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浙江省高校低年级大学生肺结核防治核心知识知晓及社会歧视的调查分析

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中国防痨杂志 2024年第4期46卷 440-448页

作者：李洋陈彬彭颖陈馨仪蒋健敏杭州师范大学公共卫生学院杭州311121 浙江省疾病预防控制中心结核病预防控制所杭州310051

目的:了解浙江省高校低年级大学生肺结核防治核心知识知晓及社会歧视现况,为采取有效措施减少校园结核病歧视提供科学依据。方法:2022年5月1.20日,采用分层整群随机抽样的方法对浙江省20所高校的低年级学生进行电子问卷调查,共发出442... 详细信息

目的:了解浙江省高校低年级大学生肺结核防治核心知识知晓及社会歧视现况,为采取有效措施减少校园结核病歧视提供科学依据。方法:2022年5月1.20日,采用分层整群随机抽样的方法对浙江省20所高校的低年级学生进行电子问卷调查,共发出4427份问卷,收回有效问卷441.份,分析对肺结核防治核心知识知晓情况及对结核病患者歧视态度的现况及其影响因素。结果:20所高校大一、大二大学生对肺结核防治核心知识的总知晓率为81.6%(28804/3531.)。学生对“得肺结核后应到指定结核病定点医疗机构看病”这一核心信息的知晓率最高,为96.2%(4248/441.),而对“肺结核(肺痨)是慢性传染病”的知晓率最低,为51.0%(2251.441.)。全部调查对象中有641.(1..5%)对结核病患者持歧视态度,3773名(85.5%)对结核病患者持非歧视态度。多因素logistic回归分析结果显示,相比于男生而言,女生对结核病患者不易产生歧视态度(OR=0.606,95%CI:0.497~0.739);相比于月均生活费≤500元的学生,月均生活费501.1.00元(OR=0.51.,95%CI:0.282~0.935)、1.01.1.00元(OR=0.459,95%CI:0.267~0.789)、1.01.2000元(OR=0.436,95%CI:0.254~0.747)和>2000元(OR=0.492,95%CI:0.283~0.857)的学生对结核病患者的歧视态度相对更低;知晓“肺结核(肺痨)是慢性传染性疾病”(OR=0.801.95%CI:0.671.0.956),“咳嗽、咳痰2周以上或痰中带血应当怀疑得了肺结核”(OR=0.608,95%CI:0.448~0.825),“在校期间,出现肺结核可疑症状或被诊断为肺结核后,应当主动向学校报告,不隐瞒病情、不带病上课”(OR=0.405,95%CI:0.332~0.494),以及“早睡早起、饮食均衡、坚持锻炼可以提高身体抵抗力”(OR=0.639,95%CI:0.503~0.81.)的调查对象对结核病患者的歧视态度明显低于其他人群。结论:浙江省高校大一、大二学生具备一定的结核病防控知识,但对肺结核的认知还不全面,且仍存在对结核病患者的歧视态度。学校应进一步加强对男生、月均生活费水平较低大学生的健康教育,并从入学初始开展理论和实践教育来改善学生对结核病患者的态度。

关键词：结核学生偏见因素分析,统计学

SLC9A7基因变异所致X连锁精神发育迟滞1.患儿的临床特征及遗传学分析

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中华医学遗传学杂志 2024年第6期41卷 730-733页

作者：李维付天骄 TAMANG SPANA 王瑶王怀立禚志红郑州大学第一附属医院儿科郑州450052 郑州大学第一附属医院儿童重症监护室郑州450052

目的:对1.临床表现为智力低下、语言及运动发育落后、癫痫的患儿进行临床和遗传学分析。方法:以1.因"间断抽搐2个月"为代主诉于2020年3月就诊于郑州大学第一附属医院儿科的患儿为研究对象。收集患儿的临床资料,采集患儿及其父母的外... 详细信息

目的:对1.临床表现为智力低下、语言及运动发育落后、癫痫的患儿进行临床和遗传学分析。方法:以1.因"间断抽搐2个月"为代主诉于2020年3月就诊于郑州大学第一附属医院儿科的患儿为研究对象。收集患儿的临床资料,采集患儿及其父母的外周血样进行高通量测序,对候选变异进行Sanger测序家系验证及生物信息学分析。结果:患儿表现为智力低下、语言及运动发育迟缓、癫痫发作。高通量测序结果显示其SLC9A7基因上存在半合剪接位点变异(NM_032591.3:c.1.30-1.>C),遗传自母亲,既往未见报道。结论:SLC9A7基因半合剪接位点变异(c.1.30-1.>C)可能是该患儿的遗传学病因。

