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Abnormal adipose tissue-derived microbes drive metabolic disorder and exacerbate postnatal growth retardation in piglet

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Life Metabolism 2024年第2期3卷 55-69页

作者： Tongxing Song Ming Qi Yucheng Zhu Nan Wang Zhibo Liu Na Li Jiacheng Yang Yanxu Han Jing Wang Shiyu Tao zhuqing ren Yulong Yin Jinshui Zheng Bie Tan College of Animal Science and Technology Huazhong Agricultural UniversityWuhanHubei 430070China College of Animal Science and Technology Hunan Agricultural UniversityChangshaHunan 410000China Laboratory of Animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangshaHunan 410125China State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhanHubei 430070China Hubei Key Laboratory of Agricultural Bioinformatics Huazhong Agricultural UniversityWuhanHubei 430070China

Postnatal growth retardation(PGR)frequently occurs during early postnatal development of piglets and induces high *** date,the mechanism of PGR remains poorly *** tissue-derived microbes have been documented to be associated with several disorders of metabolism and body ***,the connection between microbial disturbance of adipose tissue and pig PGR remains ***,we investigated piglets with PGR and found that the adipose tissue of PGR piglets was charac-terized by metabolism impairment,adipose abnormality,and specific enrichment of culturable bacteria from *** of Sphingomonas paucimobilis,a species of Sphingomonas genus from the alphaproteobacteria,induced PGR in ***,this bacterium could also lead to metabolic disorders and susceptibility to acute stress,resulting in weight loss in ***,multi-omics analysis indicated the changes in lipid metabolism as a response of adipose tissue to abnormal microbial *** experimental tests proved that one of the altered lipids phosphatidylethanolamines could rescue the metabolism disorder and growth retardation,thereby suppressing the amount of Sphingomonas in the adipose ***,these results highlight that the microbe–host crosstalk may regulate the metabolic function of adipose tissue in response to PGR.

关键词： adipose tissue microbe metabolic disorder postnatal growth retardation piglet

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Reorganization of 3D genome architecture provides insights into pathogenesis of early fatty liver disease in laying hens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1086-1100页

作者： Yanli Liu zhuqing Zheng Chaohui Wang Yumeng Wang Xi Sun Zhouzheng ren Xin Yang Xiaojun Yang College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Institute of Agricultural Biotechnology Jingchu University of TechnologyJingmen 448000China

Background Fatty liver disease causes huge economic losses in the poultry industry due to its high occurrence and lethality ***-dimensional(3D)chromatin architecture takes part in disease processing by regulating tran-scriptional *** study is carried out to investigate the alterations of hepatic 3D genome and H3K27ac profiling in early fatty liver(FLS)and reveal their effect on hepatic transcriptional reprogramming in laying *** Results show that FLS model is constructed with obvious phenotypes including hepatic visible lipid deposi-tion as well as higher total triglyceride and cholesterol in serum.A/B compartment switching,topologically associat-ing domain(TAD)and chromatin loop changes are identified by high-throughput/resolution chromosome conforma-tion capture(HiC)*** genes of these alternations in hepatic 3D genome organization significantly enrich pathways related to lipid metabolism and hepatic damage.H3K27ac differential peaks and differential expres-sion genes(DEGs)identified through RNA-seq analysis are also enriched in these ***,certain DEGs are found to correspond with changes in 3D chromatin structure and H3K27ac binding in their *** motif analysis reveals that candidate transcription factors are implicated in regulating transcriptional ***,disturbed folate metabolism is observed,as evidenced by lower folate levels and altered enzyme *** Our findings establish a link between transcriptional reprogramming changes and 3D chromatin struc-ture variations during early FLS formation,which provides candidate transcription factors and folate as targets for FLS prevention or treatment.

