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MOOC背景下创新型人才的培养

创新创业理论研究与实践 2018年第17期1卷 49-50,92页

作者：蒋卓颖北京联合大学北京100101 湘潭大学湖南湘潭411105

MOOC平台的运用,有助于对创新型人才形成兴趣的保护、能力的提升、需求的满足、价值的引领、视野的开阔。充分利用MOOC平台优势,可以进一步整合资源、优化机制、加强考核,促进创新型人才成长。

关键词： MOOC 创新型人才教学模式

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粉煤灰低密度水泥浆在塔河油田堵漏中的应用

石油与天然气化工 2018年第1期47卷 79-82页

作者：张云华蒋卓颖李雨威王乐中国石化西南石油工程有限公司固井分公司

作为西北油田的重要勘探开发区块之一,塔河油田托普台区块大部分井存在二叠系,井深4 500~5 200m,厚度50~300m,在钻遇二叠系时漏失严重,塔河10区及12区部分无二叠系井也漏失严重,增加了正常钻进难度,耽误钻井时效,可能诱发井下复杂事故,... 详细信息

作为西北油田的重要勘探开发区块之一,塔河油田托普台区块大部分井存在二叠系,井深4 500~5 200m,厚度50~300m,在钻遇二叠系时漏失严重,塔河10区及12区部分无二叠系井也漏失严重,增加了正常钻进难度,耽误钻井时效,可能诱发井下复杂事故,对油井后期固井等作业影响很大。设计优选粉煤灰低密度水泥浆体系对二叠系进行堵漏。该水泥浆体系密度1.60g/cm^3左右,抗压强度6~8 MPa,漏失严重时可在水泥浆中添加5mm、10mm纤维进行复合堵漏,纤维在裂缝中架桥,形成空间网状结构,提高堵漏效果。该水泥浆体系在现场多口井的堵漏作业表明,能有效地提高地层承压能力,大大缩短了钻井周期,为后期钻井及固井施工创造了有利条件。

关键词：二叠系堵漏固井粉煤灰低密度

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含双温敏单体的耐220℃高温降失水剂

油田化学 2024年第1期41卷 1-9页

作者：李早元陈建黄盛杜培伟蒋卓颖罗龙油气藏地质及开发工程全国重点实验室(西南石油大学) 四川成都610500 中石化西南石油工程有限公司固井分公司四川德阳618000

针对目前油井水泥降失水剂高温条件下耐温性差的问题,通过分子结构设计,以丙烯酰胺(AM)、对苯乙烯磺酸钠(SSS)、双温敏单体N,N-二甲基丙烯酰胺(DMAA)与N,N-二乙基丙烯酰胺(DEAA)为原料,通过水溶液自由基聚合法制备了一种耐高温降失水剂(... 详细信息

针对目前油井水泥降失水剂高温条件下耐温性差的问题,通过分子结构设计,以丙烯酰胺(AM)、对苯乙烯磺酸钠(SSS)、双温敏单体N,N-二甲基丙烯酰胺(DMAA)与N,N-二乙基丙烯酰胺(DEAA)为原料,通过水溶液自由基聚合法制备了一种耐高温降失水剂(LHF-1L)。以失水量为评价指标,对合成条件进行了优选,同时对LHF-1L进行了结构表征和性能评价。结果表明,在AM、SSS、DMAA、DEAA物质的量比为4∶6∶2∶0.5,引发剂为单体总质量0.75%的过硫酸钾(KPS)溶液,反应物溶液pH值为7,反应温度为65℃,反应时间为4 h的条件下制得的LHF-1L的降滤失性能最佳。在220℃、7%加量下的失水量为42 mL。FT-IR、TG和GPC测试结果表明,4个单体均成功参与聚合并生成目标产物。当温度达到273℃后,LHF-1L才出现明显的热损失,其多分散系数为1.396,数均分子量为171 351 g/mol。此外,LHF-1L对水泥浆流动度和水泥石抗压强度发展的影响较小。在220℃下,在水泥浆中加入7%LHF-1L后的失水量仍能控制在50 mL以内。在150℃、94.4 MPa下,LHF-1L不会使水泥浆急剧增稠和超缓凝,稠化曲线正常,未发生异常胶凝现象。采用双温敏单体制备LHF-1L,增强了其在高温下的温敏疏水缔合作用,从而提高了高温降滤失性能,可以满足高温条件下的固井技术需求。

关键词：降失水剂双温敏单体自由基共聚高温油井水泥固井

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构筑互联互通互动的低压网格服务模式

电力系统装备 2023年第7期 162-164页

作者：储凯戴维斯韦笑蒋卓莹镇江三新供电服务有限公司江苏镇江212000

随着物联网的普及和可再生能源利用的快速发展,低压网格的应用需求越来越迫切。但是,低压电网结构松散、规模小、单一业务等限制因素给低压网格的建设和运营带来了很大挑战,因此,如何构筑出一个互联互通互动的低压网格服务模式,成为当... 详细信息