关键词： SLC9A7基因 X连锁精神发育迟滞高通量测序

Early lung injury contributes to lung fibrosis via AT1.receptor in rats

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Acta Pharmacologica Sinica 2007年第2期28卷 227-237页

作者： Fang-ping chen~(1.2) Li-kun GONG~1.Ling ZHANG~3 Hui WANG~(1.2) Xin-ming QI~(1.2) Xiong-fei WU~(1.2) Ying XIAO~(1.2) Yan CAI~(1.2) Lin-lin LIU~(1.2) Xiang-hong LI~1.Jin REN~(1.4)1.State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 201.03,China 2 Graduate School of the Chinese Academy of Sciences,Shanghai Branch,Shanghai 200031.China 3 Shanghai Pulmonary Hospital,Shanghai 200043,China State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China Graduate School of the Chinese Academy of Sciences Shanghai Branch Shanghai China Shanghai Pulmonary Hospital Shanghai China

Aim:Angiotensin Ⅱ is believed to play an important role in tissue repair andremodeling in lungs by the angiotensin type I(AT1.receptor via a number ofpotential ***,the role of the AT1.receptor in early lung injuryhas not been ***:Bleomycin-induced pulmonary fibrosis(PF)in rats was utilized to value the treatment with valsartan,an AT1.receptorantagonist,by measurement of body weight,wet weight of the left lung,hydroxy-proline content,mRNA expression of collagen Ⅰ/Ⅲ,and the degree of fibrosis inlung tissues on d *** injury in the early phase was assessed on d 1.3 and7 by apoptosis,malondialdehyde content,myeloperoxidase activity,inflamma-tory cell count and protein *** converting enzyme(ACE)activ-ity and the AT1.receptor in lung tissues were analyzed by biochemistry methodand Western blotting,***:Valsartan ameliorated PF induced bybleomycin in the rats on d *** bleomycin was injected intratracheally,in-creases in the lung AT1.receptor and ACE activity were observed by d 1.3 and *** injury deteriorated in the early *** reduced the increase of theAT1.receptor,ACE activity and lung injury induced by bleomycin in the ***:These observations suggest that angiotensin Ⅱ may play apotent role in early lung injury via the AT1.***1.receptor antagonistsshould be assessed as potential new therapies for fibrotic lung disease.

关键词： angiotensin II AT1.receptor pulmonary fibrosis lung injury

本安型电磁阀动静态特性分析及影响参数优化研究

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工矿自动化 2024年第6期50卷 150-158页

作者：姚卓王伟韦文术卢德来李向波北京天玛智控科技股份有限公司北京101399

针对在驱动功率和电磁阀体积约束下存在的电磁铁驱动力不足、电磁阀响应速度慢的问题,分析了电磁阀的动静态特性,通过仿真分析和样机试验验证了提高本安型电磁铁电磁力可明显改善电磁阀的响应特性,确定了通过优化电磁力改善电磁阀响应... 详细信息

针对在驱动功率和电磁阀体积约束下存在的电磁铁驱动力不足、电磁阀响应速度慢的问题,分析了电磁阀的动静态特性,通过仿真分析和样机试验验证了提高本安型电磁铁电磁力可明显改善电磁阀的响应特性,确定了通过优化电磁力改善电磁阀响应特性的方案。提出了本安型电磁铁特性评价指标:有效行程指标、平均电磁力指标和静态综合性能指标,解决了因电磁铁行程不同而造成的电磁铁性能评价困难的问题。利用Maxwell电磁仿真软件分析了导向筒深度变化量δ_(a)、衔铁半径变化量δ_(b)、非工作气隙变化量δ_(c1.、非工作气隙变化量δ_(c2)、盆口高度变化量δd对电磁铁静态特性的影响,得到不同参数对静态特性的敏感度,为参数优化中尺寸控制范围的选择提供参考依据。通过正交试验结果构建了铁芯结构参数对电磁铁综合特性评价指标的二阶响应面模型,利用遗传算法对铁芯参数进行优化。样机试验结果表明:优化后电磁铁水平段电磁力提升了50%,有效行程提高了26%,本安型电磁阀的开启响应时间缩短了52.5%。

关键词：本安型电磁阀本安型电磁铁电磁力动静态特性响应特性遗传算法铁芯参数优化

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自由活塞发动机电动压气机优化及熵产分析

内燃机学报 2024年第1期42卷 78-86页

作者：陈雪康施新胡晨星北京理工大学机械与车辆学院北京100081

为了使设计工况下匹配的增压器性能更优从而提高系统能量利用率,针对自由活塞发动机匹配的电动压气机,采用遗传算法对原压气机进行了优化,研究了优化前、后压气机内部流场特性,以熵产分析的方法量化了3种不可逆因素导致的流动损失,并将... 详细信息