关键词： 3D chromatin architecture Fatty liver disease Folate H3K27ac profiling Transcription reprogramming

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Bioinspired Tactile Sensation Based on Synergistic Microcrack-Bristle Structure Design toward High Mechanical Sensitivity and Direction-Resolving Capability

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Research 2024年第1期2023卷 611-624页

作者： Yiqun Zhang Qi Liu Wenjuan ren Yangyang Song Hua Luo Yangyang Han Liang He Xiaodong Wu zhuqing Wang School of Mechanical Engineering Sichuan UniversityChengdu 610065China Med+X Center for Manufacturing West China HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China

Natural tactile sensation is complex,which involves not only contact force intensity detection but also the perception of the force direction,the surface texture,and other mechanical ***,the vast majority of the developed tactile sensors can only detect the normal force,but usually cannot resolve shear force or even distinguish the directions of the ***,we present a new paradigm of bioinspired tactile sensors for resolving both the intensity and the directions of mechanical stimulations via synergistic microcrack-bristle structure design and cross-shaped configuration *** microcrack sensing structure gives high mechanical sensitivity to the tactile sensors,and the synergistic bristle structure further amplifies the sensitivity of the *** cross-shaped configuration engineering of the synergistic microcrack-bristle structure further endows the tactile sensors with good capability to detect and distinguish the directions of the applied mechanical *** as-fabricated tactile sensors exhibit a high sensitivity(25.76 N^(−1)),low detection limit(5.4 mN),desirable stability(over 2,500 cycles),and good capability to resolve both mechanical intensity and directional *** promising application scenarios,surface texture recognition and biomimetic path explorations are successfully demonstrated with these tactile *** newly proposed tactile sensation strategy and technology have great potential applications in ingenious tactile sensation and construction of various robotic and bionic prostheses with high operational dexterity.

关键词： crack sensation directions

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Identification of four SNPs and association analysis with meat quality traits in the porcine Pitx2c gene

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Science China(Life Sciences) 2011年第5期54卷 426-433页

作者： WU WangJun ZUO Bo ren zhuqing HAPSARI A.A.R LEI MingGang XU DeQuan LI FengE XIONG YuanZhu Key Laboratory of Swine Genetics and Breeding Ministry of Agriculture and Key Laboratory of Agriculture Animal Genetics Breeding and Reproduction Ministry of Education College of Animal Science Huazhong Agricultural University Wuhan 430070 China Faculty of Animal Agriculture Diponegoro University Tembalang Campus-Semarang 50275 Indonesia

The association of the porcine Pitx2c gene with meat quality traits was investigated in the present study.A total of eight single nucleotide polymorphisms (SNPs) were *** frequencies of four SNPs were further detected in four commercial breeds and eight Chinese indigenous *** SNP and meat quality associations were analyzed in a Yorkshire×Meishan F 2 *** SNPs c.474C>T (PT (PA and c.47G>A were significantly associated with drip loss rate (DLR),water holding capacity (WHC) and meat color value (MCV1) consistently (P<0.05).Linkage disequilibrium (LD) analysis revealed that the adjacent SNPs were in *** major haplotypes were identified,and association analysis between haplotype combinations and meat quality indicated that the presence of two copies of haplotype 1-CCGG-may improve meat quality.

关键词：单核苷酸多态性肉质性状基因鉴定等位基因频率 SNPs 猪地方品种肉品质量

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超声雾化生物反应器在堆肥氨气处理中的应用研究

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华中农业大学学报 2022年第4期41卷 96-104页

作者：廖友郡孟宇翔任竹青华中农业大学动物科学技术学院武汉430070 湖北省松滋市农业农村局松滋434200

为提高生物反应器对堆肥臭气的去除效果,设计了一种新型超声雾化生物反应器,研究了该反应器在不同工艺条件下对模拟臭气的处理效果,再以猪粪和木屑为原材料进行堆肥试验,探究该反应器对实际堆肥过程中产生的臭气去除效果。结果显示,超... 详细信息

为提高生物反应器对堆肥臭气的去除效果,设计了一种新型超声雾化生物反应器,研究了该反应器在不同工艺条件下对模拟臭气的处理效果,再以猪粪和木屑为原材料进行堆肥试验,探究该反应器对实际堆肥过程中产生的臭气去除效果。结果显示,超声波空化效应能提高反应器对氨气的吸收率,超声雾化比传统喷淋模式去除氨气的效率提高10%左右;为解决体系内高氨氮的问题,将活性污泥进行耐高氨氮驯化后在反应器中挂膜,发现体系内微生物降解氨氮的能力明显提升;通过正交试验确定反应器去除氨气的最佳工艺条件。堆肥试验表明,氨气释放与堆肥温度具有高度一致性,且在堆肥第5天达到峰值(76.3 mg/m^(3)),同时,猪粪堆肥中氨气释放与pH、铵态氮和硝态氮的浓度有关;反应器对堆肥氨气的去除率高达80.6%;对其他时段的氨气去除率平均保持在90%左右,且反应器出气口的氨气质量浓度小于5 mg/m^(3),达到相关排放标准。结果表明,超声雾化生物反应器对于堆肥产生的氨气能起到良好的去除效果。