随着物联网的普及和可再生能源利用的快速发展,低压网格的应用需求越来越迫切。但是,低压电网结构松散、规模小、单一业务等限制因素给低压网格的建设和运营带来了很大挑战,因此,如何构筑出一个互联互通互动的低压网格服务模式,成为当前电力行业的一个亟需解决的问题。文章旨在探究低压网格服务模式的构建,为低压电网的智能化发展和优化提供可行性方案和技术支持。通过研究低压网格服务模式的特点和优势,探索构建一个实现互联互通,支持多种业务的低压网格服务模式。未来研究应重点解决面临的挑战和问题,探索出更加成熟和可靠的低压网格服务模式,推进低压电网的智能化和可持续发展。

关键词：低压网格互联互通互动服务模式

Responses of bacterial strains isolated from drinking water environments to N-acyI-L-homoserine lactones and their analogs during biofilm formation

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Frontiers of Environmental Science & Engineering 2014年第2期8卷 205-214页

作者： zhuoying WU1 Qing WANG, Feng GUO Shenghua ZHANG Qipei jiang Xin YU Key Laboratory of Urban Environment and Health Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China

Often as a result ofbiofilm formation, drinking water distribution systems （DWDS） are regularly faced with the problem of microbial contamination. Quorum sensing （QS） systems play a marked role in the regulation of microbial biofilm formation; thus, inhibition of QS systems may provide a promising approach to biofilm formation control in DWDS. In the present study, 22 bacterial strains were isolated from drinking water-related environments. The following properties of the strains were investigated： bacterial biofilm formation capacity, QS signal molecule N-acyl-L-homoserine lactones （AHLs） production ability, and responses to AHLs and AHL analogs, 3-chloro-4-（dichloromethyl）-5-hydroxy-2（5H）- furanone （MX） and 2（5H）-furanone. Four AHLs were added to developed biofilms at dosages ranging from 0.1 nmol.L J to 100nmol.L1. As a result, the biofilm growth of more than 1/4 of the isolates, which included AHL producers and non-producers, were significantly promoted. Further, the biofilm biomasses were closely associated with respective AHLs concentrations. These results provided evidence to support the idea that AHLs play a definitive role in biofilm formation in many of the studied bacteria. Meanwhile, two AHLs analogs demon- strated unexpectedly minimal negative effects on biofilm formation. This suggested that, in order to find an applicable QS inhibition approach for biofilm control in DWDS, the testing and analysis of more analogs is needed.

关键词： drinking water distribution systems (DWDS) biofilm quorum sensing (QS) N-acyl-L-homoserine lac- tones (AHLs) (dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) 2(5H)-furanone

Global pattern and trends of colorectal cancer survival: a systematic review of population-based registration data

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Cancer Biology & Medicine 2022年第2期19卷 175-186页

作者： Yufei jiang Huiyun Yuan zhuoying Li Xiaowei Ji Qiuming Shen Jiayi Tuo Jinghao Bi Honglan Li Yongbing Xiang State Key Laboratory of Oncogene and Related Genes&Department of Epidemiology Shanghai Cancer InstituteRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200032China Renji Hospital Shanghai Jiao Tong University School of MedicineShanghai 200127China School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200025China

This review will describe the global patterns and trends of colorectal cancer survival,using data from the population-based studies or cancer *** performed a systematic search of China National Knowledge Infrastructure(CNKI),Wanfang Data,PubMed,Web of Science,EMBASE,and SEER and collected all population-based survival studies of colorectal cancer(up to June 2020).Estimates of observed and relative survival rates of colorectal cancer by sex,period,and country were extracted from original studies to describe the temporal patterns and trends from the late 1990s to the early 21st ***,5-year observed survival rates were higher in Seoul,Republic of Korea(1993–1997;56.8%and 54.3%for colon and rectum cancers,respectively),Zhejiang province(2005–2010;52.9%for colon cancer),Tianjin(1991–1999;52.5%for colon cancer),Shanghai(2002–2006;50.0%for rectum cancer)of China,and in Japan(1993–1996,59.6%for colorectal cancer).Five-year relative survival rates of colorectal cancer in the Republic of Korea(2010–2014),Queensland,Australia(2005–2012),and the USA(2005–2009)ranked at relatively higher positions compared to other *** general,colorectal cancer survival rates are improving over time *** disparities in survival rates were also observed in the colon,rectum,and colorectal cancers in most countries or *** poorest age-specific 5-year relative survival rate was observed in patients>75 years of *** conclusion,over the past 3 decades,colorectal cancer survival has gradually *** variations,sex differences,and age gradients were also observed globally in colorectal cancer *** studies are therefore warranted to investigate the prognostic factors of colorectal cancer.