为了使设计工况下匹配的增压器性能更优从而提高系统能量利用率,针对自由活塞发动机匹配的电动压气机,采用遗传算法对原压气机进行了优化,研究了优化前、后压气机内部流场特性,以熵产分析的方法量化了3种不可逆因素导致的流动损失,并将优化前、后压气机熵产和涡度分布对比分析,进一步明确了压气机的优化策略.结果表明:叶轮和扩压器中湍流耗散、传热耗散和黏性耗散的比例近乎为6∶3∶1.不可逆损失主要集中在叶顶间隙和叶片压力面,损失来源为间隙泄漏流与部分主流掺混形成的反向涡团.压壳中湍流耗散占比超过85%,具体表现为局部损失和沿程损失.优化后压气机等熵效率提高了6%,流道内涡团的范围、幅值大幅减小,不可逆流动损失降低.上述工作揭示了压气机流场中不同耗散机制的不可逆因素对能量损失的影响机理,为压气机气动优化设计提供指导.

关键词：自由活塞发动机电动压气机不可逆流动损失熵产涡度

Oil accumulation related to migration of source kitchens in the Lukeqin structural belt, Turpan-Hami Basin, China

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Petroleum Science 2010年第3期7卷 355-361页

作者： Liu Bo Huang Zhilong Tu Xiaoxian Sang Tingyi chen Xuan State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum Beijing 102249 China PetroChina Turpan-Hami Oilfield Company Hami Xinjiang 839009 China

The Lukeqin structural belt is the main heavy oil accumulation zone in the Turpan-Hami Basin. The recent discovery of light oil in the Triassic indicates that there may be multiple source kitchens contributing to the oil accumulation. According to oil geochemical analysis and oil-source correlation, the oil in deep and shallow reservoirs of the Lukeqin Oilfield presents different physical and saturated hydrocarbon mass spectrum characteristics. The Triassic heavy oil is from the northern Upper Permian lacustrine source rocks, and the light oil represented by the Yudong-9 Well is from the northwestern Lower Jurassic coal-measure source rocks. The timing of oil charging was determined by K/Ar isotope dating, reservoir fluid inclusion analysis and the evolution history of different source rocks. In summary, the accumulation process consists of two stages. From the end of Triassic to early Jurassic, the northern Permian source kitchen generated a considerable amount of oil, which was finally degraded to heavy oil, migrated to the south and then accumulated. The northwestern Jurassic coal-measure source kitchen began to generate oil at the end of Cretaceous, while the northern source kitchen could only generate a little hydrocarbon. The heavy oil and the light oil have different source rock locations, migration directions and accumulation times. The migration of hydrocarbon source kitchens affects the distribution of heavy oil and light oil reservoirs at the present time.

关键词： Source kitchen light oil oil-source correlation timing of oil charging Turpan-Hami Basin

Long-term protection effects of national reserve to forest vegetation in 4 decades: biodiversity change analysis of major forest types in Changbai Mountain Nature Reserve, China

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Science China(Life Sciences) 2008年第10期51卷 948-958页

作者： BAI Fan1. SANG WeiGuo1. LI GuangQi1. LIU RuiGang1. chen LingZhi1.& WANG Kun2 1.State Key Laboratory of Vegetation and Environment Change, Institute of Botany, Chinese Academy of Sciences, Beijing 1.0093, China 2 Nature Reserve Bureau of Changbaishan, Jilin 21.01., China State Key Laboratory of Vegetation and Environment Change Institute of Botany Chinese Academy of Sciences Beijing China Nature Reserve Bureau of Changbaishan Jilin China

The Changbai Mountain Nature Reserve (CNR) was established in 1.60 to protect the virgin Korean pine mixed hardwood forest, a typical temperate forest of northeast China. We conducted systematic stud- ies of vascular diversity patterns on the north slope of the CNR mountainside forests (800-1.00 m a.s.l.) in 1.63 and 2006 respectively. The aim of this comparison is to assess the long-term effects of the protection on plant biodiversity of CNR during the interval 43 years. The research was carried out in three types of forests: mixed coniferous and broad-leaved forest (MCBF), mixed coniferous forest (MCF), and sub-alpine coniferous forest (SCF), characterized by different dominant species. The alpha diversity indicted by species richness and the Shannon-Wiener index were found different in the same elevations and forest types during the 43-year interval. The floral composition and the diversity of vascular species were generally similar along altitudinal gradients before and after the 43-year interval, but some substantial changes were evident with the altitude gradient. In the tree layers, the dominant species in 2006 were similar to those of 1.63, though diversity declined with altitude. The indices in the three forest types did not differ significantly between 1.63 and 2006, and these values even increased in the MCBF and MCF from 1.63 to 2006. However, originally dominant species, P. koraiensis for ex- ample, tended to decline, while the proportion of broad-leaved trees increased, and the species turn- over in the succession layers trended to shift to higher altitudes. The diversity pattern of the under canopy fluctuated along the altitudinal gradient due to micro-environmental variations. Comparison of the alpha diversity in the three forests shows that the diversity of the shrub and herb layer decreased with time. During the process of survey, we also found some rare and medicinal species disappeared. Analysis indicates that the changes of the diversity pattern

