emotional experience(B=-0.268,P<0.001),depression(B=-0.321,P<0.001),low score of intelligence(B=-0.032,P=0.042),low score of Theory of Mind test

关键词： High-functioning autism Adolescents Health-related risky behaviors Associated factors Risk factors Cross-sectional study

Pig H3K4me3,H3K27ac,and gene expression profiles reveal reproductive tissue-specific activity of transposable elements

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Zoological Research 2024年第1期45卷 138-151页

作者： Tao Jiang Zhi-Min Zhou zi-Qi ling Qing Zhang Zhong-zi Wu Jia-Wen Yang Si-Yu Yang Bin Yang Lu-Sheng Huang National Key Laboratory of Pig Genetic Improvement and Germplasm Innovation Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Regulatory sequences and transposable elements(TEs)account for a large proportion of the genomic sequences of species;however,their roles in gene transcription,especially tissue-specific expression,remain largely *** serve as an excellent animal model for studying genomic sequence biology due to the extensive diversity among their wild and domesticated ***,we conducted an integrated analysis using H3K27ac ChIP-seq,H3K4me3 ChIP-seq,and RNA-seq data from 10 different tissues of seven fetuses and eight closely related adult *** aimed to annotate the regulatory elements and TEs to elucidate their associations with histone modifications and mRNA expression across different tissues and developmental *** on correlation analysis between mRNA expression and H3K27ac and H3K4me3 peak activity,results indicated that H3K27ac exhibited stronger associations with gene expression than ***,1.45%of TEs overlapped with either the H3K27ac or H3K4me3 peaks,with the majority displaying tissue-specific ***,a TE subfamily(LTR4C_SS),containing binding motifs for SIX1 and SIX4,showed specific enrichment in the H3K27ac peaks of the adult and fetal ***-seq analysis also revealed widespread expression of TEs in the exons or promoters of genes,including 4688 TE-containing transcripts with distinct development stage-specific and tissue-specific *** note,1967 TE-containing transcripts were enriched in the *** identified a long terminal repeat(LTR),MLT1F1,acting as a testis-specific alternative promoter in SRPK2(a cell cycle-related protein kinase)in our pig *** element was also conserved in humans and mice,suggesting either an ancient integration of TEs in genes specifically expressed in the testes or parallel evolutionary ***,our findings demonstrate that TEs are deeply embedded in the genome and exhibit important tissue-specific biological functions,particularly in the reproductive

关键词： Transposable elements Porcine Histone modification Alternative promoter TE-containing transcript