关键词：氨气生物反应器超声雾化覆膜堆肥猪粪堆肥臭气去除

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悬疑·细节·主题·风格:《网络迷踪》叙事解码

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电影评介 2018年第23期 45-48页

作者：任竹青内蒙古农业大学外语学院

悬疑电影作为美国类型电影中的一种,经历了较长的历史发展进程,因其一以贯之的悬念布局、丰富多样的主题立意,在世界电影市场始终占据一席之地,并在世界电影生产中具备了重要的领导话语权。而欧美悬疑电影之所以前仆后继地涌现,则同主... 详细信息

悬疑电影作为美国类型电影中的一种,经历了较长的历史发展进程,因其一以贯之的悬念布局、丰富多样的主题立意,在世界电影市场始终占据一席之地,并在世界电影生产中具备了重要的领导话语权。而欧美悬疑电影之所以前仆后继地涌现,则同主流商业电影受众的审美取向和价值理念息息相关。在美国商业电影大片中,悬疑电影因其离奇曲折的故事情节、充满神秘性的叙事基调以及电影制作者精心策划的矛盾冲突,往往是口碑与票房兼得,并牢牢把握住了电影观众的注意力。

关键词：叙事类型电影解码网络风格历史发展进程商业电影一以贯之

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堆肥发酵功能菌株的筛选及其在鸡粪好氧堆肥中的应用

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华中农业大学学报 2022年第4期41卷 20-27页

作者：张晟国彭彦李茹玉李展鑫黄逸豪王国磊任竹青吴健华中农业大学动物科学技术学院武汉430070

为开发畜禽粪便好氧堆肥的高效降解转化和除臭固氮菌剂,进一步提高堆肥效率和品质,通过菌株产酶和除臭能力分析筛选堆肥发酵功能菌株,分别研制了2种复合菌剂(复合菌剂Ⅰ和复合菌剂Ⅱ),探究添加复合菌剂对鸡粪好氧堆肥常规理化指标、纤... 详细信息

为开发畜禽粪便好氧堆肥的高效降解转化和除臭固氮菌剂,进一步提高堆肥效率和品质,通过菌株产酶和除臭能力分析筛选堆肥发酵功能菌株,分别研制了2种复合菌剂(复合菌剂Ⅰ和复合菌剂Ⅱ),探究添加复合菌剂对鸡粪好氧堆肥常规理化指标、纤维素酶和脲酶活性、氮损失、堆肥产品质量的影响。结果显示:与空白对照组和实验室前期研制的复合菌剂Ⅲ相比,复合菌剂Ⅰ因含有机物质降解能力较高的菌株,能显著增加堆体纤维酶活性,后期纤维素酶酶活高达4.937 U/g;添加复合菌剂Ⅰ可显著提高堆体温度,最高温度可达65.8℃,比对照组高5.8℃;而复合菌剂Ⅱ因含有除臭能力较强的菌株,能显著降低堆体的脲酶活性和氮损失;添加复合菌剂Ⅱ提高了堆肥产品的总养分含量,堆肥产物总养分可达到5.32%,显著高于对照组(4.52%)。2种复合菌剂均能加快堆肥腐熟,堆肥第7天时,种子发芽指数(GI)值分别为75.12%和75.29%,而对照组GI值仅为47.89%。结果表明,本研究研制的复合菌剂Ⅰ和Ⅱ在鸡粪好氧堆肥应用中有良好的效果,可使堆肥升温、腐熟程度高,增加纤维素酶活性,降低脲酶活性,减少堆肥产物总养分流失和氮损失率。

关键词：鸡粪好氧堆肥复合菌剂纤维素酶脲酶除臭有机肥生产

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新农科建设背景下农林高校科研育人路径的探索与实践——以华中农业大学动物医学专业为例