关键词： Colorectal cancer survival rate prognosis population-based study cancer registration

Tumor-infiltrating T-Lymphocyte immunity-related immune tolerance and anti–programmed cell death protein 1/ligand of programmed cell death protein 1 therapy for advanced hepatocellular carcinoma

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Oncology and Translational Medicine 2024年第4期10卷 162-170页

作者： Lingzhen Hu Zongren Wang Yang Liao Xiaomeng jiang Huojun Lian zhuoying Lin Department of Gastroenterology Shangrao People’s HospitalShangrao 334000Jiangxi ProvinceChina

Systemic therapy has become the standard treatment for patients with advanced hepatocellular carcinoma(HCC)whose treatment options are ***,the long-term patient response to drugs and the survival outcomes remain a *** increasing exploration of the HCC microenvironment,particularly in terms of T lymphocyte immunity,a new era of immunomolecular targeted therapy,based on molecular signaling,has arrived for advanced *** the study of immune tolerance of the intrinsic HCC microenvironment,we found that multiple immunosuppressive mechanisms and immune checkpoint inhibitors,such as anti–programmed cell death protein 1/ligand of programmed cell death protein 1 therapy,have improved clinical outcomes in some patients with advanced ***,various combination therapies have been investigated,and HCC types have been categorized into different types based on anti–programmed cell death protein 1(PD-1)/ligand of programmed cell death protein 1(PD-L1)*** this paper,we first discuss the tumor-infiltrating T lymphocyte immunity and immune tolerance of *** then clarify the basic mechanism of anti–PD-1/PD-L1 therapy and discuss the types of HCC based on anti–PD-1/PD-L1 ***,we explain the relevant studies and mechanisms of combination therapy of anti–PD-1/PD-L1 with antiangiogenesis drugs or multikinase kinase inhibitors,anti–T lymphocyte–related signaling pathways in HCC,and other anti-CD8+T cell immune *** this way,this review offers a deeper understanding of anti–PD-1/PD-L1 immunotherapy for advanced HCC,in order to provide better individualized treatments for patients with advanced HCC.

关键词： Anti–PD-1/PD-L1 treatment Combination therapy Hepatocellular carcinoma Immune tolerance Tumor-infiltrating T lymphocyte immunity

Transcriptional landscape of rice roots at the single-cell resolution

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Molecular Plant 2021年第3期14卷 384-394页

作者： Qing Liu Zhe Liang Dan Feng Sanjie jiang Yifan Wang zhuoying Du Ruoxi Li Guihua Hu Pingxian Zhang Yanfei Ma Jan ULohmann Xiaofeng Gu Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China Centre for Organismal Studies Heidelberg UniversityHeidelberg 69120Germany BGI Genomics Shenzhen 518083China Fu Foundation School of Engineering and Applied Science Columbia UniversityNew YorkNY 10027USA These authors contributed equally.

There are two main types of root systems in flowering plants,namely taproot systems of dicots and fibrous root systems found in *** this fundamental split,our current knowledge of cellular and molecular mechanism driving root development is mainly based on studies of the dicot model ***,the world major crops are monocots and little is known about the transcriptional programs underlying cell-type specification in this ***,we report the transcriptomes of more than 20000 single cells derived from root tips of two agronomically important rice *** combined computational and experimental analyses we were able to robustly identify most of the major cell types and define novel cell-type-specific marker genes for both ***,we found divergent cell types associated with specific regulatory programs,including phytohormone biosynthesis,signaling,and response,which were well conserved between the two rice *** addition,we detected substantial differences between the cell-type transcript profiles of Arabidopsis and *** species-specific features emphasize the importance of analyzing tissues across diverse model species,including *** together,our study provides insight into the transcriptomic landscape of major cell types of rice root tip at single-cell resolution and opens new avenues to study cell-type specification,function,and evolution in plants.

关键词： single-cell RNA-seq transcriptional landscape rice root plants

免疫组化参数雌激素受体和孕激素受体的临界值在子宫内膜癌中的预后价值

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重庆医科大学学报 2021年第6期46卷 708-715页

作者：蒋鹏胡琢瑛重庆医科大学附属第一医院妇科重庆400016

目的:确定免疫组化参数雌激素受体(estrogen receptor,ER)和孕激素受体(progesterone receptor,PR)在子宫内膜癌中的临界值,更好地评估ER和PR作为子宫内膜癌预后和预测指标的意义。方法:纳入473例接受手术治疗的Ⅰ~Ⅲ期子宫内膜癌患者,... 详细信息

目的:确定免疫组化参数雌激素受体(estrogen receptor,ER)和孕激素受体(progesterone receptor,PR)在子宫内膜癌中的临界值,更好地评估ER和PR作为子宫内膜癌预后和预测指标的意义。方法:纳入473例接受手术治疗的Ⅰ~Ⅲ期子宫内膜癌患者,使用受试者工作特征曲线(receiver operating characteristic curve,ROC曲线)和约登指数确定用于预测子宫内膜癌复发的免疫组化参数ER、PR临界值,使用Cox回归模型分析其与子宫内膜癌预后的相关性。结果:预测Ⅰ~Ⅲ期子宫内膜癌患者复发ER、PR的最佳临界值分别为45%和33%。单因素分析显示ER(Wald=57.948,P=0.000)及PR(Wald=50.538,P=0.000)是内膜癌复发的危险因素;多因素分析显示ER(Wald=9.076,P=0.003)是内膜癌复发的独立危险因素。结论:当ER以45%为临界值时和PR以33%为临界值时最适合预测内膜癌的复发。

关键词：雌激素受体孕激素受体临界值子宫内膜癌复发