关键词： plant species diversity climate change forest community human activity Changbai Mountain

光强对木麻黄幼苗根系形态、解剖结构及其碳氮含量的影响

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生态学报 2024年第10期44卷 4377-4387页

作者：陈子川潘国营陈灿徐云鹏林晗陈煜谢安强范海兰福建农林大学林学院福州350002 森林生态系统过程与经营福建省高校重点实验室福州350002 晋江坫头国有防护林场晋江362200 福建农林大学生命科学学院福州350002

对光环境的灵敏响应使得森林中常见的光照异质性成为影响植物自我更新的关键因素,然而植物地下根系结构对光照的响应较为难测而缺乏深入研究。为探究不同光强下木麻黄根系响应策略,以一年生木麻黄(Casuarina equisetifolia)幼苗为试验材... 详细信息

对光环境的灵敏响应使得森林中常见的光照异质性成为影响植物自我更新的关键因素,然而植物地下根系结构对光照的响应较为难测而缺乏深入研究。为探究不同光强下木麻黄根系响应策略,以一年生木麻黄(Casuarina equisetifolia)幼苗为试验材料,模拟森林幼苗生长的林外(CK)、林缘(L1.、林窗(L2)和林下光环境(L3)设置4种光照强度,测定及分析木麻黄幼苗的生长、根系形态、细根解剖结构及碳氮含量等指标。结果表明:(1.L1.,幼苗采取维持高度,降低横向生长的方式,保证正常累积生物量,随光照强度的下降,株高、地径、叶片生物量及地上部分生物量逐渐下降。(2)在根系表型上,幼苗随光限制的加重呈现抑制纵伸但促进根系的横向生长,其中总根长、根平均直径及根体积达到显著差异。在径级结构上,细根发育程度随光照减弱而下降;而适当的遮光(L1.促进粗根生长但L3时除根尖数较CK上升外,根长度、根表面积、根体积均显著下降。(3)1.3级细根解剖变化较大,相较CK,1.细根皮层细胞面积显著增加,但根半径、维管柱结构、表皮厚度等指标则显著下降,2级细根根半径、皮层细胞面积、表皮厚度明显减少,但维管柱结构仅在L2、L3时显著下降;3级细根根半径、皮层细胞面积和维管柱面积均较CK显著增大,L1.维管柱结构下降,但随光照减弱加重,维管柱面积和中柱占比均明显增加。(4)在碳氮含量上,CK与L1.显著差异,TC在L2时显著下降,TN则在L2时显著上升,TC、TN均在L3达到最大,而C:N随光强降低逐渐下降。综上所述,光限制时,木麻黄生物量及碳分配稳定根茎部分生长,采取“弱化吸收,强化储存”收缩型生长策略;当限制加重时,光合和呼吸作用失衡导致植物对细根投入养分的浪费,并最终造成林木死亡。研究结果为林下植被的更新提供理论参考。

关键词：光强木麻黄根系形态结构根系解剖结构根系养分

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Normal scalar curvature and a pinching theorem in S^m×R and H^m×R

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Science China Mathematics 2011年第9期54卷 1977-1984页

作者： chen Qun 1.2 & CUI Qing 3,1.1.School of Mathematics and Statistics,Wuhan University,Wuhan 430079,China 2 International Center for Theoretical Physics,Trieste 341.0,Italy 3 School of Mathematics,Southwest Jiaotong University,chengdu 61.031.China School of Mathematics and Statistics Wuhan University Wuhan China International Center for Theoretical Physics Trieste Italy School of Mathematics Southwest Jiaotong University Chengdu China

We obtain an inequality in Sm×R and Hm×R which is similar to DDVV *** an application,we show that a minimal submanifold in H m×R with nonnegative scalar curvature must be a surface of the type γ×R,where γ is a g... 详细信息

关键词： product spaces DDVV conjecture pinching theorem