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高等农业教育 2023年第5期 33-38页

作者：周全刘焕任竹青赵书红华中农业大学湖北武汉430070 生猪健康养猪省部共建协同创新中心湖北武汉430070

作为高校十大育人体系的重要组成部分,科研育人对加强和改进高校思想政治工作、提高人才培养质量意义重大。对当前农林高校科研育人的现状、存在的问题及原因进行了剖析,并以华中农业大学动物医学专业为例,阐述了农林高校科研育人的实... 详细信息

作为高校十大育人体系的重要组成部分,科研育人对加强和改进高校思想政治工作、提高人才培养质量意义重大。对当前农林高校科研育人的现状、存在的问题及原因进行了剖析,并以华中农业大学动物医学专业为例,阐述了农林高校科研育人的实现路径:加强党建引领,建立党建+科研育人的新模式;加强“三创”文化建设,营造浓郁的科研育人氛围;加强科教产教融合,形成协同育人的合力;加强科研队伍建设,提升科技工作者的育人能力;加强制度建设,建立健全科研育人的长效机制。

关键词：农林高校科研育人实现路径

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凝视与想象:《回响》的回响——东西小说《回响》和电视剧《回响》读札

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辽宁师范大学学报（社会科学版） 2024年第1期47卷 9-13页

作者：石竹青任子钰辽宁师范大学影视艺术学院辽宁大连116081

文学作品文本与影视艺术剧本的改编由来已久。可以说,中国现当代文学作品,始终为影视创作提供着不竭的文学、文化支撑。影视短剧《回响》以其超高的文本还原度,深度地反映当下的现实情境和时代症候,在想象与现实的缝隙中建构起能够触摸... 详细信息

文学作品文本与影视艺术剧本的改编由来已久。可以说,中国现当代文学作品,始终为影视创作提供着不竭的文学、文化支撑。影视短剧《回响》以其超高的文本还原度,深度地反映当下的现实情境和时代症候,在想象与现实的缝隙中建构起能够触摸灵魂、心灵的场域,激发起警示人性的回响。本文通过对东西的长篇小说《回响》的影视化改编进行分析,从改编策略、主题哲思与心理关照等角度切入,探究在文学与影视交融中,在镜像呈现与文学想象之间,对于现实、人生和时代的多重反思和建构。

关键词：《回响》文学改编文学性想象人性

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Cyclic constitutive equations of rock with coupled damage induced by compaction and cracking

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International Journal of Mining Science and Technology 2022年第5期32卷 1153-1165页

作者： Chonghong ren Jin Yu Xueying Liu zhuqing Zhang Yanyan Cai Fujian Research Center for Tunneling and Urban Underground Space Engineering Huaqiao UniversityXiamen 361021China Xiamen Rail Transit Group Corporation Limited Xiamen 361021China

In this paper,the cyclic constitutive equations were proposed to describe the constitutive behavior of cyclic loading and ***,a coupled damage variable was derived,which contains two parts,i.e.,the compaction-induced damage and the cracking-induced *** compaction-induced damage variable was derived from a nonlinear stress–strain relation of the initial compaction stage,and the cracking-induced damage variable was established based on the statistical damage ***,based on the total damage variable,a damage constitutive equation was proposed to describe the constitutive relation of rock under the monotonic uniaxial compression conditions,whereafter,the application of this model is extended to cyclic loading and unloading *** validate the proposed monotonic and cyclic constitutive equations,a series of mechanical tests for marble specimens were carried out,which contained the monotonic uniaxial compression(MUC)experiment,cyclic uniaxial compression experiments under the variable amplitude(CUC-VA)and constant amplitude(CUC-CA)*** results show that the proposed total damage variable comprehensively reflects the damage evolution characteristic,i.e.,the damage variable firstly decreases,then increases no matter under the conditions of MUC,CUC-VA or *** a reasonable consistency is observed between the experimental and theoretical *** proposed cyclic constitutive equations can simulate the whole cyclic loading and unloading behaviors,such as the initial compaction,the strain hardening and the strain ***,the shapes of the theoretical curves are controlled by the modified coefficient,compaction sensitivity coefficient and two Weibull distributed parameters.

关键词： Cyclic constitutive equations Rock Coupled damage Compaction Cracking

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